Rewarding Leadership and Fair Procedures as Determinants of Self-Esteem.

In the present research, the authors examined the effect of procedural fairness and rewarding leadership style on an important variable for employees: self-esteem. The authors predicted that procedural fairness would positively influence people's reported self-esteem if the leader adopted a style of rewarding behavior for a job well done. Results from a scenario experiment, a laboratory experiment, and an organizational survey indeed show that procedural fairness and rewarding leadership style interacted to influence followers' self-esteem, such that the positive relationship between procedural fairness and self-esteem was more pronounced when the leadership style was high in rewarding behavior. Implications in terms of integrating the leadership and procedural fairness literature are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Rewarding elementary schoolchildren for their use of safety belts.

Tested the hypothesis that an intensive reward program could increase seat-belt use among schoolchildren, using 842 children (aged 5–11 yrs) in 2 schools. Compliant Ss received coupons redeemable for prizes. Results show that the mean compliance rate for School 1 was 4.3% during baseline, 66.2% for the reward phase across 4 wks, 60% for return to baseline, 17.2% for Follow-Up 1, and 8.5% for Follow-Up 2. For School 2, the mean percentage was 5.3% at baseline, 69.8% for the reward phase, 68.5% for return to baseline, 40.1% for Follow-Up 1, and 20% for Follow-Up 2. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Rewarding affective properties of intra-nucleus accumbens injections of testosterone.

On alternating days, adult male Long-Evans rats implanted with bilateral cannulas in the nucleus accumbens received intracerebral injections of testosterone in a water-soluble cyclodextrin inclusion complex (0.125, 0.25, or 0.5 μg/0.5 μl saline) or saline immediately prior to being confined for 30 min to 1 of 2 compartments of a place-preference apparatus. All rats received 8 days of pairings (4 hormone and 4 saline). On Day 9 the rats were given a 20-min test session during which they had access to all compartments of the apparatus. No hormone was injected prior to the test session. On the test day, rats spent significantly more time in the compartment previously paired with bilateral intra-accumbens injections of testosterone (0.25 and 0.5 μg/0.5 μl saline) than in the compartment previously paired with saline injections. The findings indicate that intra-accumbens injections of testosterone are sufficient to produce reward. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Rewarding brain stimulation: Role of tegmental cholinergic neurons that activate dopamine neurons.

Cholinergic neurons of the pedunculopontine nucleus (Ch5) are believed to monosynaptically excite ventral tegmental dopamine neurons. Muscarinic blockers injected near dopamine cells block the rewarding effect of hypothalamic or dorsal tegmental rewarding brain stimulation (RBS) in rats. Because Ch5 cells are inhibited by muscarinic agonists, muscarinic drugs were injected unilaterally near Ch5 neurons to inhibit or disinhibit them. Carbachol raised thresholds for hypothalamic self-stimulation bilaterally by over 400%, whereas scopolamine reduced thresholds by 20–80%. Pretreatment with either carbachol or scopolamine blocked the effect of the other drug, which suggests that both acted through the same receptors near Ch5 cells. Therefore, activation of Ch5 neurons is critical for hypothalamic RBS. A mechanism for the involvement of Ch5 neurons in drug rewards and antimuscarinic psychosis is also proposed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Rewarding pinball wizardry: Effects of evaluation and cue value on intrinsic interest.

Examined the effects of rewards for pinball competence on subsequent interest in the game in 3 studies with 219 Ss in which 3 components of performance-contingent reward structures—an evaluative contingency established before playing, performance feedback, and the receipt of a reward—were identified. The symbolic cue value of the reward may affect interest independently of evaluation and competence feedback. To isolate its effect, groups receiving a performance-contingent reward were compared with groups that experienced the same evaluative contingency and feedback and with feedback-only controls (Studies 1 and 3). Results show that evaluation reduced intrinsic motivation, compared with controls, whereas reward enhanced intrinsic motivation relative to evaluation. In Study 2, groups receiving rewards for attaining competence but differing in whether the evaluation was anticipated before playing were compared. Results indicate that unexpected performance-contingent rewards enhanced interest, compared with expected rewards. Findings suggest that the 3 reward properties have separate effects on intrinsic motivation. Anticipation of evaluation was responsible for negative reward effects, whereas competence feedback and due value had independent positive effects (36 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Mothers as volunteers in an oncology clinic

Mothers of children who had died of cancer were successfully utilized as volunteers in a pediatric oncology clinic to provide emotional support and practical assistance to other children afflicted with the same disease and to their families. At the start of the program these volunteers were carefully interviewed to determine their willingness and their emotional ability to participate on a consistent basis. Following an eight-week training program with a psychiatrist, a social worker, and a nurse, they began working in a large pediatric oncology clinic one day a week. Over an 18-month period they have become valuable members of the oncology team by helping to improve communications, to alleviate frustrations, and in giving additional emotional support to the children and their families.     

Intelligence of volunteers as research subjects.

