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针对大型工件内孔镀铬的要求及本厂现有镀铬生产能力状况,设计了内孔分段镀铬屏蔽装置,该装置既能隔离镀铬面实现分段镀铬,又能改变工件内孔分段镀铬交接处的电流分布,铬层搭接处不出棱,可见痕迹轻,且无起皮现象,工件镀铬部位的尺寸及镀铬层厚度完全满足产品的使用要求。 相似文献
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各种镀铬液均存在一个杂质积累问题,含稀土添加剂镀铬液也不例外,尤其大多数稀土添加剂含有氟化物而表现出对已钝化的铬有良好的活化作用,但它们对基体金属或底镀层的腐蚀性及重金属杂质积累程度如何,成为电镀工作关心的问题。通过对常规镀铬液与含稀土添加剂的镀铬液对铁,铜,镍腐蚀速度的测定,作为衡阳镀铬液中金属杂质积累倾向的大小和选取镀铬添加剂,更新镀液的重要依据,并对不同含量的铜杂质对镀铬液深镀能力的影响作一 相似文献
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Andrea Kreheov Veronika Kovaíkov Iveta Domorkov Peter Solr Alena Pastornick Andriana Pavliuk-Karachevtseva Silvia Rybrov Ingrid Hodorov Jozef Mihalik 《International journal of molecular sciences》2021,22(10)
This study aimed to describe glutathione peroxidase 4 (GPx4) in rat oocytes, preimplantation embryos, and female genital organs. After copulation, Sprague Dawley female rats were euthanized with anesthetic on the first (D1), third (D3), and fifth days of pregnancy (D5). Ovaries, oviducts, and uterine horns were removed, and oocytes and preimplantation embryos were obtained. Immunohistochemical, immunofluorescent, and Western blot methods were employed. Using immunofluorescence, we detected GPx4 in both the oocytes and preimplantation embryos. Whereas in the oocytes, GPx4 was homogeneously diffused, in the blastomeres, granules were formed, and in the blastocysts, even clusters were present mainly around the cell nuclei. Employing immunohistochemistry, we detected GPx4 inside the ovary in the corpus luteum, stroma, follicles, and blood vessels. In the oviduct, the enzyme was present in the epithelium, stroma, blood vessels, and smooth muscles. In the uterus, GPx4 was found in the endometrium, myometrium, blood vessels, and stroma. Moreover, we observed GPx4 positive granules in the uterine gland epithelium on D1 and D3 and cytoplasm of fibroblasts forming in the decidua on D5. Western blot showed the highest GPx4 levels in the uterus and the lowest levels in the ovary. Our results show that the GPx4 is necessary as early as in the preimplantation development of a new individual because we detected it in an unfertilized oocyte in a blastocyst and not only after implantation, as was previously thought. 相似文献
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Takeshi Moriishi Takuro Ito Ryo Fukuyama Xin Qin Hisato Komori Hitomi Kaneko Yuki Matsuo Noriaki Yoshida Toshihisa Komori 《International journal of molecular sciences》2022,23(6)
The relationship of lacunocanalicular network structure and mechanoresponse has not been well studied. The lacunocanalicular structures differed in the compression and tension sides, in the regions, and in genders in wild-type femoral cortical bone. The overexpression of Sp7 in osteoblasts resulted in thin and porous cortical bone with increased osteoclasts and apoptotic osteocytes, and the number of canaliculi was half of that in the wild-type mice, leading to a markedly impaired lacunocanalicular network. To investigate the response to unloading, we performed tail suspension. Unloading reduced trabecular and cortical bone in the Sp7 transgenic mice due to reduced bone formation. Sost-positive osteocytes increased