串联压电微泵特性研究

介绍了一种压电驱动的串联无阀微泵.基于收缩管/扩展管整流特性的分析,建立了微泵输出特性的表达公式.采用有限元仿真软件ANSYS对微泵内流体的流动过成进行了数值模拟,结果显示,在相同的驱动条件下,串联无阀微泵的工作性能优于单腔无阀微泵的工作性能.泵流量随着驱动电压的增加而增加.当固定的驱动电压下,存在最优的压电层厚度使得泵流量最大.研究结果为串联微泵的优化设计提供了依据.     

Fully coupled modeling and design of a piezoelectric actuation based valveless micropump for drug delivery application

The precise control over the drug delivery involved in several vital applications including healthcare is required for achieving a therapeutic effect. For such precise control/manipulation of the drugs, micropumps are used. These micropumps are basically of two types viz. check valve-based and valveless micropumps. The valveless micropumps are preferable due to the congestion-free operation of diffuser/nozzle valves. In this paper, design optimization of a valveless piezo-electric actuation based micropump is carried out using COMSOL Multiphysics 5.0 by coupling two Multiphysics interface modules namely fluid–structure interaction and piezoelectric physics modules. Using simulation studies, the influence of pump design parameters including diffuser angle, diffuser length, neck width, chamber depth, chamber diameter and diaphragm thickness on net flow rate is studied. An optimal set of design parameters for the proposed micropump is identified. Further, the influence of actuation frequency on the flow rate is analysed. It is found that the proposed micropump is capable to deliver a net flow rate of 20 µl/min and a maximum back pressure attainable is 200 Pa.

     

一种低成本压电无阀微泵的研制

提出了一种低成本的由压电材料驱动的平面扩张/收缩管无阀微泵的制作工艺.通过数值模拟确定了扩张/收缩管扩张角的最优值,在此基础上,采用光刻和湿法刻蚀工艺,刻蚀了300μm深的泵腔基片和100 μm深的盖片;使用等离子体清洗技术将其与PDMS薄膜键合,完成了可以实现单向泵送的压电无阀微泵样机制作.研究了该压电无阀微泵样机的...     

A UML-based object-oriented approach for design and simulation of a drug delivery system

Given complexity of the design and manufacturing processes of microelectromechanical system (MEMS) products, we present a unified modeling language (UML) based design approach for multi-domain products or systems like MEMS to designing and evaluating possible solutions at the early design stage to shorten their development time. Specifically, the proposed approach is used to model and analyze a novel drug delivery system combining MEMS devices and integrated circuit (IC) units. This drug delivery system aims to be used for safer and more effective therapy of the diabetics. Two design models about the whole drug delivery system and its micropump subsystem are established using UML diagrams; in particular a composition diagram with components and ports describes the topology of the system. Through design and simulation on the micropump subsystem, it is found that the variations of geometrical dimension and excitation voltage affect the characterization of the micropump. The simulation results demonstrate and validate the proposed approach, and can be used as a significant reference for the designer to design the optimal micropump.     

Study of an innovative one-sided actuating piezoelectric valveless micropump with a secondary chamber

Previous studies have indicated that a one-sided actuating piezoelectric micropump (OAPMP) combined with two valves may enhance the liquid flow rate to 4.1 ml/s and make it possible to reach the maximum pump head of 9807 Pa in a limited space. In this study, an innovative one-sided actuating piezoelectric valveless micropump (OAPMP-valveless) has been developed to actuate fluid at a higher flow rate in one direction by adding a secondary chamber. The secondary chamber plays a key role in the application of the valveless micropump: the flow rate of the pump can reach 0.989 ml/s by adding a secondary chamber. The maximum pump head is 1522.5 Pa when using the 0.3 mm-thick secondary diaphragm and the 0.5 mm-thick primary diaphragm. In addition, if a nozzle/diffuser element is applied to the OAPMP-valveless with a secondary chamber, the flow rate can be further improved to 1.183 ml/s at a frequency of 150 Hz. A three-dimensional numerical model of the valveless micropump has been built to compare the measured results with the simulated results.     

Optimization design of multi-material micropump using finite element method

This paper presents a micropump fabricated from low cost materials with specific goal of cost reduction. The micropump does not require any valve flap and comprises one plastic pump polyether–ether–ketone (PEEK) body, one metal diaphragm, and three piezoelectric ceramics to form piezoelectrically actuated diaphragm valves. The valve actuation simplifies micropump structural designs and assembly processes to make the pump attractive for low cost bio-medical drug delivery applications. A detailed optimization design of geometric parameters of the piezoelectrically actuated diaphragm is undertaken by use of 3D finite element method (FEM) to maximize piezoelectric actuation capability and ensure actuation reliability. An optimized geometric dimensional design: the ratio of thicknesses between the piezoelectric ceramics and the metal diaphragm, and the lateral dimension of the piezoelectric ceramic, is obtained through simulations. Based on the optimized design, a good agreement has been reached between simulated and measured strokes of the micropumps. The tested results show that the micropump has a high pump flow rate for air, up to 39 ml/min, and for water, up to 1.8 ml/min, and is capable of ensuring diaphragm’s maximum stress and strain is within material strength for reliable work.     

