Soluble adhesion molecules correlate with liver inflammation and fibrosis in chronic hepatitis C treated with interferon-alpha

Investigators have recently identified a two-factor structure underlying posttraumatic stress symptoms through the use of exploratory factor analysis. [Taylor et al. (1988). The structure of posttraumatic stress symptoms. Journal of Abnormal Psychology, 107, 154-160]. These two factors, which were labeled as Intrusion and Avoidance, and Hyperarousal and Numbing, are consistent with current theoretical models of posttraumatic stress disorder--PTSD [e.g. Foa et al. (1992). Uncontrollability and unpredictability in post-traumatic stress disorder: An animal model. Psychological Bulletin, 112, 218-238]. However, the authors of the Taylor et al. study issued caution in interpreting their findings because there has yet to be a systematic replication of their results. This paper presents a confirmatory factor analysis of the two-factor structure of posttraumatic stress symptoms in 217 survivors of serious motor vehicle accidents with varying degrees of PTSD symptoms. A hierarchical, confirmatory-factor analysis conducted with a structural equation modeling statistics package confirmed that the model proposed by Taylor et al. can adequately account for the presentation of PTSD symptoms in this sample of motor vehicle accident survivors. The implications for the assessment and diagnosis of PTSD are discussed.     

Stream Bank Erosion: In Situ Flume Tests

A new technique for testing the erodibility of cohesive stream banks using an in situ flume is presented. The erosion rate is estimated from direct measurements of bed surface elevations by acoustic sensors. The sediment resuspension rate is obtained using data on sediment concentrations measured by optical backscatter sensors and from water samples. The bed-load contribution to the total erosion rate is evaluated from the conservation equation for sediments. Temporal patterns of erosion and resuspension rates are studied employing stepwise increments of bed-shear stress. The data show that bed load plays a significant role in cohesive bank erosion. The data analysis suggests that erosion and resuspension thresholds observed in experiments were very low or equal to zero. The data support the power type equation for the erosion and resuspension rates with bed-shear stress as the key factor. The data also highlights the potential importance of mud content and water content on erosion.     

Flume Measurements of Sediment Erodibility in Boston Harbor

To obtain in situ measurements of sediment erodibility in defined bottom shear stress environments, a portable, straight flume was built, tested, and deployed in the field for six experiments at three locations in Quincy Bay of Boston Harbor, Mass. The flume had a 1.0-m-long inlet section, which included a boundary-layer trip and a roughened, plexiglass bottom; this design prevented erosion of the sediment bed in the boundary-layer-development region. Downstream of the inlet section was a 1.2-m-long sediment test section, which had a laboratory-verified, uniform bottom stress. In the absence of algal mats, our flume experiments on sites exhibiting a range of bed properties indicated quite uniform erodibility, with a critical shear stress τc of 0.10 ± 0.04 Pa and an erosion rate constant M of 3.2 ± 0.2 × 10?3 kg m?2 s?1 Pa?1 (R2 = 0.92, N = 17, where N is the total number of erosion rate measurements made in the absence of algal mats). The measured rates were consistent with those of many other in situ studies. We observed markedly reduced erodibility in early October 1995 when the sediment was covered by a benthic diatom mat, and measured erosion rates were lessened by 50–80%. The possibility of depth-dependent sediment erodibility in near surface (top 3 mm) was investigated by calculating a set of depth-dependent erosion parameters. The parameters obtained suggested that both the critical shear stress and the erosion rate constant were depth-sensitive (both doubling by 1 mm into the sediment).     

Am I the fifth horseman of the apocalypse? Comment on Galassi, Crace, Martin, James, and Wallace (1992) and comments on research concerning expectations about counseling.

