Blood speed imaging with an intraluminal array

In applications in which Doppler processing is not possible, such as side-looking intravascular imaging systems, decorrelation methods can be used to estimate blood speed. Here, a method is presented measuring relative blood speed using an FIR filter bank to estimate temporal decorrelation rates. It can be implemented in a modern commercially available ultrasound imaging system with no additional hardware. Both simulations and experiments using an intraluminal scanner appropriate for coronary artery applications have tested the system. In this study, the FIR filter bank is contrasted with previous methods, and its utility is further demonstrated with real-time color flow images from a pig model.     

3-D flow velocity vector estimation with a triple-beam lens transducer-experimental results

Current commercial ultrasound blood flow measurement systems only measure the axial component of the true blood flow velocity vector. In order to overcome this limitation, a technique which tracks blood cell scatterers as they move between three ultrasound beams has been developed. With this technique, the entire 3-D blood flow velocity vector can be estimated. Previous work has presented the theory behind the technique, lens transducer design and construction, as well as results of computer simulations and preliminary experimental results. This work presents the first experimental results obtained with a prototype system for continuous, fully developed flow in a flow phantom under a wide range of flow rates and flow directions. The results indicate that the accurate measurement of the 3-D flow velocity vector using this technique is possible.     

Microcirculation volumetric flow assessment using high-resolution, contrast-assisted images

To improve the resolution of contrast-assisted imaging systems, we previously developed a 25-MHz microbubbles-destruction/replenishment imaging system with a spatial resolution of 160 X 160 microm. The goal of the present study was to propose a new approach for functionally evaluating the microvascular volumetric blood flow based on this high-frequency, ultrasound imaging system. The approach includes locating the perfusion area and estimating the blood flow velocity therein. Because the correlation changes between before and after microbubble destruction in two adjacent images, a correlated-based approach was introduced to detect the blood perfusion area. We also have derived a new sigmoid-based model for characterizing the microbubbles replenishment process. Two parameters derived from the sigmoid-based model - the rate constant and inflection time - were adopted to evaluate the blood flow velocity. This model was validated using both simulations and in vitro experiments for mean flow velocities ranging from 1 to 10 mm/s, which showed that the model was in good agreement with simulated and measured microbubble-replenishment time-intensity curves. The results indicate that the actual flow velocity is highly correlated with the estimates of the rate constant and the reciprocal of the inflection time. B-mode imaging experiments for mean flow velocities ranging from 0.4 to 2.1 mm/s were used to assess the volumetric flow in the microcirculation. The results indicated the high correlation between the actual volumetric flow rate and the product of the estimated perfusion area and rate constant, and the reciprocal of the inflection time. We also found that the boundary of the microbubble destruction volume significantly affected estimations of the flow velocity. The perfusion area can be located, and the corresponding flow velocity can be estimated simultaneously in a one-stage, microbubble-destruction/replenishment process, which makes the assessment of the volumetric bloo- d flow in the microcirculation feasible using a real-time, high-frequency ultrasound system.     

结合横向振荡和空间正交的向量血流速度测量

传统的彩色多普勒成像只能测量与超声波束平行的血流速度分量,且依赖于超声波束与血管之间的夹角。超声向量血流成像是一种更加先进的血流成像技术,该方法可以直接获得血流速度的实际大小和方向,因此不依赖于超声波束与血管之间的夹角。本文从向量血流测量方法之一的横向声场法入手,简要概括了横向振荡(Transverse Oscillation, TO)法和空间正交(Spatial Quadrature, SQ)法两种方法的基本原理、成像过程及各自的优缺点,并提出了一种互相结合的方法,即奇偶振荡法(Odd Even Oscillation, OEO),该方法利用SQ法快速进行波束合成,利用TO法计算最终的速度矢量,克服了TO法和SQ法各自的缺点,能够有效解决TO法成像计算量大以及SQ法出现混叠和对噪声灵敏度高的问题。     

High frame-rate blood vector velocity imaging using plane waves: simulations and preliminary experiments

