10%溴虫腈悬浮剂的研制

采用湿式超微粉碎法加工工艺对10%溴虫腈悬浮剂进行了研究。对润湿分散剂、增稠剂、防冻剂进行筛选实验,确定了优惠配方。制剂经低温和热贮稳定性实验,外观无明显分层,水中分散性良好,各项指标均符合悬浮剂相关标准。     

29%吡·戊悬浮种衣剂的研制

采用湿式超微粉碎法加工工艺对29％吡·戊悬浮种衣剂进行了研究。对润湿分散剂、增稠剂、成膜剂、防冻剂进行筛选实验,确定了优化配方。制剂经低温和热贮稳定性实验,外观无明显分层,水中分散性良好,各项指标均符合悬浮种衣剂相关标准。     

贮气囊代替湿式贮氧柜的研究设计与应用

本文就采用贮气囊代替湿式贮气柜，应用于水电解制氢氧气供气系统中的一些工艺技术问题，进行了研究和探讨，并实际设计了一套工艺系统，成功地应用于石英玻璃熔制，加工车间供给氢氧气。作者认为，采用贮气囊代替湿式贮气柜，既可取得可观的经济效益，又具有良好的节能效果，而且更具有安全性。     

氢化燃烧合成镁基贮氢合金的研究进展

系统综述了氢化燃烧法制备镁基贮氢合金Mg2Ni的研究进展，包括其制备原理、与其它制备方法的比较、影响氢化燃烧的因素以及材料的贮氢性能。同时简要介绍了氢化燃烧合成Mg-Fe、Mg-Co和Mg-Ni-Cu等贮氢合金的一些研究成果。     

对表面活性剂在煤炭上应用及其作用原理的探讨

介绍了表面活性剂在煤炭开采、洗选加工、煤炭贮、装、运和煤炭燃烧等过程中的应用情况， 并对其作用的原理进行探讨。     

复合贮热材料的循环寿命和挥发性的测定

用熔融法制备了贮热用新戊二醇／膨润土嵌插复合材料，并采用DSC和DTA－TG等热分析手段测定了循环贮热性能和挥发性，实验数据表明，复合贮热材料和纯新戊二醇有着相同的贮热功能，并降低了新戊二醇的挥发性。     

20%噻唑锌悬浮剂的研制

介绍了20%噻唑锌悬浮剂的制备方法。采用湿式超微粉碎法加工工艺,通过对润湿分散剂、增稠剂、防冻剂、消泡剂等进行筛选,确定了优化配方。制得的20%噻唑锌悬浮剂经低温和热贮稳定性试验,外观无明显分层,水中分散性良好,悬浮率95%,有效成分分解率1.0%,产品各项指标均符合悬浮剂要求。     

3%甲维盐悬浮剂(SC)的开发暨羧酸盐分散剂GY-D09的应用

[目的]开发3%甲维盐SC小试配方,考察羧酸盐分散剂GY-D09的应用性能。[方法]采用湿法超微粉碎工艺和实验室立式砂磨机加工水悬浮剂,通过流点法筛选润湿剂,通过考察悬浮剂的关键技术指标:悬浮率,热贮、冷贮稳定性,进行助剂筛选。[结果]最佳配方润湿分散剂助剂组合为GY-D09 3.5%,GY-W10 1.5%。[结论]GY-D09在3%甲维盐SC中是一种非常合适和应用性能优良的助剂。     

30亿PIB/mL甘蓝夜蛾核多角体病毒悬浮剂的研制

本文通过对润湿分散剂、增稠剂、防冻剂、防腐剂和消泡剂等助剂的筛选,确定了最佳制剂配方为:甘蓝夜蛾核多角体病毒30亿PIB/m L,农乳600#P磷酸酯3.0%,NNO 2.0%,白炭黑1.0%,黄原胶0.05%,硅酸镁铝1.0%,丙三醇5.0%,苯甲酸钠0.3%,异辛醇1.0%,纯水补足至100%。通过湿式超微粉碎法加工工艺制成悬浮剂,结果表明,该配方制备的悬浮剂分散性好,悬浮率≥90%,热贮和冷贮稳定性合格,其他各项质量控制指标均符合要求。     

插层复合法制备纳米复合相变贮能材料

研究了利用熔融插层法将癸酸插入到蒙脱土层间制备复合相变贮能材料的方法,探索了其适宜的制备条件,用XRD、IR、DSC对其结构及贮能性能进行了分析。实验结果表明：癸酸被有效地密封在蒙脱土层间,制得的材料是一种纳米复合相变贮能材料,具有良好的贮能性能,相变过程形态稳定。     

导乐陪伴分娩结合笑气吸入用于分娩镇痛的临床分析

目的探讨导乐结合笑气吸入用于分娩镇痛的效果及其对产程的影响。方法将397例产妇用导乐陪伴结合笑气吸入进行分娩镇痛(观察组)与同期400例单用导乐陪伴分娩(对照组)比较镇痛效果、产程进展、分娩方式、产后出血量及新生儿Apgar评分。结果观察组分娩镇痛效果明显(P<0.01),观察组的活跃期和总产程短于对照组(P值均<0.05),差异有显著意义,而分娩方式、产后出血量及新生儿Apgar评分两组比较均无显著差异(P>0.05)。结论导乐陪伴笑气吸入性分娩镇痛产程时间短、效果可靠,对母儿均无不良影响,有利于产科质量的提高,值得推广。     

实行温馨产房缩短产程的观察和体会

本文对50例温馨产房分娩产妇观察,从几方面分析,造成产妇产程延长和缓解产妇紧张心理以缩短产程的对比。提倡实行温馨产房,使产妇保持良好的心理状态,在整个分娩过程中,缩短产程,保证母婴安全,是产科医护人员的一项重要任务。     