The criticisms by J. P. Galassi et al (see record 1992-17938-001) of H. E. Tinsley and B. L. Benton (1978) and the Expectations About Counseling instrument are shown to be unfounded, problems with the terminology of Galassi et al are discussed, and the technical adequacy and findings of Galassi et al are analyzed. Problems that have occurred frequently in research on expectations about counseling are attributed to lack of programmatic research, failure to critically analyze existing literature, and use of instruments designed for a single study. The devotion of too much attention to "let's change a word" and "let's change a demographic variable" research is criticized. More effort is called for (1) to identify and measure theoretically relevant expectations, (2) to examine the relations between expectations and related constructs, (3) to determine how expectations can be modified, and (4) to investigate the relation of expectations to aspects of the counseling process and outcome. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of Sand Movement on a Cohesive Substrate

Flume experiments investigated the effect of mobile sand on the erosion of cohesive beds. The fluid-induced stress alone was not enough to cause erosion, and sand motion as bed load was needed. Erosion rates and suspended sediment concentration were found to increase with increasing sand transport and to decrease with increasing median grain size. The erosion rate was found to be at a maximum during saltation, intermediate during creep, and lowest during suspension.     

Numerical Simulation of Longitudinal and Lateral Channel Deformations in the Braided Reach of the Lower Yellow River

Bank erosion frequently occurs in the Lower Yellow River (LYR), playing an important role in the evolution of this braided river. A two-dimensional (2D) composite model is developed herein that consists of a depth-averaged 2D flow and sediment transport submodel and a bank-erosion submodel. The model incorporates a new technique for updating bank geometry during either degradational or aggradational bed evolution, allowing the two submodels to be closely combined. Using the model, the fluvial processes in the braided reach of the LYR between Huayuankou and Laitongzhai are simulated, and the calculated results generally agree with the field measurements, including the water-surface elevation, variation of water-surface width, and variations of cross-sectional profiles. The calculated average water-surface elevation in the study reach was 0.09?m greater than the observed initial value, and the calculated mean bed elevation for six cross sections was 0.11?m lower than the observed value after 24 days. These errors are attributed to the large variability of flow and sediment transport processes. Sensitivity tests of three groups of parameters are conducted, and these groups of parameters are related to flow and sediment transport, bank erosion, and model application, respectively. Analysis results of parameter sensitivity tests indicate that bank erodibility coefficient and critical shear stress for bank material are sensitive to the simulated bank erosion process. The lateral erosion distance at Huayuankou will increase by 19% as the value of bank erodibility coefficient changes from 0.1 to 0.3, and it will decrease by 57% as the value of critical shear stress for bank increases from 0.6 to 1.2?N/m2. Limited changes of other parameters have relatively small effects on the simulated results for this reach, and the maximum change extent of calculated results is less than 5%. Because the process of sediment transport and bank erosion in the braided reach of the LYR is very complicated, further study is needed to verify the model.     

Upland Erosion Modeling in a Semihumid Environment via the Water Erosion Prediction Project Model

The major water quality impairment in the midwest United States is sediment eroded from agricultural lands. Yet, few understand the spatial and temporal variability of erosion, or soil erosion dynamics, in relation to precipitation, topography, land management, and severe events. The objectives of this paper are to (1) develop a methodology for estimating long-term spatial soil erosion and water runoff losses and (2) explore issues in applying an established physical-based process model, Water Erosion Prediction Project (WEPP), to a large area by establishing a prototype system for the state of Iowa. This study for the first time provides a comparison of the model predictions against long-term measurements of the sediment delivery ratio (SDR) in the South Amana Catchment of the Clear Creek Watershed (CCW), a heavily instrumented watershed that is roughly 10 times the maximum WEPP fold size. To further examine the performance of WEPP in a semihumid environment, such as the CCW, where runoff and raindrop impact to erosion may be significant, the SDR was plotted as a function of the runoff coefficient, defined as the runoff/rainfall ratio. In addition, the WEPP predictions are compared against the statistical relation of SDR vs. runoff coefficient developed by Piest et al. in 1975) for watersheds in Iowa. It is shown that WEPP follows the trend shown by Piest et al. quite closely and performs well for continuous simulations extended up to 300?years.     

