Rapid polarizing field cycling in magnetic resonance imaging

We describe the electronics for controlling the independently pulsed polarizing coil in a prepolarized magnetic resonance imaging (PMRI) system and demonstrate performance with free induction decay measurements and in vivo imaging experiments. A PMRI scanner retains all the benefits of acquiring MRI data at low field, but with the higher signal of the polarizing field. Rapidly and efficiently ramping the polarizing coil without disturbing the data acquisition is one of the major challenges of PMRI. With our modular hardware design, we successfully ramp the 0.4-T polarizing coil of a wrist-sized PMRI scanner at up to 100 T/s without causing image artifacts or otherwise degrading data acquisition.     

The Interconnection of MRI Scanner and MR-Compatible Robotic Device: Synergistic Graphical User Interface to Form a Mechatronic System

MRI scanner and magnetic resonance (MR)-compatible robotic devices are mechatronic systems. Without an interconnecting component, these two devices cannot be operated synergetically for medical interventions. In this paper, the design and properties of a graphical user interface (GUI) that accomplishes the task is presented. The GUI interconnects the two devices to obtain a larger mechatronic system by providing command and control of the robotic device based on the visual information obtained from the MRI scanner. Ideally, the GUI should also control imaging parameters of the MRI scanner. Its main goal is to facilitate image-guided interventions by acting as the synergistic component between the physician, the robotic device, the scanner, and the patient.     

乳头状胶质神经元肿瘤的MRI及病理表现

目的分析2例乳头状胶质神经元肿瘤（PGNT）同时复习文献,归纳总结其影像表现。方法使用GE公司3．0T磁共振扫描仪对1名12岁女性及1名27岁男性PGNT患者进行MR平扫及增强扫描,分析2例患者的临床表现、MRI特点及病理特征,并对文献资料进行归纳总结。结果2例患者临床表现为失神发作和癫痫。MRI表现为囊实性病变及囊性病变伴壁结节,增强扫描后实性部分及壁结节明显强化。2例均位于颞叶,其中1例与侧脑室关系密切。病理镜下可见特征性的假乳头结构和双相分化的神经胶质细胞及神经元。结论PGNT的MRI表现以囊性肿块伴壁结节多见,病灶位置多靠近脑室且与脑室关系密切,脑室旁型和脑室外型的分类有助于诊断。     

Minimizing interference from magnetic resonance imagers duringelectrocardiography

Magnetic resonance imaging (MRI) allows a physician to obtain images of internal organs noninvasively. Imaging a moving organ such as the heart requires a trigger so that successive scans can be synchronized. In the case of cardiac imaging this trigger is the electrocardiogram (ECG). When a patient is in an MRI scanner he/she is subjected to both static and dynamic magnetic fields which can cause interference In the ECG. The dynamic fields consist of 8- to 64-MHz radio frequency (RF) pulses and low-frequency magnetic gradient pulses with frequency components below 100 Hz. Conventional bandpass filters are only moderately effective because the passband allows magnetic gradient-induced interference to be superimposed on the ECG, causing distortion of the signal. This paper describes a technique which can be used to remove induced MRI gradient interference from an ECG recorded on a patient inside the bore of a MRI scanner. Induced signal from an external loop is subtracted from the ECG to minimize the low-frequency interference. The gradient induced low-frequency interference was reduced to approximately 20% of its magnitude when using conventional ECG amplifiers     

Slice-to-volume registration and its potential application to interventional MRI-guided radio-frequency thermal ablation of prostate cancer

