The effect of whole-body and local irradiation, modified by hyperglycemia, on the metastasis of Walker carcinosarcoma 256 in rats

It has been shown that the local radiation therapy, and also radiation therapy modified by the short-term hyperglycemia really increase the life-span of rats with Walker 256 carcinosarcoma. At the same time the metastatic process also increases, especially after the modified radiation therapy. The total irradiation of experimental animals in a dose of 50 sGy before the modified radiation therapy considerably decreases the frequency of metastatic process. A conclusion is drawn that the total irradiation has a prophylactic influence on metastases under conditions of modified radiation therapy.     

A chronobiological analysis of the lymphocyte dehydrogenase activity in the peripheral blood of rats with Walker 256 carcinosarcoma

In a series of experiments the alpha-glycerophosphate dehydrogenase and succinate dehydrogenase (SDH) activities were daily determined simultaneously by the cytochemical method in peripheral blood lymphocytes of normal rats and those with the Walker carcinosarcoma. Using an original algorithm a hierarchy of biorhythms was singled out by a computer according to individual changes in the dehydrogenase activity for each rat. The mean level of succinate dehydrogenase activity was higher than that of alpha-glycerophosphate dehydrogenase. A set of discovered biorhythms and their representation were identical in the both enzymes. The tumor transplantation caused changes in the phase coordination of investigated dehydrogenases in all rhythms and promoted an increase of the succinate dehydrogenase amplitude as compared with the alpha-glycerophosphate dehydrogenase amplitude in certain rhythms. It is concluded that biorhythmological parameters of these enzymes may be used for characterization of the tumor-bearing host.     

Effect of thiamine and its antimetabolite oxythiamine on the proliferative activity of carcinosarcoma Walker 256 cells

The microscopic studies of tumours from rats injected with thiamine at a dose of 20 mg/kg for 5 days have shown that sites of hemorrhages and necrosis are considerably more extensive than in tumours of control animals. Injections of the same doses of oxythiamine increase the rate of pathologic mitoses in tumour cells and decrease the tumour weight by 45%, limit the synthesis of thiamine diphosphate and inhibit the transketolase activity in tissues.     

Effect of carminomycin on the enzyme systems of the metabolism of active forms of oxygen and on free-radical lipid oxidation in August rats with Walker carcinosarcoma 256

The influence of carminomycin (CM) on enzymic systems of metabolism of oxygen active forms, free radical lipid peroxidation and microviscosity of membrane lipids as well as toxic and antitumour action of CM were studied in normal and tumour-bearing rats. Detected responses of the system of superoxide anion- and H2O2 metabolism reflected the role of active oxygen forms in CM toxicity. The investigation results of the lipid peroxidation fluorescent products level and microsomal lipid phase microviscosity did not suppose stimulation of lipid peroxidation as key mechanism for CM toxic effects. Problems on the prevention and treatment of anthracyclines side effects are discussed.     

Lactate and pyruvate metabolism in the tissues of rats with Walker carcinosarcoma injected with oxythiamine

The levels of L-lactate and pyruvate as well as the enzymes of their conversion (lactate dehydrogenase in direct and reverse reactions, pyruvate dehydrogenase, pyruvate kinase, alanine transaminase) have been studied simultaneously in the liver and skeletal muscle of rats bearing carcinosarcoma Walker 256, control animals and after additional oxythiamine administration. Properties of oxythiamine independent of its anticoenzymic activity manifest themselves in the body of tumour-bearing animals to a greater extent. After the antivitamin administration there occur strong inhibition of pyruvate kinase, activation of alanine transaminase, normalization of the L-lactate level in the tissues.     

Cellular proliferation kinetics of Walker carcinosarcoma, Zajdela's ascitic hepatoma and their metastases to the lymph nodes

The cell cycle of Walker carcinoma, Zajdela's hepatoma and their metastases into regional lymph nodes are studied. It is shown that cell cycle of metastases is shorter and the labeling index is higher than in primary tumours. The cell cycle shortening in Walker carcinosarcoma metastases is associated with a decrease in the duration of all its phases. The cell cycle of Zajdela's hepatoma metastases decreases with the S-phase length. The cell loss factor of primary tumours is less than that of their metastases. The results of the autoradiographic study correlate with the previously studied sensitivity of primary tumours and metastases to chemotherapy.     

