Finite-Element Analysis of Ex Vivo and In Vivo Hepatic Cryoablation

Cryoablation is a widely used method for the treatment of nonresectable primary and metastatic liver tumors. A model that can accurately predict the size of a cryolesion may allow more effective treatment of tumor, while sparing normal liver tissue. We generated a computer model of tissue cryoablation using the finite-element method (FEM). In our model, we considered the heat transfer mechanism inside the cryoprobe and also cryoprobe surfaces so our model could incorporate the effect of heat transfer along the cryoprobe from the environment at room temperature. The modeling of the phase shift from liquid to solid was a key factor in the accurate development of this model. The model was verified initially in an ex vivo liver model. Temperature history at three locations around one cryoprobe and between two cryoprobes was measured. The comparison between the ex vivo result and the FEM modeling result at each location showed a good match, where the maximum difference was within the error range acquired in the experiment (< 5 degC). The FEM model prediction of the lesion size was within 0.7 mm of experimental results. We then validated our FEM in an in vivo experimental porcine model. We considered blood perfusion in conjunction with blood viscosity depending on temperature. The in vivo iceball size was smaller than the ex vivo iceball size due to blood perfusion as predicted in our model. The FEM results predicted this size within 0.1-mm error. The FEM model we report can accurately predict the extent of cryoablation in the liver.     

Comparisons Between the p--q and p--q--r Theories in Three-Phase Four-Wire Systems

This paper presents a comparative analysis between results from applications of the p-q and the p-q-r theories in shunt active power filters for three-phase four-wire systems, discussing aspects related to the influence of the system voltage in the control methods that calculate the compensating currents. It is shown that in some cases, a preprocessing of the system voltage is required if the goal is to achieve sinusoidal compensated currents. On the other hand, when the goal is to compensate zero-sequence current, the need of energy storage elements in the active filter is discussed. In this case, if zero-sequence components are present simultaneously in the system voltage and load current, they produce zero-sequence power flow, and the control methods based on both theories must contain additional calculations to allow the elimination of energy storage elements in the active filter. A control strategy based on the p-q theory is proposed to eliminate the neutral current without the need of energy storage elements, with the advantage of avoiding the extra transformation from alphabeta0 to pqr coordinates that is needed in the p-q-r theory. Simulation results are presented for the purpose of comparing the performance of both control methods.     

In-Vitro and In-Vivo Trans-Scalp Evaluation of an Intracranial Pressure Implant at 2.4 GHz

Elevation of intracranial pressure is one of the most important issues in neurosurgery and neurology in clinical practice. The prevalent techniques for measuring intracranial pressure require equipments that are wired, restricted to a hospital environment, and cause patient discomfort. A novel method for measuring the intracranial pressure is described. A wireless completely implantable device, operating at an industrial-scientific-medical band of 2.4 GHz, has been developed and tested. In-vitro and in-vivo evaluations are described to demonstrate the feasibility of microwave pressure monitoring through scalp, device integrity over a long period of time, and repeatability of pressure measurements. A distinction between an epidural and sub-dural pressure monitoring techniques is also described. Histo-pathological results obtained upon a long-term device implantation favor the utilization of the sub-dural pressure monitoring method. On the other hand, in-vivo studies illustrate a maximum pressure reading error of 0.8 mm middot Hg obtained for a sub-dural device with a capacitive microelectromechanical system sensor compared to 2 mm middot Hg obtained for an epidural device with a piezoresistive sensor.     

Theoretical Analysis of Novel Multi-Order LC Oscillators

A conventional differential pair LC oscillator is capable of generating only a single fundamental oscillation frequency. This brief presents the theoretical study of a novel oscillator that incorporates higher order LC filters to produce multiple oscillation frequencies that may be several octaves apart. These multiple oscillation frequencies are obtained from a single oscillator, thereby reducing the area of the circuit when being used for multistandard wireless applications. Moreover, a multi-order oscillator does not suffer from large parasitic capacitances from switches, which is a common drawback in switched-inductor tuned oscillators. A detailed analysis is carried out, and useful design insights are provided     

