^153Sm标记DTPA—蛋白的研究

研究了以功能联接剂ＣＡＤＴＰＡ与牛血清白蛋白（ＢＳＡ），链霉亲和素（ＳＡ），ＣＥＡ单抗和ＩｇＧ的偶联反应，建立了＾１５３Ｓｍ标记蛋白的方法，选择了最佳标记条件，检测了其中一些偶联物的生物活性，测定＾１５３Ｓｍ通过双功能联接标记蛋白的体外血清稳定性，结果表明：ＤＴＰＡ－ＳＡ的生物素结合活性保存率为５６．５％，ＤＴＰＡ－ＣＥＡ单抗的免疫活性与ＣＥＡ多抗相近，＾１５３Ｓｍ标记ＣＥＡ的单抗的比活度达２．３     

亲和素-生物素系统的153Sm标记及其生物学分布动力学的研究

选用＾１５３Ｓｍ对生物素进行放射性标记,然后利用亲和素和链霉亲和素与生物素的高亲合力特性,再对亲和素和链霉亲和素进行＾１５３Ｓｍ的标记,观察到大鼠和小鼠体内的血清除率和生物学分布,并与＾１５３ＳｍＣｌ３和＾１５３Ｓｍ－ＤＴＰＡ的生物学分布进行比较。结果表明,＾１５３Ｓｍ标记的亲和素血素除迅速,肝肾放射性摄取高;＾１５３Ｓｍ标记的链霉亲和素血清除缓慢,肝、脾、肾等脏器和血液中滞留量高;而＾１５３Ｓｍ     

^125I标记的亲和素及其衍生物在小鼠体内的生物分布

为了降低鸟亲和素的高肝摄取，延长Ａｖ在血液中的滞留时间，对Ａｖ进行化学修饰，修饰后的Ａｖ衍生物用＾１２５Ｉ标记示踪，观察小鼠体内生物分布。结果表明，Ａｖ衍生物＾１２５Ｉ－ｓｕｃ－Ａｖ减少肝、肾、脾中摄取最佳；衍生物＾和２５Ｉ－ｏｃｔｏ－Ａｖ在肾中摄取较链霉亲和素低，而在有趣中仍有较高放射性浓集；衍生物＾１２５Ｉ－ｏｃｔｏ－Ａｖ－ｓｕｃ的肾摄虽较高，但代谢较＾１２５Ｉ－ＳＡ快，然而肝摄取没有明显降低     

人促甲状腺激素生物素—亲和素系统免疫放射分析法的建立

报道将ＢＡＳ引入双们点夹心ＩＲＭＡ，建立了人血清ＴＳＨ固相试管双位点夹心ＢＡＳ－ＩＲＭＡ。该法批内ＣＶ为１．４％－８．３％，批间ＣＶＯ ６．１％－８．４％，最小检出量为０．０４ｍＩＵ／Ｌ，平均回收率为１００．１６％，灵敏度约是同条件下ＩＲＭＡ的３倍；与ＩＲＭＡ对比测定２０份病人血管ＴＳＨ样品，经统计学处理，两者测定结果呈良好相关性。     

铜紫红素18对小鼠红系造血作用的研究

为了寻找再生障碍性贫血治疗药物,从四吡咯人合物中设计合成了铜紫红素１８,观察铜紫红素１８对受照射昆明种小鼠红系造血的作用。结果表明：铜紫红素１８能明显促进造血干细胞（ＣＦＵ－Ｓ）优先向红系祖细胞（ＣＦＵ－Ｅ）转人;在恢复期也有提升ＷＢＣ和骨髓有核细胞计数的作用。本结果提示。铜紫红素１８作为再生障碍性贫因防治药物具有良好的发展前景,值得进一步研究 。     

N．N．N．N─四丁基丁二酰胺在硝酸介质中萃取钍（Ⅳ）的机理

研究了Ｎ．Ｎ．Ｎ．Ｎ－四丁基丁二酰胺（ＴＢＳＡ）从硝酸介质中萃取Ｔｈ（Ⅳ）的机理，得出了萃合物的结构为Ｔｈ（ＮＯ３）４．ＴＢＳＡ，分析ＴＨＮＯ３、Ｔｈ４＋、ＴＢＳＡ的浓度及温度对Ｔｈ４＋分配比的影响，并计算出萃取反应的表观平衡常数及热力学函数。     

