亮菌甲素分子印迹聚合物的制备及选择性分子识别

以亮菌甲素为模板分子、2-乙烯基吡啶为功能单体,在N,N-二甲基甲酰胺和乙腈(60:40)混合溶剂中合成了一种新型亮菌甲素印迹聚合物.通过聚合物的吸附性能,以及液相色谱的保留行为加以研究.结果表明,聚合物通过氢键形成两类结合位点,对印迹分子具有很好的亲和性和特定的选择性,能够很好地分离亮菌甲素与其结构相似物.合成的新材料不仅可以用于复杂样品中亮菌甲素的富集,也可以作为分离介质用于亮菌甲素的高效液相色谱分离检测.     

亮菌甲素衍生物的设计、合成及抗炎活性研究

以亮菌甲素为先导化合物,对5位羟基进行结构修饰,设计并合成了一系列亮菌甲素衍生物。以3, 5-二羟基苯甲醇和2-乙氧亚甲基乙酰乙酸乙酯为起始原料,经环合、取代、氧化反应合成了15个亮菌甲素衍生物8a～8h,10a～10g。所有化合物结构经¹H NMR、¹³C NMR和ESI-MS确证,并测定了所有化合物对LPS诱导的RAW264.7细胞分泌TNF-α和IL-6的抑制作用。实验结果表明,所有目标化合物对TNF-α和IL-6具有一定的抑制作用。化合物10f的抑制活性最强,且强于先导化合物亮菌甲素。     

多溶剂萃取法精制印楝素的研究

对比研究了多溶剂萃取法与单溶剂萃取法精制印楝素的效果,并通过正交试验法选择了多溶剂萃取法精制印楝素的最佳试验条件为:萃取溶剂V(二氯甲烷):V(乙酸乙酯)1:5,分相液V(丙酮):V(水)1:1,V(萃取溶剂):V(分相液)10:3,该方法可将乙醇提取物中印楝素的质量分数从 3.68% 提高到 17.76%。多溶剂萃取法是一种简单高效的精制印楝素的方法。     

盐酸多西环素精制母液物料的回收及提纯

采用向精制母液中加5-磺基水杨酸和水的方法,从精制母液中回收出氢化物,并确定了最佳配比：5-磺基水杨酸：水：精制母液=0．025：0．5：1。由于回收氢化物中含有较多的杂质,本文采用新的成品精制方法,解决了成品拖尾峰问题。成品精制的最佳工艺为：温度控制在50℃,活性炭脱色时间20min,活性炭;氯化氢-乙醇：水：多西环素—水合物=0．025：3：3;1。     

从落叶松中提取黄酮素的吸附过程研究

黄酮素是一种广泛存在于自然界植物中的天然类胡萝卜素,又称为维生素P化合物.黄酮素在医学上具有对抗肌体老化,治疗心血管疾病的保健作用,因此近年来备受关注.从试验研究的角度,对从废弃的落叶松木质纤维中提取其中的水溶性黄酮素及副产物阿拉伯半乳糖的方法进行了详细阐述,通过水解、吸附、解吸、精制等工艺步骤得到精制的黄酮素产品.主要探讨了提取工艺中吸附过程的优化研究,得到了最佳的吸附工艺方法与条件,为开发此项目奠定了良好的研究基础.此项技术的实施将会给黑龙江森林资源的利用带来更好的前景.     

陶瓷的显微结构和物性

一、绪言瓷器起源于素陶器,但是素陶器主要用于贮藏食物,也用作炊具烧煮食物,所以只要无裂缝,无穿孔,不漏水就可以了。当进一步把素陶器作为祀神用的祭器使用时,就要求形状规整、外观颜色洁白,从而要求对原料进行选择、精制,同时也要求改进成型     

防落素

太原磷肥厂研制的新型植物生长调节剂—防落素,于1986年12月13日通过市级新产品投产鉴定。防落素化学名称为对氯苯氧乙酸钠,代号:PCPA,化学结构式:Cl--OCH_2-COOH。 PCPA系以对氯苯酚和氯乙酸为原料,经碱化、缩合、提纯、酸化、精制而制得的     

影响氯化钾镀锌层光亮度的因素

一、前言正常的钾盐镀锌层是全光亮的,但是生产中稍有忽视,就会出现光亮问题,例如,不是整个镀层光亮性差,便是高电流区光亮而低区不亮,或者镀件正面光亮而侧面和背面不亮,大平面工件出现周围亮而中间不亮或发灰发雾等.这些故障特别对锌层白钝化的装饰效果影响更大,必须研究影响光亮度的因素,采取相应对策,以保证镀锌质量.     

