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1.
Ruizhi Li Chin Ping Tan Yong-Jiang Xu Yuanfa Liu 《European Journal of Lipid Science and Technology》2021,123(12):2100100
Dietary fat has an important influence on mammalian lipid homeostasis. However, the relationship between dietary fat types and endogenous fatty acids (FAs) in organs as well as lipid homeostasis remains unclear enough. In this study, rats are randomly divided into a control group (CN), a high-colleseed oil group (COG), and a high-sunflower oil group (SOG). FAs profile in liver and visceral fats of rats in two high-fat (HF) diet groups is compared with that in CN. Oleic, γ-linolenic, eicosadienoic, and arachidonic acid accumulate in COG liver or visceral fats, but the levels of linoleic, eicosadienoic, docosanoic, and dihomo-γ-linolenic acid decrease in COG visceral fats. However, these FAs levels increased in SOG liver or visceral fats except dihomo-γ-linolenic and arachidonic acid which changed insignificantly. The trend of initial upregulation and then downregulation of lipid metabolism-related genes expression is noted in COG liver, including stearoyl-CoA desaturase. Upregulation of adiponectin (ADPN) expression in visceral fats and downregulation of ADPN receptor 2 (Adipo-R2) expression in livers of both HF groups are observed. Correlation analysis revealed positive correlations between specific FAs content and ADPN expression level. Negative correlations are observed between Adipo-R2 expression and the content of oleic, linoleic, and γ-linolenic acid in the SOG liver. Practical applications: Dietary fat not only provides energy but is also associated with lipid homeostasis. In this work, the authors investigate the distribution of fatty acids (FAs) in vivo and their influence on genes related to lipid metabolism induced by diets enriched in oleic acid or linoleic acid. The study suggests that dietary fats modulate lipid homeostasis not only by regulating endogenous FAs levels but also by affecting the expression of genes related to lipid metabolism. This study may support the research in lipid nutrition and rational intake of dietary fat. 相似文献
2.
J. T. Venkatraman D. Pehowich B. Singh R. V. Rajotte A. B. R. Thomson M. T. Clandinin 《Lipids》1991,26(6):441-444
Experimental diabetes may manifest itself in a defect in liver microsomal fatty acid desaturation and increased activity of
glucose-6-phosphatase (G-6-Pase). The present study was designed to determine whether these changes could be normalized by
a change in the dietary fat consumed. Control and streptozotocin-induced diabetic rats were fed nutritionally adequate diets
which varied in fatty acid composition. Fatty acid analysis of liver microsomal phospholipids revealed that non-diabetic control
animals fed saturated fat (beef tallow) or a diet high in ω3 fatty acids (fish oil) exhibited a significantly higher level
of 18∶2ω6 and a lower level of 20∶4ω6 in the phosphatidylcholine and phosphatidylethanolamine fractions compared with diabetic
animals. Control and diabetic animals fed the high linoleic acid diet had similar levels of 18∶2ω6 in the microsomal phosphatidylcholine
and phosphatidylserine fractions. Microsomal G-6-Pase activity was higher in diabetic than in control animals. Activity of
G-6-Pase was lower in microsomes of control animals fed the soybean oil or the fish oil diet, but was not significantly reduced
in diabetic animals fed high polyunsaturated fats. Blood glucose levels were similar in control groups fed the different diets,
but the plasma hemoglobin A1c level was lower in diabetic animals fed the soybean oil diet. Cholesterol and triglyceride levels
were lower in diabetic animals fed the fish oil-based diet. The results suggest that dietary fat manipulation has the potential
to change at least some of the abnormalities in the microsomal membrane in experimental diabetes. 相似文献
3.