In this study, we registered live-time interventional magnetic resonance imaging (iMRI) slices with a previously obtained high-resolution MRI volume that in turn can be registered with a variety of functional images, e.g., PET, SPECT, for tumor targeting. We created and evaluated a slice-to-volume (SV) registration algorithm with special features for its potential use in iMRI-guided radio-frequency (RF) thermal ablation of prostate cancer. The algorithm features included a multiresolution approach, two similarity measures, and automatic restarting to avoid local minima. Imaging experiments were performed on volunteers using a conventional 1.5-T MR scanner and a clinical 0.2-T C-arm iMRI system under realistic conditions. Both high-resolution MR volumes and actual iMRI image slices were acquired from the same volunteers. Actual and simulated iMRI images were used to test the dependence of SV registration on image noise, receive coil inhomogeneity, and RF needle artifacts. To quantitatively assess registration, we calculated the mean voxel displacement over a volume of interest between SV registration and volume-to-volume registration, which was previously shown to be quite accurate. More than 800 registration experiments were performed. For transverse image slices covering the prostate, the SV registration algorithm was 100% successful with an error of <2 mm, and the average and standard deviation was only 0.4 mm +/- 0.2 mm. Visualizations such as combined sector display and contour overlay showed excellent registration of the prostate and other organs throughout the pelvis. Error was greater when an image slice was obtained at other orientations and positions, mostly because of inconsistent image content such as that from variable rectal and bladder filling. These preliminary experiments indicate that MR SV registration is sufficiently accurate to aid image-guided therapy.     

Reconstruction of conductivity and current density images using only one component of magnetic field measurements

Magnetic resonance current density imaging (MRCDI) is to provide current density images of a subject using a magnetic resonance imaging (MRI) scanner with a current injection apparatus. The injection current generates a magnetic field that we can measure from MR phase images. We obtain internal current density images from the measured magnetic flux densities via Ampere's law. However, we must rotate the subject to acquire all of the three components of the induced magnetic flux density. This subject rotation is impractical in clinical MRI scanners when the subject is a human body. In this paper, we propose a way to eliminate the requirement of subject rotation by careful mathematical analysis of the MRCDI problem. In our new MRCDI technique, we need to measure only one component of the induced magnetic flux density and reconstruct both cross-sectional conductivity and current density images without any subject rotation.     

Evaluation of Electrorheological Fluid Dampers for Applications at 3-T MRI Environment

This paper evaluates the use of electrorheological fluids (ERFs) within a magnetic resonance imaging (MRI) environment. ERF is a semiactive variable impedance material, which could be used as an alternative type of resistive force/torque generation or in combination with other actuators as a damper/clutch to modulate the output force/torque of the actuator. In this paper, an ERF damper/brake is introduced and its magnetic resonance (MR) compatibility is examined at a 3-T MR imaging environment by measuring the output performance of the damper and the SNR of the MRI images. The experimental results showed that damper's resistive force generation while positioned within the MRI is almost the same as that in normal operation. The signal-to-noise investigation was performed both with a phantom and human. The results indicated that the ERF damper did not affect the MRI images when it was operated over 30 cm away from the MRI's RF coil. We hope that the synthesis and tables presented in this paper can facilitate the choice of ERF brake actuation principle to various applications in an MR environment.     

Nonlinear Regularization for Per Voxel Estimation of Magnetic Susceptibility Distributions From MRI Field Maps

Magnetic susceptibility is an important physical property of tissues, and can be used as a contrast mechanism in magnetic resonance imaging (MRI). Recently, targeting contrast agents by conjugation with signaling molecules and labeling stem cells with contrast agents have become feasible. These contrast agents are strongly paramagnetic, and the ability to quantify magnetic susceptibility could allow accurate measurement of signaling and cell localization. Presented here is a technique to estimate arbitrary magnetic susceptibility distributions by solving an ill-posed inversion problem from field maps obtained in an MRI scanner. Two regularization strategies are considered: conventional Tikhonov regularization and a sparsity promoting nonlinear regularization using the $ell_{1}$ norm. Proof of concept is demonstrated using numerical simulations, phantoms, and in a stroke model in a rat. Initial experience indicates that the nonlinear regularization better suppresses noise and streaking artifacts common in susceptibility estimation.      

An MRI-compatible robotic system with hybrid tracking for MRI-guided prostate intervention

This paper reports the development, evaluation, and first clinical trials of the access to the prostate tissue (APT) II system-a scanner independent system for magnetic resonance imaging (MRI)-guided transrectal prostate interventions. The system utilizes novel manipulator mechanics employing a steerable needle channel and a novel six degree-of-freedom hybrid tracking method, comprising passive fiducial tracking for initial registration and subsequent incremental motion measurements. Targeting accuracy of the system in prostate phantom experiments and two clinical human-subject procedures is shown to compare favorably with existing systems using passive and active tracking methods. The portable design of the APT II system, using only standard MRI image sequences and minimal custom scanner interfacing, allows the system to be easily used on different MRI scanners.     