Parametric characterization of piezoelectric valveless micropump

Experimental investigations are performed to determine the influence of electrical excitation and geometrical parameters on the performance of piezoelectric valveless micropumps fabricated on printed circuit board substrates. Strain gauges and shunt resistor are used in conjunction with a data acquisition system to form an effective transducer, capable of providing magnitude and phase response information pertaining to fluid–structure interaction. Effect of conical diffuser geometry on the displacement response and pressure flow characteristics are studied. With suitable variations in the design of the diffuser element and input excitation parameters, the ability of the valveless micropump can be extended to include forward, reversed and bidirectional flow features. The characteristic signatures of single and two peaks in flowrate or pressure data are captured in the displacement phase response. System identification approach is proposed to model and predict the performance of valveless micropumps.     

Transport of drug particles in micropumps through novel actuation

Micropumps with various types of actuations have been used in lab-on-a-chip devices. In order to control the delivery of drug particles both in space and time and avoid clogging, other types of actuation mechanisms may be needed. In this study, a valveless micropump with novel actuation is proposed to transport particles for biomedical and environmental applications. The transport of drug particles through the designed valveless micropump is carried out through computational fluid dynamics combined with discrete particle transport methods. After convergence studies, the effects of actuation frequency, particle size and the resident times on the particle transport are investigated. Interestingly, both the actuation frequency and particle size have a strong effect in terms of resident times and the spatial distribution of the transported particles through the designed micropump. Based on the results obtained, the relationship between actuation frequency, fluid flow, and particle transport through the designed micropump is presented. The computational analysis presented demonstrates that it is possible to optimize the proposed valveless micropump design for specific delivery of drug particles for separation and sorting applications.     

Design and modeling of electromagnetic actuator in mems-based valveless impedance pump

This study models and optimizes the electromagnetic actuator in an MEMS-based valveless impedance pump. The actuator comprises an electroplated permanent magnet mounted on a flexible PDMS diaphragm and electroplated Cu coils located on a glass substrate. In optimizing the design of the actuator, the objective is to maximize the output flow rate of the micropump while maintaining the mechanical integrity of its constituent parts. The study commences by developing optimized theoretical models for each of the components within the actuator, namely the diaphragm, the magnet, and the micro-coils. The theoretical models are then verified numerically using FEA software. The magnitude of the magnetic force acting on the flexible diaphragm is calculated using Ansoft/Maxwell3D FEA software. The simulation results obtained by ANSYS FEA software for the diaphragm deflection are found to be in good agreement with the theoretical predictions. In general, the results show that the desired diaphragm deflection of 15 μm can be obtained by passing a current of 0.6–0.7 A through the micro-coil to produce a compression force of 11 μN. The valveless micro impedance pump proposed in this study is easily fabricated and is readily integrated with existing biomedical chips due to its plane structure. The results of this study provide a valuable contribution to the ongoing development of Lab-on-a Chip systems.     

Design and fabrication of a valveless micropump based on low temperature co-fired ceramic tape technology

Low temperature co-fired ceramic (LTCC) tape technology has been widely studied in microsystems and microfluidic devices. The current study presented the manufacturing process of a simple and inexpensive micropump which is made of LTCC. The components of micropump including fluidic channels, diaphragm, chamber, and planar diffuser valves were integrated in one LTCC module. Geometries of these components were designed based on numerical analysis. The finite element analysis was used to characterize the displacement of a piezoelectric actuator and the computational fluid dynamics was applied to design the diffuser. The performance of the micropump was optimized and performance of the designed micropump was carefully examined in the experiments. The data revealed that the performance of a micropump can be significantly increased by adding a pair of pockets. Overall, the study demonstrated that LTCC tape technology is a simple and reliable method to fabricate a valveless micropump.     