Conventional ultrasound methods for acquiring color images of blood velocity are limited by a relatively low frame-rate and are restricted to give velocity estimates along the ultrasound beam direction only. To circumvent these limitations, the method presented in this paper uses 3 techniques: 1) The ultrasound is not focused during the transmissions of the ultrasound signals; 2) A 13-bit Barker code is transmitted simultaneously from each transducer element; and 3) The 2-D vector velocity of the blood is estimated using 2-D cross-correlation. A parameter study was performed using the Field II program, and performance of the method was investigated when a virtual blood vessel was scanned by a linear array transducer. An improved parameter set for the method was identified from the parameter study, and a flow rig measurement was performed using the same improved setup as in the simulations. Finally, the common carotid artery of a healthy male was scanned with a scan sequence that satisfies the limits set by the Food and Drug Administration. Vector velocity images were obtained with a frame-rate of 100 Hz where 40 speckle images are used for each vector velocity image. It was found that the blood flow approximately followed the vessel wall, and that maximum velocity was approximately 1 m/s, which is a normal value for a healthy person. To further evaluate the method, the test person was scanned with magnetic resonance (MR) angiography. The volume flow derived from the MR scanning was compared with that from the ultrasound scanning. A deviation of 9% between the 2 volume flow estimates was found.     

In-vivo synthetic aperture flow imaging in medical ultrasound

A new method for acquiring flow images using synthetic aperture techniques in medical ultrasound is presented. The new approach makes it possible to have a continuous acquisition of flow data throughout the whole image simultaneously, and this can significantly improve blood velocity estimation. Any type of filter can be used for discrimination between tissue and blood flow without initialization, and the number of lines used for velocity estimation is limited only by the nonstationarity of the flow. The new approach is investigated through both simulations and measurements. A flow rig is used for generating a parabolic laminar flow, and a research scanner is used for acquiring RF data from individual transducer elements. A reference profile is calculated from a mass flow meter. The parabolic velocity profile is estimated using the new approach with a relative standard deviation of 2.2% and a mean relative bias of 3.4% using 24 pulse emissions at a flow angle of 45 degrees. The 24 emissions can be used for making a full-color flow map image. An in-vivo image of flow in the carotid artery for a 29-year-old male also is presented. The full image is acquired using 24 emissions.     

Directional velocity estimation using focusing along the flow direction. I: Theory and simulation

A new method for directional velocity estimation is presented. The method uses beam formation along the flow direction to generate data in which the correct velocity magnitude can be directly estimated from the shift in position of the received consecutive signals. The shift is found by cross-correlating the beamformed lines. The approach can find the velocity in any direction, including transverse to the traditionally emitted ultrasound beam. The velocity estimation is studied through extensive simulations using Field II. A 128-element, 7-MHz linear array is used. A parabolic velocity profile with a peak velocity of 0.5 m/s is simulated for different beam-to-flow angles and for different emit foci. At 45/spl deg/ the relative standard deviation over the profile is 1.6% for a transmit focus at 40 mm. At 90/spl deg/ the approach gave a relative standard deviation of 6.6% with a transmit focus of 80 mm, when using 8 pulse-echo lines and stationary echo canceling. Pulsatile flow in the femoral artery was also simulated using Womersley's flow model. A purely transverse flow profile could be obtained with a relative standard deviation of less than 10% over the whole cardiac cycle using 8 pulse emissions for each imaging direction, which is sufficient to show clinically relevant transverse color flow images.     

Clutter filters adapted to tissue motion in ultrasound color flow imaging

The quality of ultrasound color flow images is highly dependent on sufficient attenuation of the clutter signals originating from stationary and slowly moving tissue. Without sufficient clutter rejection, the detection of low velocity blood flow will be poor, and the velocity estimates will have a large bias. In some situations, e.g., when imaging the coronary arteries or when the operator moves the probe in search for small vessels, there is considerable movement of tissue. It has been suggested that clutter rejection can be improved by mixing down the signal with an estimate of the mean frequency prior to high pass filtering. In this paper, we compare this algorithm with several other adaptive clutter filtering algorithms using both experimental data and simulations. We found that realistic accelerations of the tissue have a large effect on the clutter rejection. The best results were obtained by mixing down the signal with non-constant phase increments estimated from the signal. This adapted the filter to a possibly accelerated tissue motion and produced a significant improvement in clutter rejection     

Frequency domain compensation for inhomogeneous layers in ultrasound holography

A frequency-domain compensation method is presented that is based on the ultrasound holography B-scan (UHB) imaging principle. In an acoustic imaging system, the wavefront-angle-dependent distortions caused by any kind of known inhomogeneous reason can be compensated by this method. It is applied here in the frequency domain using the so-called rear-ranging operation for the longitudinal distortion and the multiplication of phase factors for the lateral distortion. The method is especially suitable for compensating different velocity layers in acoustic imaging systems. The results of both computer simulations and water-tank experiments are promising.     