Michihiro Sugano Takashi Ide Mitsuko Kohno Midori Watanabe Young-J. Cho Yasuo Nagata 《Lipids》1983,18(3):186-192
Male Wistar rats were fed cholesterol-free or cholesterol-enriched diets containing partially hydrogenated soybean oil with different levels of trans-fatty acids or unhydrogenated soybean oil at the 10% level. The linoleic acid content of hydrogenated fat diets was adjusted to 3.6% of the total energy. Hydrogenated fat diets contained 29% and 41% trans-acids, mainly as t-18:1. Trans-fats exerted no untoward effects on growth parameters, but increased liver weight. Dietary hydrogenated fats influenced neither the concentration nor composition of biliary steroids, irrespective of the presence or absence of cholesterol in the diet. In rats fed a cholesterol-free diet, daily fecal output of neutral and acidic steroids was enhanced by hydrogenated fats and the magnitude of augmentation was proportional to the dietary level of trans-fatty acids. The increased fecal steroid excretion corresponded to an increase in total excreta. Hydrogenated fats also tended to enhance bile acid excretion when feeding a cholesterol-enriched diet. The results suggest that dietary trans-fatty acids, in relation to cis-polyunsaturated fatty acids, provoke demonstrable change in steroid homeodynamics. 相似文献
4.
Johnson O. C. Perkins E. Sugal M. Kummerow F. A. 《Journal of the American Oil Chemists' Society》1957,34(12):594-597
Summary The present results indicated that the thermal oxidation products from the polyunsaturated fatty acids, primarily linoleic
acid, are responsible for much of the loss of nutritional value in thermally oxidized edible oils. Oils which have a high
linoleic acid content are more likely to undergo thermal oxidative damage than those with lower linoleic contents. Also the
ratio of linoleic acid to total unsaturation has some effect on the nutritive stability of the oil when it has been thermally
oxidized. An oil with a high iodine value but with a low linoleic acid value appears to be more stable to thermal oxidation
than an oil with an iodine value one half as great but with most of the unsaturation in the oil caused by linoleic acid.
The products formed during thermal oxidation which cause the loss of nutritional value are those which do not form urea-inclusion
compounds. They are probably polymeric in nature, but thermally oxidized oils also contain carboxylic acids and carbonyl groups
which might cause some of the nutritional loss observed when thermally oxidized oils are fed.
The rate ofin vitro hydrolysis of the thermally oxidized corn oil by pancreatic lipase, also the rate of absorption from the intestine of the
male rats, were found to be decreased. However the percentage of absorption in 24 hrs. was the same with both fresh and thermally
oxidized oil.
The liver-body weight ratio of rats fed a diet containing the thermally oxidized oil were found to be significantly larger
than the liver-body weight ratio in animals fed diets containing fresh oil. However the livers of animals fed the thermally
oxidized oil diets did not differ in lipide percentage or total solid content, and histopathological investigations did not
show any abnormal conditions. 相似文献
5.
Helen Zmachinski Arthur Waltking James D. Miller 《Journal of the American Oil Chemists' Society》1966,43(7):425-428
In partially hydrogenated fats containing residual linoleic acid, linoleic acid isomers are found which have no essential
fatty acid activity but contribute to the C-18 diene acid values; i.e., to the so-called linoleic acid values obtained by
the usual physicochemical methods. Such hydrogenated fats and oil blends, particularly margarine oils, have now been analyzed
by a biochemical procedure in the attempt to measure specifically the essential fatty acid content by a direct method. The
latter procedure makes use of a lipoxidase enzyme specific for thecis, cis, methylene interrupted diene structure in polyunsaturated fatty acids having two or more double bonds. It is concluded that
the biochemical method is equally as reliable as the combined use of the spectrophotometric and thiocyanometric procedures
for estimating with precision the essential fatty acid content of hydrogenated fats containing residual dienes; the simplicity
and speed of the biochemical method make it the procedure of choice. 相似文献
6.
High fat diets promote the development of mammary tumors induced in rats by 7,12-dimethylbenz(a)anthracene (DMBA), and polyunsaturated
fats are more effective than saturated fats. This difference is related to the linoleic acid content of polyunsaturated vegetable
oils, but the amount of linolealte required for maximum tumor promotion appears to be higher than indicated by earlier experiments.
Comparison of the effects of a polyunsaturated vegetable oil (corn oil) containing linoleate with a fish oilo (menhaden oil)
containing polyunsaturated fatty acids derived from linolenic acid showed that higher dietary mammary tumors, while corresponding
levels of menhaden oil had an inhibitory effect. This is further evidence that promotion of mammary tumorigenesis by polyunsaturated
vegetable oils may be mediated by prostaglandins or other biologically active eicosanoids derived from n−6 fatty acids. 相似文献
7.
