Summary The synthesis of six novel electrono-donor monomers containing 3,6-dihalogencarbazole [N-(2-hydroxyethyl)-3, 6-dichlorocarbazolyl methacrylate, N-(2-hydroxyethyl)-3, 6-dichlorocarbazolyl acrylate, N-(2-hydroxyethyl)-3, 6-dibromocarbazolyl methacrylate, N-(2-hydroxyethyl)-3, 6-dibromocarbazolyl acrylate, N-(2-hydroxyethyl)-3, 6-diiodocarbazolyl methacrylate and N-(2-hydroxyethyl)-3,6-diiodocarbazolyl acrylate], of the corresponding polymers and of the monomeric models is described. The ionization potentials values of the monomeric models were determined. 相似文献
The title compound 4 underwent Sommelet and Stevens rearrangements induced by a number of bases. Ionization of the thenyl methylene group of 4 to the corresponding ylid 10 was the prevalent process, yielding subsequently N-[2-(2′-thienyl)-2-phenethyl]dimethylamine 12 and N-[α-(o-tolyl)-2-thenyl]-dimethylamine 13 . The strong trend of the 2-thenyl ylids to produce large relative amounts of the Sommelet amine was confirmed. Minor products are N-[2-(2′-thienyl)-1-phenethyl]dimethylamine 15 and N-[α-phenyl-2-(3-methylthienyl)]dimethylamine 16 derived from the benzyl ylid 11 . 相似文献
The carboxylic amphoteric surfactants containing ether and substituted amine groups such as 0-(2-alkylaminoethyl)-3-oxypropionic-and
N-(2-alkyloxyethyl)-3-aminopropionic acids were synthesized, and their antibacterial activities in terms of growth inhibition
ofStaphylococcus aureus andEscherichia coli were examined. The structural effect, such as bonding position of ether and amino groups, and the chain length effect between
undecyloxy-, dodecyloxy- and tridecyloxy radicals were examined, but no definite correlation between positional isomers and
chain length and antibacterial activities was observed. Furthermore, to study the effect of the increase of the number of
ether or amino groups on the antibacterial activities, N-(2-(2-dodecyloxyethyl)-aminoethyl)-3-aminopropionic acid and N-(2-(2-dodecyloxyethyl)oxyethyl)-3-aminopropionic
acid were synthesized. Their antibacterial activities were almost as effective as the corresponding amino or ether acids.
Moreover aqueous solution of these substituted propionic acids showed better surface activities at pH 4.0, 7.0 and 10.0. 相似文献
Methods for changing the selectivity in the N- vs. C- tricyanovinylation are discussed. In acetonitrile, 2,3-, 2,4-, 3,4- and 3, 5-dimethylanilines are N-tricyanovinylated, 2,6-dimethyl- and 2, 6-diethylanilines are p-tricyanovinylated, and 2,5-dimethyl- and 2-ethylaniline give mixtures of N- and p-tricyanovinyl derivatives. The UV, IR, NMR and mass spectra of the products are discussed in relation to the position of the tricyanovinyl group and to electronic and steric effects. 相似文献
Three silanized silicon substrates were prepared by treating cleaned oxidized silicon wafers with N-(3-triethoxysilylpropyl)octadecanamide (1), 9-[N-(triethoxysilylpropyl)amino]-9-oxononanoic acid methyl ester (2), and N-(3-triethoxysilylpropyl)-12-nitrododecanamide (4). The carbomethoxyl of 2 immobilized on silicon was hydrolysed to yield the corresponding ω-carboxylic surface (3) and the nitro group of the surface 4 reduced to afford the ω-amino surface (5). All five silanized surfaces were treated with octadecanoic acid and octadecanamine used as models for acidic and basic polymeric adhesives and the interactions were followed by ellipsometry and X-ray photoelectron spectroscopy. While the surfaces 1 and 2 reacted only by physisorption, the carboxylic surface 3 and the amino surface 5 showed a strong reaction with octadecanamine and octadecanoic acid, respectively. The nitro surface 4 exhibited a strong interaction with both probes, but by different pathways. 相似文献
The substituted glycine-type amphoteric surfactants containing long chain alkoxy and methylated amino groups, such as N-(2-alkoxyethyl)methylaminoacetic
acids and (N-[2-alkoxyethyl]-N-[carboxymethyl] dimethylammonium) chlorides, or N-(N-[2-alkoxyethyl]-2-aminoethyl) aminoacetic
acids were synthesized, and their growth inhibitory activities against g positive, g negative bacilli, and some fungi were
studied. The effect of substitution of methyl groups upon the amino group of the long chain alkoxyaminoacetic acids on their
antimicrobial activities was examined, and the increasing effect, due to methyl substitution, was confirmed. The introduction
of an aminoethyl radical between the alkoxyethyl and amino radicals of the substituted glycines also increased their antimicrobial
activities. Dimethylsubstituted betain-type amphoterics showed less antimicrobial activities than the corresponding glycinetype
amphoterics. Moreover, aqueous solution of these substituted glycine-type amphoteric compounds showed better surface activities
at pH 4.0, 10.0 than at neutral pH. 相似文献
Acidolysis of 2-(p-biphenylyl)isopropyl N-(5-nitro-2-pyridyloxy)carbamate (IV) resulted in loss of carbon dioxide and formation of N-2-(p-biphenylyl)isopropyl-O-(5-nitro-2-pyridyl) hydroxylamine (V). The mechanism of this unusual reaction is discussed. 相似文献
