共查询到20条相似文献,搜索用时 15 毫秒
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Artiom Skripka Vitalijus Karabanovas Greta Jarockyte Riccardo Marin Vivienne Tam Marta Cerruti Ricardas Rotomskis Fiorenzo Vetrone 《Advanced functional materials》2019,29(12)
Theranostic nanoagents targeted for personalized medicine provide a unified platform for therapeutics and diagnostics. To be able to discretely control each individually, allows for safer, more precise, and truly multifunctional theranostics. Rare earth doped nanoparticles can be rationally tailored to best match this condition with the aid of core/shell engineering. In such nanoparticles, the light‐mediated theranostic approach is functionally decoupled—therapeutics or diagnostics are prompted on‐demand, by wavelength‐specific excitation. These decoupled rare earth nanoparticles (dNPs) operate entirely under near‐infrared (NIR) excitation, for minimized light interference with the target and extended tissue depth action. Under heating‐free 806 nm irradiation, dNPs behave solely as high‐contrast NIR‐to‐NIR optical markers and nanothermometers, visualizing and probing the area of interest without prompting the therapeutic effect beforehand. On the contrary, 980 nm NIR irradiation is upconverted by the dNPs to UV/visible light, which triggers secondary photochemical processes, e.g., generation of reactive oxygen species by photosensitizers coupled to the dNPs, causing damage to cancer cells. Additionally, integration of NIR nanothermometry helps to control the temperature in the vicinity of the dNPs avoiding possible overheating and quenching of upconversion (UC) emission, harnessed for photodynamic therapy. Overall, a new direction is outlined in the development of state‐of‐the‐art rare earth based theranostic nanoplatforms. 相似文献
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Theranostics: One‐Pot Synthesis of Dual Stimulus‐Responsive Degradable Hollow Hybrid Nanoparticles for Image‐Guided Trimodal Therapy (Adv. Funct. Mater. 47/2016) 下载免费PDF全文
Koichiro Hayashi Takuma Maruhashi Michihiro Nakamura Wataru Sakamoto Toshinobu Yogo 《Advanced functional materials》2016,26(47):8795-8795
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Bioimaging: An Integrated Multifunctional Nanoplatform for Deep‐Tissue Dual‐Mode Imaging (Adv. Funct. Mater. 11/2018) 下载免费PDF全文
Fan Yang Artiom Skripka Antonio Benayas Xianke Dong Sung Hwa Hong Fuqiang Ren Jung Kwon Oh Xinyu Liu Fiorenzo Vetrone Dongling Ma 《Advanced functional materials》2018,28(11)
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Flexible Electronics: 3D Micromolding of Arrayed Waveguide Gratings on Upconversion Luminescent Layers for Flexible Transparent Displays without Mirrors,Electrodes, and Electric Circuits (Adv. Funct. Mater. 28/2015) 下载免费PDF全文
Satoshi Watanabe Takeo Asanuma Takafumi Sasahara Hiroshi Hyodo Mutsuyoshi Matsumoto Kohei Soga 《Advanced functional materials》2015,25(28):4369-4369
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Theranostics: High‐Efficient Clearable Nanoparticles for Multi‐Modal Imaging and Image‐Guided Cancer Therapy (Adv. Funct. Mater. 2/2018) 下载免费PDF全文
Qiaolin Wei Yao Chen Xibo Ma Jianfeng Ji Yue Qiao Bo Zhou Fei Ma Daishun Ling Hong Zhang Mei Tian Jie Tian Min Zhou 《Advanced functional materials》2018,28(2)
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Theranostics: Multifunctional Photonics Nanoparticles for Crossing the Blood–Brain Barrier and Effecting Optically Trackable Brain Theranostics (Adv. Funct. Mater. 39/2016) 下载免费PDF全文
Ajay Singh Woong Kim Youngsun Kim Keunsoo Jeong Chi Soo Kang YoungSoo Kim Joonseok Koh Supriya D. Mahajan Paras N. Prasad Sehoon Kim 《Advanced functional materials》2016,26(39):7025-7025
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