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《化学与生物工程》2017,(5)
以苄达赖氨酸、大豆卵磷脂、胆固醇为原料制备了苄达赖氨酸脂质体。以包封率为主要指标,选取药脂比、超声时间、水相pH值和孵育温度4个因素进行正交实验优化制备工艺,用紫外分光光度计测定包封率,用粒度和Zeta电位分析仪测定所制备脂质体的粒径分布及Zeta电位。确定最佳制备工艺条件为:药脂比1∶5(g∶g)、超声时间15min、水相pH值5、孵育温度60℃,在该条件下所制得的3批苄达赖氨酸脂质体的平均包封率为81.54%,平均粒径为(99.85±9.60)nm,平均Zeta电位为(-30.6±1.8)mV,体外释放实验证明释放速度慢于市售制剂。表明所制备的苄达赖氨酸脂质体包封率高、稳定性好。 相似文献
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《现代化工》2018,(11)
以乙醇为溶剂,采用薄膜分散法制备二甲基姜黄素(ASC-J9)脂质体。通过单因素试验和正交试验优化得到最佳制备工艺:磷脂与胆固醇的质量比为10∶1、磷脂与ASC-J9的质量比为1 000∶10、水化温度为60℃以及磷脂质量浓度为6. 67 mg/mL。最佳条件下制备的ASC-J9脂质体的包封率为97. 99%,平均粒径为145. 7 nm,其粒径分布较窄且在水中分散较好。4℃下ASC-J9脂质体的稳定性较好,且脂质体可以较好地保护包载的ASC-J9。该制备工艺具有绿色环保、操作简便、产品性能好等特点,所制ASC-J9脂质体可以有效改善ASC-J9的热稳定性和水溶性。 相似文献
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采用薄膜分散法,制备包封率高、粒径均匀、稳定性好的芦丁脂质体,并建立芦丁脂质体中芦丁含量和包封率的测定方法。以包封率为主要指标,通过正交设计优化芦丁脂质体的制备工艺,同时采用反相高效液相色谱法进行芦丁含量和包封率测定。结果表明,薄膜分散法制备的脂质体平均包封率为66.50%,外观均匀、稳定性良好。建立的反相高效液相色谱法能将芦丁与辅料分离良好,芦丁浓度在4~40μg/L范围内与峰面积呈现良好的线性关系(r=0.999 2,n=5),平均回收率为99.0%,可用于测定芦丁脂质体的药物含量与包封率。 相似文献
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探讨了卵磷脂对脂质体载药性能的影响。用逆相蒸发法制备阿糖胞苷脂质体,通过测定脂质体的包封率、平均粒径和药物渗漏量,考察了蛋黄卵磷脂、大豆卵磷脂及猪脑卵磷脂对脂质体载药性能的影响。实验结果表明,在n(PC)∶n(CHOL)=1∶1的条件下,蛋黄卵磷脂脂质体的平均粒径为2.59μm,包封率为(17.02±0.21)%,在37℃经40 h温育后,平均粒径增加0.53μm,药物渗漏量为(0.18±0.01)mg/h。平均粒径和包封率均高于大豆卵磷脂脂质体及猪脑卵磷脂脂质体,平均粒径增加值低于大豆卵磷脂脂质体及猪脑卵磷脂脂质体,渗漏速度高于猪脑卵磷脂脂质体,但低于大豆卵磷脂脂质体。对比实验证明,蛋黄卵磷脂脂质体的载药性能较好。 相似文献
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《化学与生物工程》2017,(10)
以包封率为评价指标,氯仿-乙醚混合溶剂(2∶3,体积比)为有机相,固态大豆卵磷脂和胆固醇为膜材,采用逆向蒸发法制备南极冰藻DNA光修复酶脂质体。经单因素实验和正交实验确定光修复酶脂质体的最佳制备工艺条件为:膜材比3∶1、药脂比1∶10、油相与水相体积比4∶1、超声时间6min,在此条件下,光修复酶脂质体的平均包封率达到(44.13±2.90)%。所制得的光修复酶脂质体呈圆形或椭圆形,平均粒径为(490.9±2.3)nm,Zeta电位在-30~-60mV范围内,制剂的质量标准符合中国药典(2015版)要求,为DNA光修复酶在日用防晒品中的应用提供了可靠的理论依据。 相似文献
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为了制备7-乙基-10-羟基喜树碱(SN-38)脂质体并进行相关制剂学评价,采用薄膜分散法制备SN-38脂质体,以包封率为评价指标,用高效液相色谱法进行测定,通过单因素实验考察优化SN-38脂质体的制备工艺并进行质量评价。结果表明:制备工艺中,磷脂浓度3%,药脂比为1∶20,胆固醇与磷脂比为1∶6,水化温度为50℃,包封率平均值为92.0%,选择质量分数为10%的甘露醇为冻干保护剂,制备SN-38脂质体的冻干品;质量评价方面,SN-38脂质体的外观澄清带有蓝色乳光,平均粒径为147 nm。选用载体成膜法制备SN-38脂质体的工艺操作简便、合理可行。 相似文献
