激光主动成像图像降噪方法

针对激光主动成像图像的特点,并考虑到实时性的要求,提出了一种基于中值滤波与提升小波变换级联的图像降噪方法。首先在空域中对图像进行快速中值滤波,然后对含噪图像进行提升小波分解,最后在小波域内对高频子带进行阈值降噪处理。采用信噪比（SNR）、运行时间T和图像灰度曲面图作为图像降噪效果的评估,将该算法与传统小波降噪、传统小波与中值滤波结合降噪等进行对比实验。实验结果表明,该算法能有效滤除激光图像中的噪声,提高图像的信噪比,且运算速度更快,同时满足了工程应用中对降噪效果和实时性的要求。     

Universal Glucose Models for Predicting Subcutaneous Glucose Concentration in Humans

This paper tests the hypothesis that a “universal,” data-driven model can be developed based on glucose data from one diabetic subject, and subsequently applied to predict subcutaneous glucose concentrations of other subjects, even of those with different types of diabetes. We employed three separate studies, each utilizing a different continuous glucose monitoring (CGM) device, to verify the model's universality. Two out of the three studies involved subjects with type 1 diabetes and the other one with type 2 diabetes. We first filtered the subcutaneous glucose concentration data by imposing constraints on their rate of change. Then, using the filtered data, we developed data-driven autoregressive models of order 30, and used them to make short-term, 30-min-ahead glucose-concentration predictions. We used same-subject model predictions as a reference for comparisons against cross-subject and cross-study model predictions, which were evaluated using the root-mean-squared error (RMSE) and Clarke error grid analysis (EGA). We found that, for each studied subject, the average cross-subject and cross-study RMSEs of the predictions were small and indistinguishable from those obtained with the same-subject models. These observations were corroborated by EGA, where better than 99.0% of the paired sensor-predicted glucose concentrations lay in the clinically acceptable zone A. In addition, the predictive capability of the models was found not to be affected by diabetes type, subject age, CGM device, and interindividual differences. We conclude that it is feasible to develop universal glucose models that allow for clinical use of predictive algorithms and CGM devices for proactive therapy of diabetic patients.      

基于提升小波变换和中值滤波的图像去噪方法研究

针对实际拍摄的背景复杂、目标对比度和信噪比低的图像,在综合考滤图像去噪平滑效果、图像清晰程度和时间复杂度的基础上,提出一种基于提升小波变换和中值滤波的图像去噪方法.首先对含噪图像进行提升小波分解,再在图像高频部分进行中值滤波以改善图像的消噪效果,最后采用信噪比(SNR)与均方根误差(RMSE)和图像灰度曲面图作为图像去噪效果的评估,将提升小波变换和中值滤波相结合的图像去噪方法与小波去噪、小波与中值滤波结合消噪等进行对比实验.实验结果表明,该方法既能消除图像噪声又能达到保持其图像边缘要求,且时间度较低.     

Neural network incorporating meal information improves accuracy of short-time prediction of glucose concentration

Diabetes mellitus is one of the most common chronic diseases, and a clinically important task in its management is the prevention of hypo/hyperglycemic events. This can be achieved by exploiting continuous glucose monitoring (CGM) devices and suitable short-term prediction algorithms able to infer future glycemia in real time. In the literature, several methods for short-time glucose prediction have been proposed, most of which do not exploit information on meals, and use past CGM readings only. In this paper, we propose an algorithm for short-time glucose prediction using past CGM sensor readings and information on carbohydrate intake. The predictor combines a neural network (NN) model and a first-order polynomial extrapolation algorithm, used in parallel to describe, respectively, the nonlinear and the linear components of glucose dynamics. Information on the glucose rate of appearance after a meal is described by a previously published physiological model. The method is assessed on 20 simulated datasets and on 9 real Abbott FreeStyle Navigator datasets, and its performance is successfully compared with that of a recently proposed NN glucose predictor. Results suggest that exploiting meal information improves the accuracy of short-time glucose prediction.     

Enhancing the accuracy of subcutaneous glucose sensors: a real-time deconvolution-based approach

Minimally invasive continuous glucose monitoring (CGM) sensors can greatly help diabetes management. Most of these sensors consist of a needle electrode, placed in the subcutaneous tissue, which measures an electrical current exploiting the glucose-oxidase principle. This current is then transformed to glucose levels after calibrating the sensor on the basis of one, or more, self-monitoring blood glucose (SMBG) samples. In this study, we design and test a real-time signal-enhancement module that, cascaded to the CGM device, improves the quality of its output by a proper postprocessing of the CGM signal. In fact, CGM sensors measure glucose in the interstitium rather than in the blood compartment. We show that this distortion can be compensated by means of a regularized deconvolution procedure relying on a linear regression model that can be updated whenever a pair of suitably sampled SMBG references is collected. Tests performed both on simulated and real data demonstrate a significant accuracy improvement of the CGM signal. Simulation studies also demonstrate the robustness of the method against departures from nominal conditions, such as temporal misplacement of the SMBG samples and uncertainty in the blood-to-interstitium glucose kinetic model. Thanks to its online capabilities, the proposed signal-enhancement algorithm can be used to improve the performance of CGM-based real-time systems such as the hypo/hyper glycemic alert generators or the artificial pancreas.     