Royan M Meng GY Othman F Sazili AQ Navidshad B 《International journal of molecular sciences》2011,12(12):8581-8595
An experiment was conducted on broiler chickens to study the effects of different dietary fats (Conjugated linoleic acid (CLA), fish oil, soybean oil, or their mixtures, as well as palm oil, as a more saturated fat), with a as fed dose of 7% for single fat and 3.5 + 3.5% for the mixtures, on Peroxisome Proliferator-Activated Receptors (PPARs) gene expression and its relation with body fat deposits. The CLA used in this experiment was CLA LUTA60 which contained 60% CLA, so 7% and 3.5% dietary inclusions of CLA LUTA60 were equal to 4.2% and 2.1% CLA, respectively. Higher abdominal fat pad was found in broiler chickens fed with a diet containing palm oil compared to chickens in the other experimental groups (P ≤ 0.05). The diets containing CLA resulted in an increased fat deposition in the liver of broiler chickens (P ≤ 0.05). The only exception was related to the birds fed with diets containing palm oil or fish oil + soybean oil, where contents of liver fat were compared to the CLA + fish oil treatment. PPARγ gene in adipose tissue of chickens fed with palm oil diet was up-regulated compared to other treatments (P ≤ 0.001), whereas no significant differences were found in adipose PPARγ gene expression between chickens fed with diets containing CLA, fish oil, soybean oil or the mixture of these fats. On the other hand, the PPARα gene expression in liver tissue was up-regulated in response to the dietary fish oil inclusion and the differences were also significant for both fish oil and CLA + fish oil diets compared to the diets with palm oil, soybean oil or CLA as the only oil source (P ≤ 0.001). In conclusion, the results of present study showed that there was a relationship between the adipose PPARγ gene up-regulation and abdominal fat pad deposition for birds fed with palm oil diet, while no deference was detected in n-3 and n-6 fatty acids, as well as CLA on PPARγ down regulation in comparison to a more saturated fat. When used on its own, fish oil was found to be a more effective fat in up-regulating hepatic PPARα gene expression and this effect was related to a less fat deposition in liver tissue. A negative correlation coefficient (-0.3) between PPARα relative gene expression and liver tissue fat content confirm the anti-lipogenic effect of PPARα, however, the change in these parameters was not completely parallel. 相似文献
8.
High-fat ketogenic diets are used to treat intractable seizures in children, but little is known of the mechanism by which
these diets work or whether fats rich in n−3 polyunsaturates might be beneficial. Tissue lipid and fatty acid profiles were
determined in rats consuming very high fat (80 weight%), low-carbohydrate ketogenic diets containing either medium-chain triglyceride,
flaxseed oil, butter, or an equal combination of these three fat sources. Ketogenic diets containing butter markedly raised
liver triglyceride but had no effect on plasma cholesterol. Unlike the other fats, flaxseed oil in the ketogenic diet did
not raise brain cholesterol. Brain total and free fatty acid profiles remained similar in all groups, but there was an increase
in the proportion of arachidonate in brain total lipids in the medium-chain triglyceride group, while the two groups consuming
flaxseed oil had significantly lower arachidonate in brain, liver, and plasma. The very high dietary intake of α-linolenate
in the flaxseed group did not change docosahexaenoate levels in the brain. Our previous report based on these diets showed
that although ketosis is higher in rats consuming a ketogenic diet based on medium-chain triglyceride oil, seizure resistance
in the pentylenetetrazol model is not clearly related to the degree of ketosis achieved. In combination with our present data
from the same seizure study, it appears that ketogenic diets with widely differing effects on tissue lipids and fatty acid
profiles can confer a similar amount of seizure protection. 相似文献
9.