ENaCs mRNA在自发性高血压大鼠和Wistar大鼠组织中的差异表达

目的检测自发性高血压大鼠(SHR)和Wistar大鼠的ENaCs在mRNA水平的表达差异,探讨机械敏感性离子(Mechanosensitive Ion Channels,MS)对动脉压力感受器重调的作用。方法SHR大鼠和Wistar大鼠各6只,分别取左侧颈动脉窦、主动脉弓,异硫氰酸胍-酚氯仿法抽提总RNA。采用荧光定量PCR法,分别测定αENaC、βENaC、γENaC在各组织的相对表达水平。结果正常血压的Wistar大鼠ENaCs表达在主动脉弓和颈动脉窦区域相对定量较SHR组大鼠高,在颈动脉窦区域表现更明显。结论高血压状态下,ENaCs在压力感受器区域下调表达,提示压力敏感性离子通道在压力反射重调方面可能发挥着一定作用。     

The effect of oxygen on the epitaxial growth of diamond

We studied the effect of oxygen on the growth quality of diamond epitaxial layers. After oxygen is added during the growth of the diamond epitaxial layer, as the thickness of the epitaxial layer increases, the full width at half maximum of the rocking curve of the (004) plane of diamond epitaxial layer increases continuously, and, in addition, the intensities of both the Raman peaks and the free exciton emission peaks of the diamond epitaxial layer decrease continuously. These experimental results demonstrate that as the thickness of the diamond epitaxial layer increases, the quality of the diamond epitaxial layer degrades. The strong etching effect of the OH radical groups in the plasma on the diamond epilayers leads to the degradation of their crystallinity.     

局部注射不同浓度骨保护素对大鼠正畸牙移动影响的研究

目的：研究局部注射不同浓度骨保护素对大鼠牙齿移动的影响。方法：选用10周龄雄性sD大鼠60只,分为实验组与对照组,实验组分0．5mg／kgOPG组和0．05mg／kgOPG组,每组20只。在右上颌第一磨牙施加40G左右力使其移向近中。在实验组和对照组大鼠右上颌第一磨牙腭侧粘骨膜下分别注入重组人骨保护素rhOPG—Fe和...     

Magnetization oscillations in a ferromagnet/nonmagnetic metal/ferromagnet nanostructure under the action of the spin-polarized current

Oscillations of magnetization of a ferromagnetic disk included in the ferromagnet/nonmagnetic metal/ferromagnet nanostructure under the action of the spin-polarized current are studied in the macrospin approximation. Conditions for switching and oscillations of magnetization are determined for four cases of the magnetic crystallographic anisotropy near the transition instability region depending on the ratio between disk dimensions and current density. It is shown that the region of disk magnetization instability corresponds to the minimum values of the current density that are necessary for excitation of the oscillations or switching of magnetization. Depending on the value and direction of the anisotropy and the relaxation parameter, the frequency of the observed oscillations varies within 0.1–30 GHz.     

火箭燃气射流中颗粒衍射散射对莫尔偏折图的影响

本文根据Fourier光学和衍射散射理论分析了火箭燃气射流中Al_2O_3颗粒衍射散射对莫尔偏折图的影响,从实验上研究了Al_2O_3颗粒衍射散射造成莫尔条纹模糊的现象。实验结果表明,对Al粉含量较低(3～8％)的固体推进剂,莫尔偏折法能够用于其燃气射流场的显示。     

慢性间歇性缺氧对大鼠性腺轴的影响

目的：制作可应用于常压慢性间歇性缺氧研究的动物模型,探讨慢性间歇性缺氧对性腺轴影响。方法：大鼠分别给予空气（对照组,UC组）、间断低氧4周（慢性间歇性缺氧组,CIH组）及复氧4周（复氧组,RH组）处理后用放射免疫法测定血清睾酮（T）、促卵泡生成素（FSH）、促黄体生成素（LH）水平。结果：与UC组、RH组比较,CIH组的T、FSH、LH,UC组和RH组无明显改变。结论：慢性间歇性缺氧致使大鼠性腺轴功能异常,反馈调节紊乱,复氧能使其恢复正常。     

The effect of lymphocytes on the growth of transplanted adenocarcinoma of the colon in mice

The activation of spleen lymphocytes during tumour growth on the syngeneic mice has been shown. The activated lymphocytes were able to restore the tumour growth after cyclophosphane induction of immunodeficiency. Activated lymphocytes of mice acted the same way with liver regeneration and isoproterenol induction of salivary gland hyperplasia. The inhibitory effect of lymphocytes has been also shown during this process. Both stimulation and inhibition were the function of the ThyI lymphocytes. The regularities shown may reflect important processes of cell proliferation regulation in multicellular organisms.     

