共查询到17条相似文献,搜索用时 62 毫秒
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随着系统生物学和医学的迅速发展,基因调控网络已经成为一个热点研究领域.布尔网络作为研究生物系统和基因调控网络的一种重要模型,近年来引起了包括生物学家和系统科学家在内的很多学者的广泛关注.本文利用代数状态空间方法,研究了概率级联布尔网络的集镇定问题.首先给出概率级联布尔网络集镇定的定义,并利用矩阵的半张量积给出了概率级联布尔网络的代数表示.其次基于该代数表示,定义了一组合适的概率能达集,并给出了概率级联布尔网络集镇定问题可解的充要条件.最后将所得的理论结果应用于概率级联布尔网络的同步分析及n人随机级联演化布尔博弈的策略一致演化行为分析. 相似文献
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布尔网络作为研究基因调控网络的一种重要模型,近年来引起了国内外很多学者的广泛关注.本文利用代数状态空间表示方法,研究具有切换概率分布的概率布尔网络的依分布稳定和镇定问题.首先,回顾针对切换布尔网络稳定性分析的现有的研究结果.其次,给出具有切换概率分布的概率布尔网络依分布稳定的定义,并利用矩阵的半张量积建立具有切换概率分布的概率布尔网络的代数表示.再次,基于该代数表示,建立具有切换概率分布的概率布尔网络的依分布稳定的充分必要条件.最后,给出具有切换概率分布的概率布尔控制网络镇定问题可解的充要条件,并给出相应的控制设计方法. 相似文献
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使用模型检测解决概率布尔网络优化控制 总被引:1,自引:1,他引:0
系统生物学期望对复杂生物系统建立一个真实的、可计算的模型,以便于以系统的角度去理解生物系统的演变过程。在系统生物学中,一个重要的主题是通过外部的干预控制发展关于基因调控网络的控制理论,以作为未来基因治疗技术。目前,布尔网络及其扩展的概率布尔网络已经被广泛用于对基因调控网络进行建模。在控制问题的研究中,概率布尔控制网络的状态迁移本质上构成一条有限状态空间的离散时间马尔科夫决策过程。依据马尔科夫决策过程的理论,通过概率模型检测方法解决网络中有限范围优化控制问题和无限范围优化控制问题。针对带有随机干扰且上下文相关的概率布尔控制网络,使用概率模型检测器PRISM对其进行形式化建模,然后将两类优化控制问题描述为相应的时序逻辑公式,最后通过模型检测寻找出最优解。实验结果表明,提出的方法可以有效地用于生物网络的分析和优化控制。 相似文献
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切换布尔网络是一种典型的网络化控制系统, 在基因调控、信息安全、人工智能、电路设计等领域具有重要应用. 本文基于牵制控制方法, 研究切换布尔网络在任意切换下的分布式集合镇定问题. 首先, 利用矩阵半张量积方法,得到切换布尔网络的代数形式. 其次, 基于代数形式, 提出构造性的算法来实现切换布尔网络在牵制控制的作用下任意切换集合镇定, 并设计出状态反馈牵制控制器. 再次, 利用逻辑矩阵分解技术和分布式控制方法, 设计任意切换下切换布尔网络的分布式集合镇定控制器, 并提出分布式控制器存在的充分条件. 文中给出3个例子来说明所获得结果的有效性. 相似文献
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针对布尔控制网络在非周期性拒绝服务(DoS)攻击下的镇定控制问题, 研究服从独立同分布过程的非周期性DoS攻击. 首先, 将遭受攻击的布尔控制网络转化为概率布尔网络, 进而得到系统能够全局随机稳定的充分必要条件; 其次, 基于可达集构造方法, 设计能够保证系统稳定的状态反馈控制器; 最后, 通过仿真实验验证所提出理论与控制方法的有效性. 相似文献
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The controllability of probabilistic Boolean control networks(PBCNs)is first considered.Using the input-state incidence matrices of all models,we propose a reachability matrix to characterize the joint reachability.Then we prove that the joint reachability and the controllability of PBCNs are equivalent,which leads to a necessary and sufcient condition of the controllability.Then,the result of controllability is used to investigate the stability of probabilistic Boolean networks(PBNs)and the stabilization of PBCNs.A necessary and sufcient condition for the stability of PBNs is obtained first.By introducing the control-fixed point of Boolean control networks(BCNs),the stability condition has finally been developed into a necessary and sufcient condition of the stabilization of PBCNs.Both necessary and sufcient conditions for controllability and stabilizability are based on reachability matrix,which are easily computable.Hence the two necessary and sufcient conditions are straightforward verifiable.Numerical examples are provided from case to case to demonstrate the corresponding theoretical results. 相似文献
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In this paper, the finite-time observability (FO ) of probabilistic Boolean control networks (PBCNs ) based on set reachability and parallel extension is investigated. Under algebraic state space representation of PBCNs , finite-time set reachability (FSR ), finite-time single input sequence set reachability (FSSSR ), finite-time arbitrary input sequence set reachability (FASSR ), as well as finite-time output feedback set reachability (FOSR ) are addressed, where some efficient criteria are proposed. In the second part of this paper, several types of FO are provided, which can be converted to the corresponding FSR based on the parallel extension technique. Consequently, the obtained results for FSR are utilized to deal with FO . Finally, two examples including a biological network are given to demonstrate the theoretical results. 相似文献