蓄电池硫酸的精制及其机理

蓄电池硫酸的精制及其机理王辉亮，程秀娟（广东省茂名市化学制品总厂）我厂原名茂名市化肥厂，硫酸生产采用两转两吸工艺，串联两台ＪＣＦ换热器。生产中，二吸酸质量有时能直接达到蓄电池硫酸的要求，但透明度、ＳＯ。、Ｆｅ和灼烧残渣等指标有时达不到要求。为了得到质...     

化妆品配方

种族发质专用香波,调理香波,凝胶,定型凝胶,护发乳,护发素,亮发膏,头发修护霜,头发定型剂,透明凝胶,柔滑香波,护发素……     

Bioavailability of EPA and DHA delivered by gelled emulsions and soft gel capsules

This study presents data comparing the bioavailability of DHA and EPA delivered by two different formulations: One group received TAG fish oil in traditional soft gel capsules, whereas the other group received the TAG oil as droplets trapped inside a gelatin matrix (gelled emulsions). The incremental area under the curve (AUC_{0–26 h}) of EPA and EPA + DHA in blood plasma from the gelled emulsions was significantly increased by 44.9 and 43.3%, respectively, compared to soft gel capsules. The maximum incremental concentration of EPA and EPA + DHA was significantly increased by 100.4 and 105.6%, respectively, compared to soft gel capsules. These results suggest that improved bioavailability of EPA and DHA may be achieved by incorporating emulsified TAG fish oil in a gel matrix prior to oral ingestion. Practical applications: This study presents a new type of vehicle for the delivery of PUFAs. The vehicles are soft and chewable with the possibility of adding flavours, sweeteners and colour, and this makes the vehicles ideal for delivery of PUFAs to consumers having problems swallowing large capsules or cod liver oil. The vehicles are already applied in products in several countries, including Norway.     

Microencapsulation of Zanthoxylum limonella oil (ZLO) in genipin crosslinked chitosan–gelatin complex for mosquito repellent application

Essential oil containing chitosan gelatin complex microcapsules crosslinked with genipin were prepared by complex coacervation process. The effects of various parameters such as oil loading, ratio of chitosan to gelatin, degree of crosslinking on oil content, encapsulation efficiency, and the release rate of the essential oil were studied. Scanning electron microscopy study indicated that the surface of the microcapsules were more irregular as the amount of oil loading increased. Thermal stability of microcapsules improved with the increase in the amount of chitosan in chitosan–gelatin matrix as revealed by thermogravimetric analysis. FT‐IR spectroscopy and differential scanning calorimetry study indicated that there was no significant interaction between chitosan–gelatin complex and oil. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009     

快速膜乳化法制备尺寸均一的载硫酸亚铁明胶微球

采用快速膜乳化技术,以大豆油为油相、葡萄糖为固化剂,制备均一载硫酸亚铁明胶微球,考察了制备参数对明胶微球形貌和均一性的影响. 结果表明,优化的制备参数为明胶溶液浓度0.200 g/mL、乳化剂浓度0.07 g/mL、初乳均质转速10000 r/min、固化反应时间20 min. 在该条件下制备了球形圆整、平均粒径为50 μm的均一载FeSO4明胶微球,FeSO4包埋率达44.12%,Fe2+含量为60.8%.     