慢性间歇性缺氧对大鼠下丘脑-垂体-性腺轴的影响

目的：制作可应用于常压慢性间歇性缺氧研究的动物模型,探讨慢性间歇性缺氧对大鼠下丘脑-垂体-性腺轴影响。方法：大鼠分别给予空气（对照组,UC组）、间断低氧4周（慢性间歇性缺氧组,CIH组）及复氧4周（复氧组,RH组）处理后用放射免疫法测定血清睾酮（T）、促卵泡生成素（FSH）、促黄体生成素（LH）水平,免疫组织化学测定下丘脑促性腺激素释放激素（GnRH）含量。结果：与UC组、RH组比较,CIH组的T、FSH、LH、GnRH明显减低,UC组和RH组无明显改变。结论：慢性间歇性缺氧致使大鼠下丘脑-垂体-性腺轴异常,反馈调节紊乱,复氧能使其恢复正常。     

Cytogenetic characteristics of H3 oxide induced myeloid leukemia in Wistar rats

Frequency and spectrum of chromosomal aberrations were studied in hemopoietic cells of Wistar rats myeloid leukaemia induced by the prolonged exposure to tritium oxide. Differences in quantitative and structural damages of chromosomes were revealed by the cytogenetic assessment of eighteen rats with acute myeloid leukaemia (AML) and six rats with chronic myeloid leukaemia (CML). The most characteristic chromosomal aberrations for AML appeared to be rearrangements in chromosomes 1-3. In CML translocations by one of chromosomes 15-20 coupled with defects in the groups of chromosomes 5-10 seemed to be nonrandom.     

The effect of tin grain structure on whisker growth

Tin whisker growth has become a major concern in the electronics industry as banning Lead application. In order to further understanding whisker growth with varied grain structures, three different grain structures (columnar, semi-columnar, and horizontal) and three mixed type deposits were prepared by changing the deposition conditions. The grain structure of deposited layer and intermetallics (IMC) were examined by focused ion beam (FIB) and chemical etching. After 4000 h of testing in 55 °C with 85% RH, whisker growth on the columnar sample was easily observed, and caused by the wedge type IMC. The semi-columnar tin grains formed small amounts of long straight whiskers accompanied with hillocks, and also seeing uneven IMC. The horizontal type tin grains formed only hillocks, accordingly finding the IMC more uniform than the others. Mixed grain structures were prepared, and consisted of different structures on the top and bottom layers. The top layer dominates the forms of whiskers or hillocks, owing to the grain boundary guiding the diffusion of tin atoms, and the bottom layer affects the density of whiskers or hillocks due to local stress building up from the formation of intermetallic phase.     

The blastomogenic effect of 249Bk in rats

It is shown that 249Bk nitrate injected intraperitoneally in a wide range of doses to albino mongrel female rats is preferentially accumulated in the bony tissue (39.8%) and liver (18.4%). Incorporation of 249Bk to rats results in development of osteosarcomas, neoplasms of hemopoietic and lymphoid tissues, mammary tumours, thyroid and pituitary glands.     

FM24C256在仪表中的应用

FM24C256是RAMTRONINTERNATIONAL公司推出的一种新型铁电存贮器 ,该存贮器可以随总线速度无限次地擦写 ,而且功耗低,其性能优越于EEPROM型AT24C256等存贮器。文中介绍了FM24C256的主要特点、引脚功能、读写时序和与单片机的接口电路 ,同时给出了其读写数据的子程序清单。     

The effect of strain on abnormal grain growth in Cu thin films

To understand a grain growth mechanism in Cu thin films that were deposited on rigid substrates by sputter deposition and subsequently annealed at various temperatures, microstructures of the Cu films with or without the rigid substrates were analyzed by x-ray diffraction (XRD), transmission electron microscopy (TEM), and electrical resistivity measurements. Significant grain growth (with bimodal grain size distribution) was observed during room-temperature storage in the Cu films deposited on the Si₃N₄ and rock salt substrates. However, in the free-standing Cu films, no grain growth was observed during room temperature storage. The present result suggested that the grain growth rates in the Cu thin films were strongly influenced by the existence of the rigid substrates, indicating stress (or strain) introduced in the films was a primary factor to induce the grain growth in the Cu films.     

The effect of gas phase growth parameters on the composition of InGaAs in the hydride VPE process

A 1.4-μm thick InGaAs layer exhibiting an x-ray diffraction linewidth of 18 arcs has been grown on an InP substrate. This is the best crystalline perfection ever reported for InGaAs, as far as the author is aware. The effect of gas composition on lattice mismatch has been investigated for InGaAs layers grown under a variety of conditions. An empirical equation has been developed which relates lattice mismatch(Δa/a) to metals ratio, mole fraction of AsH₃ and mole fraction of HC1. Values of(Δa/a) calculated using this equation are in good agreement with experiment. The metals ratio for lattice match is shown to vary linearly with the growth rate. This observation is shown to be consistent with mass transfer limitation in the gas phase. As a further consequence, relationships between layer thickness uniformity and lattice mismatch uniformity and between growth rate and gas composition are derived.