Intellectual functioning in old and very old age: Cross-sectional results from the Berlin Aging Study.

This study documents age trends, interrelations, and correlates of intellectual abilities in old and very old age (70–103 years) from the Berlin Aging Study (N?=?516). Fourteen tests were used to assess 5 abilities: reasoning, memory, and perceptual speed from the mechanic (broad fluid) domain and knowledge and fluency from the pragmatic (broad crystallized) domain. Intellectual abilities had negative linear age relations, with more pronounced age reductions in mechanic than in pragmatic abilities. Interrelations among intellectual abilities were highly positive and did not follow the mechanic-pragmatic distinction. Sociobiographical indicators were less closely linked to intellectual functioning than sensory-sensorimotor variables, which predicted 59% of the total reliable variance in general intelligence. Results suggest that aging-induced biological factors are a prominent source of individual differences in intelligence in old and very old age. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The role of gender in very old age: profiles of functioning and everyday life patterns

Older men and women have different life contexts as a function of differential longevity and socio-structural opportunities over the life course. The question is whether gender-related differences also occur in psychological and everyday functioning in older adults. Examined were 258 men and 258 women between the ages of 70 and 103 years (M = 85 years), participants in the Berlin Aging Study. Significant gender differences were observed in 13 of 28 aspects of personality, social relationships, everyday activity patterns, and reported well-being. Cluster analysis identified 11 subgroups whose profiles of life conditions and health and psychological functioning could be categorized as more or less desirable (functional). The relative risk of a less desirable profile was 1.6 times higher for women than for men. For older adults, gender as a variable carries differences in physical frailty and life conditions that likely have consequences for psychological functioning.     

Terminal decline and cognitive performance in very old age: Does cause of death matter?

Cross-sectional differences and longitudinal changes in cognitive functioning in relation to mortality across a 7-year follow-up period, with 3 times of measurement, were examined in a population-based sample of very old adults. The authors also sought to determine whether cause of death (cerebro/cardiovascular disease [CVD]; non-CVD) modified the magnitude of mortality-related cognitive deficits. Cognitive performance was indexed by tests of general cognitive ability, episodic memory, primary memory, verbal fluency, and visuospatial ability. Results indicated cross-sectional differences on all domains of functioning, with persons who would die within 3 years after baseline testing performing more poorly. Longitudinally, greater decrements were observed on all domains for persons who would die after the first follow-up period, as compared with survivors. Cause of death failed to modify the magnitude of the cross-sectional and longitudinal deficits. The pattern of results point to the general nature of this phenomenon. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The etiology of isolated thyroid stimulating hormone deficiency

Umbilical hernia (UH) is a common condition in infants and young children, especially in those of Afro-Caribbean origin. Spontaneous closure occurs in a majority of cases before the age of 4 years unless the neck of the sac is greater than 2 cm in diameter. Complications are rare, and conservative management is therefore advised during this time. We present three cases of incarcerated UH in boys under 4 years old, all of whom presented with small-bowel obstruction. Interestingly, in two of them undigested vegetable matter in the small bowel appeared to have precipitated the obstruction. A survey of the literature suggests that the incidence of this complication is approximately 1:1,500 UHs. We conclude that the present policy of expectant management is safe for the vast majority of children, but parents and general practitioners should be aware of the small risk and early symptoms of incarceration.     

Influences of cognitive slowing on age differences in intelligence.

A large cross-sectional sample took a battery of psychometric tests measuring multiple primary abilities, including the Primary Mental Abilities (PMA) test used in Schaie's (1983) longitudinal studies. The battery also included measures of perceptual speed and speed in working with the PMA answer sheets. There were large age differences for several abilities. Regression analysis showed that (a) these age differences were dramatically attenuated by partialing speed and (b) a substantial proportion of age-related variance is shared in common with speed. The PMA vocabulary test showed an age-related increase in its correlation with answer sheet speed, suggesting an age-related performance bias due to slowing. Substantial speed/intelligence relationships require renewed attention to the role of information-processing speed in age changes on psychometric test performance. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Stress-related cognitive interference predicts cognitive function in old age.

Both subjective distress and cognitive interference have been proposed as mechanisms underlying the negative effects of stress on cognition. Studies of aging have shown that distress is associated with lower cognitive performance, but none have examined the effects of cognitive interference. One hundred eleven older adults (Mage=80) completed measures of working memory, processing speed, and episodic memory as well as self-report measures of subjective distress and cognitive interference. Cognitive interference was strongly associated with poorer performance on all 3 cognitive constructs, whereas distress was only modestly associated with lower working memory. The results suggest that cognitive process related to stress is an important predictor of cognitive function in advanced age. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The heritability of cognitive functioning in very old adults: Evidence from Danish twins aged 75 years and older.