We report here the synthesis and the conformation analysis by 1H NMR spectroscopy and computer simulations of six potent sweet molecules, N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-alpha-L-aspartyl-S-tert-butyl-L-cysteine 1-methylester (1; 70 000 times more potent than sucrose), N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-alpha-L-aspartyl-beta-cyclohexyl-L-alanine 1-methylester (2; 50 000 times more potent than sucrose), N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-alpha-L-aspartyl-4-cyan-L-phenylalanine 1-methylester (3; 2 000 times more potent than sucrose), N-[3,3-dimethylbutyl]-alpha-L-aspartyl-(1R,2S,4S)-1-methyl-2-hydroxy-4-phenylhexylamide (4; 5500 times more potent than sucrose), N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-alpha-L-aspartyl-(1R,2S,4S)-1-methyl-2-hydroxy-4-phenylhexylamide (5; 15 000 times more potent than sucrose), and N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-alpha-L-aspartyl-(1R,2S,4S)-1-methyl-2-hydroxy-4-phenylhexylamide (6; 15 000 times more potent than sucrose). The "L-shaped" structure, which we believe to be responsible for sweet taste, is accessible to all six molecules in solution. This structure is characterized by a zwitterionic ring formed by the AH- and B-containing moieties located along the +y axis and by the hydrophobic group X pointing into the +x axis. Extended conformations with the AH- and B-containing moieties along the +y axis and the hydrophobic group X pointing into the -y axis were observed for all six sweeteners. For compound 5, the crystal-state conformation was also determined by an X-ray diffraction study. The result indicates that compound 5 adopts an L-shaped structure even in the crystalline state. The extraordinary potency of the N-arylalkylated or N-alkylated compounds 1-6, as compared with that of the unsubstituted aspartame-based sweet taste ligands, can be explained by the effect of a second hydrophobic binding domain in addition to interactions arising from the L-shaped structure. In our examination of the unexplored D zone of the Tinti-Nofre model, we discovered a sweet-potency-enhancing effect of arylalkyl substitution on dipeptide ligands, which reveals the importance of hydrophobic (aromatic)-hydrophobic (aromatic) interactions in maintaining high potency. 相似文献
A series of new phosphate type of amphoterics having a 2-hydroxyalkyl group as a hydrocarbon chain, 2-(N-2-hydroxyalkyl-N,N-dimethylammonio)ethyl
hydrogen phosphates (alkyl[R]:dodecyl, tetradecyl, hexadecyl), was synthesized and their physicochemical properties—isoelectric
point, critical micelle concentration (CMCs), occupied area/molecule at interface and the change of free energy of micellization—and
antimicrobial properties were investigated in comparison with those of sodium 2-(N-alkyl-N-methylamino)ethyl hydrogen phosphates.
It was found that the CMCs and the occupied areas were observed to decrease due to a phosphobetaine moiety and a 2-hydroxyethyl
group. Solution properties of the binary system of SDS/2-(N-2-hydroxytetradecyl-N,N-dimethylammonio)ethyl hydrogen phosphate
in aqueous solutions were studied in terms of surface tension and pH value. On the other hand, it was observed that the Minimum
inhibitory concentration (MICs) of 2-(N-2-hydroxyhexadecyl-N,N-dimethylammonio)ethyl hydrogen phosphate against fungi were
smaller than those of chlorhexidine digluconate. 相似文献
Synthesis of four N-(heterocyclic)-9-aminoacridine derivatives was investigated. The synthesized compounds, N-thiazolyl-9-aminoacridine (AC1), N-(1,3,4-thiadiazolyl)-9-aminoacridine (AC2), N-(5-methyl-1,3,4-thiadiazolyl)-9-aminoacridine (AC3), and N-(5-phenyl-1,3,4-thiadiazolyl)-9-aminoacridine (AC4) were characterized by FT-IR, 1H NMR, mass-spectral, and elemental analysis. Amine-imine tautomerism was suggested by density functional theory (DFT) calculations. The optimized structures were obtained using B3LYP/6–311++G(d,p) level of theory. The UV–Vis absorption spectra were measured in various organic solvents. The synthesized compounds AC1–AC4 exhibit absorption spectra characteristic of typical donor–acceptor compounds. The highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) analysis have been used to explain the internal charge transfer (ICT) phenomena within the molecules. Also, simulated UV spectra were calculated using TD-DFT (B3LYP/6–311++G(d,p) and the results were compared with the experimental values. 相似文献
Three Component Reactions. XIV. 2-Imidazolines and 1,2,4-Triazoles by Ring Closure Reactions of N-(2-Chloro-alkyl)imidchlorides with Hydrazine and Hydrazones N-(2-Chloro-alkyl)benzimidchlorides ( 1a and 1b ) give with hydrazine in dependence on the reaction medium 1,1′-bis(2-imidazolines) ( 4 ), 1-benzamido-2-imidazolines ( 5 ) or 1,2,4-triazoles ( 6 and 7 ) and also N-(2-chloro-alkyl)benzamides ( 8 ). From imidchlorides ( 1a–c ) and hydrazones Schiff bases ( 10 ) of 1-amino-2-imidazolines are obtained. They are not cleavable into free 1-amino-2-imidazolines. 相似文献