Application of Powder-Layering Technology and Film Coating for Manufacture of Sustained-Release Pellets Using a Rotary Fluid Bed Processor

The main objective of this study was to prepare pellets in a Roto-processor using the powder-layering process onto inert nonpareils and to evaluate the applicability of the Roto-processor setup for film coating. Nonpareils were loaded with phenylpropanolamine hydrochloride and coated with ethyl cellulose polymeric dispersion (Surelease®). The drug loading was analyzed to test the eficiency of powder layering. The effect of polymer level on the drug release from the pellets and the pore size distribution in the membrane were studied. The yields for powder layering were greater than 90%. The dissolution studies on the Blm-coated pellets showed sustained release over a 10-hr period. The time required for 50% of drug release increased and the mean pore diameter decreased with an increase in polymer coating.     

流化床对撞式气流粉碎制备SiC超微粉

采用流化床对撞式气流粉碎(QLM-80K)对工业用SiC粉体进行超微化处理，考察了工作压力对超微化的影响；并采用激光粒度分布仪、扫描电镜、XRD对超微化前后的SiC粉体进行粒度、形貌及结构的研究。研究结果表明：工作压力愈高，SiC粉体的超微化效果愈明显。工作压力为0．6MPa时，超微化前后SiC粉体的平均粒径由3．0lμm降至0．75μm，粒径小于2．5μm的比例由82．86％升至99．85％，粒径主要分布由0．4～1．5μm和8～23μm的双峰分布变为0．4～1．2μm的单峰分布，分布宽度从25．125降到0．833；颗粒主要以片状、小块状存在，分布均匀，超微化前存在的大块状颗粒基本消失，团聚现象明显减少；超微化前后SiC粉体的晶型都属于α-SiC(6H)，超微化后各主要衍射峰的强度减弱、半高宽有所宽化。     

Important Parameters for the Manufacture of Slow-Release Matrix Pellets With an Aqueous Dispersion of Quaternary Poly(meth)acrylates in the Rotary Fluidized Bed

ABSTRACT

The manufacture of slow-release matrix pellets with an aqueous dispersion of quaternary poly(meth)acrylates was investigated in the rotary fluidized bed. By considering the moisture content of the fluidized bed to be the key process parameter, it was measured on-line throughout the whole manufacturing process. A specially designed sampling device opened new ways to apply NIR spectrometry in laboratory scale processes. It was shown that reproducibly improved pellet properties can be achieved by reproducing the moisture content of the (rotary) fluidized bed. Moisture plateaus proved to be a suitable way to optimize the sphericity of the pellets. Premoisturizing was found to be a very effective tool to achieve slow-release dissolution of the model drug theophylline.     

流化床气流磨粉碎制备超细SiC片晶的实验研究

超细SiC片晶由于其高强度、高弹性模量和导热系数已成为替代价值昂贵、制备技术复杂SiC晶须的理想的增韧材料。本文中通过对流化床气流磨粉碎机理,以及粉碎腔内工质压强与喷嘴个数对SiC颗粒形貌影响的研究,得出工质压强、喷嘴个数等参数对粉碎的颗粒形貌有很大的影响的结论,其中粉碎腔采用高的工质压强以增加粉碎强度。采用两喷嘴以增加颗粒互相撞击的几率是制备片状SiC粉的有效方法;采用流化床式气流磨加多级涡轮分级机的粉碎系统可以制备产品质量较好的多级别超细SiC片晶微粉。     

液-固流化床回收废旧印刷电路板金属研究

采用液-固流化床对废旧印刷电路板资源化利用进行研究,通过分析颗粒在流化床中的运动机理,计算不同颗粒在流化床中的沉降末速度,并探讨影响颗粒沉降末速度的因素。结果表明,颗粒干扰沉降末速度随着颗粒密度和粒度的增大而增大,随着颗粒体积分数的增大而减小;对不同粒级不同给料量进行分选,随着上升水速的增大,金属回收率随之下降,品位随之提高;在实验范围内,给料量对液-固流化床中金属与非金属的分选效果基本无影响。     