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Asynchronous behavior is significant for real biological systems. This paper explores the impact of state-dependent asynchronous updating rule (SDAUR) on the set reachability and set stability of Boolean networks (BNs). First, a set of state-dependent control variables is introduced to describe the SDAUR. Second, a new asynchronous set reachablity matrix is constructed based on an auxiliary input and semi-tensor product. Third, using the asynchronous set reachablity matrix, several necessary and sufficient conditions are obtained for the set reachablity and set stability of BNs with SDAUR. Finally, the new results proposed in this paper are verified through the immunomic network. 相似文献
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Controllability of Boolean control networks avoiding states set 总被引:1,自引:0,他引:1
In this paper, using semi-tensor product and the vector form of Boolean logical variables, the Boolean control network (BCN) is expressed as a bilinear discrete time system about state and control variables. Based on the algebraic form, the reachability and controllability avoiding undesirable states set are discussed. The reachability and controllability discussed here are under certain constraint and tile definitions of reachability and controllability avoiding undesirable states set have practical meaning. Also, the necessary and sufficient conditions for reachability and controllability are given. At last, the control sequence that steers one state to another is constructed. 相似文献
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Fangfei Li 《International journal of systems science》2016,47(12):2996-3003
In the literatures, to design state feedback controllers to make the response Boolean network synchronise with the drive Boolean network is rarely considered. Motivated by this, feedback control design for the complete synchronisation of two coupled Boolean networks is investigated in this paper. A necessary condition for the existence of a state feedback controller achieving the complete synchronisation is established first. Then, based on the necessary condition, the feedback control law is proposed. Finally, an example is worked out to illustrate the proposed design procedure. 相似文献
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Zhengping Ji 《Asian journal of control》2019,21(6):2521-2531
Many Boolean control networks contain independent uncontrollable subnetworks, which may affect other nodes; and the rest of the system is called subspace of sub‐controllable states. This paper investigates the problem of subspace controllability under free input sequences, while the presumption that the initial states of those independent subnetworks are designable is canceled. An algorithm based on the common asymptotic periodic properties of the states is developed to find the reachable sets. Accordingly, the existing controllability criteria for subspaces when initial states of subnetworks are designable is improved, and a necessary and sufficient condition of subspace controllability via subnetworks and free inputs is derived. A design technique involving a kind of newly defined addition is presented to construct desired controls. 相似文献