共查询到19条相似文献,搜索用时 10 毫秒
1.
Morteza Jeyhani Risavarshni Thevakumaran Niki Abbasi Dae Kun Hwang Scott S. H. Tsai 《Small (Weinheim an der Bergstrasse, Germany)》2020,16(7)
Higher order emulsions are used in a variety of different applications in biomedicine, biological studies, cosmetics, and the food industry. Conventional droplet generation platforms for making higher order emulsions use organic solvents as the continuous phase, which is not biocompatible and as a result, further washing steps are required to remove the toxic continuous phase. Recently, droplet generation based on aqueous two‐phase systems (ATPS) has emerged in the field of droplet microfluidics due to their intrinsic biocompatibility. Here, a platform to generate all‐aqueous double and triple emulsions by introducing pressure‐driven flows inside a microfluidic hybrid device is presented. This system uses a conventional microfluidic flow‐focusing geometry coupled with a coaxial microneedle and a glass capillary embedded in flow‐focusing junctions. The configuration of the hybrid device enables the focusing of two coaxial two‐phase streams, which helps to avoid commonly observed channel‐wetting problems. It is shown that this approach achieves the fabrication of higher‐order emulsions in a poly(dimethylsiloxane)‐based microfluidic device, and controls the structure of the all‐aqueous emulsions. This hybrid microfluidic approach allows for facile higher‐order biocompatible emulsion formation, and it is anticipated that this platform will find utility for generating biocompatible materials for various biotechnological applications. 相似文献
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A Bioinspired Mineral Hydrogel as a Self‐Healable,Mechanically Adaptable Ionic Skin for Highly Sensitive Pressure Sensing
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Zhouyue Lei Quankang Wang Shengtong Sun Wencheng Zhu Peiyi Wu 《Advanced materials (Deerfield Beach, Fla.)》2017,29(22)
In the past two decades, artificial skin‐like materials have received increasing research interests for their broad applications in artificial intelligence, wearable devices, and soft robotics. However, profound challenges remain in terms of imitating human skin because of its unique combination of mechanical and sensory properties. In this work, a bioinspired mineral hydrogel is developed to fabricate a novel type of mechanically adaptable ionic skin sensor. Due to its unique viscoelastic properties, the hydrogel‐based capacitive sensor is compliant, self‐healable, and can sense subtle pressure changes, such as a gentle finger touch, human motion, or even small water droplets. It might not only show great potential in applications such as artificial intelligence, human/machine interactions, personal healthcare, and wearable devices, but also promote the development of next‐generation mechanically adaptable intelligent skin‐like devices. 相似文献
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Siow‐Feng Chong Rona Chandrawati Brigitte Städler Jeongju Park Jinhan Cho Yajun Wang Zhongfan Jia Volga Bulmus Thomas P. Davis Alexander N. Zelikin Frank Caruso 《Small (Weinheim an der Bergstrasse, Germany)》2009,5(22):2601-2610
Polymer hydrogels are used in diverse biomedical applications including drug delivery and tissue engineering. Among different chemical linkages, the natural and reversible thiol–disulfide interconversion is extensively explored to stabilize hydrogels. The creation of macro‐, micro‐, and nanoscale disulfide‐stabilized hydrogels commonly relies on the use of oxidizing agents that may have a detrimental effect on encapsulated cargo. Herein an oxidization‐free approach to create disulfide‐stabilized polymer hydrogels via a thiol–disulfide exchange reaction is reported. In particular, thiolated poly(methacrylic acid) is used and the conditions of polymer crosslinking in solution and on colloidal porous and solid microparticles are established. In the latter case, removal of the core particles yields stable, hollow, disulfide‐crosslinked hydrogel capsules. Further, a procedure is developed to achieve efficient disulfide crosslinking of multilayered polymer films to obtain stable, liposome‐loaded polymer‐hydrogel capsules that contain functional enzymatic cargo within the liposomal subcompartments. This approach is envisaged to facilitate the development of biomedical applications of hydrogels, specifically those including fragile cargo. 相似文献