流化床法制备太阳能级多晶硅用沉积硅粒的性能研究

在流化过程中,为保证硅粒在流化床中分布状态良好,提高硅的沉积产率,同时要达到产生太阳能级纯度的多晶硅,对流化床中流化的硅粒的粒径和纯度要求是非常严格的,本文采用球磨技术,通过正交实验,对球磨时间、球磨介质、球的均匀度工艺参数对沉积硅粒的粒径影响及球磨污染程度和形貌特征进行试验研究。试验表明：选择合适的球磨罐和球磨介质,以高纯工业硅进行实验,制得的硅粒平均粒径处于145—166um和166—180um之间时,在进行流态化试验时,完全满足太阳能级多晶硅用沉积硅粒在流化床中流态化分布的要求。     

Effect of Parameters on Treatment of Industrial Effluents Using Inverse Fluidized Bed Bioreactor: Statistical Analysis

Phenolic wastewater (effluents from steel plant) was treated in an inverse fluidized bed (IFB) bioreactor. Effects of different system parameters (viz. residence time (t), settled bed to bioreactor volume ratio (Vb/Vr), water flow rate, static bed height, and gas flow rate) on removal of chemical oxygen demand (COD) were studied to determine the optimum conditions. Optimal conditions corresponding to the largest COD removal were obtained at Vb/Vr ratio of 0.55 and gas flow of 40 LPH with time period greater than 62 h. COD removal was also measured with the addition of mineral salts in the wastewater. The results thus obtained with and without the addition of mineral salt to the wastewater were compared. Addition of nutrient salts to the wastewater yielded better percentage of COD removal. The effect of different types of salts on COD removal was also studied with respect to the biomass growth. Experiments were also carried out by continuous culturing of biomass samples. Conversions greater than 68% and 84% were achieved with batch and continuous mode operation respectively, implying that IFB bioreactor can be used successfully for the treatment of industrial effluents.     

应用外力场制备自生梯度复合材料的研究进展

综述了利用外力场(离心铸造法和电磁分离法)制备自生梯度复合材料的研究现状.指出利用多物理场的复合作用制备新型梯度复合材料将是今后研究的重要方向.     

混合增粘熔体发泡法制备泡沫铝及其压缩性能的研究

为了减少泡沫铝熔体发泡法中单质钙的用量及增加泡沫铝的强度,研究了单质钙增粘、碳化硅增粘以及混合增粘3种不同的增粘方式,并试图通过混合增粘来达到这一目的。结果表明,借助单质钙和碳化硅组成的混合增粘剂可以制备出形状规则、孔结构均匀的泡沫铝试样。碳化硅增粘为机械增粘,而单质钙增粘为化合物增粘,混合增粘将两种增粘机制结合起来,实现了共同增加粘度的作用。混合增粘可以在达到熔体发泡所需粘度的同时减少单质钙的用量,还可以在一定程度上提高泡沫铝的强度,达到了碳化硅颗粒增粘和增强的双重目的。     

CVD制备3C-SiC及其应用于MEMS的研究进展

高温、强振、强腐蚀、高湿等恶劣环境中的监测和控制系统对MEMS(Microelectromechanical systems)提出了新的挑战。SiC具有化学惰性,高热导率及优良的力学、电学、高温性能,在MEMS技术中备受青睐,成为Si-MEMS体系极具竞争力的替代材料。综述了关于立方相碳化硅(3C-SiC)薄膜的化学气相沉积(CVD)制备方法,介绍了其力学、电学性能的最新研究进展,最后举例说明了3C-SiC薄膜在MEMS器件中应用的研究现状。     

国内文创产品设计方法研究综述——基于对《包装工程》所刊发的文创产品设计主题论文的分析

目的 理清国内文创设计方法研究进展,为读者提供了解研究现状的机会,为研究者提供文创设计方法发展动向资讯。方法 文章整理了发表于《包装工程》的1100余篇文创产品设计文献,根据文献引文完善了文创产品设计研究的论文网络,通过泛读与精读相结合的方式,对文献中的文创设计方法进行了分类,依照文创设计的基本流程范式（即撷取文化符号特色、形成设计概念定位、展开文创产品设计）,形成了国内文创产品设计方法研究综述。结论 文章向读者提供了快速认识文创产品设计方法研究流派、脉络及范式的机会,有助于读者了解当前文创产品设计方法研究中的不足与潜在机会,也有助于相关研究者树立研究目标、明确研究方向。