Heritable influences on cognitive functioning were investigated in a sample of 403 pairs of like-sex Danish twins aged 75 years and older. Twins completed the Mini-Mental State Examination and 3 other cognitive tests. Genetic factors accounted for 26–54% of the variance on these measures, with the balance being due to environmental factors that create differences rather than similarities among reared-together relatives. Deleting twins with severe cognitive impairment had little effect on the results, indicating that the heritability of cognitive functioning was not due entirely to genes affecting dementia. Neither age nor gender moderated twin similarity, and differential social contact could not account for correlation differences between monozygotic and dizygotic twins. These results replicate G. E. McClearn et al.'s (1997) study in indicating substantial genetic influences on late-life cognitive functioning. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The role of cognitive stimulation on the relations between age and cognitive functioning.

To make a convincing argument that cognitive stimulation moderates age trends in cognition there must be (a) a negative relation between age and level of cognitive stimulation, (b) a positive relation between level of cognitive stimulation and level of cognitive functioning, and (c) evidence of an interaction between age and cognitive stimulation in the prediction of cognitive functioning. These conditions were investigated in a study in which 204 adults between 20 and 91 years of age completed an activity inventory and performed a variety of cognitive tasks. Only the 1st condition received empirical support, and, thus, the results of this study provide little evidence for the hypothesis that cognitive stimulation preserves or enhances cognitive functioning that would otherwise decline. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Everyday activity patterns and sensory functioning in old age.

In the present study the authors investigated the relationship between visual and auditory acuity and everyday activity functioning. Participants were 516 older adults (70–103 years; equal numbers of men and women) who were members of the age-stratified Berlin Aging Study. Two categories of everyday activity functioning, perceived competence with basic activities of daily living (BaCo; basic competence) and amount of participation in discretionary social and leisure tasks (ExCo; expanded competence), were examined. The results revealed that sensory acuity, particularly vision, was a significant predictor of both BaCo and ExCo (rs ranging from .32 to .47). Indeed, hearing and vision could explain most of the age-related variance in everyday activities. At the same time, in the context of a broader model, evidence for the differential prediction of BaCo and ExCo was found, although there was also evidence for strong general age-related predictive variance that was common to both measures. Discussion focuses on the role of sensory acuity constructs as mediators of age-related variance in psychological and behavioral outcomes and the potential causal implications of this mediation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sensory functioning and intelligence in old age: A strong connection.

Relations among age, sensory functioning (i.e., visual and auditory acuity), and intelligence were examined in a heterogeneous, age-stratified sample of old and very old individuals (N?=?156, M age?=?84.9 yrs, age range?=?70–203). Intelligence was assessed with 14 tests measuring 5 cognitive abilities (speed, reasoning, memory, knowledge, and fluency). Together, visual and auditory acuity accounted for 49.2% of the total and 93.1% of the age-related reliable variance in intelligence. The data were consistent with structural models in which age differences in intelligence, including speed, are completely mediated by differences in vision and hearing. Results suggest that sensory functioning is a strong late-life predictor of individual differences in intellectual functioning. Explanations are discussed, including the possibility that visual and sensory acuity are indicators of the physiological integrity of the aging brain (common cause hypothesis). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Combined deficiency of thyroid stimulating hormone and growth hormone in a diabetic patient with Hashimoto thyroiditis

We report the case of a 36-year-old female patient with insulin dependent diabetes who developed hypothyroidism of pituitary origin after giving birth. She had low levels of free T4 and TSH with no response to i.v. TRH. Antimicrosome antibodies were increased (1/25000), suggesting Hashimoto's thyroiditis. The other hormones were normal except for a low level of growth hormone and insulin growth factor 1. There were no antibodies against the pituitary. MRI of the pituitary was normal. We suspect a vascular origin for this partial pituitary deficiency.     

Effects of death within 11 years on cognitive performance in old age.

