Mood influences on acute smoking responses are independent of nicotine intake and dose expectancy.

Acute responses to smoking are influenced by nicotine and by nonpharmacological factors such as nicotine dose expectancy and sensory effects of smoke inhalation. Because negative mood increases smoking reinforcement, the authors examined whether these effects may be altered by mood context. Smokers (n=200) participated in 2 sessions, negative or positive mood induction, and were randomized to 1 of 5 groups. Four groups comprised the 2×2 balanced placebo design, varying actual (0.6 mg vs. 0.05 mg yield) and expected nicotine dose (expected nicotine vs. denicotinized [denic]) of cigarettes. A fifth group was a no-smoking control. Smoking, versus not smoking, attenuated negative affect, as well as withdrawal and craving. Negative mood increased smoking reinforcement. However, neither actual nor expected nicotine dose had much influence on these responses; even those smokers receiving and expecting a denic cigarette reported attenuated negative affect. A follow-up comparison suggested that the sensory effects of smoke inhalation, but not the simple motor effects of smoking behavior, were responsible. Thus, sensory effects of smoke inhalation had a greater influence on relieving negative affect than actual or expected nicotine intake. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

High-dose transdermal nicotine and naltrexone: Effects on nicotine withdrawal, urges, smoking, and effects of smoking.

Although treatment with transdermal nicotine replacement (TNR) has improved smoking abstinence rates, higher doses of TNR could improve effects on urge to smoke, nicotine withdrawal, and reinforcement from smoking, and naltrexone might further reduce reinforcement and urges. A laboratory investigation with 134 smokers using a 3 × 2 parallel-group design evaluated the effects of TNR (42-mg, 21-mg, or 0-mg patch) as crossed with a single dose of naltrexone (50 mg) versus placebo on urge to smoke, withdrawal, and responses to an opportunity to smoke (intake, subjective effects) after 10 hr of deprivation. Urge and withdrawal were assessed both prior to and after cigarette cue exposure. Only 42 mg TNR, not 21 mg, prevented urge to smoke, heart rate change, and cue-elicited increase in withdrawal. Both 21 and 42 mg TNR blocked cue-elicited drop in heart rate and arterial pressure. Naltrexone reduced cue-elicited withdrawal symptoms but not urges to smoke or deprivation-induced withdrawal prior to cue exposure. Neither medication significantly affected carbon monoxide intake or subjective effects of smoking except that 42 mg TNR resulted in lower subjective physiological activation. No interaction effects were found, and no results differed by gender. Results suggest that starting smokers with 42 mg TNR may increase comfort during initial abstinence, but limited support is seen for naltrexone during smoking abstinence. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Automatic affective responses to smoking cues.

The authors examined automatic emotional reactions to smoking cues among 35 smokers and 25 nonsmokers (32 women and 28 men), using a novel implicit measure, the Affect Misattribution Procedure. Associative-learning theories of addiction suggest that smokers develop positive responses to cues linked to the rewarding effects of nicotine. Prior research, however, has yielded mixed evidence for whether smokers have favorable or unfavorable automatic responses to smoking cues. These findings may depend on the methods used to measure implicit responses. Using the Affect Misattribution Procedure, the authors found that nonsmokers responded to smoking cues with clear negative affect, whereas smokers' responses depended on individual differences in current smoking withdrawal. Smokers having withdrawal symptoms and those most motivated to smoke showed favorable emotional responses to smoking cues, but those with no withdrawal or low motivation to smoke showed negative responses. These results help integrate previous studies finding that smokers have negative automatic responses to cigarettes with those studies finding that smokers' responses were relatively positive. The results are important for theories that emphasize the role of cue conditioning in maintaining addiction because these theories assume, consistent with the current findings, that smoking cues can take on positive reward value. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Daily Processes in Stress and Smoking: Effects of Negative Events, Nicotine Dependence, and Gender.

The author used a multilevel daily process design to examine relations among daily negative events, perceived stress, smoking, and smoking urges. The moderating effects of gender and nicotine dependence were also explored. Fifty-one adult community-residing smokers recorded negative events, perceived stress, cigarette smoking, and urges to smoke 4 times daily for 14 days. Analyses of within-person relations showed that participants smoked more cigarettes and experienced more urges to smoke on occasions with higher numbers of negative events and higher levels of perceived stress. These relations were stronger for men than for women. Nicotine dependence did not interact with events or stress in predicting smoking or urges. These findings build on laboratory studies and cross-sectional surveys by showing that in naturalistic settings, occasions with negative events and perceived stress are associated with smoking and urges to smoke. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Testing the influence of external and internal cues on smoking motivation using a community sample.

