共查询到20条相似文献,搜索用时 9 毫秒
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Lipase‐Triggered Water‐Responsive “Pandora's Box” for Cancer Therapy: Toward Induced Neighboring Effect and Enhanced Drug Penetration 下载免费PDF全文
Cheng Wang Shaoqing Chen Yunxin Wang Xuerong Liu Fuqiang Hu Jihong Sun Hong Yuan 《Advanced materials (Deerfield Beach, Fla.)》2018,30(14)
Insufficient drug release as well as poor drug penetration are major obstacles for effective nanoparticles (NPs)‐based cancer therapy. Herein, the high aqueous instability of amorphous calcium carbonate (ACC) is employed to construct doxorubicin (DOX) preloaded and monostearin (MS) coated “Pandora's box” (MS/ACC–DOX) NPs for lipase‐triggered water‐responsive drug release in lipase‐overexpressed tumor tissue to induce a neighboring effect and enhance drug penetration. MS as a solid lipid can prevent potential drug leakage of ACC–DOX NPs during the circulatory process, while it can be readily be disintegrated in lipase‐overexpressed SKOV3 cells to expose the ACC–DOX core. The high aqueous instability of ACC will lead to burst release of the encapsulated DOX to induce apoptosis and cytotoxicity to kill the tumor cells. The liberated NPs from the dead or dying cells continue to respond to the ubiquitous aqueous environment to sufficiently release DOX once unpacked, like the “Pandora's box”, leading to severe cytotoxicity to neighboring cells (neighboring effect). Moreover, the continuously released free DOX molecules can readily diffused through the tumor extracellular matrix to enhance drug penetration to deep tumor tissue. Both effects contribute to achieve elevated antitumor benefits. 相似文献
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Direct Solvent‐Derived Polymer‐Coated Nitrogen‐Doped Carbon Nanodots with High Water Solubility for Targeted Fluorescence Imaging of Glioma 下载免费PDF全文
Yi Wang Ying Meng Shanshan Wang Chengyi Li Wei Shi Jian Chen Jianxin Wang Rongqin Huang 《Small (Weinheim an der Bergstrasse, Germany)》2015,11(29):3575-3581
Cancer imaging requires biocompatible and bright contrast‐agents with selective and high accumulation in the tumor region but low uptake in normal tissues. Herein, 1‐methyl‐2‐pyrrolidinone (NMP)‐derived polymer‐coated nitrogen‐doped carbon nanodots (pN‐CNDs) with a particle size in the range of 5–15 nm are prepared by a facile direct solvothermal reaction. The as‐prepared pN‐CNDs exhibit stable and adjustable fluorescence and excellent water solubility. Results of a cell viability test (CCK‐8) and histology analysis both demonstrate that the pN‐CNDs have no obvious cytotoxicity. Most importantly, the pN‐CNDs can expediently enter glioma cells in vitro and also mediate glioma fluorescence imaging in vivo with good contrast via elevated passive targeting. 相似文献
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A “Solid Dual‐Ions‐Transformation” Route to S,N Co‐Doped Carbon Nanotubes as Highly Efficient “Metal‐Free” Catalysts for Organic Reactions 下载免费PDF全文
Fan Wang Shuyan Song Kai Li Junqi Li Jing Pan Shuang Yao Xin Ge Jing Feng Xiao Wang Hongjie Zhang 《Advanced materials (Deerfield Beach, Fla.)》2016,28(48):10679-10683
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Superior Potassium Ion Storage via Vertical MoS2 “Nano‐Rose” with Expanded Interlayers on Graphene 下载免费PDF全文
Keyu Xie Kai Yuan Xin Li Wei Lu Chao Shen Chenglu Liang Robert Vajtai Pulickel Ajayan Bingqing Wei 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(42)
Potassium has its unique advantages over lithium or sodium as a charge carrier in rechargeable batteries. However, progresses in K‐ion battery (KIB) chemistry have so far been hindered by lacking suitable electrode materials to host the relatively large K+ ions compared to its Li+ and Na+ counterparts. Herein, molybdenum disulfide (MoS2) “roses” grown on reduced graphene oxide sheets (MoS2@rGO) are synthesized via a two‐step solvothermal route. The as‐synthesized MoS2@rGO composite, with expanded interlayer spacing of MoS2, chemically bonded between MoS2 and rGO, and a unique nano‐architecture, displays the one of the best electrochemical performances to date as an anode material for nonaqueous KIBs. More importantly, a combined K+ storage mechanism of intercalation and conversion reaction is also revealed. The findings presented indicate the enormous potential of layered metal dichalcogenides as advanced electrode materials for high‐performance KIBs and also provide new insights and understanding of K+ storage mechanism. 相似文献
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