by unloading on the compression side, but not on the tension side of cortical bone in the wild-type femurs. However, these differential responses were lost in the Sp7 transgenic femurs. Serum Sost increased in the Sp7 transgenic mice, but not in the wild-type mice. Unloading reduced the Col1a1 and Bglap/Bglap2 expression in the Sp7 transgenic mice but not the wild-type mice. Thus, Sp7 transgenic mice with the impaired lacunocanalicular network induced Sost expression by unloading but lost the differential regulation in the compression and tension sides, and the mice failed to restore bone formation during unloading, implicating the relationship of lacunocanalicular network structure and the regulation of bone formation in mechanoresponse. 相似文献
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污泥生物炭中氮硫元素含量高,其氮硫行为和环境效应对全球气候变化的影响不容忽视。以往的研究中,研究者往往以富碳生物炭作为主要研究对象,关注碳对全球气候变化的行为和功效,而对氮硫元素的作用关注不够。本文从原始污泥基本性质到其热解过程,再到生物炭的老化,逐步对污泥生物炭整个生命周期内氮硫的行为及其环境效应研究进行综述,并对未来应注重开展的研究方向进行展望,为生物炭中氮硫元素固定、释放及与之关联的环境效应和温室气体排放控制研究提供理论基础。分析表明,污泥中氮元素含量普遍高于硫元素,且热解过程中氮比硫更容易转移至气相产物。氮硫元素随热解温度的增加,在三相产物中的分配都是炭中持续减少,油中先增后减,气中一直增加。高温(>800℃)条件下,气相中的氮含量高于固相,而硫元素则仍然主要存在于固相中。污泥生物炭老化及其环境效应研究表明,污泥生物炭氮硫元素与土壤的相互作用及其温室效应问题在今后的研究中应引起重视。 相似文献
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Daniel Styburski Wojciech wiereo Marta Skrka-Majewicz Marta Goschorska Irena Baranowska-Bosiacka Joanna Kabat-Koperska Dariusz Chlubek Izabela Gutowska 《International journal of molecular sciences》2020,21(23)
The ideal immunosuppressive regimen should provide for excellent immunosuppression with no side effects. Yet, current immunosuppressive therapy regimens commonly used in clinical applications fail to meet this criterion. One of the complications caused by immunosuppressive drugs is mineralization disorders in hard tissues. In this study, we evaluated the effects of three immunosuppressive therapies used after transplantation on the levels of potassium, iron, chromium, zinc, aluminum, sodium and molybdenum in the bones and teeth of female rats and their offspring. The study was conducted on 32 female Wistar rats, subjected to immunosuppressive regimens (cyclosporine A, mycophenolate mofetil and prednisone; tacrolimus, mycophenolate mofetil and prednisone; and cyclosporine A, everolimus and prednisone). The hard tissues of rats were analyzed using inductively coupled plasma optical emission spectrometry (ICP-OES, ICAP 7400 Duo, Thermo Scientific) equipped with a concentric nebulizer and a cyclonic spray chamber. All the immunosuppressive regimens included in the study affected the concentrations of the studied minerals in hard tissues of female rats and their offspring. The therapy based on cyclosporine A, everolimus and prednisone led to a decline in the levels of iron in bone, zinc in teeth, and molybdenum in the bone and teeth of mothers, while in the offspring, it caused a decline of bone potassium, with a decrease in iron and increase of molybdenum in teeth. Moreover, the regimen caused an increase in aluminum and chromium in the teeth and aluminum in the bones of the offspring, and consequently, it seems to be the therapy with the most negative impact on the mineral metabolism in hard tissues. 相似文献