Inorganic nanoparticles as carriers for efficient cellular delivery

Cellular delivery involving the transfer of various drugs and bio-active molecules (peptides, proteins and DNAs, etc.) through the cell membrane into cells has attracted increasing attention because of its importance in medicine and drug delivery. This topic has been extensively reviewed. The direct delivery of drugs and biomolecules, however, is generally inefficient and suffering from problems such as enzymic degradation of DNAs. Therefore, searching for efficient and safe transport vehicles (carriers) to delivery genes or drugs into cells has been challenging yet exciting area of research. In past decades, many carriers have been developed and investigated extensively which can be generally classified into four major groups: viral carriers, organic cationic compounds, recombinant protiens and inorganic nanoparticles. Many inorganic materials, such as calcium phosphate, gold, carbon materials, silicon oxide, iron oxide and layered double hydroxide (LDH), have been studied. Inorganic nanoparticles show low toxicity and promise for controlled delivery properties, thus presenting a new alternative to viral carriers and cationic carriers. Inorganic nanoparticles generally possess versatile properties suitable for cellular delivery, including wide availability, rich functionality, good biocompatibility, potential capability of targeted delivery (e.g. selectively destroying cancer cells but sparing normal tissues) and controlled release of carried drugs. This paper reviews the latest advances in inorganic nanoparticle applications as cellular delivery carriers and highlights some key issues in efficient cellular delivery using inorganic nanoparticles. Critical properties of inorganic nanoparticles, surface functionalisation (modification), uptake of biomolecules, the driving forces for delivery, and release of biomolecules will be reviewed systematically. Selected examples of promising inorganic nanoparticle delivery systems, including gold, fullerences and carbon nanotubes, LDH and various oxide nanoparticles in particular their applications for gene delivery will be discussed. The fundamental understanding of properties of inorganic nanoparticles in relation to cellular delivery efficiency as the most paramount issue will be highlighted.     

Controlled drug delivery systems: the next 30 years

The drug delivery scientists need to reexamine the advances made during the past 60 years, analyze our current abilities, and design the future technologies that will propel us to achieve the next level of drug delivery technologies. History shows that the first generation (1G) of drug delivery research during 1950–1980 was quite productive, while the second generation (2G) technologies developed during 1980–2010 were not as prolific. The ultimate goal of drug delivery research is to develop clinically useful formulations to treat various diseases. Effective drug delivery systems can be developed by overcoming formulation barriers and/or biological barriers. The engineering approach has a limit in solving the problem, if biological difficulties are not clearly identified and understood. The third generation (3G) drug delivery systems will have to focus on understanding the biological barriers so that they can be overcome by engineering manipulation of the drug delivery systems. Advances in the next 30 years will be most accelerated by starting open dialogues without any preconceived ideas on drug delivery technologies. The new generation of drug delivery scientists needs to be aware of the successes and limitations of the existing technologies to design the new technologies for meaningful advances in the future.     

Fluorescent Reporters for Drug Delivery Monitoring

Monitoring of drug delivery is an essential technique for innovative medical treatments, including cancer therapy. Fluorescence imaging has become an important tool in tracking drug delivery and thus improving treatment efficacy. Binding fluorescent reporters to therapeutic agents paves the way to real time monitoring of drug delivery and drug distribution in vitro and in vivo. This review discusses fluorescent reporters used in drug delivery monitoring and provides an overview of recent achievements in the development of fluorescence based drug delivery systems.     

可降解高分子纳米纤维药物控释系统的研究进展

可降解高分子药物控释系统通过对药物剂量的有效控制,能够降低药物的毒副作用,提高药物的稳定性和利用率。近年来,静电纺丝纳米纤维因其具有比表面积大等特点,作为新型药物控制释放载体受到研究者的广泛关注。本文综述了可降解高分子纳米纤维药物控释系统的研究进展,对可降解高分子纳米纤维的制备及其在药物控释方面的研究进行介绍,并讨论了影响可降解高分子纳米纤维药物释放的因素。     

平衡氨压缩机段间负荷改造

对合成氨装置大改造后,氨压缩机段间负荷变动,进行分析并提出改造方案,改进操作手段,以减少重复做功。     

Enhanced penetration strategies for transdermal delivery

Transdermal delivery offers several advantages in drug distribution, including convenience, painless administration, avoidance of first-pass metabolism, and ease of termination. However, the natural protective barriers of the skin, such as the stratum corneum, the topmost layer of skin, limit the systemic absorption of external therapeutics via transdermal delivery. Therefore, extensive application of transdermal delivery in medical treatment has been limited. Over the past few years, many formulation strategies and physical technologies, therefore, have been developed to enhance transdermal delivery. This review summarizes various formulation strategies proposed for transdermal delivery and their application in medical treatment.     

Silk for Drug Delivery Applications: Opportunities and Challenges

Silk fibers have been used in textiles for more than 5,000 years and as a suturing material for many centuries. The recent development of new applications for silks include drug delivery. An overview of this new field is provided, summarizing the development of emerging drug delivery applications which include silk-based nanomedicines and transdermal delivery systems We also highlight some of the challenges in developing silk-based drug delivery systems.     

对PET短纤维直接纺丝熔体输送工艺条件的探讨

根据ＨＶ系列年产１．５万ｔ涤纶短纤维的生产实践，结合传热和流体输送的有关理论，对连续聚合直接纺丝装置的熔体输送过程的熔体停留时间、熔体温度控制和熔体压力设定等方面进行了系统讨论，提出熔体在输送管道中的停留时间应根据温度和熔体特性决定；熔体温度可用静态混合器来调节；用输送过程的熔体热降解程度和熔体温度分布及变化作为评价熔体输送系统优劣的标准。