An In Vitro Model of a Retinal Prosthesis

Epiretinal prostheses are being developed to bypass a degenerated photoreceptor layer and excite surviving ganglion and inner retinal cells. We used custom microfabricated multielectrode arrays with 200-mum-diameter stimulating electrodes and 10-mum-diameter recording electrodes to stimulate and record neural responses in isolated tiger salamander retina. Pharmacological agents were used to isolate direct excitation of ganglion cells from excitation of other inner retinal cells. Strength-duration data suggest that, if amplitude will be used for the coding of brightness or gray level in retinal prostheses, shorter pulses (200 mus) will allow for a smaller region in the area of the electrode to be excited over a larger dynamic range compared with longer pulses (1 ms). Both electrophysiological results and electrostatic finite-element modeling show that electrode-electrode interactions can lead to increased thresholds for sites half way between simultaneously stimulated electrodes (29.4 plusmn 6.6 nC) compared with monopolar stimulation (13.3 plusmn 1.7 nC, < 0.02). Presynaptic stimulation of the same ganglion cell with both 200- and 10- m-diameter electrodes yielded threshold charge densities of 12 plusmn 6 and 7.66 plusmn 1.30 nC/cm², respectively, while the required charge was 12.5 plusmn 6.2 and 19 plusmn 3.3 nC.     

Dual-Band LC VCO Architecture With a Fourth-Order Resonator

A dual-band LC voltage-controlled oscillator (VCO) architecture suitable for GSM/PCS/DCS applications is presented. The VCO utilizes a fourth-order resonance tank and avoids quality-factor-deteriorating switches. The paper outlines the design tradeoffs and the VCO when using a fourth-order resonator. The 0.8-GHz/1.8-GHz test chip was fabricated in the 0.5-mum IBM-5AM SiGe process and has achieved phase noise of -134 dBc/Hz at a 1-MHz frequency offset from the carrier, with 56-MHz and 121-MHz tuning ranges in the corresponding bands. The VCO core consumes 15 mW from a 2.5-V power supply     

Adaptive Impedance-Matching Techniques for Controlling L Networks

The link quality of mobile phones suffers from antenna mismatch due to fluctuating body effects. Techniques for adaptive control of impedance-matching L networks are presented, which provide automatic compensation of antenna mismatch. To secure reliable convergence, a cascade of two control loops is proposed for independent control of the real and imaginary parts of impedance. A secondary feedback path is used to enforce operation into a stable region when needed. These techniques exploit the basic properties of tunable series and parallel LC networks. A generic quadrature detector that offers a power-independent orthogonal reading of the complex impedance value is presented, which is used for direct control of variable capacitors. This approach renders calibration and elaborate software computation superfluous and allows for autonomous operation of adaptive antenna-matching modules.      

A High-Throughput Maximum a Posteriori Probability Detector

This paper presents a maximum a posteriori probability (MAP) detector, based on a forward-only algorithm that can achieve high throughputs. The MAP algorithm is optimal in terms of bit error rate (BER) performance and, with Turbo processing, can approach performance close to the channel capacity limit. The implementation benefits from optimizations performed at both algorithm and circuit level. The proposed detector utilizes a deep-pipelined architecture implemented in skew-tolerant domino and experimentally measured results verify the detector can achieve throughputs greater than 750 Mb/s while consuming 2.4 W. The 16-state EEPR4 channel detector is implemented in a 0.13$ mu{hbox {m}}$ CMOS technology and has a core area of 7.1 ${hbox {mm}}^{2}$.      

In Vivo Impedance Imaging With Total Variation Regularization

We show that electrical impedance tomography (EIT) image reconstruction algorithms with regularization based on the total variation (TV) functional are suitable for in vivo imaging of physiological data. This reconstruction approach helps to preserve discontinuities in reconstructed profiles, such as step changes in electrical properties at interorgan boundaries, which are typically smoothed by traditional reconstruction algorithms. The use of the TV functional for regularization leads to the minimization of a nondifferentiable objective function in the inverse formulation. This cannot be efficiently solved with traditional optimization techniques such as the Newton method. We explore two implementations methods for regularization with the TV functional: the lagged diffusivity method and the primal dual–interior point method (PD-IPM). First we clarify the implementation details of these algorithms for EIT reconstruction. Next, we analyze the performance of these algorithms on noisy simulated data. Finally, we show reconstructed EIT images of in vivo data for ventilation and gastric emptying studies. In comparison to traditional quadratic regularization, TV regulariza tion shows improved ability to reconstruct sharp contrasts.      

