Meningoradiculitis revealing an occult medulloblastoma-PNET in an adult

Neoplastic meningitis as the presentation of occult primitive neuroectodermal tumor (PNET) is occasionally described in children. We report the case of an 64 year old-man who presented a meningo-radiculopathy with progressive injury of the cauda equina and then the ocular motor nerves, revealing an occult medulloblastoma-PNET.     

Designing of an electric regime for an arc steel-melting furnace using a heat-exchange model for an arc

New methods for choosing the operating current and the electric circuit parameters of a designed ASF, which are based on a heat-exchange model of an electric arc, are considered.     

Production of an antibiotic by an organism from human feces

An antibiotic-producing, gram-positive, rod-shaped bacterium was isolated from an individual who often lacked coliforms and fungi in fecal samples. The cell-free antibiotic is 1,200 daltons and Pronase sensitive and was shown to have activity against some coliforms and yeast.     

Temperaturmessungen an Sauerstoffschiebern

Die Aufklärung von Unfällen an Sauerstoffschiebern, die gegen eine drucklose Leitung öffneten, ließ thermodynamische Ursachen vermuten. Bei der hohen Affinität des Schieberwandmaterials Stahl zum reinen Sauerstoff genügt die punktförmige Erzeugung der Entzündungstemperatur zum Beginn einer explosionsartigen Verbrennung des Schieberkörpers. Theoretisch und versuchsmäßig wird nachgewiesen, daß thermodynamische Prozesse existieren, die bei geeigneter Abstimmung der beteiligten geometrischen und thermodynamischen Parameter als Unfallursache in Frage kommen. Zur Nachprüfung wurde das Temperaturverhalten realer Sauerstoffschieber beim Betrieb mit Druckluft experimentell ermittelt.     

Untersuchungen an Thomasschienenstahl

Untersuchungen zur Ermittlung der Ursachen für das Auftreten schwarzer Flecken und senkrechter Nierenbrüche in Schienen aus Thomasstahl. Veränderung des Sauerstoffgehaltes des Schienenstahls vom Zeitpunkt kurz vor dem Ausleeren bis zum Abgußende und dessen Zusammenhang mit dem Gehalt der Schiene an nichtmetallischen Einschlüssen. Prüfung der Schienen mit Ultraschall auf nichtmetallische Einschlüsse. Ermittlung von Spannungsrissen und ihrer Entstehungsursachen in Schienen. Untersuchung der Ursache von Oberflächenfehlern an Schienen.     

Writing an abstract

Infectious and inflammatory disorders cause a disturbance in iron metabolism that leads to a sequestration of iron in the reticuloendothelial (R-E) system and a sometimes sharp and sudden decline in red blood cell indices. Underlying inflammatory conditions can decrease responsiveness to Epoetin alfa in dialysis patients and complicate anemia management. Understanding the possible infectious and inflammatory etiologies that can affect enemia management is essential to enhancing the nursing care of dialysis patients. Nurses caring for patients receiving Epoetin alfa must be aware of the possible effects of these conditions and know how to assess, detect, intervene, and evaluate factors that detract from an optimal erythropoietic response.     

Perineurioma: an unusual cause of an external auditory canal polyp

BACKGROUND: Home parenteral nutrition (HPN) is used to treat intestinal failure. A minority of HPN patients are dependent on opiates and benzodiazepines to control pain and anxiety. The aim of this study was to determine what effects such drug dependence had on patient outcomes. METHODS: Ten dependent patients were prospectively compared with 10 well-matched, nondependent HPN patients for the same 12-month period. Episodes of line sepsis and other complications were documented and the cost of treatment estimated. Health status was measured using the SF36 and EuroQol instruments. RESULTS: The dependent group had significantly more episodes of central line sepsis (p = .0007) as well as other complications (p = .0002). This led to significantly longer periods of inpatient care (p = .0004) and therefore higher costs of treatment. Health status was lower in the dependent group; they reported more pain (p = .04) and less energy (p = .04). CONCLUSIONS: The complication rate and increased cost of treatment for opiate- and sedative-dependent patients receiving HPN significantly detract from the overall outcome of this therapy.     

Development of an outcomes management program at an academic medical center

Donor CD4+ and CD8+ T cells mediate graft-vs.-leukemia (GVL) responses in the allogeneic bone marrow transplantation (alloBMT) setting. To evaluate the role of functional T cell subsets in the mediation of GVL, alloreactive donor CD4+ (Th1/Th2) and CD8+ (Tc1/Tc2) T cells of defined cytokine phenotype were generated by in vitro culture. A leukemia/transplantation model (B6 into B6C3F1; 1050 cGy host irradiation) was established using the bcr/abl-transfected myeloid leukemia line, 32Dp210 (P210; H-2k). Leukemia control mice (1X10(4) P210 cells per recipient) died at day 12.0 post-BMT. Recipients of the CD4+, Th1-type or CD8+, Tc1-type populations were conferred a survival advantage (death at 20.7 and 23.5 days post-BMT, respectively). In contrast, the CD4+, Th2-type population did not mediate GVL (death at 12.3 days). Furthermore, cell mixing experiments demonstrated that the Th2 subset abrogated both Th1- and Tc1-mediated GVL. The CD8+, Tc2 population, which secreted type II cytokines and lysed the P210 leukemia target in vitro, mediated GVL in some experiments; interestingly, the magnitude of Tc2-mediated GVL was inversely related to the level of interleukin-10 (IL-10) secreted in vitro by the Tc2 population. These studies therefore indicate that alloreactive T cells of type I phenotype maximally generate GVL, and that type I/type II interactions are an important consideration for allogeneic transplantation in the setting of leukemic hosts.