Electrical conductivity imaging using gradient B, decomposition algorithm in magnetic resonance electrical impedance tomography (MREIT)

In magnetic resonance electrical impedance tomography (MREIT), we try to visualize cross-sectional conductivity (or resistivity) images of a subject. We inject electrical currents into the subject through surface electrodes and measure the z component Bz of the induced internal magnetic flux density using an MRI scanner. Here, z is the direction of the main magnetic field of the MRI scanner. We formulate the conductivity image reconstruction problem in MREIT from a careful analysis of the relationship between the injection current and the induced magnetic flux density Bz. Based on the novel mathematical formulation, we propose the gradient Bz decomposition algorithm to reconstruct conductivity images. This new algorithm needs to differentiate Bz only once in contrast to the previously developed harmonic Bz algorithm where the numerical computation of (inverted delta)2Bz is required. The new algorithm, therefore, has the important advantage of much improved noise tolerance. Numerical simulations with added random noise of realistic amounts show the feasibility of the algorithm in practical applications and also its robustness against measurement noise.     

Spread spectrum magnetic resonance imaging

We propose a novel compressed sensing technique to accelerate the magnetic resonance imaging (MRI) acquisition process. The method, coined spread spectrum MRI or simply s(2)MRI, consists of premodulating the signal of interest by a linear chirp before random k-space under-sampling, and then reconstructing the signal with nonlinear algorithms that promote sparsity. The effectiveness of the procedure is theoretically underpinned by the optimization of the coherence between the sparsity and sensing bases. The proposed technique is thoroughly studied by means of numerical simulations, as well as phantom and in vivo experiments on a 7T scanner. Our results suggest that s(2)MRI performs better than state-of-the-art variable density k-space under-sampling approaches.     

Analysis and measurements of magnetic field exposures for healthcare workers in selected MR environments.

There are concerns about workers repeatedly exposed to magnetic fields exceeding regulatory limits with respect to modern magnetic resonance imaging (MRI). As a result, there is need for an ambulatory magnetic field dosimeter capable of measuring these fields in and around an MRI scanner in order to evaluate the regulatory guidelines and determine any underlying exposure risks. This study presents results of tri-axial measurements using an ambulatory magnetic field dosimeter worn by workers during normal working shifts. We recorded and analyzed magnetic field exposures in and around 1.5 T, 2 T, and 4 T magnets during routine patient procedures. The data was integrated and averaged over time and evaluated against the latest exposure standards. Time-varying magnetic fields occur when individuals move through spatially non-uniform static magnetic fields or during gradient-pulsed magnetic fields or a combination of both. Our previous numerical analysis shows that at certain positions surrounding the MRI scanner ends, such fields may induce current densities and electric fields that may exceed the relevant EU, ICNIRP, and IEEE standards. A high-speed acquisition version of the dosimeter measured gradient- pulsed fields at positions accessible by MRI workers near the scanner ends, and the results were evaluated and compared against the numerical simulations and the standards. Our measurements confirm that workers can be exposed to magnetic fields exceeding the guidelines at positions near the gradient coil ends during clinical imaging and a high degree of correlation exists with the numerical results. While the time-weighted average magnetic field exposures in 1.5 T, 2 T, and 4 T were all within the regulatory limits during static magnetic field measurements, the peak limits for the head can be exceeded in some circumstances. This study presents a small number of routine shifts of data that provide indicative results of magnetic field exposure in real situations.     

Design of a novel MRI compatible manipulator for image guided prostate interventions

This paper reports a novel remotely actuated manipulator for access to prostate tissue under magnetic resonance imaging guidance (APT-MRI) device, designed for use in a standard high-field MRI scanner. The device provides three-dimensional MRI guided needle placement with millimeter accuracy under physician control. Procedures enabled by this device include MRI guided needle biopsy, fiducial marker placements, and therapy delivery. Its compact size allows for use in both standard cylindrical and open configuration MRI scanners. Preliminary in vivo canine experiments and first clinical trials are reported.     