A Novel Driving Scheme for Synchronous Rectifiers in LLC Resonant Converters

This paper proposes a novel synchronous rectifier (SR) driving scheme for resonant converters. It is very suitable for high-frequency, high-efficiency, and high-power-density dc–dc resonant converters with SRs. In this paper, an LLC resonant converter with the proposed synchronous rectification is designed and analyzed. With the proposed driving scheme, the SR body diode conduction is reduced to almost zero. The driving scheme eliminates the reverse-recovery problem of SRs. Both current and voltage stresses are greatly decreased, and the conduction loss and switching loss of SRs are also reduced considerably. The experimental results show that the proposed LLC resonant converter with SRs can achieve low stress, high efficiency, and high power density.      

Digital Wireless—Regulation and Control Free?

Considers how different our present state of technological prowess would be if wireless systems had not been discovered and implemented, then forecasts where we are headed in the real world and what the role of government and regulators may be.     

System Design and Control of Anthropomorphic Walking Robot LOLA

This paper presents the 25-DOF full-size humanoid robot LOLA . Our goal is to realize fast and human-like walking. Furthermore, we want to increase the robot’s autonomous, vision-guided walking capabilities. LOLA is characterized by a redundant kinematic configuration, an extremely lightweight design, joint actuators with brushless motors and an electronics architecture using decentralized joint control. Special emphasis was put on an improved mass distribution to achieve good dynamic performance. Center of mass trajectories are calculated in real-time from footstep locations using a spline collocation method. Reference trajectories are modified by a stabilizing control system based on hybrid force/position control with an inner joint position control loop.      

High-Program/Erase-Speed SONOS With In Situ Silicon Nanocrystals

In this letter, for the first time, we have successfully fabricated silicon-oxide-nitride-oxide-silicon (SONOS) devices with embedded silicon nanocrystals (Si-NCs) in silicon nitride using in situ method. This process is simple and compatible to modern IC processes. Different Si-NCs deposition times by in situ method were investigated at first. SONOS devices with embedded Si-NCs in silicon nitride exhibit excellent characteristics in terms of larger memory windows (> 5.5 V), lower operation voltage, high P/E speed, and longer retention time (> 10⁸ s for 13% charge loss).     

Miniature in vivo Robots for Remote and Harsh Environments

Long-term human space exploration will require contingencies for emergency medical procedures including some capability to perform surgery. The ability to perform minimally invasive surgery (MIS) would be an important capability. The use of small incisions reduces surgical risk, but also eliminates the ability of the surgeon to view and touch the surgical environment directly. Robotic surgery, or telerobotic surgery, may provide emergency surgical care in remote or harsh environments such as space flight, or extremely forward environments such as battlefields. However, because current surgical robots are large and require extensive support personnel, their implementation has remained limited in forward environments, and they would be difficult, or impossible, to use in space flight or on battlefields. This paper presents experimental analysis of miniature fixed-base and mobile in vivo robots to support MIS surgery in remote and harsh environments. The objective is to develop wireless imaging and task-assisting robots that can be placed inside the abdominal cavity during surgery. Such robots will provide surgical task assistance and enable an on-site or remote surgeon to view the surgical environment from multiple angles. This approach is applicable to long-duration space flight, battlefield situations, and for traditional medical centers and other remote surgical locations.     