Six different cognitive tests and the Beck Depression Inventory (BDI) were given to 3,572 active community residents aged 49 to 93 years. Causes of death were ascertained for 443 who died between 36 and 3,903 days later. Subsequent survival predicted test scores during the 3,903 days and independently during Days 36 to 1,826 and Days 1,827 to 3,903. Scores on the BDI and cumulative verbal learning and vocabulary tests predicted mortality after demographics and performance on other cognitive tests had been considered. Predictors were similar for deaths from heart disease, malignancies, and other causes. A new finding that cognitive tests did not predict survival duration within the sample of deceased explains previous findings of greater terminal decline in performance for young than for elderly adults. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A systemic–wholistic view of psychological functioning in very old age: Introduction to a collection of articles from the Berlin Aging Study.

Introduced are articles from the Berlin Aging Study (BASE) that collectively illustrate systemic–wholistic approaches to psychological functioning in old age. A systemic–wholistic perspective aims to elucidate structural and functional interdependencies between domains and to provide an integrative account of individual functioning. The special features of BASE (age range, 70–105 years; heterogeneous sample stratified by age and gender, and multidisciplinary data collection) are suited to this purpose. This article outlines the design of BASE. describes the cross-sectional sample (N?=?516: 258 men and 258 women), and reports sample selectivity analyses on 25 criterion variables in which the Pearson-Lawley selection formulas were used. Although the BASE sample is positively biased. it is not restricted in heterogeneity and does not exhibit major differences in patterns of covariation among variables. This finding supports the use of BASE data for the intended systemic–wholistic analyses. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Predictors of longitudinal changes in memory, visuospatial, and verbal functioning in very old demented adults

Longitudinal changes in memory, visuospatial and verbal functioning in a sample of demented persons were examined. The role of several demographic, psychometric, and biological indices in predicting the rate of cognitive deterioration was also investigated. The sample consisted of 31 very old (mean age at entry = 83.5 years, range = 75-95) persons with Alzheimer's disease (n = 22) and vascular dementia (n = 9) from a community-based study. Subjects were tested on two occasions separated by approximately 2.5 years. Results indicated significant longitudinal decline in verbal fluency and visuospatial ability, but only on 1 of 3 measures of episodic memory. Results from regression analyses indicated that a variety of putatively important variables, including age, gender, education, digit span, as well as a number of biological (vitamin B12, TSH), dementia etiology, and psychometric (digit span) indicators, exhibited no relationship to rate of memory, visuospatial, or verbal decline. The results suggest that the rate of cognitive deterioration in dementia is highly variable, and this variability in change appears to include a variety of characteristics. A possible reason thereof may be that the role of individual-difference variables for cognitive functioning in dementia is overshadowed by the pathogenetic process itself.     

The 24-hour rhythms in plasma growth hormone, prolactin and thyroid stimulating hormone: effect of sleep deprivation

Twenty-four hour secretory rhythms of growth hormone (GH), prolactin (PRL) and thyroid stimulating hormone (TSH) were investigated in 9 normal adult men by means of serial blood sampling at 30 min intervals. The profiles of pituitary hormones were compared in 6 subjects between in normal nocturnal sleep condition and in delayed sleep condition. Plasma GH was measured with use of highly sensitive enzyme immunoassay (EIA) recently developed. Plasma TSH was also evaluated by highly sensitive time-resolved fluorometric immunoassay (TR-FIA). Time series analysis of plasma GH and PRL was performed by auto- and cross- correlation and spectral analysis. The detection limit of EIA for GH was 0.3 pg/ml and all plasma GH levels were within the detectable range of this EIA. Cross-correlation and spectral analysis suggested the presence of approximately 2-3 h rhythmicity of plasma GH. Plasma PRL appeared to have some 24-hour rhythmicity besides its sleep-dependent component. Sleep deprivation caused marked elevation of plasma TSH during night time. It is suggested that there appears two mechanisms regulating GH secretion: one has a sleep-independent and ultradian rhythm and another has a sleep-dependent rhythm.     

Basic forms of cognitive plasticity extended into the oldest-old: Retest learning, age, and cognitive functioning.

To address the question of whether cognitive plasticity varies by age and level of cognitive functioning in the older population, the authors used a self-guided retest paradigm to assess the basic forms of plasticity of 34 young-olds (M = 74.4 years, range = 70-79) and 34 oldest-olds (M = 84.0 years, range = 80-91), with half in each age group screened for high or low (midrange) level of cognitive functioning. As a whole, members of the sample represent about the upper two thirds of their age cohorts. Results show persistent, though age-reduced, learning in all samples and across all tests. However, age is not differentially "kinder" to the more able with respect to the age-graded decline in learning. (PsycINFO Database Record (c) 2010 APA, all rights reserved)