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以氯化苄和三水合乙酸钠为原料,正丁醇为溶剂,十六烷基三甲基基溴化铵(CTAB)为相转移催化剂合成乙酸苄酯,该反应最佳反应条件是∶n(氯化苄)∶n(三水合乙酸钠)∶n(CTAB)为1∶1.3∶0.03,正丁醇的用量为15 m l(氯化苄为0.1mol时),反应温度为120℃左右,回流1.5h,乙酸苄酯的产率达90.6%。 相似文献
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以邻硝基氯苄为起始原料,经缩合和还原得到2,2'-二氨基联苄,探索了反应的影响因素。结果表明,2,2'-二硝基联苄较佳合成条件为:n(邻硝基氯苄)∶n(金属钠)=1∶2,回流,反应7 h,收率85.00%,HPLC纯度97.32%;2,2'-二氨基联苄的较佳合成条件:n(2,2'-二硝基联苄)∶n(Fe)=1∶7,采用水与无水乙醇混合溶剂,V(水)∶V(乙醇)=2∶1,反应时间4 h,反应温度90℃,收率97.50%,HPLC纯度98.86%。产品结构经1H NMR、13C NMR和LC-MS分析表征确认。 相似文献
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相转移催化合成乙酸苄酯的研究 总被引:1,自引:0,他引:1
以无水乙酸钠和苄基氯为原料,用相转移催化法(PTC)合成了乙酸苄酯。考察了聚乙二醇(PEG)、聚乙烯醇(PVA)和苄基三乙基溴化铵(TEBA)催化剂对酯化反应的影响,结果表明,以TEBA为催化剂,操作简单、反应快、产率高;研究了原料比、TEBA用量以及反应时间等因素对乙酸苄酯合成的影响,得出了适宜的合成条件:无水乙酸钠和苄基氯的摩尔比1:1.2,TEBA用量为2g,反应时间2h,反应温度为110~120℃。在此条件下,合成的产品的产率为84.67%,气相色谱分析其含量为93.86%,红外光谱表明产品的结构与乙酸苄酯相符。 相似文献
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以对羟基苯甲腈、氯代苄为原料,四丁基溴化铵为催化剂,合成了对苄氧基苯甲腈.考察了催化剂用量、温度、原料配比和时间对产率的影响.优化条件为:催化剂用量1.5 g,n(对羟基苯甲腈):n(氯代苄)=1.1∶1.0,反应温度为70℃,反应时间为8 h.对苄氧基苯甲腈产率达到89%. 相似文献
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研究了以邻氯苄氯和乙酸钠为主要原料,在相转移催化剂的存在下发生酯化反应生成乙酸邻氯苄酯,然后用30%的氢氧化钠水解,制备邻氯苄醇.同时考察了催化剂、反应物的配比和搅拌速率等因素对邻氯苄醇收率的影响. 相似文献
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N-苄氧羰基氨基酸的合成 总被引:1,自引:0,他引:1
以甘氨酸和氯甲酸苄酯为原料,合成N-苄氧羰基甘氨酸,通过正交实验考察工艺条件对反应的影响。结果表明,最佳工艺条件为:底物摩尔比n(甘氨酸)∶n(氯甲酸苄酯)=1∶1,反应时间2 h,反应温度20℃,反应液pH值为9,收率90.2%。此法反应条件温和,操作简单,收率良好。 相似文献
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The overall production rate equation of benzyl acetate by L-L phase transfer catalyzed acetate displacement of benzyl chloride were derived. The experimental results of the effects of stirring speed, structure and amount of catalyst, reaction temperature, amount of sodium acetate, and phase volume-ratio on the production rate of benzyl acetate are elucidated with the rate equation. Benzyltributylammonium chloride is the recommended catalyst. The apparent activation energy of the displacement of benzyl chloride with the ion pairs of benzyltributylammonium acetate is 8.13kcal/mol. Sodium sulfate is a suitable salt to improve the partition coefficient of the phase transfer catalyst. The cocatalyst, sodium iodide, can greatly improve the production rate of benzyl acetate when its amount do not exceed 3 mol% of the substrate, benzyl chloride. Under the conditions of 5mol% benzyltributylammonium chloride, phase volume-ratio 0.429, stirring speed 520 rpm, reaction temperature 70°C, and 50% aqueous sodium acetate, about 80% yield of benzyl acetate can be obtained within 2 hrs. of reaction time. 相似文献
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采用溶胶-凝胶法及改性技术制备了稀土掺杂纳米固体超强酸SO4^2-/TiO2-Y3+催化剂,主要研究了它的制备、表征以及应用于催化合成乙酸苄酯,并用正交设计实验法确定了催化合成反应的最佳条件。实验结果表明:SO4^2-/TiO2-Y3+具有良好的催化活性;在催化剂焙烧温度550℃,催化剂用量2.O%(质量分数),反应物n(乙酸):n(苯甲醇)=1:2.0,反应时间2.0h,带水剂苯用量15%(质量分数)的最佳条件下,乙酸苄酯的酯化率可达95%以上。 相似文献
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Benzyl acetate was synthesized by the reaction of benzyl chloride with sodium acetate in a two-phase system of an aqueous solution and toluene using tetrahexylammonium chloride (QCl) as a phase-transfer catalyst at 85 °C. The distribution coefficient and chemical equilibrium constants of QCl and tetrahexylammonium acetate were used to analyze the kinetics of the esterification. Two models such as the simple ion exchange across the interface (interface model) and the anion exchange in the aqueous phase (bulk model) were used to obtain the reaction rate constant.
The overall reaction can be described by a first-order reaction with respect to the molar concentration of benzyl chloride and the active intermediate (tetrahexylammonium acetate) produced by the reaction between QCl and acetate ion in the aqueous phase, respectively. 相似文献