Interference and Outage in Clustered Wireless Ad Hoc Networks

In the analysis of large random wireless networks, the underlying node distribution is almost ubiquitously assumed to be the homogeneous Poisson point process. In this paper, the node locations are assumed to form a Poisson cluster process on the plane. We derive the distributional properties of the interference and provide upper and lower bounds for its distribution. We consider the probability of successful transmission in an interference-limited channel when fading is modeled as Rayleigh. We provide a numerically integrable expression for the outage probability and closed-form upper and lower bounds. We show that when the transmitter–receiver distance is large, the success probability is greater than that of a Poisson arrangement. These results characterize the performance of the system under geographical or MAC-induced clustering. We obtain the maximum intensity of transmitting nodes for a given outage constraint, i.e., the transmission capacity (of this spatial arrangement) and show that it is equal to that of a Poisson arrangement of nodes. For the analysis, techniques from stochastic geometry are used, in particular the probability generating functional of Poisson cluster processes, the Palm characterization of Poisson cluster processes, and the Campbell–Mecke theorem.      

In Situ Acoustic Temperature Measurement During Variable-Frequency Microwave Curing

Variable-frequency microwave (VFM) curing can perform the same processing steps as conventional thermal processing in minutes, without compromising intrinsic material properties. With increasing demand for novel dielectrics, there is a corresponding demand for new processing techniques that lead to comparable or better properties than conventional methods. VFM processing can be a viable alternative to conventional thermal techniques. However, current limitations include a lack of reliable temperature measuring techniques. This research focuses on developing a reliable temperature measuring system using acoustic techniques to monitor low-k polymer dielectrics cured on silicon wafers in a VFM furnace. The acoustic sensor exhibits the capability to measure temperatures from 20degC to 300degC with an attainable accuracy of plusmn2 degrees.     

On Simple Methods for Shape Reconstruction of Unknown Scatterers

Efficient and reliable reconstruction of location and shape of dielectric targets via microwave imaging is relevant in many applications. In this respect, the linear sampling method is an effective candidate to pursue this task. However, despite its simplicity and computational effectiveness, still its use is restricted to the mathematical community wherein it has been originally developed. Starting from this observation, in this paper we propose and test a simple and original "physical" interpretation of the linear sampling methods, which shows its relationship with electromagnetic focusing problems. Taking advantage of this result we discuss merits and limitations of the method and suggest new guidelines for a successful application. The analysis is supported with results against experimental data     

Low Phase Noise Self-Switched Biasing CMOS LC Quadrature VCO

A self-switched biasing quadrature voltage-controlled oscillator (VCO) is presented. It is implemented by directly injecting the oscillation signal of one VCO core into the other VCO core through the divided tail current sources without additional active devices for coupling. The proposed coupling structure automatically switches the NMOS field-effect transistors used in VCO cores and current sources from strong inversion to accumulation. Since the deep switching of MOSFETs was reported to physically reduce flicker noise, the proposed quadrature VCO (QVCO) is expected to improve the phase noise performance, which is confirmed experimentally. The designed QVCO using 0.18- $mu{hbox{m}}$ CMOS technology operates from 1.86 to 2.2 GHz with a 17% frequency tuning range. The measured phase noise is from $-$ 129.1 to $-$ 134.5 dBc/Hz at a 1-MHz offset, which is really close to ideal simulation results with the NMOS model disabling the flicker noise components. The average measured phase noise is 7.2 dB below the simulated one with a flicker noise model, which verifies the physical reduction of flicker noise by deep switching of the MOSFET. The phase noise figure-of-merit ranges from 179 to 185 over the entire tuning range. The QVCO dissipates 20 mA from a 1.8-V supply.      

Temperature Control and In Situ Fault Detection of Wafer Warpage

Warped wafers can affect device performance, reliability, and linewidth control in various processing steps. We propose in this paper an in situ fault detection technique for wafer warpage in lithography. The use of advanced process control results in very small temperature disturbance making it suitable for industrial implementation     

Explicit Model-Predictive Control of a PWM Inverter With an LCL Filter

This paper deals with the control of pulsewidth modulation inverters connected to the grid through resonant LCL filters. It proposes two alternative (piecewise affine) models that account for the switched behavior of the converter. Based on these improved models, an explicit model-predictive control scheme is derived in order to provide a fast response, making it very suitable for applications, such as active filtering, where a large bandwidth is required. A state observer and a grid voltage estimator are used in order to reduce the number of required sensors and to eliminate noise. The control scheme relies only on filtered current measurements and on the dc voltage.