The personal characteristics of people who volunteer for research is becoming increasingly important to behavioral scientists. The intelligence of prison inmates who volunteered for medical experiments was compared with that of inmates who did not volunteer. The results show that groups of 40 volunteers for 2 individual experiments demonstrated significantly higher scores on the Revised Beta Examination than did 40 nonvolunteers. The implications of these findings to behavioral research were examined. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Tolerance of volunteers to cyclosporine A-dilauroylphosphatidylcholine liposome aerosol

Cyclosporine A (CsA) in liposomes of dilauroylphosphatidylcholine (DLPC), containing 118 micrograms of CsA/L of aerosol with a particle size of 1.6 to 1.7 micron diameter, was inhaled by 10 nonsmoking, normal volunteers each for 45 min. Aerosol was administered through an Aerotech II nebulizer (CIS-US, Inc., Bedford, MA) mouthpiece. Eight of the 10 volunteers had tracheal irritation and intermittent coughing following exposure. FEV1 and FVC values were mildly reduced, but returned to normal in 1 h. Blood chemical and hematologic values were unchanged at any time point after as opposed to before inhalation. Nine of the 10 volunteers later inhaled DLPC only, administered through the nebulizer mouthpiece. There was no change in FEV1 or FVC values, and there was no coughing or tracheal irritation. Subsequently, five of the volunteers who had previously had respiratory reactions inhaled CsA-DLPC liposome aerosol for 45-min, but through a mouth-only face mask. There was no tracheal irritation, coughing, or changes in spirometric measures. Blood concentrations of CsA at 15 min after the 45-min inhalation with a face mask averaged 83 +/- 42 ng/ml (mean +/- SD). At 24 h after treatment, CsA was undetectable in blood of the initial 10 volunteers. These studies indicate that CsA-DLPC liposome aerosol can be safely explored as a treatment for patients with moderately severe asthma.     

Pharmacokinetics of tablet huperzine A in six volunteers

AIM: To study pharmacokinetics of tablet huperzine A (Hup-A) in Chinese volunteers to help establishing its drug administration schedule. METHODS: For 6 volunteers after a single oral dose of 0.99 mg, drug concentrations in plasma were assayed by reverse phase high pressure liquid chromatography (HPLC) at 0.5, 0.75, 1.0, 1.25, 1.5, 2, 4, 6, 8, and 10 h. The pharmacokinetic parameters were calculated with a 3P87 program by computer. RESULTS: The time course of plasma concentrations conformed to a one-compartment open model with a first order absorption. The pharmacokinetic parameters were as follows: T 1/2ka = 12.6 min, T 1/2ke = 288.5 min, Tmax = 79.6 min, Cmax = 8.4 micrograms L-1, AUC = 4.1 mg L-1 min. CONCLUSION: Hup-A was absorbed rapidly, distributed widely in the body, and eliminated at a moderate rate.     

Birth order of volunteers for sensory deprivation.

Published data have indicated the preponderance of 1st-born individuals among volunteer Ss in experiments involving group interaction and cooperation. The results were explained on the basis of strong affiliative tendencies among 1st borns. This report shows a similarly high proportion of 1st borns among individuals volunteering for a sensory deprivation study which called for total isolation of the S, and suggests that an explanation based only on affiliation motives may not be adequate for an understanding of the overrepresentation of 1st borns among volunteer Ss. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Pulmonary perfusion and density gradients in healthy volunteers

The goal of this study was to measure regional pulmonary perfusion using SPECT and transmission tomography for attenuation correction and density measurements. METHODS: Regional pulmonary perfusion was studied after intravenous injection of radiolabeled particles in 10 supine healthy volunteers using SPECT. Transmission tomography was used to correct for attenuation, measure lung density and delineate the lungs. The effects of attenuation correction on pulmonary perfusion gradients were investigated. RESULTS: In perfusion measurements not corrected for attenuation, we found significant perfusion gradients in the direction of gravity but also significant gradients at isogravitational level. After correction for attenuation, the gravitational gradient was significantly greater than before correction, and gradients at isogravitational level were no longer observed. Perfusion in the ventral lung zone was half of that in the dorsal lung zone. Mean lung density was 0.28 +/- 0.03 g/ml, and density showed a significant increase in the direction of gravity and at isogravitational level. CONCLUSION: We found that SPECT perfusion studies of the lung not corrected for attenuation gave a false impression of nongravitational gradients and underestimate the gradient that is gravity-dependent. Transmission tomography, used for attenuation correction, also quantifies lung density and shows gravity dependent and nondependent density gradients.     