PMCBP与中性萃取剂对铕的协同萃取

研究了１－苯基－３－甲基－４（２－氯苯氯基）哟唑酮－５（ＰＭＣＢＰ）与三辛基氧化膦（ＴＯＰＯ）、二正辛基亚砜（ＤＯＳＯ、二环己基亚砜（ＤＣｙＨＳＯ）和磷酸酸古丁酯（ＴＢＰ）的二甲苯溶液从盐酸介质中对肴的协同萃取，实验证实有明显的协萃效应，采用斜率法测定了ＰＭＣＢＰ单独和协萃铕的配合物组成，它们分别为ＥｕＡ２．Ｃｌ．ＨＡ和ＥｕＡ２．Ｃｌ．Ｂ（Ｂ为ＴＯＰＯ、ＤＯＳＯ、ＤＣｙＨＳＯ ＴＢＰ）。计算了它们     

^90Y标记抗体的双功能络合剂的研究—异硫氰基苄基DTPA与…

比较了异硫氰基苄基ＤＴＰＡ（ＳＣＮ－Ｂｚ－ＤＴＰＡ）、环化ＤＴＰＡ酸酐（ＣＤＴＰＡ）两种双功能络合剂与单克隆抗体（ＭｃＡｂ）的偶联、偶联物与＾９０Ｙ标记和标记物稳定性的差异。结果表明，无论在络合剂对单克隆抗体免疫活性影响方面，还是在标记物稳定性方面，ＳＣＮ－Ｂｚ－ＤＴＰＡ都优于ＣＤＴＰＡ。     

ASSESSMENT OF COLLECTIVE DOSE FOR TRAVELLERS BY WATERS

ＡＳＳＥＳＳＭＥＮＴＯＦＣＯＬＬＥＣＴＩＶＥＤＯＳＥＦＯＲＴＲＡＶＥＬＬＥＲＳＢＹＷＡＴＥＲＳＹｕｅＱｉｎｇｙｕ（岳清宇）；ＪｉａｎｇＰｉｎｓ（姜萍）ａｎｄＪｉｎＨｕａ（金花）（ＣｈｉｎａＩｎｓｔｉｔｕｔｅｏｆＡｔｏｍｉｃＥｎｅｒｇｙ，Ｂｅｉｊｉｎｇ...     

同步辐射4W1B光束线及XAFS实验系统

同步辐射４Ｗ１Ｂ束线及ＸＡＦＳ实验站的设计建筑任务是北京正负电子对撞机工程（ＢＥＰＣ工程）的一个组成部分。１９９０年４月，核束线及实验站联调成功。第一次获取了同步辐射ＸＡＦＳ谱。迄今，ＸＡＦＳ实验站已达到了９０％的机时对用户开放的水平，累计开放机时已近３０００ｈ，有来自全国各大院校及研究机构的几十个用户进行了实验，催化剂，高温超导材料，固熔体等领域做出了一批有意义的成果。本文首先介绍了ＸＡＦＳ实验     

游离三碘甲腺原氨酸(FT3)生物素-亲合素酶联免疫分析

采用T3抗体包被酶标板微孔、生物素化T3和辣根过氧化物酶(HRP)标记链亲合素作为信号放大体系,一系列定量游离T3(FT3)为标准品,并以四甲基联苯胺-过氧化氢为显色底物,建立了FT3的生物素-亲合素(BA)酶联免疫分析(FT3-BA-EIA)法。其灵敏度为0.90pmol/L,标准曲线范围0.9～45.0pmol/L,批内变异系数3.1%～8.1%,批间变异系数4.9%～10.6%。测定了101例临床血样,其中正常人46例,实测范围2.5～11.1pmol/L,均值为5.1±2.0pmol/L;27例甲亢病人,实测范围9.7～37.3pmol/L,均值为20.5±7.1pmol/L;20例甲低病人,实测范围0.9～3.8pmol/L,均值为2.0±0.9pmol/L;8例孕妇,实测范围为3.4～8.5pmol/L,均值为6.0±2.5pmol/L。通过对临床血样的检测,本法与化学发光法(CIA)及放免法(RIA)的测定结果有良好的相关性。应用本法可有效地诊断甲状腺疾病,具有操作简便、灵敏、快速的特点,适于临床检测和科研应用。     