可调谐激光痕量气体检测中的数字滤波技术的优选

为改善可调谐二极管激光吸收光谱(TDLAS)系统的检测性能,以浓度为50×10-6和17×10-6的H2S气体检测为例,根据TDLAS系统的噪声特征,选择了4种数字滤波技术并利用Visual C++软件分别编写了程序对二次谐波原始信号进行压噪和有效信号的提取。结果表明,采用非线性最小二乘法与数字平均滤波技术相结合,使系统理论检测极限由原来的30×10-6提高到了5×10-6量级;对于反演后气体的浓度信号则采用Kalman滤波进行再去噪,使信噪比提高了近8倍。比较结果表明,经过上述滤波处理,TDLAS系统的信噪比和检测极限性能有明显改善。本文的上述方法实际应用到我们的TDLAS在线工业排放气体的测量系统中,取得了良好的效果。     

Joint demosaicing and denoising.

The output image of a digital camera is subject to a severe degradation due to noise in the image sensor. This paper proposes a novel technique to combine demosaicing and denoising procedures systematically into a single operation by exploiting their obvious similarities. We first design a filter as if we are optimally estimating a pixel value from a noisy single-color (sensor) image. With additional constraints, we show that the same filter coefficients are appropriate for color filter array interpolation (demosaicing) given noisy sensor data. The proposed technique can combine many existing denoising algorithms with the demosaicing operation. In this paper, a total least squares denoising method is used to demonstrate the concept. The algorithm is tested on color images with pseudorandom noise and on raw sensor data from a real CMOS digital camera that we calibrated. The experimental results confirm that the proposed method suppresses noise (CMOS/CCD image sensor noise model) while effectively interpolating the missing pixel components, demonstrating a significant improvement in image quality when compared to treating demosaicing and denoising problems independently.     

Smoothing low-SNR molecular images via anisotropic median-diffusion

We propose a new anisotropic diffusion filter for denoising low-signal-to-noise molecular images. This filter, which incorporates a median filter into the diffusion steps, is called an anisotropic median-diffusion filter. This hybrid filter achieved much better noise suppression with minimum edge blurring compared with the original anisotropic diffusion filter when it was tested on an image created based on a molecular image model. The universal quality index, proposed in this paper to measure the effectiveness of denoising, suggests that the anisotropic median-diffusion filter can retain adherence to the original image intensities and contrasts better than other filters. In addition, the performance of the filter is less sensitive to the selection of the image gradient threshold during diffusion, thus making automatic image denoising easier than with the original anisotropic diffusion filter. The anisotropic median-diffusion filter also achieved good denoising results on a piecewise-smooth natural image and real Raman molecular images.     

ECG denoising and compression using a modified extended Kalman filter structure

This paper presents efficient denoising and lossy compression schemes for electrocardiogram (ECG) signals based on a modified extended Kalman filter (EKF) structure. We have used a previously introduced two-dimensional EKF structure and modified its governing equations to be extended to a 17-dimensional case. The new EKF structure is used not only for denoising, but also for compression, since it provides estimation for each of the new 15 model parameters. Using these specific parameters, the signal is reconstructed with regard to the dynamical equations of the model. The performances of the proposed method are evaluated using standard denoising and compression efficiency measures. For denosing, the SNR improvement criterion is used, while for compression, we have considered the compression ratio (CR), the percentage area difference (PAD), and the weighted diagnostic distortion (WDD) measure. Several Massachusetts Institute of Technology–Beth Israel Deaconess Medical Center (MIT–BIH) ECG databases are used for performance evaluation. Simulation results illustrate that both applications can contribute to and enhance the clinical ECG data denoising and compression performance. For denoising, an average SNR improvement of 10.16 dB was achieved, which is 1.8 dB more than the next benchmark methods such as MABWT or EKF2. For compression, the algorithm was extended to include more than five Gaussian kernels. Results show a typical average CR of 11.37:1 with WDD ≪ 1.73%. Consequently, the proposed framework is suitable for a hybrid system that integrates these algorithmic approaches for clean ECG data storage or transmission scenarios with high output SNRs, high CRs, and low distortions.      