Exposing smokers to either external cues (e.g., pictures of cigarettes) or internal cues (e.g., negative affect induction) can induce urge to smoke and other behavioral and physiological responses. However, little is known about whether the two types of cues interact when presented in close proximity, as is likely the case in the real word. Additionally, potential moderators of cue reactivity have rarely been examined. Finally, few cue-reactivity studies have used representative samples of smokers. In a randomized 2 × 2 crossed factorial between-subjects design, the current study tested the effects of a negative affect cue intended to produce anxiety (speech preparation task) and an external smoking cue on urge and behavioral reactivity in a community sample of adult smokers (N = 175), and whether trait impulsivity moderated the effects. Both types of cues produced main effects on urges to smoke, despite the speech task failing to increase anxiety significantly. The speech task increased smoking urge related to anticipation of negative affect relief, whereas the external smoking cues increased urges related to anticipation of pleasure; however, the cues did not interact. Impulsivity measures predicted urge and other smoking-related variables, but did not moderate cue-reactivity. Results suggest independent rather than synergistic effects of these contributors to smoking motivation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Reactivity to instructed smoking availability and environmental cues: Evidence with urge and reaction time.

Reactivity to drug-related cues has been proposed as a possible mechanism to explain maintenance of drug use and relapse. This study examined whether cognitions associated with drug use (the belief that nicotine is available for use) also elicit reactivity. Smokers (N?=?132) were randomly assigned in a 2 (Smoking Availability)?×?2 (Smoking Stimuli) factorial design. Reactivity was measured by self-reported urge and probe reaction time. A main effect for availability was found in that participants who had been told that they could smoke shortly reported greater urges than those who had been told that smoking would not be permitted for 3 hr. Moreover, smoking-related stimuli produced increases in urge ratings only when participants had been told that smoking would be available shortly. Probe reaction time, in contrast, increased in the presence of smoking stimuli only when participants were told that cigarettes were unavailable. The theoretical and treatment implications of drug availability as a moderator of cue reactivity, as well as the utility of reaction time as an index of drug use motivation, are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of expectancies and coping on pain-induced motivation to smoke.

The prevalence of tobacco smoking among persons with recurrent pain is approximately twice that observed in the general population. Smoking has been associated with the development and exacerbation of several chronically painful conditions. Conversely, there is both experimental and cross-sectional evidence that pain is a potent motivator of smoking. A recent study provided the first evidence that laboratory-induced pain could elicit increased craving and produce shorter latencies to smoke (Ditre & Brandon, 2008). To further elucidate interrelations between pain and smoking, and to identify potential targets for intervention, in the current study, we tested whether several constructs derived from social–cognitive theory influence the causal pathway between pain and increased motivation to smoke. Smokers (N = 132) were randomly assigned to 1 of 4 conditions in this 2 × 2 between-subjects experimental design. Results indicated that manipulations designed to (a) challenge smoking-related outcome expectancies for pain reduction and (b) enhance pain-related coping produced decreased urge ratings and increased latencies to smoke, relative to controls. An unexpected interaction effect revealed that although each manipulation was sufficient to reduce smoking urges, the combination was neither additive nor synergistic. These findings were integrated with those of the extant literature to conceptualize and depict a causal pathway between pain and motivation to smoke as moderated by smoking-related outcome expectancies and mediated by the use of pain coping behaviors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Responses to depressed interpersonal behavior: Mixed reactions in a helping role.

We placed 144 female subjects in a helping role and randomly assigned them to interact with a confederate in a 3?×?3?×?2?×?2 (Psychopathology?×?Blaming?×?Advice Seeking?×?Sex of Confederate) factorial design. In order to study behaviors that mediate interpersonal responses to depression, male and female confederates enacted depressed, anxious, or normal roles and blamed themselves, others, or no one for their problems. The confederates requested advice in half of the conditions. Results indicated that depressed confederates were rejected more on questionnaire measures; however, depressed confederates received more conversational advice and support from subjects than did the equally disturbed anxious confederates. The self-blaming and advice-seeking manipulations did not interact with depression to produce more negative reactions in subjects. There was no evidence of a negative mood induction in subjects, nor did the sex of the confederate have important interpersonal consequences. Results are discussed in terms of theoretical and methodological issues in studies of interpersonal factors in depression. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Paced smoking in the laboratory and in the natural smoking setting: differential situation-specific effects in light and heavy smokers

The present study examined the situation-specific effects of smoking using a paced regimen of smoking to control the smoke intake. The subjects were first required to sham smoke and then actually smoke one of their cigarettes in two different test contexts: 1) in the laboratory where they had never previously smoked and 2) at home, alone in a quiet room where they regularly smoke. Light (< 10 cigarettes/day) and heavy smokers (> 15 cigarettes/day) were studied to test for a possible effect of the paced regimen itself. In the light smokers, smoking produced a larger increase in heart rate (HR) in the laboratory than in the natural smoking environment; however, in the heavy smokers the smoking had a larger effect in the normal smoking environment than in the laboratory. There were no significant group or test situation differences for baseline HR, skin conductance and finger temperature. The groups also did not differ in the intensity of drawing on the cigarette or inhaling, as indicated by a puff sensor and a respiratory belt, respectively. It was concluded that differences between the effects of a cigarette in a laboratory setting and in a natural smoking environment may reflect pharmacodynamic effects of smoking that are modified by the subjects' prior experience with smoking. The data are discussed with regard to conditioned tolerance to the effect of smoking.     