Modeling of single and multilayer polyvinylidene fluoride film for micro pump actuation

Micro pumps are essential components of micro devices such as drug delivery systems. Large numbers of pumps have been proposed based on different actuating principles. Piezoelectric actuation offers advantages such as reliability and energy efficiency. Lead zirconate titanate (PZT) based piezoelectric actuation for micro pumps is predominantly explored despite its disadvantages such as brittle nature, low straining and difficulties in processing. Polymer piezoelectric materials like polyvinylidene fluoride (PVDF) could be promising replacements for PZT owing to their availability in form of films and good strain coefficients. Very limited literature on micro pump with PVDF as an actuator is available. In this paper, finite element analysis (FEA) model of a micro pump actuator using single and multilayer PVDF for actuation is developed in ANSYS^?. The model takes into account the influence of driving voltage and actuator geometry. The central deflection of the pump diaphragm which is instrumental in defining the pump performance is studied for driving voltages of 100?C200?V. The deflection of the pump diaphragm for single layer and multilayer actuation are determined from the model. It could be inferred from the initial part of the study that pump performance depends on driving voltage and actuator film thickness. In order to reduce driving voltage requirement multilayer stacked actuator is tried with four different configurations of the layers. It is concluded that stacking configuration of parallel energized straight polarity PVDF layers yielded best central deflection. An attempt is made to compare the performance of multilayer actuator with an equivalent single thick layer actuator. It is noticed that the multilayer actuator performance was better by about 101% when number of layers is doubled.     

Design and optimization of MEMS based piezoelectric actuator for drug delivery systems

In this paper, piezoelectric principle based an actuator is design for a micropump, which is suitable for drug delivery systems. The natural frequency and stress analysis have been performed to determine the reliability of the device in terms of minimum safety factor. We have observed the uniform deflections of the actuators by varying the thicknesses of the piezoelectric layer of the actuator. The design of the actuators is considered in circular and rectangular geometry. The materials are selected appropriately such that the component is biocompatible and can be used in biomedical applications. Among the various considerations made on dimensions and geometry, it is observed that the circular piezoelectric actuator undergoes a high displacement of 2950 μm at an infinitesimal thickness of 0.1 μm. At minimum safety factor of one, the maximum stress and voltage the actuator can hold is 596 GPa and 8500 V respectively.

     

基于微振动马达的无阀微泵的研究

研制了一种可在低电压下工作的新型无阀微泵,该微泵利用有机玻璃(PMMA)制作泵腔,采用了扩散口/喷口的结构,以PDMS作为振动膜,利用微振动马达作为驱动部件。采用ANSYS软件进行有限元分析得到微泵扩散口/喷口的最佳尺寸。对微泵的振动频率和输出流量进行了测试,结果显示:电压为1.0～1.8 V时,微泵的输出流量随着电压的升高而增加,当电压为1.8～3.3 V时,微泵输出的流量保持稳定,达到150μL/min。该无阀微泵结构简单,驱动电压低,具有良好的性能和低廉的成本。     

Peristaltic micropump system with piezoelectric actuators

This work presents a driving system for a peristaltic micropump that is based on piezoelectric actuation. The effects of the actuation sequence on pump performance are also considered. A valveless peristaltic micropump based on piezoelectric actuation is designed and fabricated using microelectromechanical system technology. The pump has three parts––silicon, Pyrex glass and commercially available bulk PZT (lead zirconate titanate) chips. The peristaltic micropump actuated by PZT chips comprises three chambers that are in series. The driving system consists of an ATmega 8535 microprocessor, a high voltage power supply, three differential amplifiers, a phase controller, an A/D converter, a 555 oscillator and an LCD module. It is supplied via a 110 Vrms 60-Hz AC line and is programmable. The system can produce step-function signals with voltages of up to 100 V_pp and frequencies ranging from 10 Hz to 1 kHz, as the inputs for the pump. Fluid pumping with air is successfully demonstrated. Additionally, 3-, 4- and 6-phase actuation sequences for the pump are designed and used to study the effects on pump performance, as revealed by the flow rate and the displacement of a pump diaphragm. The experimental results show that the flow rate and the displacement of the diaphragm actuated by the 4-phase sequence exceed those actuated by the 3- and 6-phase sequences. A flow rate of 17.6 μl min⁻¹ and a displacement of 2.91 μm (peak-to-peak) in 4-phase peristaltic motion are achieved at 100 Hz and 100 V_pp. The results demonstrate that the pump actuated in the 4-phase sequence is the most efficient. Consequently, the actuation sequences can affect the pump performance.     