Two-branch wavelet denoising for accurate spectrum sensing in cognitive radios

In order to detect the unused spectrum bands (the spectrum holes) efficiently in cognitive radios with low signal-to-noise radio (SNR), we propose to adopt two independent branches of wavelet to detect the singularities of the received signals’ power spectrum density (PSD). The sensing structure is flexible such that we can use one or two branches to cope with different SNRs. Under low SNR condition, each branch uses distinct characteristics between noise and signals in the wavelet transform to eliminate the singularities generated by the noise. By using bandpass filter to calculate PSD values of the subbands which are distinguished by the signal’s singularities, the subband with the minimum PSD value among all of the subbands could be found. Then, the results of the two branches are merged and analyzed in order to make the final decision. Finally, we use signal reconstruction to further remove the noise and then accurately detect the spectrum holes. When the SNR is high, only one branch through the denoising procedure is needed to get accurate sensing result. Our simulation results show that the two-branch wavelet method is more accurate than conventional approaches under given SNRs.     

Denoising functional MR images: a comparison of wavelet denoising and Gaussian smoothing

We present a general wavelet-based denoising scheme for functional magnetic resonance imaging (fMRI) data and compare it to Gaussian smoothing, the traditional denoising method used in fMRI analysis. One-dimensional WaveLab thresholding routines were adapted to two-dimensional (2-D) images, and applied to 2-D wavelet coefficients. To test the effect of these methods on the signal-to-noise ratio (SNR), we compared the SNR of 2-D fMRI images before and after denoising, using both Gaussian smoothing and wavelet-based methods. We simulated a fMRI series with a time signal in an active spot, and tested the methods on noisy copies of it. The denoising methods were evaluated in two ways: by the average temporal SNR inside the original activated spot, and by the shape of the spot detected by thresholding the temporal SNR maps. Denoising methods that introduce much smoothness are better suited for low SNRs, but for images of reasonable quality they are not preferable, because they introduce heavy deformations. Wavelet-based denoising methods that introduce less smoothing preserve the sharpness of the images and retain the original shapes of active regions. We also performed statistical parametric mapping on the denoised simulated time series, as well as on a real fMRI data set. False discovery rate control was used to correct for multiple comparisons. The results show that the methods that produce smooth images introduce more false positives. The less smoothing wavelet-based methods, although generating more false negatives, produce a smaller total number of errors than Gaussian smoothing or wavelet-based methods with a large smoothing effect.     

一种新型混合并行粒子滤波频率估计方法

针对高动态、低信噪比环境下的载波频率信号跟踪问题,提出一种新的混合并行粒子滤波算法（ Multi-ple Extend Kalman Filter Independent Metropolis Hastings ,M-E-IMH）。该算法具有并行运算结构,实时性较基本粒子滤波有较大的提高。该算法直接利用同相支路（In-phase,I）和正交支路（Quadrature,Q）作为观测量,避免了传统方法中的鉴别器引入而引起的信噪比损耗。在高斯和非高斯环境下,与现有的载波跟踪方法如扩展卡尔曼滤波器（ EKF ）,粒子滤波器（ PF）,卡尔曼滤波器（ KF）等仿真对比表明,该方法在低信噪比下具有更高的跟踪精度。     

基于自适应多尺度形态滤波与EMD的激光雷达回波信号去噪方法

在使用经验模式分解(Empirical Mode Decomposition,EMD)对激光雷达回波信号进行去噪处理时,由于信号含有脉冲及间歇等间断事件而产生模态混叠,导致不能很好地分解出有用信号成分,影响去噪效果。针对这一问题,提出了一种形态滤波与EMD相结合的组合算法。首先,使用自适应多尺度形态滤波器作为前置单元,对信号进行初步处理,剔除信号中的间断事件干扰。之后,应用EMD对处理过的信号去噪。采用仿真数据及真实激光雷达回波数据进行了去噪实验。实验结果表明,文中算法相比于直接EMD去噪,在仿真试验中信噪比提高了8.89 dB,均方根误差降低了0.0514;在真实回波数据去噪实验中,6 km以后平均信噪比提高了3.356 4 dB。该组合算法有效地抑制了模态混叠现象,具有良好的去噪效果及应用前景。     

Multiresolution Bilateral Filtering for Image Denoising

The bilateral filter is a nonlinear filter that does spatial averaging without smoothing edges; it has shown to be an effective image denoising technique. An important issue with the application of the bilateral filter is the selection of the filter parameters, which affect the results significantly. There are two main contributions of this paper. The first contribution is an empirical study of the optimal bilateral filter parameter selection in image denoising applications. The second contribution is an extension of the bilateral filter: multiresolution bilateral filter, where bilateral filtering is applied to the approximation (low-frequency) subbands of a signal decomposed using a wavelet filter bank. The multiresolution bilateral filter is combined with wavelet thresholding to form a new image denoising framework, which turns out to be very effective in eliminating noise in real noisy images. Experimental results with both simulated and real data are provided.      