MMPI-2 profiles of motivated fakers given specific symptom information: A comparison to matched patients.

Two groups of normal adults were given specific symptom information on posttraumatic stress disorder (PTSD) and paranoid schizophrenia, respectively, and instructed to simulate these disorders on the MMPI-2. Monetary prizes were offered for successful faking. To determine whether symptom information helped Ss produce responses that closely resembled patients' profiles, scores from fakers were compared with scores from patients with these disorders, using a 2?×?2 (Disorder?×?Response Style) ANOVA. Results showed significant differences for response style, with fakers in both groups producing lower scores on K and higher scores on F, Fb, F–K, Ds, as well as on all 10 clinical scales, than patients. The findings suggest that having specific information about the symptoms of psychological disorder does not enable fakers to avoid detection and/or produce profiles equivalent to those produced by patients with the disorder. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Urge and affect: A facial coding analysis of smokers.

This study used an established facial coding system to assess participants' immediate affective responses during a smoking cue exposure protocol. Current smokers, randomly assigned to either a 12-hr smoking-deprived or a smoking-nondeprived condition, were exposed to both smoking and control cues. During exposure, the authors manipulated participants' perceived opportunity to smoke. Participants' reactions to the cues were videotaped and coded using P. Ekman and W. V. Friesen's (1978) Facial Action Coding System. Information regarding smoking opportunity, although altering participants' expressed affect, had no effect on the strength of their reported urge to smoke. The facial coding data are consistent with previous findings using self-report measures of affect and support the use of facial coding as a sensitive and unobtrusive measure of the affective responses to drug cue exposure. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Autonomic arousal, interpersonal climate, and orality.

Electrodermal responses in 34 male undergraduates who gave at least 4 oral-dependent Rorschach responses or no more than 2 such responses were assessed both before and after Ss had either a warm, friendly interaction or a cold, unfriendly interaction with a confederate. Following a 10-min interaction, there was a significant 3-way interaction (Period?×?Condition?×?Orality) in tonic conductance. Analysis produced one simple effect: Highly oral Ss responded differentially to warm or cold treatment by the confederate. Three groups—nonorals in either condition and orals in the cold condition—increased in physiological arousal over time. Only the highly oral Ss interacting with the warm confederate showed no such increase in arousal, presumably because the presence of a friendly other person inhibits physiological activation. (25 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Behavioral self-control of smoking through aversive conditioning and self-management.

Evaluated self-control variants of aversive conditioning and self-management procedures for the modification of cigarette smoking. 16–37 yr old smokers (90% undergraduates) were assigned to 10 treatment conditions arranged in a 2?×?5 (Self-Management?×?Aversive Conditioning) factorial design; another 20 smokers were included in a no-apply control group. Five varieties of aversive conditioning were used: aversive conditioning, placebo shock, therapist-delivered shock, S-delivered shock, and imagined aversive scene. Half of the smokers under each variety of aversive conditioning received additional training in a package of self-management techniques. Smokers were seen by individual therapists in 6 sessions over 3 wks. The treatment effects of aversive conditioning were negligible, and in some instances they were surpassed by the effects of controls for nonspecific treatment factors and placebo effects. The addition of self-management to aversive conditioning significantly reduced smoking beyond aversive conditioning effects over a 20-wk follow-up. However, no treatment combination led to reductions in smoking beyond controls for nonspecific factors, nor were reductions maintained over follow-up times. Implications for behavioral self-control strategies are discussed. (49 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Pain as a motivator of smoking: Effects of pain induction on smoking urge and behavior.

Tobacco smoking has been associated with the development and exacerbation of chronically painful conditions. Conversely, there is reason to believe that smokers may be motivated to use tobacco as a means of coping with their pain. To date, no controlled, experimental studies have tested for a causal relationship between pain and smoking motivation. The primary aim of the current study was to test the hypothesis that laboratory-induced cold pressor pain would enhance smoking motivation, as measured by self-reported urge to smoke and observation of immediate smoking behavior. Smokers (N = 132) were randomly assigned to either pain or no pain conditions. Results indicated that situational pain increased urge ratings and produced shorter latencies to smoke. The relationship between pain and increased urge to smoke was partially mediated by pain-induced negative affect. The relationship between pain and shorter latency to smoke was fully mediated by pain-induced urge to smoke. This study provides the 1st experimental evidence that situational pain can be a potent motivator of smoking. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Influence of acute smoking exposure on the subsequent reinforcing value of smoking.