Numerical Model of Turbidity Currents with a Deforming Bottom Boundary

A numerical model of turbidity currents with a deforming bottom boundary has been developed. The model predicts the vertical structure of the flow velocity and concentration as well as change in the bed level due to erosion and deposition of suspended sediment. The Reynolds-averaged Navier–Stokes equations for dilute suspension have been solved using a finite volume method. The bottom boundary and the grid system are allowed to adjust in response to sediment deposition and entrainment during the computation. The model has been applied to simulate the evolution of a conservative saline density current and turbidity currents along an 11.6?m long flume that includes a slope followed by a horizontal bed. The model successfully simulates the evolution of the currents. Model results have been compared with the experimental data. Good similarity profiles of velocity and excess density or suspended sediment concentration are obtained at both the upstream supercritical and the downstream subcritical flow regions. A turbulent Schmidt number larger than one has been found to be appropriate for providing a good match with the experimental data. Changes in bed level predicted by the model have also been found to be in agreement with the experiment data.     

Performances of Hydraulics and Bedload Sediment Flushing in Rigid Channel Using Surge Flows

This paper presents an investigation of the performance of the hydraulic and sediment removal of a flushing system in a detention basin. A hydraulic criterion for the design of the flushing system is proposed. An equation for the maximum height of the flushing wave front as a function of the distance from the gate, the initial water depth in the chamber, and the chamber length is proposed. The Lauber and Hager equation for the maximum velocity of a flushing wave is also verified. Effective removal of sediment particles on the bed is a direct function of the bed shear stress generated by the flushing flow. This study reveals that the bed shear stress on the channel bed induced by the flushing flow can be attributed to the hydrostatic pressure, the flow acceleration, and the convection-induced momentum. The shear stress associated with fluid distortion and the turbulent viscosity may be neglected. Significant error would occur if the hydrostatic pressure component were used as an estimate of the bed shear stress on a mild slope channel. The energy slope method may provide an overestimate of the bed shear stress. Finally, an appropriate equation to evaluate the maximum bed shear stress is proposed.     

Computational Dam-Break Hydraulics over Erodible Sediment Bed

This paper presents one of the first dedicated studies on mobile bed hydraulics of dam-break flow and the induced sediment transport and morphological evolution. A theoretical model is built upon the conservative laws of shallow water hydrodynamics, and a high-resolution numerical solution of the hyperbolic system is achieved using the total-variation-diminishing version of the second-order weighted average flux method in conjunction with the HLLC approximate Riemann solver and SUPERBEE limiter. It is found that a heavily concentrated and eroding wavefront first develops and then depresses gradually as it propagates downstream. In the early stage of the dam-break, a hydraulic jump is formed around the dam site due to rapid bed erosion, which attenuates progressively as it propagates upstream and eventually disappears. While the backward wave appears to migrate at the same speed as over a fixed bed, the propagation of the forward wavefront shows a complex picture compared to its fixed-bed counterpart as a result of the domination of rapid bed erosion initially, the density difference between the wavefront and the downstream ambient water in the intermediate period, and the pattern of the deformed bed profile in the long term. It is also found that the free surface profiles and hydrographs are greatly modified by bed mobility, which has considerable implications for flood prediction. The computed wave structure in the intermediate period exhibits great resemblance to available experiments qualitatively, and yet the existence of a shear wave is found in lieu of a secondary rarefaction postulated in an existing analysis. Finally, the use of the complete, rather than simplified, conservation equations is shown to be essential for correct resolution of the wave and bed structures, which suggests that previous models need reformulating.     