用小波变换抑制SAR图像中的斑点噪声

抑制合成孔径雷达图像中的斑点噪声一直是处理图像并得到准确图像信息的难点，提出了一种基于小波变换抑制合成孔径雷达（SAR）图像中的斑点噪声的方法，对原有的小波变换方法作了改进，能更好地保留图像的边缘信息，并能简化计算量。在仿真实验中使用了合成的模拟图像和真实的合成孔径雷图像，并与以往的小波去噪滤波方法以及一些经典的斑点噪声滤波方法（包括中值滤波，Lee滤波，Frost滤波）进行比较，在综合考虑了滤波算法在均匀区域对斑点噪声的抑制能力以及保留边缘信息能力的情况下，提出的算法有更好的效果。     

Denoising recovery for compressive sensing based on selective measure

In order to reduce the effect of noise folding (NF) phenomenon on the performance of sparse signal recon-struction,a new denoising recovery algorithm based on selective measure was proposed.Firstly,the NF phenomenon in compressive sensing (CS) was explained in theory.Secondly,a new statistic based on compressive measurement data was proposed,and its probability density function (PDF) was deduced and analyzed.Then a noise filter matrix was constructed based on the PDF to guide the optimization of measurement matrix.The optimized measurement matrix can selectively sense the sparse signal and suppress the noise to improve the SNR of the measurement data,resulting in the improvement of sparse reconstruction performance.Finally,it was pointed out that increasing the measurement times can further enhance the performance of denoising reconstruction.Simulation results show that the proposed denoising recon-struction algorithm has a better improvement in the performance of reconstruction of noisy signal,especially under low SNR.     

基于小波变换的光寻址电位传感器信号去噪研究

基于(LAPS)(光寻址电位传感器)技术的生化传感器中的光生电流是一种微弱的非平稳信号,信噪比(SNR)低。为了提取清晰的LAPS信号,且鉴于传统的傅里叶方法去噪后信号失真严重,本文采用小波变换的方法对LAPS信号进行去噪处理。通过小波变换将信号分解为3层,得到各层的小波系数以及阈值。根据每一层系数特点,按阈值进行分别处理,得到新的小波系数。最后根据新的小波系数,重构信号。对去噪后的信号进行频谱分析发现,信号频谱为有效的LAPS信号谱段。将傅里叶去噪和小波去噪方法进行对比发现,小波去噪得到信号的SNR和平滑度(SR)要高于傅里叶去噪,表明小波变换是LAPS信号去噪的有效方法。     

A new framework for particle detection in low-SNR fluorescence live-cell images and its application for improved particle tracking

Image denoising and signal enhancement are two common steps to improve particle contrast for detection in low-signal-to-noise ratio (SNR) fluorescence live-cell images. However, denoising may oversmooth features of interest, particularly weak features, leading to false negative detection. Here, we propose a robust framework for particle detection in which image denoising in the grayscale image is not needed, so avoiding image oversmoothing. A key to our approach is the new development of a particle enhancement filter based on the recently proposed particle probability image to obtain significantly enhanced particle features and greatly suppressed background in low-SNR and low-contrast environments. The new detection method is formed by combining foreground and background markers with watershed transform operating in both particle probability and grayscale spaces; dynamical switchings between the two spaces can optimally make use the information in images for accurate determination of particle position, size, and intensity. We further develop the interacting multiple mode filter for particle motion modeling and data association by incorporating the extra information obtained from our particle detector to enhance the efficiency of multiple particle tracking. We find that our methods lead to significant improvements in particle detection and tracking efficiency in fluorescence live-cell applications.     

A nonlinear Bayesian filtering framework for ECG denoising

In this paper, a nonlinear Bayesian filtering framework is proposed for the filtering of single channel noisy electrocardiogram (ECG) recordings. The necessary dynamic models of the ECG are based on a modified nonlinear dynamic model, previously suggested for the generation of a highly realistic synthetic ECG. A modified version of this model is used in several Bayesian filters, including the Extended Kalman Filter, Extended Kalman Smoother, and Unscented Kalman Filter. An automatic parameter selection method is also introduced, to facilitate the adaptation of the model parameters to a vast variety of ECGs. This approach is evaluated on several normal ECGs, by artificially adding white and colored Gaussian noises to visually inspected clean ECG recordings, and studying the SNR and morphology of the filter outputs. The results of the study demonstrate superior results compared with conventional ECG denoising approaches such as bandpass filtering, adaptive filtering, and wavelet denoising, over a wide range of ECG SNRs. The method is also successfully evaluated on real nonstationary muscle artifact. This method may therefore serve as an effective framework for the model-based filtering of noisy ECG recordings.