Solid-Liquid Equilibria of trans-1,2-Cyclohexanediol＋Butyl Acetate＋ Water Ternary System

Using a laser observation technique,the solubilities of trans-1,2-cyclohexanediol in butyl acetate＋wa- ter were measured at the temperature range from 298.15K to 323.15K by a synthetic method at atmospheric pres- sure.It is shown that the solubilities of trans-1,2-cyclohexanediol in butyl acetate＋water were affected greatly by the proportion of butyl acetate and water,and presented maximum value at given temperature.The UNIFAC model was used to correlate the experimental data.The average relative deviation（ARD）between experimental and calculated values is 3.03%.     

1,2-环已二醇在溶液中的溶解度

The solubility of trans-1,2-cyclohexanediol in water, methyl acetate, acetic ester, propyl acetate, butyl acetate, methyl acrylate, ethyl acrylate, 2-pentanone and acetoacetic ester was measured at temperatures ranging from about 300K to 330K, using a modification of the experimental technique of laser monitoring observation system. The solubilities were calculated by λh method, in which new parameters were introduced to express the activity coefficients of trans-1,2-cyclohexanediol, and determined from the experimental data. The new parameters provide good calculated results. The experimental data were also correlated with a simple model, and results were compared with present λh model.     

1,2-环己二醇在溶剂中的溶解度

1 INTRODUCTION The solubility of solid in liquids is an excellent tool to investigate solute-solvent intermolecular forces in the liquid state. In this work the solubility of trans-1,2-cyclohexanediol in some polar solvents (wa- ter, methyl acetate, acetic ester, propyl acetate, butyl acetate, methyl acrylate, and ethyl acrylate) was mea- sured at temperatures ranging from about 300 K to 330 K, using a modification of the experimental tech- nique of laser monitoring observation system. So…     

273.15-303.15K下尼扎替丁在甲醇-水、乙醇-水和异丙醇-水中的溶解度(英文)

The solubilities of nizatidine in methanol + water, ethanol + water and i-propanol + water mixtures were determined in the temperature range from 273.15 K to 303.15 K at atmospheric pressure by a static analytical method. The general single model was used to correlate the experimental data, which fits the data very well.     

(S)-(+)-2,2-二甲基环丙烷甲酰胺在不同溶剂中溶解度的测定与关联

（S）-（＋）-2,2-dimethylcyclopropane carbox amide is a key intermediate of Cilastatin, an inhibitor of dehydropeptidase-I. Its corresponding solid-liquid equilibrium data will provide essential support for industrial design and further theoretical studies. The solubilities of （S）-（＋）-2,2-dimethylcyclopropane carbox amide in toluene, dichloromethane, trichloromethane, ethyl acetate, ethanol and pure water at different temperature were measured using the synthetic method by a laser monitoring observation technique. The solubility data were correlated with the modified Apelblat equation.The calculated values were good in agreement with the experimental values.     

1,2-环己二醇的焓和热容数据研究

The thermodynamic properties of different geometric structures of 1,2-cyclohexanediol which were rarely reported in literature, such as combustion enthalpy, formation enthalpy, melting enthalpy and heat ca-pacities, were determined by NETZSCH DSC 204 Scanning Calorimeter. The relationship between the melting point and the composition for the mixture system of cis-1,2-cyclohexanediol and trans-1,2-cyclohexanediol was investigated and corresponding phase diagram was obtained. "The melting enthalpies of both cis-1,2-cyclohexanediol and trans-1,2-cyclohexanediol are 20.265kJ·mol-1 and 16.368kJ·mol-1 respectively. The standard combustion enthalpies of cia- and trans-1,2-cyclohexaneddiol were determined by calorimeter. They are respec-tively -3507.043 kJ·mol-1 and - 3497.8 kJ·mol-1 at 298.15 K.The standard formation enthalpies are respectively 568.997 kJ·mol-1 and 578.240 kJ·mol-1 for cia- and trans -1,2-cyclohexaneddiol.     