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通过研究木质素分别在超临界甲醇和乙醇溶剂中的液化过程,分析反应温度(260~340℃)及反应时间(0~120min)对木质素在两种溶剂中的转化率、生物油收率及其组分差异的影响。实验表明,木质素在超临界乙醇中的转化率及产物收率均高于甲醇。当反应温度340℃,反应时间60min,木质素在超临界乙醇中的转化率和生物油收率比在甲醇中分别提高了16.23%和11.54%,残渣收率降低了16.23%。通过GC-MS和FTIR对生物油和残渣分析,发现生物油组分中芳香族化合物相对含量较高,在甲醇和乙醇溶剂中分别达到66.13%和58.84%;随着反应时间的延长,甲醇溶剂中残渣的醚键官能团逐渐增强,而在乙醇溶剂中则先增强后减弱。分析认为在木质素降解过程中,超临界乙醇和甲醇均可产生氢自由基作为供氢体,攻击木质素及其大分子片段中的官能团,同时使液化产物中的活性片段减活,减弱重聚合反应,从而更利于芳烃产物的生成。而甲醇在液化过程中容易与木质素断键产生的苯酚中间体发生脱氢缩合反应,通过醚键聚合产生长链芳香族化合物,形成残渣,降低生物油收率。 相似文献
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The dentate gyrus (DG), an important part of the hippocampus, plays a significant role in learning, memory, and emotional behavior. Factors potentially influencing normal development of neurons and glial cells in the DG during its maturation can exert long-lasting effects on brain functions. Early life stress may modify maturation of the DG and induce lifelong alterations in its structure and functioning, underlying brain pathologies in adults. In this paper, maturation of neurons and glial cells (microglia and astrocytes) and the effects of early life events on maturation processes in the DG have been comprehensively reviewed. Early postnatal interventions affecting the DG eventually result in an altered number of granule neurons in the DG, ectopic location of neurons and changes in adult neurogenesis. Adverse events in early life provoke proinflammatory changes in hippocampal glia at cellular and molecular levels immediately after stress exposure. Later, the cellular changes may disappear, though alterations in gene expression pattern persist. Additional stressful events later in life contribute to manifestation of glial changes and behavioral deficits. Alterations in the maturation of neuronal and glial cells induced by early life stress are interdependent and influence the development of neural nets, thus predisposing the brain to the development of cognitive and psychiatric disorders. 相似文献
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Effect of processing on flavor precursor amino acids and volatiles of sesame paste (tehina) 总被引:1,自引:0,他引:1
F. Shahidi T. Aishima H. A. Abou-Gharbia M. Youssef A. Adel Y. Shehata 《Journal of the American Oil Chemists' Society》1997,74(6):667-678
The content of flavor precursor free amino acids in dehulled sesame seeds, subjected to roasting (R), steaming (S), roasting
plus steaming (RS) and microwaving (M), was determined and compared with those of the raw (RW) seeds. R, RS, and S had major
effects in reducing the content of free amino acids from 2360 μg/g to 582, 795 and 884 μg/g, respectively; M had no effect
on the content of free amino acids. Meanwhile, flavor volatiles of the raw and processed seeds were compared by means of a
dynamic headspace analyzer/gas chromatograph-mass spectrometer. Volatiles of RW seeds contained 85 compounds, whereas under
the analytical conditions employed, seeds subjected to R, RS, S, and M had 117, 97, 93 and 87 compounds, respectively. Among
volatiles identified in the RW seeds were 36 hydrocarbons, 8 aldehydes, 4 ketones, 8 alcohols, 2 acids, 2 esters, and 1 pyrazine.