Predicting Boundary Shear Stress and Sediment Transport over Bed Forms

To estimate bed-load sediment transport rates in flows over bed forms such as ripples and dunes, spatially averaged velocity profiles are frequently used to predict mean boundary shear stress. However, such averaging obscures the complex, nonlinear interaction of wake decay, boundary-layer development, and topographically induced acceleration downstream of flow separation and often leads to inaccurate estimates of boundary stress, particularly skin friction, which is critically important in predicting bed-load transport rates. This paper presents an alternative methodology for predicting skin friction over 2D bed forms. The approach is based on combining the equations describing the mechanics of the internal boundary layer with semiempirical structure functions to predict the velocity at the crest of a bedform, where the flow is most similar to a uniform boundary layer. Significantly, the methodology is directed toward making specific predictions only at the bed-form crest, and as a result it avoids the difficulty and questionable validity of spatial averaging. The model provides an accurate estimate of the skin friction at the crest where transport rates are highest. Simple geometric constraints can be used to derive the mean transport rates as long as bed load is dominant.     

Earth Pressure due to Vibratory Compaction

This paper presents experimental data on the variation of lateral earth pressure against a nonyielding retaining wall due to soil filling and vibratory compaction. Air-dry Ottawa sand was placed in five lifts and each lift was compacted to achieve a relative density of 75%. Each compacted lift was 0.3?m thick. The instrumented nonyielding wall facility at National Chiao Tung University in Taiwan was used to investigate the effects of vibratory compaction on the change of stresses at the soil-wall interface. Based on the experimental data it has been found that, for a compacted backfill, the vertical overburden pressure can also be properly estimated with the traditional equation σv = γz. The effects of vibratory compaction on the vertical pressure in the backfill were insignificant. On the vertical nonyielding wall, extra horizontal earth pressure was induced by vibratory compaction. After compaction, the lateral earth pressure measured near the top of the wall was almost identical to the passive Rankine pressure. It is concluded that as the cyclic compacting stress applied on the surface of the backfill exceeded the ultimate bearing capacity of the foundation soil, a shear failure zone would develop in the uppermost layer of the backfill. For a soil element under lateral compression, the vertical overburden pressure remained unchanged, and the horizontal stress increased to the Rankine passive pressure. It was also found that the compaction-influenced zone rose with the rising compaction surface. The horizontal earth pressure measured below the compaction-influenced zone converged to the Jaky state of stress.     

Erosion of Finite Thickness Sediment Beds by Single and Multiple Circular Jets

Sediment management in reservoirs with the help of water jets has motivated this work. Erosion caused by single and multiple submerged circular turbulent wall jets on a noncohesive sediment bed of finite thickness lying on a fixed boundary was studied with the help of laboratory experiments. Different combinations of jet diameter, jet separation, and sediment thickness to jet diameter ratio were tested. Results show a relation between dimensionless parameters characterizing the steady state bed profile and the densimetric particle Froude number F0 given by the velocity at the nozzle and the effective diameter and submerged specific density of the sediment. Evolution of scour with time confirms previous studies where the erosion was found to initially grow with the logarithm of time up to a certain reference time t*. This time, made dimensionless with a time scale tc involving the volume of sediment scoured and the rate of erosion, was also related to the densimetric Froude number. A comparison with studies regarding erosion of a semiinfinite layer of sediment is also presented.     

Influence of Grouting Pressure and Overburden Stress on the Interface Resistance of a Soil Nail

Grouted soil nails are widely used in slope stabilization. The influence of both grouting pressure and overburden stress on the soil-nail pullout interface shear resistance is still not well understood due to the complex of soil-grout interactions. A series of laboratory soil-nail pullout tests have been carried out on a completely decomposed granite soil in nearly saturated condition under a combination of different grouting pressures and overburden stresses. The pullout tests simulate the real construction process of a soil nail, including establishment of initial soil stresses in a soil slope, drilling a hole with stress release, grouting, and soil-nail pullout when the slope is sliding. The pullout box is well instrumented. Test data are collected automatically by a data logger. Typical test results are presented, explained, and discussed in this paper. The soil-nail interface shear resistance data from all tests are analyzed and interpreted. The study shows that the grouting pressure and overburden stress have interactional influence on the soil-nail pullout resistance. Based on the test results, a new empirical liner equation with two grouting pressure dependent parameters is proposed for calculation of soil-nail pullout resistance considering both grouting pressure and overburden stress. New understandings and findings from the study are presented.     