MEMS-based micropumps in drug delivery and biomedical applications

This paper briefly overviews progress on the development of MEMS-based micropumps and their applications in drug delivery and other biomedical applications such as micrototal analysis systems (μTAS) or lab-on-a-chip and point of care testing systems (POCT). The focus of the review is to present key features of micropumps such as actuation methods, working principles, construction, fabrication methods, performance parameters and their medical applications. Micropumps have been categorized as mechanical or non-mechanical based on the method by which actuation energy is obtained to drive fluid flow. The survey attempts to provide a comprehensive reference for researchers working on design and development of MEMS-based micropumps and a source for those outside the field who wish to select the best available micropump for a specific drug delivery or biomedical application. Micropumps for transdermal insulin delivery, artificial sphincter prosthesis, antithrombogenic micropumps for blood transportation, micropump for injection of glucose for diabetes patients and administration of neurotransmitters to neurons and micropumps for chemical and biological sensing have been reported. Various performance parameters such as flow rate, pressure generated and size of the micropump have been compared to facilitate selection of appropriate micropump for a particular application. Electrowetting, electrochemical and ion conductive polymer film (ICPF) actuator micropumps appear to be the most promising ones which provide adequate flow rates at very low applied voltage. Electroosmotic micropumps consume high voltages but exhibit high pressures and are intended for applications where compactness in terms of small size is required along with high-pressure generation. Bimetallic and electrostatic micropumps are smaller in size but exhibit high self-pumping frequency and further research on their design could improve their performance. Micropumps based on piezoelectric actuation require relatively high-applied voltage but exhibit high flow rates and have grown to be the dominant type of micropumps in drug delivery systems and other biomedical applications. Although a lot of progress has been made in micropump research and performance of micropumps has been continuously increasing, there is still a need to incorporate various categories of micropumps in practical drug delivery and biomedical devices and this will continue to provide a substantial stimulus for micropump research and development in future.     

新型压电微泵的结构设计与理论分析

微泵在微流控化学分析芯片中有很大的应用前景,日益成为人们研究的热点。从结构设计、理论分析和工艺加工3个方面研究了微阀与微泵,设计出用压电驱动和聚二甲基硅氧烷(PDMS)作为泵膜的集成微阀与微泵,其特点是原理新颖、结构简单、易于加工、操作方便。结构主要是由PDMS泵膜、硅片和压电驱动器组成,其中,PDMS既是泵膜和缓冲单元,也是主动阀片。在直流电压的驱动下,其工作状态是微阀,阻止流体的单向流通,在方波信号的驱动下,其工作状态是微泵,实现流体的吸入与泵出。给出各种几何参数、工作原理和工艺流程。     

Design optimization of an electromagnetic actuation based valveless micropump for drug delivery application

Microsystem Technologies - A valveless micropump based on an electromagnetic actuation for drug delivery application has been designed. The parametric studies are performed to examine the effects...     

Characteristic studies of a novel piezoelectric impedance micropump

Microsystem Technologies - This study reports the design, fabrication and test of an innovative valveless piezoelectric impedance micropump. The impedance micropump includes two nickel...     

A cross-junction channel valveless-micropump with PZT actuation

A gas-jet micro pump with novel cross-junction channel has been designed and fabricated using a Si micromachining process. The valveless micro pump is composed of a piezoelectric lead zirconate titanate (PZT) diaphragm actuator and fluidic network. The design of the valveless pump focuses on a cross-junction formed by the neck of the pump chamber and one outlet and two opposite inlet channels. The structure of cross-junction allows differences in fluidic resistance and fluidic momentum inside the channels during each PZT diaphragm vibration cycle, which leads to the gas flow being rectified without valves. The flow channels were easily fabricated by using silicon etching process. To investigate the effects of the structure of the cross-junction on the gas flow rate, two types of pump with different cross-junction were studied. The design and simulation were done using ANSYS-Fluent software. The simulations and experimental data revealed that the step-nozzle structure is much more advantageous than the planar structure. A flow rate of 5.2 ml/min was obtained for the pump with step structure when the pump was driven at its resonant frequency of 7.9 kHz by a sinusoidal voltage of 50 V_p–p.     

Characteristic studies of the piezoelectrically actuated micropump with check valve

This study presents the design and fabrication of a novel piezoelectric actuator for a micropump with check valve having the advantages of miniature size, light weight and low power consumption. The micropump is designed to have five major components, namely a piezoelectric actuator, a stainless steel chamber layer with membrane, two stainless steel channel layers with two valve seats, and a nickel check valve layer with two bridge-type check valves. A prototype of the micropump, with a size of 10 × 10 × 1.0 mm, is fabricated by precise manufacturing. The check valve layer was fabricated by nickel electroforming process on a stainless steel substrate. The chamber and the channel layer were made of the stainless steel manufactured using the lithography and etching process based on MEMS fabrication technology. The experimental results demonstrate that the flow rate of micropump accurately controlled by regulating the operating frequency and voltage. The flow rate of 1.82 ml/min and back pressure of 32 kPa are obtained when the micropump is driven with alternating sine-wave voltage of 120 Vpp at 160 Hz. The micropump proposed in this study provides a valuable contribution to the ongoing development of microfluidic systems.