The use of electron‐poor, fluoro‐containing arylboronic acids as general coupling partners for nickel(0)/tricyclohexylphosphine‐catalyzed cross‐coupling of aryl arenesulfonates is described. Electron‐poor fluoro‐containing arylboronic acids were found to react faster than electron‐rich/neutral arylboronic acids, with (4‐methoxyphenyl)(4‐methylbenzenesulfonato‐κO)bis(tricyclohexylphosphine)nickel. Bis(1,5‐cyclooctadiene)nickel(0)/tricyclohexylphosphine, (4‐methoxyphenyl)(4‐methylbenzenesulfonato‐κO)bis(tricyclohexylphosphine)nickel and bis(tricyclohexylphosphine)nickel(II) bromide were all found to be efficient catalysts/catalyst precursors.
The palladium(II)‐catalyzed hydroarylation of diphenylphosphorylallenes (via 1,2‐addition of the allenic double bond) with arylboronic acids in the presence of sodium hydroxide and oxygen is developed. The regioselectivities turn out to be well controlled, affording 2‐aryl‐3‐(diphenylphosphinyl)alkenes as the only product. Moreover, the stereoselectivities for reactions of γ‐substituted allenes can also be nicely controlled, resulting in the formation of Z‐alkenes. The reaction shows high substituent loading capability and tolerance of various substituents. A mechanism, including transmetalation of arylboronic acid with palladium halides, insertion of the 1,2‐allenic double bond to the Pd−Ar bond, and protonation to afford the final hydroarylation product is proposed.
An efficient and simple method is reported for the cyanation on arylboronic acid using various simple/indole thiocyanates using a new IL-PdCl4 catalyst. The cascade process involves a coupling reaction without any additive to give a wide range of cyanide derivatives. Cyanation on various arylboronic acids underwent smoothly affording the corresponding arylnitriles in good to high yields. 相似文献
A novel synthesis of arylboronic esters by a reductive electrochemical coupling reaction between aromatic halides and pinacolborane (HBpin, pin=pinacolate) has been carried out leading to arylboronic esters in moderate to good yields. 相似文献
A two‐step route to biologically important 3‐arylindole‐2‐carboxylic esters has been successfully established: o‐nitrophenyl‐substituted alkynoates underwent copper‐catalyzed hydroarylation in the presence of commercially available arylboronic acids to afford 3,3‐diarylacrylates, which were then converted to indolecarboxylates via a modified Cadogan cyclization using a molybdenum catalyst and triphenylphosphine. 相似文献
A selective and general route to (E)‐1,3‐diaryl‐prop‐1‐enes and (E)‐3‐arylallyl acetates has been developed by palladium‐catalyzed Heck‐type reactions of allylic esters with arylboronic acids or potassium aryltrifluoroborates. The present method selectively proceeds including β‐OAc elimination or β‐H elimination on the basis of the boronic acids. Whereas a variety of allylic esters were reacted with arylboronic acids, palladium(II) acetate [Pd(OAc)2], tetra(n‐butyl)ammonium chloride [(n‐Bu)4NCl] and postassium dihydrogen phosphate (KH2PO4) to afford the corresponding diarylation products in moderate to good yields, treatment of allylic esters with potassium aryltrifluoroborates furnished the corresponding monoarylation products. 相似文献