共查询到20条相似文献,搜索用时 46 毫秒
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邻甲酰氨基苯甲酰胺类农药研究概述 总被引:6,自引:0,他引:6
邻甲酰胺基苯甲酰胺类杀虫剂具有高效、低毒和作用机制独特等特点,是目前最具发展潜力的杀虫活性化合物。笔者结合第一个商品化的邻甲酰胺基苯甲酰胺类杀虫剂氯虫酰胺对邻甲酰胺基苯甲酰胺类杀虫剂的发现、合成、生物学、毒理学、作用机理和生态安全等方面的研究情况做一概述。 相似文献
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新型邻甲酰胺基苯甲酰胺衍生物的合成与生物活性研究 总被引:1,自引:0,他引:1
合成了9个新型邻甲酰胺基苯甲酰胺衍生物,其结构经1H NMR进行确证。初步杀虫、杀螨活性测试表明所合成的化合物在1 000 mg/L浓度下对磷翅目的粘虫(Mythimna separata)有100%的致死率。在500 mg/L浓度下,大多化合物对同翅目的蚕豆蚜(Aphis fabae)以及稻黑尾叶蝉(Nephotettix cincticeps)具有明显活性,如化合物3-溴-1-(3-氯-2-吡啶基)-N-[4-氯-2-甲基-6-[((3,3-二氯烯丙氧基)氨基)羰基]苯基]-1H-吡唑-5-甲酰胺(14c)对蚕豆蚜的致死率达到89.29%;化合物14b对叶蝉的致死率达到81.82%。在500 mg/L浓度下,所合成化合物对蜱螨目棉红蜘蛛(Tetranchus urticae)没有表现出明显活性。 相似文献
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氯虫苯甲酰胺是一种新型高效、低毒杀虫剂,对鳞翅目害虫具有显著杀虫效果。综述了近几年来国内外有关氯虫苯甲酰胺的合成方法,并从经济角度、环境因素、可操作性等方面进行综合评价。 相似文献
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Hwani Ryu Ky-Youb Nam Hyo Jeong Kim Jie-Young Song Sang-Gu Hwang Jae Sung Kim Joon Kim Jiyeon Ahn 《International journal of molecular sciences》2021,22(14)
More than 80% of colorectal cancer patients have adenomatous polyposis coli (APC) mutations, which induce abnormal WNT/β-catenin activation. Tankyrase (TNKS) mediates the release of active β-catenin, which occurs regardless of the ligand that translocates into the nucleus by AXIN degradation via the ubiquitin-proteasome pathway. Therefore, TNKS inhibition has emerged as an attractive strategy for cancer therapy. In this study, we identified pyridine derivatives by evaluating in vitro TNKS enzyme activity and investigated N-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-1-(2-cyanophenyl)piperidine-4-carboxamide (TI-12403) as a novel TNKS inhibitor. TI-12403 stabilized AXIN2, reduced active β-catenin, and downregulated β-catenin target genes in COLO320DM and DLD-1 cells. The antitumor activities of TI-12403 were confirmed by the viability of the colorectal cancer cells and its lack of visible toxicity in DLD-1 xenograft mouse model. In addition, combined 5-FU and TI-12403 treatment synergistically inhibited proliferation to a greater extent than that in a single drug treatment. Our observations suggest that TI-12403, a novel selective TNKS1 inhibitor, may be a suitable compound for anticancer drug development. 相似文献
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新型广谱、安全的鱼尼丁受体杀虫剂 总被引:20,自引:6,他引:14
近期日本农药公司、拜耳公司和杜邦公司的科研人员宣布已经发现2类广谱的杀虫剂。此2类杀虫剂分属邻苯二甲酰胺类(phthalic acid diamides)和邻甲酰氨基苯甲酰胺类(anthranilic diamides),是首次发现作用于靶标鱼尼丁受体(ryanodine receptor)的合成杀虫剂,是继双酰肼类之后又一重大发现。该发现将有利于抗性问题的解决,是选择性差、对人体健康有害的、神经毒剂有机磷类杀虫剂的重要替代品,也将为世界人类身体健康做出重要的贡献。 相似文献
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Fabio Maria Sabbatini Dr. Romano Di Fabio Dr. Mauro Corsi Dr. Paolo Cavanni Dr. Steve M. Bromidge Dr. Yves St‐Denis Dr. Lucilla D'Adamo Dr. Marilisa Rinaldi Dr. Chiara Savoia Dr. Claudia Mundi Dr. Benedetta Perini Dr. Andrew J. Carpenter Dr. Giovanna Dal Forno Dr. Federico Faggioni Dr. Michela Tessari Dr. Francesca Pavone Dr. Alberto Buson Dr. Mario Mattioli Dr. Elisabetta Perdona' Dr. Sergio Melotto Dr. 《ChemMedChem》2010,5(9):1450-1455