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M. S. J. Simmonds W. M. Blaney F. Delle Monache M. Marquina Mac-Quhae G. B. Marini Bettolo 《Journal of chemical ecology》1985,11(12):1593-1599
Vismiones and ferruginins, representatives of a new class of lypophilic anthranoids from the genusVismia were found to inhibit feeding in larvae of species ofSpodoptera, Heliothis, and inLocusta migratoria. 相似文献
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Cheng-Le Zhao Shane Porzio Alan Smith Haiyan Ge H. T. Davis L. E. Scriven 《Journal of Coatings Technology and Research》2006,3(2):109-115
Despite its industrial importance, the subject of freeze-thaw (F/T) stability of latex coatings has not been studied extensively.
There is also a lack of fundamental understanding about the process and the mechanisms through which a coating becomes destabilized.
High pressure (2100 bar) freezing fixes the state of water-suspended particles of polymer binder and inorganic pigments without
the growth of ice crystals during freezing that produce artifacts in direct imaging scanning electron microscopy (SEM) of
fracture surfaces of frozen coatings. We show that by incorporating copolymerizable functional monomers, it is possible to
achieve F/T stability in polymer latexes and in low-VOC paints, as judged by the microstructures revealed by the cryogenic
SEM technique. Particle coalescence as well as pigment segregation in F/T unstable systems are visualized. In order to achieve
F/T stability in paints, latex particles must not flocculate and should provide protection to inorganic pigment and extender
particles. Because of the unique capabilities of the cryogenic SEM, we are able to separate the effects of freezing and thawing,
and study the influence of the rate of freezing and thawing on F/T stability. Destabilization can be caused by either freezing
or thawing. A slow freezing process is more detrimental to F/T stability than a fast freezing process; the latter actually
preserves suspension stability during freezing.