Steady-state pharmacokinetic properties of pramipexole in healthy volunteers

Pramipexole is a dopamine receptor agonist that has proved effective in the treatment of Parkinson's disease. The pharmacokinetic properties of pramipexole at steady-state concentrations were studied in 16 healthy men and women at four dose levels throughout the range recommended for Parkinson's patients. Plasma and urine samples collected within the four dose intervals were assayed for concentrations of pramipexole, using high-performance liquid chromatography. The total oral clearance for all participants was 419 mL/min. The mean volume of distribution and elimination half-life for all participants was 486 +/- 93.2 L and 12.9 +/- 3.27 hours. Concentrations of pramipexole were proportional to dose, although the drug's pharmacokinetic properties differed between men and women. The area under the concentration-time curve for each dose level was 35% to 43% greater in women, mainly because of a 24% to 27% lower oral clearance. The mean creatinine clearance in men and women was 112 +/- 12.8 mL/ min/1.73 m2 and 80.9 +/- 15.6 mL/min/1.73 m2, respectively. The renal clearance of pramipexole accounts for approximately 80% of oral clearance, and there was a significant correlation between renal and creatinine clearances. The influence of gender could not be distinguished from the influence of age and the resulting reduced creatinine clearance, but the measurement of pharmacokinetic properties produced linear results in both men and women.     

Cardiovascular effects of ozone exposure in human volunteers

We hypothesized that ozone (O3) exposure acutely affects cardiovascular hemodynamics in humans and, in particular, in subjects with essential hypertension. We studied 10 nonmedicated hypertensive and six healthy male adults. Each subject, after catheterization of the right heart and a radial artery, was exposed in an environmentally controlled chamber to filtered air (FA) on one day and to 0.3 ppm O3 on the following day for 3 h with intermittent exercise. Relative to FA exposure, O3 exposure induced no statistically significant changes in cardiac index, ventricular performance, pulmonary artery pressure, pulmonary and systemic vascular resistances, ECG, serum cardiac enzymes, plasma catecholamines and atrial natriuretic factor, and SaO2. The overall results did not indicate major acute cardiovascular effects of O3 in either the hypertensive or the control subjects. However, mean preexposure to postexposure changes were significantly (p < 0.02) larger with O3 than with FA for rate-pressure product (1,353 beats/min/mm Hg) and for heart rate (8 beats/min); these responses were not significantly different between the hypertensive and the control subjects. Significant O3 effects were also observed for mean FEV1 (-6%), and AaPO2 (> 10 mm Hg increase), which were not significantly different between the two groups. These results suggest that O3 exposure can increase myocardial work and impair pulmonary gas exchange to a degree that might be clinically important in persons with significant preexisting cardiovascular impairment, with or without concomitant lung disease.     

Neuropeptide Y in cortisol-induced hypertension in male volunteers

1. Cortisol-induced blood pressure rises in men are not accompanied by increases in plasma catecholamines. The present study examines the effects of cortisol on the sympathetic co-transmitter, neuropeptide Y (NPY). 2. Eight normal men were given cortisol 200 mg/day over 5 days and haemodynamic, metabolic and hormonal measures were taken. Plasma NPY-like immunoreactivity (NPY-LI) concentrations were measured by direct radio-immunoassay. 3. Cortisol significantly increased systolic, diastolic and mean arterial pressure, bodyweight, plasma glucose and total white cell concentration and decreased plasma potassium and total eosinophil count, as in previous studies. Plasma NPY concentrations were not altered significantly during cortisol treatment, but increased following cessation of cortisol treatment (P = 0.006). 4. The essentially unchanged pattern for NPY concentration with cortisol treatment resembles that previously reported for adrenaline and noradrenaline, but the increase in NPY on cortisol withdrawal was not seen for adrenaline or noradrenaline. These data do not support a role for sympathetic activation in the genesis of cortisol-induced hypertension.     

Rewarding and punishing by mothers: The influence of progressive changes in the quality of their sons' apparent behavior.

30 mothers (Ms [24–45 yrs old]), separated from their sons (4–7.5 yrs old), were randomly assigned to 1 of 3 experimental conditions in which the proportion of their children's correct to incorrect responses on a learning task appeared to vary systematically. The boys' (Bs) performances either progressively improved, declined, or remained stable over 90 trials. Signals from the researchers defined successes and errors for which Ms respectively presented or removed up to 9 candies. Systematic trends in Bs' simulated responses exerted differential control over Ms' patterns of reward and punishment. When performances improved, the magnitude of reward increased while the intensity of punishment did not change. In the stable-response condition, patterns of both reward and punishment remained unchanged over trials. When Bs' performances appeared to decline, the magnitudes of both reward and punishment increased. At times, Ms chose neither to reward nor to punish; on these rare occasions, errors were more often overlooked than were successes. (13 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Epidemiologic features of hospital pyo-septic infection in a cardiosurgical hospital

The results of the epidemiological analysis of morbidity in purulent septic infection in a cardiosurgical hospital during the period of 1990-1963 is presented. As revealed by this analysis, until 1993 the dominating causative agent of this infection was Pseudomonas aeruginosa O16, and since 1994 Staphylococcus epidermidis prevailed. The morbidity dynamics for several years and during individual years is shown. The main risk factors were established. The reanimation department was found to be the main areas where the contamination of patients occurred.