The reinforcing value of smoking (i.e., the degree to which a smoker will work to obtain smoking) after varying the magnitude of prior smoke exposure in smokers not trying to quit was examined. Eight men and 8 women participated in 5 sessions involving manipulation of prior exposure to smoking: 0, 2, 6, or 12 puffs after overnight smoking abstinence or ad-lib smoking before the session. After exposure, participants engaged in a computer task involving concurrent schedules of reinforcement for smoke puffs (16% all trials) versus money (4–64%). Only the greatest amount of prior exposure (ad lib) produced a significant reduction in subsequent responding for smoke puffs. No exposure condition significantly increased responding above that for 0 puffs, indicating no priming effect. By contrast, self-report measures of desire to smoke and amount of money participants would pay for a cigarette declined sharply with greater prior exposure. These measures were correlated only weakly with smoke-reinforced responding on the behavioral task, suggesting that subjective versus behavioral measures assess different dimensions of smoking's reward value. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Expectancy and pharmacological effects of alcohol on human cognitive and motor performance: The compensation for alcohol effect.

42 male undergraduate social drinkers were led to expect either alcohol or tonic. After actually consuming no alcohol, a low dosage, or a moderate dosage, they performed various cognitive and motor tasks. A questionnaire assessed Ss' responses to the expectancy manipulation and either preceded or followed task administration. A 2?×?3?×?2 MANOVA resulted in a significant Expectancy?×?Dosage interaction for cognitive tasks (letter cancellation, digit span, Raven Progressive Matrices). Ss apparently compensated for alcohol-induced deterioration on these tasks when they were aware they had consumed alcohol. No consistent effects were found for motor tasks (finger tapping, stylus monitoring, standing steadiness, and walking steadiness). (9 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Focal adhesion kinase in integrin signaling

Using radiotelemetry, this study aimed to evaluate the influence of tobacco smoke on heart rate (H), body temperature (T) and locomotor activity (A) daily rhythms in rats. The tobacco smoke intoxication was produced with a smoking apparatus. H, T, and A data were captured by radiotelemetry. The study was divided into three periods: a 1-week control period (P1), a 1-week stress period (P2), in order to evaluate the stress induced by the animals' restraint in the smoking apparatus, and a 1-week daily tobacco smoke intoxication period (P3). For P1, P2, and P3, a power spectrum analysis was applied in order to determine the dominant period of rhythmicity. Then, characteristics of the rhythms were determined by cosinor analysis. Statistical comparisons were done by ANOVA. Power spectrum analysis showed that neither stress nor tobacco suppressed the daily rhythmicity. Cosinor revealed some modifications: H amplitude was decreased during P2 and P3 with a greater reduction during P3, while T and A amplitudes were decreased during P2 and P3 without difference between P2 and P3. T acrophase was delayed during P2, while A acrophase was delayed during P2 and P3 without any difference between P2 and P3. These perturbations may reflect the effects of stress and tobacco on the suprachiasmatic nucleus by a dopaminergic mechanism.     

Effects of smoking opportunity on attentional bias in smokers.

The emotional Stroop task was used to examine the influence of opportunity to smoke on attentionall bias to smoking-related stimuli. At the outset of the study, 92 nicotine-deprived smokers were told that they (a) would, (b) would not, or (c) might be able to smoke during the experiment. Next, participants completed an emotional Stroop task, in which they were presented with smoking-related or -unrelated words in an unblocked format. Smokers demonstrated interference to the smoking words, relative to matched neutral words, F(1, 87)?=?18.0, p?F(2, 87)?=?4.35, p?     

Effects of Transdermal Nicotine During Imaginal Exposure to Anxiety and Smoking Cues in College Smokers.

In a 2 (patch) × 2 (smoking) × 2 (anxiety) mixed design, 52 undergraduate smokers randomly received a nicotine (21 mg) or placebo patch. After a 4-hr nicotine absorption/deprivation period, participants imagined several scenarios varying in cue content: (a) anxiety plus smoking, (b) anxiety, (c) smoking, and (d) neutral. Although smoking urge increased in both the nicotine and placebo conditions after the absorption/deprivation period, those who received the placebo reported significantly greater urge. During the cue reactivity trials, a significant Patch × Smoking × Anxiety interaction effect was observed for urge. However, participants who received nicotine still experienced moderate urges, indicating that nicotine did not attenuate cue-elicited urge. Transdermal nicotine did not diminish anxiety during the absorption/deprivation period or in response to the cues. (PsycINFO Database Record (c) 2010 APA, all rights reserved)