Presented at the 82nd Annual Meeting of the Federation of Societies for Coatings Technology, October 27–29, 2004 in Chicago,
IL. Tied for first place in The John A. Gordon Best Paper Competition. 相似文献
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It is well established that a wide range of drugs of abuse acutely boost the signaling of the sympathetic nervous system and the hypothalamic–pituitary–adrenal (HPA) axis, where norepinephrine and epinephrine are major output molecules. This stimulatory effect is accompanied by such symptoms as elevated heart rate and blood pressure, more rapid breathing, increased body temperature and sweating, and pupillary dilation, as well as the intoxicating or euphoric subjective properties of the drug. While many drugs of abuse are thought to achieve their intoxicating effects by modulating the monoaminergic neurotransmitter systems (i.e., serotonin, norepinephrine, dopamine) by binding to these receptors or otherwise affecting their synaptic signaling, this paper puts forth the hypothesis that many of these drugs are actually acutely converted to catecholamines (dopamine, norepinephrine, epinephrine) in vivo, in addition to transformation to their known metabolites. In this manner, a range of stimulants, opioids, and psychedelics (as well as alcohol) may partially achieve their intoxicating properties, as well as side effects, due to this putative transformation to catecholamines. If this hypothesis is correct, it would alter our understanding of the basic biosynthetic pathways for generating these important signaling molecules, while also modifying our view of the neural substrates underlying substance abuse and dependence, including psychological stress-induced relapse. Importantly, there is a direct way to test the overarching hypothesis: administer (either centrally or peripherally) stable isotope versions of these drugs to model organisms such as rodents (or even to humans) and then use liquid chromatography-mass spectrometry to determine if the labeled drug is converted to labeled catecholamines in brain, blood plasma, or urine samples. 相似文献
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Ethanol and (−)-α-Pinene: Attractant Kairomones for Bark and Ambrosia Beetles in the Southeastern US
In 2002–2004, we examined the flight responses of 49 species of native and exotic bark and ambrosia beetles (Coleoptera: Scolytidae
and Platypodidae) to traps baited with ethanol and/or (−)-α-pinene in the southeastern US. Eight field trials were conducted
in mature pine stands in Alabama, Florida, Georgia, North Carolina, and South Carolina. Funnel traps baited with ethanol lures
(release rate, about 0.6 g/day at 25–28°C) were attractive to ten species of ambrosia beetles (Ambrosiodmus tachygraphus, Anisandrus sayi, Dryoxylon onoharaensum, Monarthrum mali, Xyleborinus saxesenii, Xyleborus affinis, Xyleborus ferrugineus, Xylosandrus compactus, Xylosandrus crassiusculus, and Xylosandrus germanus) and two species of bark beetles (Cryptocarenus heveae and Hypothenemus sp.). Traps baited with (−)-α-pinene lures (release rate, 2–6 g/day at 25–28°C) were attractive to five bark beetle species
(Dendroctonus terebrans, Hylastes porculus, Hylastes salebrosus, Hylastes tenuis, and Ips grandicollis) and one platypodid ambrosia beetle species (Myoplatypus flavicornis). Ethanol enhanced responses of some species (Xyleborus pubescens, H. porculus, H. salebrosus, H. tenuis, and Pityophthorus cariniceps) to traps baited with (−)-α-pinene in some locations. (−)-α-Pinene interrupted the response of some ambrosia beetle species
to traps baited with ethanol, but only the response of D. onoharaensum was interrupted consistently at most locations. Of 23 species of ambrosia beetles captured in our field trials, nine were
exotic and accounted for 70–97% of total catches of ambrosia beetles. Our results provide support for the continued use of
separate traps baited with ethanol alone and ethanol with (−)-α-pinene to detect and monitor common bark and ambrosia beetles
from the southeastern region of the US. 相似文献
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Peter A. Edwards Grant Striemer Dean C. Webster 《Journal of Coatings Technology and Research》2005,2(7):517-527
Glycidyl carbamate chemistry combines the excellent properties of polyurethanes with the crosslinking chemistry of epoxy resins.
Glycidyl carbamate functional oligomers were synthesized by the reaction of polyfunctional isocyanate oligomers and glycidol.
The oligomers were formulated into coatings with several amine functional crosslinkers at varying stoichiometric ratios and
cured at different temperatures. Properties such as solvent resistance, hardness, and impact resistance were dependent on
the composition and cure conditions. Most coatings had an excellent combination of properties. Studies were carried out to
determine the kinetics of the curing reaction of the glycidyl carbamate functional oligomers with multifunctional and model
amines. Detailed kinetic analysis of the curing reactions was also undertaken. The results indicated that the glycidyl carbamate
functional group is more reactive than a glycidyl ether group.
Presented at the 82nd Annual Meeting of the Federation of Societies for Coatings Technology, on October 27–29, 2004, in Chicago,
IL. 相似文献