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超临界抗溶剂技术在药物微粒化领域的研究进展 总被引:1,自引:0,他引:1
总结了超临界抗溶剂技术在微粉化药物和制备缓释药物微球方面的研究现状和发展。在药物微粉化方面,着重介绍了超临界辅助原子化法对水溶性药物的处理,包括该方法的原理、操作方法以及操作参数对产品性能的影响,证明该方法用于改善水溶性药物的微粉化具有良好的效果;在制备药物微球方面,重点介绍了不同操作条件和不同分子质量的载体、不同配比的复合载体对药物微球性能的影响以及表面活性剂在亲脂性及离子型药物微球制备中的应用,指出添加表面活性剂将更有利于得到该类药物的微球。 相似文献
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介绍了超临界二氧化碳抗溶剂结晶过程的基本原理,综述了超临界二氧化碳抗溶剂结晶在制药技术中应用的最新进展,讨论了超临界二氧化碳抗溶剂结晶技术中需要进一步研究的问题和开发的领域. 相似文献
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超临界CO2抗溶剂法制备酶微胶囊过程研究 总被引:1,自引:0,他引:1
研究了以木瓜蛋白酶为芯材,乙基纤维素为膜材的超临界流体抗溶剂(GAS)法制备酶微胶囊过程。在正交实验结果初步表明压力、温度、芯膜比和膜材料浓度依次是GAS法制备微胶囊过程较主要的影响因素基础上,进一步较系统地考察了这些因素对制备的微胶囊的粒径分布、包裹率、释放等性能的影响。 相似文献
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介绍了超临界抗溶剂技术制备缓释胶囊的原理、方法及研究进展,分析了颗粒性质的影响因素,总结了超临界抗溶剂技术在制备缓释胶囊方面存在的问题及展望。 相似文献
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通过理论分析并结合实际工程案例中湿法烟气脱硫装置中的腐蚀与磨损现象,探讨了湿法烟气脱硫装置中腐蚀与磨损的原因,对于不同设备、不同部位、不同系统有针对性地提出了解决方案,在提供理论分析和技术解决方案的同时,指出了防腐施工工艺过程中施工人员及施工管理人员素质及责任心的重要性。 相似文献
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丁香油的超临界CO2萃取及其微胶囊的制备 总被引:2,自引:0,他引:2
在70℃和10 MPa条件下通过对丁香花蕾进行超临界CO2萃取得到丁香油,萃取率达19%~21%.气质联用分析结果表明,丁香油中主要化学成分包括丁香酚、β-石竹烯和乙酰基丁香酚等.以丁香油为囊芯,探讨利用干酵母细胞作为囊壁材料制备微胶囊的可行性.通过正交试验考察了包埋温度、包埋时间、丁香油与干酵母配比(芯材比)对微胶囊化丁香油的影响.结果表明,在包埋温度70℃、包埋时间9 h和芯材比为1∶1(w/w)的条件下,微胶囊中丁香油包埋率达到41.26%.通过扫描电镜观察,丁香油微胶囊呈规则的球形,大小均一,颗粒直径在2.0~4.0 μm.在100℃下对经微胶囊化的丁香油加热20 h,其挥发率只有15.04%,远低于相同条件下丁香油的挥发率(58.29%).这种新型的微胶囊化方法,具有制备过程简单、包埋率高和不引入有机溶剂的优点. 相似文献
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Mathieu Martino Adil Mouahid Paolo Trucillo Elisabeth Badens 《European Journal of Lipid Science and Technology》2021,123(4):2000358
A batch process for producing lutein-loaded liposomes using supercritical CO2 is studied. The effects of the variation of pressure (10 and 15 MPa), temperature (308, 313, and 318 K), and lutein to lipid ratio (0.5 and 1 wt%) on the liposome average size and size distribution are investigated, as well as on the encapsulation efficiency (EE) of lutein. This process is worked in a repeatable manner and is allowed the production of nanoliposomes with mean diameters (MDs) ranging from 65 ± 33 to 77 ± 40 nm, obtaining lutein EEs ranging from 82.1 ± 3.7% to 91.9 ± 2.9%. Temperature, pressure, and lutein to lipid ratio seem to have no impact on size, size distribution, and EE on formed liposomes. The use of low temperatures and low pressures allows the obtainment of liposomes with diameters less than 100 nm and limits the process energy cost. Moreover, the supercritical CO2-assisted batch process effectively encapsulates lutein into liposome, an antioxidant molecule used for the prevention of retinal damage. Liposomes formed by this supercritical process have the desired characteristics for human target delivery. Practical applications: This work on the optimization of a process for developing liposomes in a supercritical environment has applications in medicine. Indeed, the liposomes formed with this process are nanoliposomes with a size of less than 80 nm. In addition, excellent lutein EEs (hydrophobic molecules) show that the liposomes formed constitute excellent coating matrices for the protection of active ingredients. These reasons make these liposome matrices applicable in nanomedicine (injection of sensitive drugs requiring protection before injection). The elaboration process also makes it possible to form liposomes with desired properties by changing pressure, temperature, or lecithin concentration. Therefore, this work focuses on the properties of liposomes as a function of the operating conditions. 相似文献
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在参考相关文献中关于涂层耐沾污测试方法的基础上,结合国内涂层的耐沾污性测试标准,对有机硅乳液涂料(A)、丙烯酸酯乳液涂料(B)和全氟丙烯酸酯乳液涂料(C)进行耐沾污性测试对比,结果表明:总体耐沾污性顺序为C>A,B,同时证明了全氟丙烯酸酯涂料具有优秀的耐水性、耐酸碱性和耐沾污性能。 相似文献
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采用负载-浸渍法制备了一系列SO42-/ZrO2-CeO2固体超强酸,用于催化合成聚乳酸,考察了催化剂用量、聚合时间、聚合方法等因素对聚乳酸合成的影响。结果表明,当CeO2与ZrO2的摩尔比为1∶20,0.8 mol/L硫酸浸渍,650℃焙烧时,得到的固体超强酸酸强度最大,掺杂的CeO2处于高度分散,增强了固体超强酸的酸强度,合成的聚乳酸的分子量与固体超强酸的酸强度具有很好的相关性,当催化剂用量为乳酸质量的1%,反应时间为30 h时,得到了粘均分子量为11.6×103的聚乳酸。 相似文献
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The epoxy–imidazole resin system is used to form the anisotropic conducting film. The latent character of the system is very significant. In this study, imidazole (Im) or 2‐methylimidazole (2MI) was encapsulated for the latent curing system to use in the reaction of epoxy resin. Polycaprolactone was used as a wall material, and the solvent evaporation method was used to form the microcapsule using W/O/W emulsion. The shelf life of the microcapsules was studied for the epoxy resin, and the curing behavior of the microcapsules for epoxy resin was examined using a differential scanning calorimeter. The curing times at 150 and 180°C were estimated using an indentation method. The microcapsules of Im or 2MI exhibited a long shelf life for epoxy resin. When comparing the results of the previous methods with the results of this study using the W/O/W emulsion, finer microcapsules were formed and the microcapsule has longer shelf life. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 相似文献
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超临界流体技术在纤维素中的应用 总被引:9,自引:0,他引:9
综述了超临界流体技术在纤维素方面的研究进展和应用,包括超临界萃取,超临界流体制浆,纤维素超临界降解,木材超临界热解,超临界水处理,木材超临界流体辅助改性和超临界染色等。并对其应用前景进行了讨论。 相似文献