2-氯-5-氯甲基吡啶在不同溶剂中溶解度的测定与关联(英文)

2-Chloro-5-chloromethylpyridine is a crucial intermediate of pesticides. Its solid-liquid equilibrium data will provide essential support for industrial design and further theoretical studies. The solubilities of 2-chloro-5-chloromethylpyridine in water, methanol, ethanol, ethyl acetate, acetone, trichloromethane and toluene at different temperatures were measured using the synthetic method by a laser monitoring observation technique. The solubility data were correlated with the modified Apelblat equation and Wilson equation. The calculated values were in good agreement with the experimental values.     

Solubilities of Cimaterol and Mabuterol in SF-CO2

The solubilities of two β-agonists, cimaterol and mabuterol, in supercritical carbon dioxide (SF-CO2) were measured by a recirculating method at temperatures of 40℃ and 60℃ and pressures between 9 MPa to 49 MPa.The compounds exhibit very limited solubilities in the range of 10^-5 to 10^-7 (mole fraction). Cimaterol has a higher solubility than that of mabuterol. The experimental data of solubility were correlated by four density-based models.The correlation accuracy highly depends on the system investigated, which is mainly determined by the density ranges and temperature.     

Experimental determination of solubilities and supersolubilities of 2,2′,4,4′,6,6′-hexanitrostilbene in different organic solvents

The laser monitor technique was used to determine solubilities and supersolubilities of HNS in N,N-dimethylformamide, dimethyl sulfoxide, acetonitrile, N-methyl-2-pyrrolidone and 1,4-butyrolactone. The experimental solubility values were correlated with λh equation, modified Apelblat equation and NRTL model. Furthermore, the dissolution enthalpy, dissolution entropy and the Gibbs energy of HNS were calculated by the experimental data. The results show that the solubilities of HNS in the above solvents increase with the increasing temperature. Besides, at the same temperature, the order of solubility is N-methyl-2-pyrrolidone dimethyl sulfoxide N,N-dimethylformamide 1,4-butyrolactone acetonitrile. The temperature dependence of predicted solubility is in agreement with the experimental data.     

一氧化碳在苯酚+乙醇中的溶解度测量和关联

The solubility of carbon monoxide in phenol＋ethanol mixed solvents at elevated pressures is reported in this article. The experimental results revealed the influence of pressure on the solubility of CO in phenol＋ethanol mixtures. These mixtures are a poorer solvent for carbon monoxide. The solubility of CO is a linear function of pressure, and the extended Henry＇s constants were presented at different concentrations of phenol. The cubic Soave-Redlich-Kwong equation of state was used to correlate the experimental gas liquid equilibrium data and to predict the solubility of CO. At the same time, the binary interaction parameters, kO, for CO-phenol, CO-ethanol and phenol-ethanol systems were estimated by fitting experimental GLE data at 303.15 K and at 2.0-9.0 MPa. Hence, a model was suggested for the solubility of CO in phenol＋ethanol mixed solvents. The agreement between experimental and calculated solubilities with the proposed model was rather satisfactory.     

反式-1，2-环己二醇在乙酸甲酯与水混合溶剂中的溶解度

采用激光监视技术测定了1，2-环己二醇在乙酸甲酯和水混合溶剂中的溶解度，并用UNIFAC模型进行了关联，其溶解度预测值与实测值吻合程度良好。     

1，2-环己二醇溶解度的测定及关联

采用激光监视技术测定了1,2-环己二醇在乙酸甲酯、乙酸乙酯、乙酸丙酯、乙酸丁酯、丙烯酸甲酯、丙烯酸乙酯、甲基丙基酮、乙酰乙酸乙酯和水中的溶解度,并用UNIFAC模型进行了关联,其溶解度预测值与实测值吻合良好.     