Decorrelation-based blood flow velocity estimation: effect of spread of flow velocity,linear flow velocity gradients,and parabolic flow

In recent years, a new method to measure transverse blood flow, based on the decorrelation of the radio frequency (RF) signals has been developed. In this paper, we investigated the influence of nonuniform flow on the velocity estimation. The decorrelation characteristics of transverse blood flow using an intravascular ultrasound (IVUS) array catheter are studied by means of computer modeling. Blood was simulated as a collection of randomly located point scatterers; moving this scattering medium transversally across the acoustical beam represented flow. First-order statistics were evaluated, and the signal-to-noise ratio from the signals were measured. The correlation coefficient method was used to present the results. Three velocity profiles were simulated: random spread of blood-flow velocity, linear blood-flow velocity gradient, and parabolic blood-flow. Radio frequency and envelope signals were used to calculate the decorrelation pattern. The results were compared to the mean decorrelation pattern for plug blood-flow. The RF signals decorrelation patterns were in good agreement with those obtained for plug blood flow. Envelope decorrelation patterns show a close agreement with the one for plug blood flow. For axial blood flow, there is a discrepancy between decorrelation patterns. The results presented here suggest that the decorrelation properties of an IVUS array catheter for measuring quantitative transverse blood flow probably will not be affected by different transverse blood-flow conditions     

Blood flow imaging--A new real-time, 2-D flow imaging technique

This paper presents a new method for the visualization of two-dimensional (2-D) blood flow in ultrasound imaging systems called blood flow imaging (BFI). Conventional methods of color flow imaging (CFI) and power Doppler (PD) techniques are limited as the velocity component transversal to the ultrasound beam cannot be estimated from the received Doppler signal. The BFI relies on the preservation and display of the speckle pattern originating from the blood flow scatterer signal, and it provides qualitative information of the blood flow distribution and movement in any direction of the image. By displaying speckle pattern images acquired with a high frame rate in slow motion, the blood flow movement can be visually tracked from frame to frame. The BFI is easily combined with conventional CFI and PD methods, and the resulting display modes have been shown to have several advantages compared to CFI or PD methods alone. Two different display modes have been implemented: one combining BFI with conventional CFI, and one combining BFI with PD. Initial clinical trials have been performed to assess the clinical usefulness of BFI. The method especially has potential in vascular imaging, but it also shows potential in other clinical applications.     

Lateral blood flow velocity estimation based on ultrasound speckle size change with scan velocity

Conventional (Doppler-based) blood flow velocity measurement methods using ultrasound are capable of resolving the axial component (i.e., that aligned with the ultrasound propagation direction) of the blood flow velocity vector. However, these methods are incapable of detecting blood flow in the direction normal to the ultrasound beam. In addition, these methods require repeated pulse-echo interrogation at the same spatial location. A new method has been introduced which estimates the lateral component of blood flow within a single image frame using the observation that the speckle pattern corresponding to blood reflectors (typically red blood cells) stretches (i.e., is smeared) if the blood is moving in the same direction as the electronically-controlled transducer line selection in a 2-D image. The situation is analogous to the observed distortion of a subject photographed with a moving camera. The results of previous research showed a linear relationship between the stretch factor (increase in lateral speckle size) and blood flow velocity. However, errors exist in the estimation when used to measure blood flow velocity. In this paper, the relationship between speckle size and blood flow velocity is investigated further with both simulated flow data and measurements from a blood flow phantom. It can be seen that: 1) when the blood flow velocity is much greater than the scan velocity (spatial rate of A-line acquisition), the velocity will be significantly underestimated because of speckle decorrelation caused by quick blood movement out of the ultrasound beam; 2) modeled flow gradients increase the average estimation error from a range between 1.4% and 4.4%, to a range between 4.4% and 6.8%; and 3) estimation performance in a blood flow phantom with both flow gradients and random motion of scatterers increases the average estimation error to between 6.1% and 7.8%. Initial attempts at a multiple-scan strategy for estimating flow by a least-squares model suggest the possibility of increased accuracy using multiple scan velocities.     