Analysis and correction of count rate reduction during simultaneous MR-PET measurements with the BrainPET scanner

In hybrid magnetic resonance-positron emission tomography (MR-PET) studies with the Siemens 3T MR-BrainPET scanner an instantaneous reduction of the PET sensitivity was observed during execution of certain MR sequences. This interference was investigated in detail with custom-made as well as standard clinical MR sequences. The radio-frequency pulses, the switched gradient fields and the constant magnetic field were examined as the relevant parameters of the magnetic resonance imaging (MRI) system as well as the air temperature within the PET detectors. Our investigation comprised the analysis of the analog PET signals, the total count rates, the geometric distribution of the count rate reduction within the BrainPET detector as well as reconstructed images. The fast switching magnetic field gradients were identified to distort the analog PET detector signals. The measured count rate reduction was found to be less than 3%, but only up to 2% in the case of echo planar imaging sequences, as applied in functional MRI. For clinical sequences routinely used in hybrid MR-BrainPET measurements, a correction method has been designed, implemented, and evaluated .     

Analysis and Measurements of Magnetic Field Exposures for Healthcare Workers in SelectedMR Environments

There are concerns about workers repeatedly exposed to magnetic fields exceeding regulatory limits with respect to modern magnetic resonance imaging (MRI). As a result, there is need for an ambulatory magnetic field dosimeter capable of measuring these fields in and around an MRI scanner in order to evaluate the regulatory guidelines and determine any underlying exposure risks. This study presents results of tri-axial measurements using an ambulatory magnetic field dosimeter worn by workers during normal working shifts. We recorded and analyzed magnetic field exposures in and around 1.5 T, 2 T, and 4 T magnets during routine patient procedures. The data was integrated and averaged over time and evaluated against the latest exposure standards. Time-varying magnetic fields occur when individuals move through spatially non-uniform static magnetic fields or during gradient-pulsed magnetic fields or a combination of both. Our previous numerical analysis shows that at certain positions surrounding the MRI scanner ends, such fields may induce current densities and electric fields that may exceed the relevant EU, ICNIRP, and IEEE standards. A high-speed acquisition version of the dosimeter measured gradient-pulsed fields at positions accessible by MRI workers near the scanner ends, and the results were evaluated and compared against the numerical simulations and the standards. Our measurements confirm that workers can be exposed to magnetic fields exceeding the guidelines at positions near the gradient coil ends during clinical imaging and a high degree of correlation exists with the numerical results. While the time-weighted average magnetic field exposures in 1.5 T, 2 T, and 4 T were all within the regulatory limits during static magnetic field measurements, the peak limits for the head can be exceeded in some circumstances. This study presents a small number of routine shifts of data that provide indicative results of magnetic field exposure in real situations.     

Comparison of MRI-Compatible Mechatronic Systems With Hydrodynamic and Pneumatic Actuation

The strong magnetic fields and limited space make it challenging to design the actuation for mechatronic systems intended to work in MRI environments. Hydraulic and pneumatic actuators can be made MRI-compatible and are promising solutions to drive robotic devices inside MRI environments. In this paper, two comparable haptic interface devices, one with hydrodynamic and another with pneumatic actuation, were developed to control one-degree-of-freedom translational movements of a user performing functional MRI (fMRI) tasks. The cylinders were made of MRI-compatible materials. Pressure sensors and control valves were placed far away from the end-effector in the scanner, connected via long transmission lines. It has been demonstrated that both manipulandum systems were MRI-compatible and yielded no artifacts to fMRI images in a 3-T scanner. Position and impedance controllers achieved passive as well as active subject movements. With the hydrodynamic system we have achieved smoother movements, higher position control accuracy, and improved robustness against force disturbances than with the pneumatic system. In contrast, the pneumatic system was back-drivable, showed faster dynamics with relatively low pressure, and allowed force control. Furthermore, it is easier to maintain and does not cause hygienic problems after leakages. In general, pneumatic actuation is more favorable for fast or force-controlled MRI-compatible applications, whereas hydrodynamic actuation is recommended for applications that require higher position accuracy, or slow and smooth movements.     