Male weanling rats were fed semi-synthetic diets high in saturated fat (beef tallow) vs high in linoleic acid (safflower oil)
with or without high levels of α-linolenic acid (linseed oil) for a period of 28 days. The effect of feeding these diets on
cholesterol content and fatty acid composition of serum and liver lipids was examined. Feeding linseed oil with beef tallow
or safflower oil had no significant effect on serum levels of cholesterol. Serum cholesterol concentration was higher in animals
fed the safflower oil diet than in animals fed the beef tallow diet without linseed oil. Feeding linseed oil lowered the cholesterol
content in liver tissue for all dietary treatments tested. Consumption of linseed oil reduced the arachidonic acid content
with concomitant increase in linoleic acid in serum and liver lipid fractions only when fed in combination with beef tallow,
but not when fed with safflower oil. Similarly, ω3 fatty acids (18∶3ω3, 20∶5ω3, 22∶5ω3, 22∶6ω3) replaced ω6 fatty acids (20∶4ω6,
22∶4ω6) in serum and liver lipid fractions to a greater extent when linseed oil was fed with beef tallow than with safflower
oil. The results suggest that the dietary ratio of linoleic acid to saturated fatty acids or of 18∶3ω3 to 18∶2ω6 may be important
to determine the cholesterol and arachidonic acid lowering effect of dietary α-linolenic acid. 相似文献
10.
Lipid metabolism was studied in rats fed diets containing corn oil, coconut oil, or medium-chain triglyceride (MCT), a glyceride
mixture containing fatty acids of 8 and 10 carbons in length. The ingestion of MCT-supplemented, cholesterolfree diets depressed
plasma and liver total lipids and cholesterol as compared with corn oil-supplemented diets. In rats fed cholesterol-containing
diets, plasma cholesterol levels were not influenced by dietary MCT, but liver cholesterol levels were significantly lower
than in animals fed corn oil. In vitro cholesterol synthesis from acetate-1-14C was lower in liver slices of rats that consumed MCT than in similar preparations from corn oil-fed rats. Studies of fatty
acid carboxyl labeling from acetate-1-14C and the conversion of palmitate-1-14C to C18 acids by liver slices showed that chain-lengthening activity is greater in the liver tissue of rats fed MCT than in the liver
of animals fed corn oil. The hepatic fatty acid desaturation mechanisms, evaluated by measuring the conversion of stearate-2-14C to oleate, was also enhanced by feeding MCT.
Adipose tissue of rats fed MCT converts acetate-1-14C to fatty acids at a much faster rate than does tissue from animals fed corn oil. Evidence is presented to show that the
enhanced incorporation of acetate into fatty acids by the adipose tissue of rats fed MCT represents de novo synthesis of fatty
acids and not chain-lengthening activity. Data are also presented on the fatty acid composition of plasma, liver, and adipose
tissue lipids of rats fed the different fats under study. 相似文献
11.
Nutritional properties of the triglycerides of saturated fatty acids of medium chain-length 总被引:1,自引:0,他引:1
Hans Kaunitz Charles A. Slanetz Ruth Ellen Johnson Vigen K. Babayan George Barsky 《Journal of the American Oil Chemists' Society》1958,35(1):10-13
Summary The influence of a purified rat diet containing 20 or 33% of the saturated medium chain-length triglycerides (MCT) with and
without linoleic acid supplements on growth, caloric requirements for weight maintenance and weight increase, fertility, lactation
performance, and serum cholesterol levels was compared with that of similar diets containing lard, coconut oil, or no fat.
Among male rats maintained on diets containing 20% lard or 20% MCT and .09% linoleic acid for 18 months no differences were
observed between the groups other than the depressed body weight and lowered serum cholesterol levels of the group fed MCT.
When groups of male rats were kept at constant weight by the daily restricted feeding of diets containing lard, MCT, or coconut
oil or no fat plus 2% linoleic acid, the weight-maintenance requirements of the group fed MCT were higher than of those on
lard and coconut oil and even somewhat higher than the requirements of the animals fed the fat-free diet. The requirements
for weight increase over those for maintenance were 0.9 g. per gram increase for all diets. Additional linoleic acid in the
MCT diet decreased the weight and maintenance differences between groups fed MCT and lard.
The lactation performance of mothers on MCT plus .09% linoleic acid was poor. The second generation animals initially showed
signs of more severe linoleic acid deficiency which however disaappeared without linoleic acid supplements.
Some cholesterol levels of animals on MCT were significantly below those of groups on lard. Addition of linoleic acid to the
MCT diet did not change the results.