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Ionic iridium(III) complexes are emerging with great promise for organic electronic devices, owing to their unique features such as ease of molecular design and synthesis, excellent photophysical properties, superior redox stability, and highly efficient emissions of virtually all colors. Here, recent progress on new material design, regarding photo‐ and electroluminescence is highlighted, including several interesting topics such as: i) color‐tuning strategies of cationic iridium(III) complexes, ii) widespread utilization in phosphorescent light‐emitting devices fabricated by not only solution processes but also vacuum evaporation deposition, and iii) potential applications in data record, storage, and sercurity. Results on anionic iridium(III) complexes and “soft salts” are also discussed, indicating a new related subject. Finally, a brief outlook is suggested, pointing out that ionic iridium(III) complexes should play a more significant role in future organic electronic materials technology. 相似文献
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Youchuang Chao Sze Yi Mak Shakurur Rahman Shipei Zhu Ho Cheung Shum 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(39)
Droplets containing ternary mixtures can spontaneously phase‐separate into high‐order structures upon a change in composition, which provides an alternative strategy to form multiphase droplets. However, existing strategies always involve nonaqueous solvents that limit the potential applications of the resulting multiple droplets, such as encapsulation of biomolecules. Here, a robust approach to achieve high‐order emulsion drops with an all‐aqueous nature from two aqueous phases by osmosis‐induced phase separation on a microfluidic platform is presented. This technique is enabled by the existence of an interface of the two aqueous phases and phase separation caused by an osmolality difference between the two phases. The complexity of emulsion drops induced by phase separation could be controlled by varying the initial concentration of solutes and is systematically illustrated in a state diagram. In particular, this technique is utilized to successfully achieve high‐order all‐aqueous droplets in a different aqueous two‐phase system. The proposed method is simple since it only requires two initial aqueous solutions for generating multilayered, organic‐solvent‐free all‐aqueous emulsion drops, and thus these multiphase emulsion drops can be further tailored to serve as highly biocompatible material templates. 相似文献
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以异佛尔酮二异氰酸酯(IPDI)、聚醚二元醇(N220)、三羟甲基丙烷聚乙二醇单甲醚(N120)为主要原料并通过改变N120的质量分数合成一系列梳状非离子水性聚氨酯(NPU),再添加LiClO4制备不同的固态聚合物电解质(SPE)。傅里叶变换红外光谱研究锂离子与醚氧基(C-O-C)作用结果表明,当N120质量分数为25%时,锂离子与C-O-C络合数量达到最大;交流阻抗测试结果显示,聚合物电解质离子电导率此时达到最大值,为3.08×10~(-6)S/cm,温度与离子电导率关系基本符合Arrhenius方程。热学和力学测试结果显示,随着N120含量增加,SPE的玻璃化转变温度降低,耐热性增加,拉伸强度降低,而断裂生长率增加,当N120质量分数为10%时,拉伸强度达到最大值,为10.58 MPa。 相似文献
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采用自由基聚合法合成了聚乙二醇双丙烯酸酯(PEGDA)/甲基丙烯酸β-羟乙酯(HEMA)共聚物水凝胶,材料表面在非反应性气体氩气气氛下进行等离子体表面处理,并在紫外光辐照条件下进行丙烯酰胺接枝共聚。红外谱图证明PEGDA/HEMA共聚物水凝胶上接枝了酰胺基团,材料的亲水性提高,等离子体表面处理后,材料表面形成含氧基团,氮原子含量增加。 相似文献
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Photosensitive Nanoparticles Combining Vascular‐Independent Intratumor Distribution and On‐Demand Oxygen‐Depot Delivery for Enhanced Cancer Photodynamic Therapy
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Caiyan Zhao Yujia Tong Xianlei Li Leihou Shao Long Chen Jianqing Lu Xiongwei Deng Xuan Wang Yan Wu 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(12)