Parallel algorithms for maximum a posteriori estimation of spin density and spin-spin decay in magnetic resonance imaging

A maximum a posteriori (MAP) algorithm is presented for the estimation of spin-density and spin-spin decay distributions from frequency and phase-encoded magnetic resonance imaging data. Linear spatial localization gradients are assumed: the y-encode gradient applied during the phase preparation time of duration tau before measurement collection, and the x-encode gradient applied during the full data collection time t>/=0. The MRI signal model developed in M.I. Miller et al., J. Magn. Reson., ser. B (Apr. 1995) is used in which a signal resulting from M phase encodes (rows) and N frequency encode dimensions (columns) is modeled as a superposition of MN sinc-modulated exponentially decaying sinusoids with unknown spin-density and spin-spin decay parameters. The nonlinear least-squares MAP estimate of the spin density and spin-spin decay distributions solves for the 2MN spin-density and decay parameters minimizing the squared-error between the measured data and the sine-modulated exponentially decay signal model using an iterative expectation-maximization algorithm. A covariance diagonalizing transformation is derived which decouples the joint estimation of MN sinusoids into M separate N sinusoid optimizations, yielding an order of magnitude speed up in convergence. The MAP solutions are demonstrated to deliver a decrease in standard deviation of image parameter estimates on brain phantom data of greater than a factor of two over Fourier-based estimators of the spin density and spin-spin decay distributions. A parallel processor implementation is demonstrated which maps the N sinusoid coupled minimization to separate individual simple minimizations, one for each processor.     

MRI/fMRI-compatible robotic system with force feedback for interaction with human motion

This paper presents a robotic system that is compatible with anatomical magnetic resonance imaging (MRI) as well as with the more sensitive functional MRI (fMRI), and can safely and smoothly interact with human motion during the imaging. The system takes advantage of the electromagnetic shield that encloses the MR room by placing the interfering or sensitive components outside the shield, in the control room. This eliminates the need for extensive compatibility testing before each use. The concept is based on a conventional actuator placed outside the scanner room and a hydrostatic connection to transmit force and motion to an MR-compatible slave placed next to or inside the MR scanner. A force sensor, based on reflected light intensity measurement over optical fibers, measures interaction forces with the human subject. A robotic interface for wrist motion demonstrates the MR compatibility of this concept and the possibility to interact with various dynamic environments during functional imaging. This technology provides a basis for applications such as assistive devices for interventional MRI and haptic interfaces for neuroscience investigations.     

Device visualization for interventional MRI using local magneticfields: basic theory and its application to catheter visualization

This paper addresses one of the major problems in interventional magnetic resonance imaging (MRI): the visualization of interventional devices. For visualization locally induced magnetic fields are used, which disturb the homogeneity of the main magnetic field of the MR scanner. This results in signal loss in the vicinity of the device due to intravoxel dephasing, and leads to a disturbance of the phase image. The local fields are established by a low current in a closed copper loop along the device. This method is introduced as a means for catheter visualization. The basic theory behind this method is presented. Simulations are performed to determine the effect of intravoxel dephasing, without interfering effects like susceptibility or radio-frequency artifacts. Scanned and simulated data is used to verify the theoretical consideration. Different configurations of wire loops are discussed and two types of catheter visualization scans are proposed. Results from a pig study show that this methods holds promise for intravascular interventions under MRI guidance     

Simultaneous ultrasound and MRI system for breast biopsy: compatibility assessment and demonstration in a dual modality phantom

Simultaneous capturing of ultrasound (US) and magnetic resonance (MR) images allows fusion of information obtained from both modalities. We propose an MR-compatible US system where MR images are acquired in a known orientation with respect to the US imaging plane and concurrent real-time imaging can be achieved. Compatibility of the two imaging devices is a major issue in the physical setup. Tests were performed to quantify the radio frequency (RF) noise introduced in MR and US images, with the US system used in conjunction with MRI scanner of different field strengths (0.5 T and 3 T). Furthermore, simultaneous imaging was performed on a dual modality breast phantom in the 0.5 T open bore and 3 T close bore MRI systems to aid needle-guided breast biopsy. Fiducial based passive tracking and electromagnetic based active tracking were used in 3 T and 0.5 T, respectively, to establish the location and orientation of the US probe inside the magnet bore. Our results indicate that simultaneous US and MR imaging are feasible with properly-designed shielding, resulting in negligible broadband noise and minimal periodic RF noise in both modalities. US can be used for real time display of the needle trajectory, while MRI can be used to confirm needle placement.