Experimental investigations and CFD modeling for flow of highly concentrated iron ore slurry through horizontal pipeline

Considering a large number of higher solids concentration iron ore slurry pipelines operating across the world and their associated problems, the present study aims to generate an extensive experimental dataset from the pilot plant test facility and to carry out computational fluid dynamics (CFD) simulations for better understanding of the flow behavior in such pipelines. The paper has presented experimental data of 12?µm iron-ore slurry flow cases through 105?mm pipe with flow velocity range 1.35–5.11?m/s and efflux concentration range 2.63–31%. The obtained results are validated using CFD using appropriate model. In addition, qualitative analysis of iron-ore slurry flow cases using simulated results has been presented.     

Hydrodynamic studies on fluidization of Red mud: CFD simulation

Hydrodynamic studies are carried out for the fluidization process using fine i.e. Geldart-A particles. Effects of superficial velocity on bed pressure drop and bed expansion is studied in the present work. Commercial CFD software package, Fluent 13.0 is used for simulations. Red mud obtained as waste material from Aluminum industry having average particle size of 77 microns is used as the bed material. Eulerian–Eulerian model coupled with kinetic theory of granular flow is used for simulating unsteady gas–solid fluidization process. Momentum exchange coefficients are calculated using the Gidaspow drag functions. Standard k–ε model has been used to describe the turbulent pattern. Bed pressure drop and bed expansion studies are simulated by CFD which are explained with the help of contour and vector plots. CFD simulation results are compared with the experimental findings. The comparison shows that CFD modeling is capable of predicting the hydrodynamic behaviors of gas–solid fluidized bed for fine particles with reasonable accuracy.     

A full-wave Helmholtz model for continuous-wave ultrasound transmission

A full-wave Helmholtz model of continuous-wave (CW) ultrasound fields may offer several attractive features over widely used partial-wave approximations. For example, many full-wave techniques can be easily adjusted for complex geometries, and multiple reflections of sound are automatically taken into account in the model. To date, however, the full-wave modeling of CW fields in general 3D geometries has been avoided due to the large computational cost associated with the numerical approximation of the Helmholtz equation. Recent developments in computing capacity together with improvements in finite element type modeling techniques are making possible wave simulations in 3D geometries which reach over tens of wavelengths. The aim of this study is to investigate the feasibility of a full-wave solution of the 3D Helmholtz equation for modeling of continuous-wave ultrasound fields in an inhomogeneous medium. The numerical approximation of the Helmholtz equation is computed using the ultraweak variational formulation (UWVF) method. In addition, an inverse problem technique is utilized to reconstruct the velocity distribution on the transducer which is used to model the sound source in the UWVF scheme. The modeling method is verified by comparing simulated and measured fields in the case of transmission of 531 kHz CW fields through layered plastic plates. The comparison shows a reasonable agreement between simulations and measurements at low angles of incidence but, due to mode conversion, the Helmholtz model becomes insufficient for simulating ultrasound fields in plates at large angles of incidence.     

基于磁流体动力学的电磁流量计数值模拟

通过计算流体力学和磁流体动力学的耦合计算,直接给出了一种电磁流量计二维模型里流动(层流)和外加磁场(均匀稳态)的相互作用结果,并得到信号输出即感应电动势与流量的基本关系以及其他变量如感应电场与感应电流的详细空间分布。模拟结果符合理论值,表明可利用磁流体动力学数值模拟来广泛研究不同流场和外加磁场分布下电磁流量计特性。     