The only pyrazine identified in the RW seeds was 2,5-dimethylpyrazine. Pyrazines, generally recognized as contributors to
the roasted aroma of foods, were more numerous (10 in R, 6 in RS, 2 in S, and 2 in M) and prevalent (8.71% in R, 2.97% in
RS, 2.04% in S, 0.53% in M, and 0.25% in RW) in the volatiles of processed sesame seeds. The chemical nature of pyrazines
also depended on the process employed. Multivariant analysis indicated a highly negative correlation between the loss of free
amino acids and production of volatile flavor compounds in the R and RS samples, while the M sample remained unchanged. Furthermore,
both R and RS seeds contained dimethyl sulfide and dimethyl disulfide, whereas no sulfur-containing compounds were present
in other samples. Of the processed seeds, the flavors of R and RS samples were considered as acceptable, and the flavor intensity
of the former was deemed stronger than that of the latter by the experimenters. 相似文献
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《Ceramics International》2020,46(8):11443-11465
Doping hydroxyapatite (HAp) with foreign ions has been increasing in popularity as a chemical approach to augment the existing and impart new properties to it. However, it is uncertain whether this approach can elicit properties strong enough to make HAp competitive for commercial applications in biomedicine and elsewhere. In particular, material properties, such as grain size, morphology, surface charge, porosity, topology and others may prove to be more effective in controlling properties of HAp than the dopant choice and concentration. This study tackles this question through a meta-analysis of the dependence of selected materials properties on dopant concentrations reported across the literature, showing that doping is a convenient way of controlling some, but not all properties in HAp and should be implemented ideally in combination with other structural and compositional factors of influence. This meta-analysis is coupled to a bibliographic analysis of the evolution of trends in terms of the type, frequency and concurrency of dopants in HAp, covering the entire Periodic Table, all 72 elements incorporated into HAp so far and the 1990 – 2019 period split into successive lustra. The study demonstrates a continuously ascending trend in popularity of certain elements, such as Sr, Ce and Se, and a continuously declining trend of others in the past two decades, including F, Y, I, Ti and most lanthanides. For the fourth period transition metals a trend of constancy was observed and for yet other elements, including Ag and Mg, a period of ascent was succeeded by a steady decline, the onset of which coincided in the case of Ag with the peak in the airing of the concerns over its cytotoxicity by the scientific community. Reasons for these trends with respect to most elements are explained and connected with trends governing broader realms of materials science. It is shown that the choice of ions as dopants in HAp is largely driven by broader trends in materials science, rendering the doped HAp a mirror to view these existing and past trends in. Theoretically, by following the historic progression of these trends, a gaze in this mirror could assist in extrapolation of future trends, which normally come at the cost extinguishing some of the existing ones. This immersion in more general developments in materials science opened the path toward drawing connections between the bibliographically assessed geopolitical trends in doped HAp and in broader aspects of the scientific community, including the growing gap between the rich and the poor pervading it. The analysis reported here is conceptually novel and could be applied to numerous other materials. 相似文献
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Ekaterina N. Baranova Inna A. Chaban Ludmila V. Kurenina Ludmila N. Konovalova Natalia V. Varlamova Marat R. Khaliluev Alexander A. Gulevich 《International journal of molecular sciences》2020,21(24)
Crystal-bearing cells or idioblasts, which deposit calcium oxalate, are located in various tissues and organs of many plant species. The functional significance of their formation is currently unclear. Idioblasts in the leaf parenchyma and the development of crystal-bearing cells in the anther tissues of transgenic tomato plants (Solanum lycopersicon L.), expressing the heterologous FeSOD gene and which showed a decrease in fertility, were studied by transmission and scanning electron microscopy. The amount of calcium oxalate crystals was found to increase significantly in the transgenic plants compared to the wild type (WT) ones in idioblasts and crystal-bearing cells of the upper part of the anther. At the same time, changes in the size and shape of the crystals and their location in anther organs were noted. It seems that the interruption in the break of the anther stomium in transgenic plants was associated with the formation and cell death regulation of a specialized group of crystal-bearing cells. This disturbance caused an increase in the pool of these cells and their localization in the upper part of the anther, where rupture is initiated. Perturbations were also noted in the lower part of the anther in transgenic plants, where the amount of calcium oxalate crystals in crystal-bearing cells was reduced that was accompanied by disturbances in the morphology of pollen grains. Thus, the induction of the formation of crystal-bearing cells and calcium oxalate crystals can have multidirectional effects, contributing to the regulation of oxalate metabolism in the generative and vegetative organs and preventing fertility when the ROS balance changes, in particular, during oxidative stresses accompanying most abiotic and biotic environmental factors. 相似文献