In drug delivery, the poor tumor perfusion results in disappointing therapeutic efficacy. Nanomedicines for photodynamic therapy (PDT) greatly need deep tumor penetration due to short lifespan and weak diffusion of the cytotoxic reactive oxygen species (ROS). The damage of only shallow cells can easily cause invasiveness and metastasis. Moreover, even if the nanomedicines enter into deeper lesion, the effectiveness of PDT is limited due to the hypoxic microenvironment. Here, a deep penetrating and oxygen self‐sufficient PDT nanoparticle is developed for balanced ROS distribution within tumor and efficient cancer therapy. The designed nanoparticles (CNPs/IP) are doubly emulsified (W/O/W) from poly(ethylene glycol)‐poly(ε‐caprolactone) copolymers doped with photosensitizer IR780 in the O layer and oxygen depot perfluorooctyl bromide (PFOB) inside the core, and functionalized with the tumor penetrating peptide Cys‐Arg‐Gly‐Asp‐Lys (CRGDK). The CRGDK modification significantly improves penetration depth of CNPs/IP and makes the CNPs/IP arrive at both the periphery and hypoxic interior of tumors where the PFOB releases oxygen, effectively alleviating hypoxia and guaranteeing efficient PDT performance. The improved intratumoral distribution of photosensitizer and adequate oxygen supply augment the sensitivity of tumor cells to PDT and significantly improve PDT efficiency. Such a nanosystem provides a potential platform for improved therapeutic index in anticancer therapy. 相似文献
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3D Printing: 3D Printing of Highly Stretchable and Tough Hydrogels into Complex,Cellularized Structures (Adv. Mater. 27/2015)
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Sungmin Hong Dalton Sycks Hon Fai Chan Shaoting Lin Gabriel P. Lopez Farshid Guilak Kam W. Leong Xuanhe Zhao 《Advanced materials (Deerfield Beach, Fla.)》2015,27(27):4034-4034
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Simon Matoori Yinyin Bao Aaron Schmidt Eric J. Fischer Rafael Ochoa‐Sanchez Mlanie Tremblay Mariana M. Oliveira Christopher F. Rose Jean‐Christophe Leroux 《Small (Weinheim an der Bergstrasse, Germany)》2019,15(50)
Ammonia‐scavenging transmembrane pH‐gradient poly(styrene)‐b‐poly(ethylene oxide) polymersomes are investigated for the oral treatment and diagnosis of hyperammonemia, a condition associated with serious neurologic complications in patients with liver disease as well as in infants with urea cycle disorders. While these polymersomes are highly stable in simulated intestinal fluids at extreme bile salt and osmolality conditions, they unexpectedly do not reduce plasmatic ammonia levels in cirrhotic rats after oral dosing. Incubation in dietary fiber hydrogels mimicking the colonic environment suggests that the vesicles are probably destabilized during the dehydration of the intestinal chyme. The findings question the relevance of commonly used simulated intestinal fluids for studying vesicular stability. With the encapsulation of a pH‐sensitive dye in the polymersome core, the local pH increase upon ammonia influx could be exploited to assess the ammonia concentration in the plasma of healthy and cirrhotic rats as well as in other fluids. Due to its high sensitivity and selectivity, this polymersome‐based assay could prove useful in the monitoring of hyperammonemic patients and in other applications such as drug screening tests. 相似文献
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Daniel Dikovsky Havazelet Bianco‐Peled Dror Seliktar 《Advanced Engineering Materials》2010,12(6):B200-B209
We develop a biomaterial based on protein–polymer conjugates where poly(ethylene glycol) (PEG) polymer chains are covalently linked to multiple thiols on denatured fibrinogen. We hypothesize that conjugation of large diacrylate‐functionalized linear PEG chains to fibrinogen could govern the molecular architecture of the polymer network via a unique protein–polymer interaction. The hypothesis is explored using carefully designed shear rheometry and swelling experiments of the hydrogels and their precursor PEG/fibrinogen conjugate solutions. The physical properties of non‐cross‐linked and UV cross‐linked PEGylated fibrinogen having PEG molecular weights ranging from 10 to 20 kDa are specifically investigated. Attaching multiple hydrophilic, functionalized PEG chains to the denatured fibrinogen solubilizes the denatured protein and enables a rapid free‐radical polymerization cross‐linking reaction in the hydrogel precursor solution. As expected, the conjugated protein‐polymer macromolecular complexes act to mediate the interactions between radicals and unsaturated bonds during the