Presented at the 48th Annual Meeting, American Oil Chemists’ Society, April 28 to May 1, 1957, New Orleans, La. 相似文献
12.
A semisynthetic diet containing 15% by weight of dietary fat was fed to six groups of male Wistar rats for 28 days. Two groups
received the distilable fraction of fresh corn oil (DCO) or fresh olive oil (DOO), two groups the distillable fraction of
the thermally oxidized fats (OCO,OOO), and two groups received the respective fresh fats as controls (FCO, FOO). Substantial
changes in the fatty acid composition occurred in the fats upon thermal oxidation. Only the rats that received OOO showed
overt symptoms of heated fat toxicity. This was reflected in the histological scores of these animals, with the liver sustaining
the most numerous and severe lesions. Tissue fatty acid changes of any significance were confined largely to the polar liver
lipids of the rats that were fed OCO or OOO. The results of this study would suggest that the relatively greater toxicity
of OOO, compared to OCO, may in part be due to the high oleic:linoleic acid ratio of the fresh olive oil and in part to a
higher tocopherol content of the corn oil. 相似文献
13.
Three groups of rats were fed diets with either 10 weight percent (wt%) of evening primrose oil, safflower oil or soybean
oil for 11 weeks. Diets contained 7.1 wt% linoleic acid +0.8 wt% γ-linolenic acid, 7.6 wt% linoleic acid, or 5.3 wt% linoleic
acid +0.7 wt% α-linolenic acid, respectively. In liver mitochondria as well as in heart, dietary γ-linolenic acid did not
affect the fatty acid profiles of phosphatidylcholnes (PC), phosphatidylethanolamines (PE) or cardiolipins (CL), whereas dietary
α-linolenic acid caused an increased formation of (n−3) polyunsaturated fatty acids (PUFA). The liver Δ6− and Δ5-desaturase
activities determined in vitro were not affected by the dietary fats. In brain PE, which are rich in C22− and C20-(n−3) PUFA,
as well as in testes PC and PE, which are rich in (n−6) PUFA, no effects were found from a partial replacement of dietary
linoleic acid with γ-linolenic acid or α-linolenic acid. In kidney PC, PE, phosphatidylinositol (PI) and CL, 20∶3(n−6) was
moderately elevated to ca. 1% following intake of γ-linolenic acid, whereas partial replacement of linoleic acid with α-linolenic
acid was followed by increased deposition of 22∶6(n−3) in PC and PE of testes and kidney. Thus, no general effect of evening
primrose oil on the content of (n−6) PUFA in rat tissue phospholipids was observed, wheras a significant incorporation of
γ-linolenic acid into liver and adipose tissue triglycerides was found. 相似文献
14.
W. I. Kimoto R. Ellis A. E. Wasserman R. Oltjen 《Journal of the American Oil Chemists' Society》1974,51(9):401-403
Growing and mature steers with increased linoleic acid (18∶2) in their adipose tissues were reared by the Nutrition Institute, U.S. Department of Agriculture. The 18∶2 content of rendered fats from these animals fed protected safflower oil varied from 6.5–20.6% and from 3.4–5.8% for the growing and mature steers, respectively. Increasing the 18∶2 levels resulted in decreased stability to autoxidation of the rendered subcutaneous fats. 相似文献
15.
C. Okkerse A. de Jonge J. W. E. Coenen A. Rozendaal 《Journal of the American Oil Chemists' Society》1967,44(2):152-156
Many investigators associate the poor keeping properties of soybean oil with its linolenic acid content. On the other hand
the high linoleic acid content is a desired property from a nutritional point of view. We have therefore developed a process
for the preferential reduction of the linolenic acid content by selective hydrogenation. Conventional catalysts for the hydrogenation
of fats have a rather low selectivity in this respect. When linolenic acid in soybean oil is hardened (e.g., with a nickel
catalyst), most of the linoleic acid is converted into less unsaturated acids.
It was found that linolenic acid is hydrogenated much more preferentially in the presence of copper catalysts than in that
of nickel and other hydrogenation catalysts. At a linolenic acid content of 2%, soybean oil hardened with nickel catalyst
contained about 28% linoleic acid, whereas with copper catalyst the hardened soybean oil contained 49% linoleic acid.