Stable and unbiased flow turbulence estimation from pulse echo ultrasound

A new method for stable and unbiased flow turbulence estimation has been developed for medical ultrasonic color flow imaging. Conventional turbulence estimates from a finite number of transmitted pulses could be biased, unreliable, and erroneous. We found that a conventional method cannot provide quantitative estimates of variance of flow velocity. We propose a new approach for flow turbulence estimation that is based on analysis of the flow velocity vectors. The new method estimates the variance of the flow velocity and provides reliable estimates for flow turbulence. Numerical examples, computer simulations, and experiments using a flow phantom demonstrate that the new method can estimate variance of flow velocity accurately and without bias. This work also reports a complete derivation in the time domain for both unbiased velocity and turbulence estimations. The results include two velocity estimation equations agreeing with the 1-D and 2-D autocorrelation methods derived from the frequency domain. The results indicate that the new method for flow turbulence is particularly useful when the 2-D autocorrelation method is used for color flow imaging. The new method also appears to be able to detect low turbulence; therefore, it may be useful for diagnosing abnormalities such as minor stenoses and valvular jets.     

高压均质物料流场的数值分析

 利用计算流体动力学商业软件对均质阀内部流场进行可视化研究.采用CFD建模并模拟求解所得到的结果与先前研究人员采用半经验半理论的研究方法所得结果较为吻合.基于研究结果,提出一种计算压降与间隙的基本数学模型,并采用遗传算法和非线性回归算法对数值结果进行拟合,验证了模型的合理性.该研究结果能够给出均质阀体内流场中各个参数变化的详细信息,同时展示了实验手段所不能观察到的流动现象,对进行均质阀结构设计以及对流场的深入分析具有一定的指导作用.     

Quantitative blood speed imaging with intravascular ultrasound

Previously, we presented a method of real-time arterial color flow imaging using an intravascular ultrasound (IVUS) imaging system, where real-time RF A-scans were processed with an FIR (finite-impulse response) filter bank to estimate relative blood speed. Although qualitative flow measurements are clinically valuable, realizing the full potential of blood flow imaging requires quantitative flow speed and volume measurements in real time. Unfortunately, the rate of RF echo-to-echo decorrelation is not directly related to scatterer speed in a side-looking IVUS system because the elevational extent of the imaging slice varies with range. Consequently, flow imaging methods using any type of decorrelation processing to estimate blood speed without accounting for spatial variation of the radiation pattern will have estimation errors that prohibit accurate comparison of speed estimates from different depths. The FIR filter bank approach measures the rate of change of the ultrasound signal by estimating the slow-time spectrum of RF echoes. A filter bank of M bandpass filters is applied in parallel to estimate M components of the slow-time DFT (discrete Fourier transform). The relationship between the slow-time spectrum, aperture diffraction pattern, and scatterer speed is derived for a simplified target. Because the ultimate goal of this work is to make quantitative speed measurements, we present a method to map slow time spectral characteristics to a quantitative estimate. Results of the speed estimator are shown for a simulated circumferential catheter array insonifying blood moving uniformly past the array (i.e., plug flow) and blood moving with a parabolic profile (i.e., laminar flow)     

A new formalism for the quantification of tissue perfusion by the destruction-replenishment method in contrast ultrasound imaging

A new formalism is presented for the destruction-replenishment perfusion quantification approach at low mechanical index. On the basis of physical considerations, best-fit methods should be applied using perfusion functions with S-shape characteristics. These functions are first described for the case of a geometry with a single flow velocity, then extended to the case of vascular beds with blood vessels having multiple flow velocity values and directions. The principles guiding the analysis are, on one hand, a linearization of video echo signals to overcome the log-compression of the imaging instrument, and, on the other hand, the spatial distribution of the transmit-receive ultrasound beam in the elevation direction. An in vitro model also is described; it was used to confirm experimentally the validity of the approach using a commercial contrast agent. The approach was implemented in the form of a computer program, taking as input a sequence of contrast-specific images, as well as parameters related to the ultrasound imaging equipment used. The generated output is either flow-parameter values computed in regions-of-interest, or parametric flow-images (e.g., mean velocity, mean transit time, mean flow, flow variance, or skewness). This approach thus establishes a base for extracting information about the morphology of vascular beds in vivo, and could allow absolute quantification provided that appropriate instrument calibration is implemented.