Heart rate perception in the Type A personality.

Compared 28 male students with Type A (coronary prone) behavior with 28 Type B (noncoronary prone) behavior males for accuracy in estimating their own heart rates at rest and in response to a mild cognitive stressor. Type A behavior was measured by the Jenkins Activity Survey of D. S. Krantz et al (1974). Both types had significant heart rate increases in the stress periods, but these were greater for Type A Ss. Type A Ss overestimated their heart rate at rest and during stress more often than did Type B Ss. Feedback resulted in more nearly correct estimations by both groups. Type A Ss perceived themselves as being more aroused than did Type B Ss, a finding inconsistent with the hypothesis that Type A individuals underestimate their response to stress. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Interpreting hospital admissions data across the K?rner divide: the example of diabetes in the north western region

Hospital admission rates and hospital bed utilization rates are presented for all admissions assigned to diabetes mellitus as principal cause in the North Western Region from 1980/81 to 1990/91. Data are derived from Hospital Activity Analysis (1980/81-1986/87) and from the Regional Information System (1988/89-1990/91). Admission rates for all categories of diabetes combined showed little change until 1986/87 after which they rose progressively each year. Hospital bed utilization rates fell progressively from 1986/87 onwards, the number of bed days attributed to diabetes falling from 1.9% to 0.8% of the total for all causes. Most of the rise in admission rates from 1988/89 onwards was attributable to diabetes with ophthalmic complications (ICD 250.4). This was heavily influenced by the enumeration of day cases in the Regional Information System. When these are discounted, admission rates for the more recent years are stable. Diabetes without mention of complications (ICD 250.0) showed the most dramatic decline in its contribution to hospital bed utilization. This may be the result of increasing outpatient support from diabetes specialist nurses whose numbers increased in inverse proportion to the fall in bed utilization attributed to ICD 250.0.     

管道内气固两相流冲刷磨损特性数值模拟

针对有色冶金中低温烟气对管道材料的冲刷磨损,利用计算流体力学软件Fluent对气固两相流开展数值模拟研究,讨论了冲刷磨损量和切应力在不同烟气速度、颗粒直径、颗粒含量时的变化情况。结果表明：气固两相流冲刷集中磨损区位于管道前部约1/5处,最大磨损发生在管道入口后部;烟气速度增大时,磨损量与切应力都增大;在一定颗粒直径范围内,颗粒直径增大时,磨损量减小,切应力几乎不变;随着颗粒含量增加,磨损量增大,切应力基本不变。     

Ecological study of reasons for sharp decline in mortality from ischaemic heart disease in Poland since 1991

OBJECTIVE: To investigate the reasons for the decline in deaths attributed to ischaemic heart disease in Poland since 1991 after two decades of rising rates. DESIGN: Recent changes in mortality were measured as percentage deviations in 1994 from rates predicted by extrapolation of sex and age specific death rates for 1980-91 for diseases of the circulatory system and selected other categories. Available data on national and household food availability, alcohol consumption, cigarette smoking, socioeconomic indices, and medical services over time were reviewed. MAIN OUTCOME MEASURES: Age specific and age standardised rates of death attributed to ischaemic heart disease and related causes. RESULTS: The change in trend in mortality attributed to diseases of the circulatory system was similar in men and women and most marked (> 20%) in early middle age. For ages 45 to 64 the decrease was greatest for deaths attributed to ischaemic heart disease and atherosclerosis (around 25%) and less for stroke (< 10%). For most of the potentially explanatory variables considered, there were no corresponding changes in trend. However, between 1986-90 and 1994 there was a marked switch from animal fats (estimated availability down 23%) to vegetable fats (up 48%) and increased imports of fruit. CONCLUSION: Reporting biases are unlikely to have exaggerated the true fall in ischaemic heart disease; neither is it likely to be mainly due to changes in smoking, drinking, stress, or medical care. Changes in type of dietary fat and increased supplies of fresh fruit and vegetables seem to be the best candidates.