By means of our process it is possible to manufacture a good keepable oil of, e.g., I.V. 115 and containing 1% linolenic acid
and 46% linoleic acid. The storage stability of this product is comparable with that of sunflower-seed oil. A liquid phase
yield of 86% is obtained after winterization at 5C for 18 hr.
The high selectivity for linolenate reduction of copper catalysts must be ascribed to the copper part of the catalyst. Investigations
into the structure of the catalyst indicate that the active center consists of copper metal crystallites; whether these centers
are promoted by the carrier or traces of other substances is under investigation. 相似文献
16.
The effect of various dietary fats on membrane lipid composition, fatty acid profiles and membrane-bound enzyme activities
of rat cardiac sarcolemma was assessed. Four groups of male weanling Charles Foster Young rats were fed diets containing 20%
of groundnut, coconut, safflower or mustard oil for 16 weeks. Cardiac sarcolemma was prepared from each group and the activities
of Na+,K+-ATPase, 5′-nucleotidase, Ca2+-ATPase and acetylcholinesterase were examined. ATPase activities were similar in all groups except the one fed coconut oil,
which had the highest activities. Acetylcholinesterase activity was also similar in all the groups, however, it was significantly
higher in the group fed mustard oil. No significant changes were observed among the groups in 5′-nucleotidase activity, in
the cholesterol-to-phospholipid molar ratio and in sialic acid content. The coconut, safflower and mustard oil diets significantly
increased cholesterol and phospholipid contents and the lipid-to-protein ratio of cardiac sarcolemma as compared to feeding
the groundnut oil diet. The fatty acid composition of membrane lipids was quite different among the various groups, reflecting
the type of dietary fat given. The total unsaturated-to-saturated fatty acid ratio was not different among the various groups;
however, the levels of some major fatty acids such as palmitic (16∶0), oleic (18∶1) and linoleic (18∶2) acids were significantly
different. Cardiac sarcolemma of the group fed safflower oil had the highest polyunsaturated fatty acid content. The results
suggest that dietary fats induce changes not only in the fatty acid composition of the component lipids but also in the activities
of sarcolemmal enzymes involved in the regulation of cardiac function. 相似文献
17.
Roslyn B. Alfin-Slater Daniel Melnick 《Journal of the American Oil Chemists' Society》1964,41(2):145-150
Biological assays of oil and fat products, free from isomers of the naturally-occurringcis-9,cis-12 linoleic acid, have been shown to provide estimates of essential fatty acid content which agree well with values obtained by spectrophoto-metric analysis. However, when partially hydrogenated fats, such as those used in margarines, are bio-assayed the estimates obtained are only about 60% of those derived by spectro-photometric tests. In a blended corn oil margarine, good agreement was obtained for linoleic acid content by using biological assay or spectrophotometry, thio-cyanometric procedure, column chromatography for saturates plus iodine value, and gas liquid partition (GLP) chromatography. This margarine fat contained about 29% of the essential form of linoleic acid, and had a ratio to saturated fatty acids of 1.6:1. The hydrogenated corn oil margarine is unlike conventional margarines in providing high amounts of the isomeric forms of linoleic acid which lack essential fatty acid activity. For this reason, poor agreement was obtained between biological assay results and those by physico-chemical measurements of linoleic acid content. Such fat contains only about 6% of the essential form of linoleic acid, with a ratio to saturated fatty acids of ca. 0.3.1. From this study it is now possible to characterize, even without bio-assay data, the fatty acid composition of a highly isomerized fat, such as is found in hydrogenated corn oil margarine. The characterization groups the fatty acids into saturates and total linoleic acids, with the latter including estimates of the positional isomers of linoleic acid with widely spaced double bonds,trans forms of linoleic acid with methylene-in-terrupted double bonds, linoleic acids with the double bonds in conjugated position, andcis-9,cis-12 linoleic acid. The combined use of the spectrophotometric and thiocyanometric procedures makes it possible to estimate the essential fatty acid content of hydrogenated fats containing residual dienes. 相似文献
18.