free‐radical polymerization reaction, when compared to control PEG hydrogels. Accordingly, the cross‐linking kinetics and stiffness of the cross‐linked hydrogel are highly influenced by the protein–polymer conjugate architecture and molecular entanglements arising from hydrophobic/hydrophilic interactions and steric hindrances. The proteolytic degradation products of the protein–polymer conjugates proves to be were different from those of the non‐conjugated denatured protein degradation products, indicating that steric hindrances may alter the proteolytic susceptibility of the PEG–protein adduct. A more complete understanding of the molecular complexities associated with this type of protein‐polymer conjugation can help to identify the full potential of a biomaterial that combines the advantages of synthetic polymers and bioactive proteins. 相似文献
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Flexible Ionic‐Electronic Hybrid Oxide Synaptic TFTs with Programmable Dynamic Plasticity for Brain‐Inspired Neuromorphic Computing
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Rohit Abraham John Jieun Ko Mohit R. Kulkarni Naveen Tiwari Nguyen Anh Chien Ng Geok Ing Wei Lin Leong Nripan Mathews 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(32)
Emulation of biological synapses is necessary for future brain‐inspired neuromorphic computational systems that could look beyond the standard von Neuman architecture. Here, artificial synapses based on ionic‐electronic hybrid oxide‐based transistors on rigid and flexible substrates are demonstrated. The flexible transistors reported here depict a high field‐effect mobility of ≈9 cm2 V?1 s?1 with good mechanical performance. Comprehensive learning abilities/synaptic rules like paired‐pulse facilitation, excitatory and inhibitory postsynaptic currents, spike‐time‐dependent plasticity, consolidation, superlinear amplification, and dynamic logic are successfully established depicting concurrent processing and memory functionalities with spatiotemporal correlation. The results present a fully solution processable approach to fabricate artificial synapses for next‐generation transparent neural circuits. 相似文献
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Hydrogels: Skin‐Inspired Multifunctional Autonomic‐Intrinsic Conductive Self‐Healing Hydrogels with Pressure Sensitivity,Stretchability, and 3D Printability (Adv. Mater. 31/2017)
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Mohammad Ali Darabi Ali Khosrozadeh Rene Mbeleck Yuqing Liu Qiang Chang Junzi Jiang Jun Cai Quan Wang Gaoxing Luo Malcolm Xing 《Advanced materials (Deerfield Beach, Fla.)》2017,29(31)
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Skin‐Inspired Multifunctional Autonomic‐Intrinsic Conductive Self‐Healing Hydrogels with Pressure Sensitivity,Stretchability, and 3D Printability
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Mohammad Ali Darabi Ali Khosrozadeh Rene Mbeleck Yuqing Liu Qiang Chang Junzi Jiang Jun Cai Quan Wang Gaoxing Luo Malcolm Xing 《Advanced materials (Deerfield Beach, Fla.)》2017,29(31)
The advent of conductive self‐healing (CSH) hydrogels, a class of novel materials mimicking human skin, may change the trajectory of the industrial process because of their potential applications in soft robots, biomimetic prostheses, and health‐monitoring systems. Here, the development of a mechanically and electrically self‐healing hydrogel based on physically and chemically cross‐linked networks is reported. The autonomous intrinsic self‐healing of the hydrogel is attained through dynamic ionic interactions between carboxylic groups of poly(acrylic acid) and ferric ions. A covalent cross‐linking is used to support the mechanical structure of the hydrogel. Establishing a fair balance between the chemical and physical cross‐linking networks together with the conductive nanostructure of polypyrrole networks leads to a double network hydrogel with bulk conductivity, mechanical and electrical self‐healing properties (100% mechanical recovery in 2 min), ultrastretchability (1500%), and pressure sensitivity. The practical potential of CSH hydrogels is further revealed by their application in human motion detection and their 3D‐printing performance. 相似文献