矩形通道的流固耦合传热模拟

针对带发热板的矩形通道,利用CFX程序对其进行流固耦合传热模拟,并对网格进行传热方面的敏感性分析,得到较好的网格尺度。最后,通过与直接添加表面热流密度模拟的对比,分析流固耦合传热模拟的好处。研究结果表明,流固耦合传热模拟能更准确地研究通道的薄弱环节,提高热工性能。     

Conjugate Gradient Like Methods and Their Application to Fixed Source Neutron Diffusion Problems

This paper presents a number of fast iterative methods for solving systems of linear equations appearing in fixed source problems for neutron diffusion. We employed the conjugate gradient and conjugate residual methods. In order to accelerate the conjugate residual method, we proposed the conjugate residual squared method by transforming the residual polynomial of the conjugate residual method. Since the convergence of these methods depends on the spectrum of coefficient matrix, we employed the incomplete Choleski (IC) factorization and the modified IC (MIC) factorization as preconditioners. These methods were applied to some neutron diffusion problems and compared with the successive overtaxation (SOR) method. The results of these numerical experiments showed superior convergence characteristics of the conjugate gradient like method with MIC factorization to the SOR method, especially for a problem involving void region. The CPU time of the MICCG, MICCR and MICCRS methods showed no great difference. In order to vectorize the conjugate gradient like methods based on (M)IC factorization, the hyperplane method was used and implemented on the vector computers, the HITAC S-820/80 and ETA10-E (one processor mode). Significant decrease of the CPU times was observed on the S-820/80. Since the scaled conjugate gradient (SCG) method can be vectorized with no manipulation, it was also compared with the above methods. It turned out the SCG method was the fastest with respect to the CPU times on the ETA10-E. These results suggest that one should implement suitable algorithm for different vector computers.     

Elastic–plastic analysis of nuclear structures with millions of DOFs using the hierarchical domain decomposition method

The hierarchical domain decomposition method (HDDM) proposed by Comp. Sys. Eng. 4 (1993) 495 is applied to the large scale elastic–plastic finite element (FE) analysis of nuclear structures. The HDDM is a method to implement the finite element method (FEM) on various kinds of parallel environments. The substructure-based iterative methods can effectively be used with the HDDM to solve the large scale linear algebraic equations derived from the implicit FEM. In this paper, some key techniques to parallelize the static elastic–plastic FE analysis by the HDDM are described. As illustrative examples, a support structure of the high temperature engineering test reactor (HTTR), a pressure vessel, and an internal pump of a pressure vessel are analyzed. The structure of HTTR and the pressure vessel are modeled by hexahedral solid elements whose total degrees of freedom (DOFs) are about 1.3 millions (M) and 3 M, respectively. The internal pump is modeled by quadratic tetrahedral elements whose total DOFs are about 2 M. The elastic–plastic analysis of a simple cube with 10 M DOFs is also carried out. Both the conjugate gradient method for solving the linear equations and the Newton–Raphson method for solving nonlinear problems successfully converge.     