A. Seher G. Assmann Gisela Werner H. J. Oslage 《European Journal of Lipid Science and Technology》1983,85(6):215-219
Physiological Effect of Various Mixtures of Oleic, Linoleic and Linolenic Acids on Growing Pigs: 2. Influence on Depot Fats and Blood Lipids At the end of the feeding trials described extensively in the first contribution, from all animals saddle bacon and leaf fat as well as serum lipids have been investigated on effects of the various food fats. Earlier results have been confirmed according to which the increased supply of unsaturated fatty acids results in an increase of the content in depot fat and in a decrease of palmitic and stearic acid. The storage of linoleic and linolenic acids is linked to the consumed amount of these acids in a linear way. Some hints have been found for the occurrence of yellow fat desease that besides the deficiency of vitamin E an enzyme activating effect of higher amounts of linolenic acid may be responsible. Furthermore the attacked animals showed a linear dependence of the fat content in the yellow tissue from its peroxide value. As well linolenic acid as oleic acid led to a significant decrease of the serum triglycerides. Besides, linolenic acid lowered the content of serum cholesterol, whereas linoleic acid caused a significant increase of the HDL content. 相似文献
19.
Epidemiological and laboratory animal model studies have provided evidence that the effect of dietary fat on colon tumorigenesis
depends on the amount of fat and its composition. Because of the importance of the composition of dietary fat and of tissue
membrane fatty acid composition in tumor promotion, experiments were designed to investigate the relative effects of high
fat diets rich in ω3, ω6 and ω9 fatty acids and colon carcinogen on the phospholipid fatty acid composition of liver, colon,
small intestine, erythrocytes and blood plasma. At 6 wk of age, groups of animals were fed diets containing 5% corn oil (LFCO),
23.5% corn oil (HFCO), 23.5% olive oil (HFOO), and 20.5% fish oil plus 3% corn oil (HFFO). Two weeks later all the animals
except the vehicle-treated animals received azoxymethanes.c. once weekly for 2 wk at a dose rate of 15 mg/kg body weight. Animals were sacrificed 5 d later and liver, colon, small intestine
and erythrocytes and blood plasma were analyzed for phospholipid fatty acids. The results indicate that the phospholipid fatty
acid composition of liver, colon and small intestine of HFCO diet fed animals, were not significantly different from those
fed the LFCO diet. The levels of palmitoleic acid and linoleic acid were increased in erythrocytes and blood plasma of the
animals fed the HFCO diet compared to those fed the LFCO diet. Feeding the HFCO diet significantly increased the oleic acid
content and decreased the linoleic acid and arachidonic acid levels in various organs when compared to the HFCO diet. Animals
fed the HFFO diet showed a marked increase in eicosapentaenoic acid and docosahexaenoic acid and a decrease in linoleic acid
and arachidonic acid levels as compared to those fed the HFCO diet. The results also indicate that carcinogen treatment had
only a minimal effect on the phospholipid fatty acid composition. 相似文献
20.
R. G. Vernon 《Lipids》1976,11(9):662-669
The effects of different dietary fats on ovine adipose tissue metabolism have been investigated. Six-month old sheep were
fed for 6 weeks a control diet or diets supplemented with either tallow or a mixture of sunflower seed oil and soybean oil,
treated to protect the fats from hydrolysis and hydrogenation in the rumen, or with maize oil. The rates of fatty acid, glyceride
glycerol, and CO2 formation were measured in perirenal and subcutaneous adipose tissue slices by following the incorporation of either14C from labeled acetate or glucose, or3H from tritiated water into the appropriate product. Feeding protected tallow or maize oil but not protected sunflower seed
oil plus soybean oil resulted in reduced rates of fatty acid biosynthesis in both perirenal and subcutaneous adipose tissue
slices and CO2 formation in perirenal adipose tissue. Feeding the fat-supplemented diets had no effect on the rate of glyceride glycerol
formation. The fat-supplemented diets also resulted in reduced activities of various enzymes, thought to be involved in lipogenesis,
measured in 105,000× g supernatant fractions from adipose tissue homogenates. The results suggested that ovine adipose tissue
lipogenesis is sensitive to both the amount and the nature of dietary fat. 相似文献