反式-1,2-环己二醇和甲酸钠的结晶介稳区研究

采用激光测量装置在不同温度、不同搅拌速度下研究了反式-1,2-环己二醇在水和乙酸乙酯中的溶解和超溶解特性,亦测定了甲酸钠在水中不同温度下的溶解和超溶解特性,得到了反式-1,2-环己二醇和甲酸钠的结晶介稳区。反式-1,2-环己二醇在水中和乙酸乙酯中的溶解度、超溶解度和介稳区宽度丛均随温度的升高而增加,且反式-1,2-环己二醇在水中的溶解度、超溶解度和介稳区宽度ΔS远远大于其在乙酸乙酯中的溶解度、超溶解度和介稳区宽度ΔS;反式-1,2-环己二醇在水中的超溶解度和介稳区宽度△S均随搅拌速度的提高而减小。高速搅拌下反式-1,2-环己二醇在水中的介稳区宽度△θ为4℃左右,中速搅拌下为7℃左右;在乙酸乙酯中的介稳区宽度△θ为3℃左右。甲酸钠在水中的溶解度、超溶解度和介稳区宽度△S均随温度的升高而呈线性增加,介稳区宽度△θ在4～5℃之间。     

1,2-环己二醇标准摩尔燃烧焓和定压热容测定

采用GR-3500型氧弹量热计实验测定了顺式-1,2-环己二醇和反式-1,2-环己二醇的标准燃烧焓,分别为-3507.043kJ/mol和-3497.8kJ/mol,并用萘作标准物验证测试仪器,其实验测定值与文献值相对误差为0.053%,同时推算出环己二醇的标准摩尔生成热,分别为568.997kJ/mol(顺式)和578.240kJ/mol(反式)。用NETZSCHDSC204型差示扫描量热仪测定了1,2-环己二醇的定压热容,拟合出环己二醇摩尔定压热容与温度之间的函数关系;同时还测定了1,2-环己二醇的熔点和熔化热,为该产品的新工艺开发、工程设计和工业化生产提供了基础数据。     

反式阿魏酸在溶剂中的溶解度

由微波辅助提取技术应用到从稻壳中提取阿魏酸的过程中,采用溶剂萃取法分离提纯反式-阿魏酸。本文研究了反式-阿魏酸在8种二元物系相平衡数据,采用激光监视技术测定了反式-阿魏酸在乙酸甲酯,乙酸乙酯,乙酸丁酯,甲醇,乙醇,二氯甲烷,三氯甲烷和水混合溶剂中的溶解度,并用简单模型进行了关联,其溶解度关联值与实测值吻合程度良好。     

双酚A在苯酚-丙酮-水中溶解度测定与关联

采用差示扫描量热法,以升温扫描速率2K-min^-1,测定了双酚A分别在溶剂苯酚及二元混合溶剂苯酚-丙酮、苯酚．水和三元混合溶剂苯酚．丙酮．水中的溶解度数据,溶质及各溶剂的浓度范围分别为：双酚A 7％～30％(wt)：苯酚70％～93％(wt);丙酮0%～5％(wt)：水0%～5％(wt)。为每一物系,提出了关联实验数据温度与溶解度关系的数学方程式,方程式参数不超过4个,并根据最小二乘法拟合得到。对每一物系进行关联,关于温度的均方根偏差分别为036K,0．68K．0．68K和0．78K,关联结果十分成功。实验结果可用于双酚A结晶过程。     

1,6-己二醛合成工艺研究

根据环己烯分子结构特点及相关反应的基础理论,提出在甲酸作为载氧剂的条件下,以过氧化氢氧化环己烯制备反式-1,2-环己二醇的工艺路线;并使用高碘酸钠/硅胶体系氧化反式-1,2-环己二醇制备1,6-己二醛.通过单因素实验法对在合成过程中的物料配比、反应温度、反应时间、重结晶方法等诸多因素对反应的影响进行考察.以气相色谱对产品纯度进行分析,得出反式-1,2-环己二醇及1,6-己二醛的纯度分别为98.93%和99.97%,并利用GC、红外光谱、核磁共振等分析方法对其产品化学结构进行确认.