CFR600泵支承氩气空间部分三维传热数值模拟

利用流体力学软件Fluent对中国示范快堆（CFR600）氩气空间及相关结构部件进行稳态共轭传热计算,验证分析泵支承结构位于氩气空间部分的热工设计。模拟结果显示,原型设计方案泵支承结构位于氩气空间部分周向温度分布有较大温度梯度,泵支承结构靠近主容器支承径侧温度明显高于远离支承径侧,改进的结构设计减小了泵支承周向的温度梯度,为优化泵支承结构设计提供了技术支撑。     

中子传输矩阵研究

通过简化假设,分析了中子传输矩阵的物理意义,推导出中子传输矩阵数学模型,并利用以往的数据进行了验证.同时根据矩阵的共轭梯度算法理论,研究利用堆外核探测器系统(RPN)的功率量程通道(PRC)6节电离室信号及堆内中子通量测量系统(RIC)获得的堆内通量分布信号计算中子传输矩阵的方法.这种算法得到的中子传输矩阵,可以植入冷却剂丧失(LOCA)监测系统(LSS系统);通过LSS系统可以实时监测堆芯轴向功率分布,进而监测堆芯轴向线功率密度.     

生长抑素-葡聚糖的99Tcm标记及体外结合分析

采用还原氨化方法，将天然生长抑素（SMS）与葡聚糖(Dx20)偶联，并以125I－奥曲肽（125I-Tyr3-Octreotide)为放射配基，进行受体竞争结合实验，测定了SMS-Dx50的IC50；以SnCl2为还原剂对SMS-Dx50进行99Tcm标记，并进行99Tcm- SMS-Dx50受体结合分析，考察其对生长抑素受体的亲合能力。结果表明：SMS-Dx50保持了对SMS 2型受体的高亲和力；其IC50与奥曲肽的IC50（0.79 nmol/L）相近,为5.95 nmol/L；99Tcm- SMS-Dx50标记率>85％, 经PD-10柱分离纯化，其放化纯度>98%；99Tcm- SMS-Dx50对生长抑素2型受体特异性结合为25%～40％，保持了较高的亲和力；SMS-Dx50适合于99Tcm标记，可用于生长抑素受体阳性肿瘤诊断的进一步研究     

Coupled fluid/structure analyses of the MEGAPIE spallation source target during transients

The paper describes some R&D activities undertaken in support of the design and safe operation of MEGAPIE (MEGAwatt PIlot Experiment) spallation source target, which is scheduled to be irradiated by a proton beam in the SINQ facility at the Paul Scherrer Institute in 2006. The target material is lead bismuth eutectic (LBE), which also acts as the primary coolant. As a consequence of the spallation reactions, about 600 kW of heat would be deposited in the target during operation, and considerable R&D effort is being expended to demonstrate continuing coolability and structural integrity under a variety of operational and abnormal conditions. The paper gives three examples of transient analyses carried out as part of the safety assessment of the target: (1) a beamline trip and recovery; (2) failure of the primary electro-magnetic pump (EMP); (3) failure of the secondary EMP (used to cool the base of the target). The study involves the simultaneous application of a system-analysis code, in our case a version of RELAP5, a computational fluid dynamics (CFD) tool (CFX-4), and a structural analysis code (ABAQUS). The RELAP5 code is used to provide transient boundary conditions for a localized conjugate heat transfer analysis of the lower target region, undertaken using CFD, and includes the feed-back effects arising from the secondary cooling and control systems. A conjugate heat transfer problem is then solved using CFD, which provides time-dependent thermal and flow data within the LBE, together with the thermal and mechanical loads to the target structures. Finally, an in-house interface program is employed to transfer mesh geometry, model topology and (time-dependent) thermal/mechanical data to enable stress analysis of the principal lower-target structural components to be performed. It is demonstrated that none of the transients considered result in critical stress conditions occurring in the target components, but that further operation is not recommended unless both pumps are fully operational.     

集装箱CT检测系统中贝叶斯图像重建算法的应用探讨

最大后验概率(Maximum a posteriori,MAP)图像重建算法是一种贝叶斯算法(Bayesian Reconstruction,BR),可克服最大似然(Maximum Likelihood,ML)算法不能抑制噪声、重建时间较长的缺点.探讨了适合集装箱CT检测的两种MAP重建算法:加权最小二乘-最大后验概率-共轭梯度算法(weighted-least-squares MAP conjugate gradient,WLS-MAP-CG)和有序子集-贝叶斯算法(modified ordered subset,MOS-BR)并讨论了合适的先验知识分布.