乳化法明胶亚微米粒子的制备

以A型明胶为原料,石蜡油为油相,采用乳化化学交联方法制备了明胶亚微米粒子. 用扫描电子显微镜(SEM)观察了明胶亚微米粒子的形貌和粒径. 研究了影响微球粒径的多种因素,包括明胶溶液浓度、乳化搅拌速度、乳化温度、乳化剂和固化剂. 结果表明,采用戊二醛为固化剂、增加明胶的浓度、提高乳化搅拌速度、使用混合性的乳化剂都有利于降低明胶粒子的粒径. 此外,对制备工艺进行了优化,并在7000 r/min左右高速搅拌的条件下,得到了成球性较好的粒径约为450 nm的明胶亚微米粒子.     

表面胶的特点及其应用

本报告中就碱法骨胶(B)型、酸法骨胶(A型)为代表的两种类型的表面胶,分别作了冻力、粘度、凝冻时间、坚膜性能及离子含量的测定,并讨论了A、B两类胶在物化性能方面的区别。把A、B两种类型的表面胶应用于油彩正的护膜、隔层,获得了良好的结果。     

载5-氟尿嘧啶壳聚糖/明胶微粒的制备及药物释放性能

壳聚糖及明胶是生物相容性良好的高分子药物载体,制备载5-氟尿嘧啶壳聚糖/明胶微粒,并进行体外释药研究。以石蜡油为外相,壳聚糖/明胶为内相,用乳化交联法制备微粒,以吸附药量为指标,采用正交设计实验优化获得最佳制备条件,用红外光谱、SEM对最佳条件下制备的微粒进行表征。结果表明壳聚糖/明胶微粒的最佳制备条件如下:水油比1:7,壳聚糖/明胶浓度比1:3,乳化剂100.7mmol/L,乳化5min,乳化温度60℃,交联剂戊二醛用量5.5mmol/L,交联时间1h。在此条件下,载药微粒的载药量为34.93%,包封率为38.36%。红外光谱图表明壳聚糖/明胶微粒已负载5-氟尿嘧啶,SEM表明微粒成球状,表面较光滑。模拟胃肠释放表明,微粒具有一定的缓释性能。采用乳化交联法制备载5-氟尿嘧啶壳聚糖/明胶微粒方法简单,重现性好,且其体外释放实验显示出明显的缓释作用。     

Study of Complex Coacervation of Gelatin A with Sodium Carboxymethyl Cellulose: Microencapsulation of Neem (Azadirachta indica A. Juss.) Seed Oil (NSO)

The efficiency of complex coacervation of gelatin A with sodium carboxymethyl cellulose (SCMC) was measured by checking viscosity, coacervate yield (%), and turbidity of the mixture. Maximum coacervation occurred at pH 3.5 and SCMC: gelatin ratio of 1.0: 2.33. Encapsulation efficiency, oil content, oil load, and release behavior of the microcapsules were studied. The size and nature of the microcapsules varied with the concentration of polymer and NSO as revealed by scanning electron microscopy study. Fourier transform infrared (FTIR) spectroscopy indicated that there was no significant interaction between the polymer and NSO.     

Ethylcellulose microparticles containing chitosan and gelatin: pH-dependent release caused by complex coacervation

Ethylcellulose microparticles containing chitosan and gelatin were prepared by spray drying water-in-oil (W/O) emulsion. Water phase was chitosan:gelatin solution in distilled water, and oil phase was ethylcellulose solution in dichloromethane. FITC-dextran was included in water phase as a fluorescence dye. The maximum coacervation was observed at pH 6.0 when the ratio of chitosan to gelatin was 1:15. Microparticles containing chitosan and gelatin in the ratio showed a higher release under acidic condition (e.g. pH 4.0) and neutral condition (e.g. pH 7.0), but a lower release at pH 5.0 and pH 6.0. The complex coacervate composed of chitosan and gelatin was efficiently formed at those pHs, and the formation of coacervate would be responsible for the lower release.     

Microencapsulation of Lactococcus lactis within cross-linked gelatin membranes

Lactococci were encapsulated within gelatin membranes cross-linked with toluene-2,4-diisocyanate at an oil/water interface. Reagent toxicity was avoided by use of vegetable or silicone oil as a dispersant, and by minimizing cell exposure to the water insoluble cross-linking agent during membrane formulation. Growth of cells within the gelatin microcapsules was observed during fermentation and acidification activity of the encapsulated cells increased with subsequent reuse. A microencapsulated cell density of 10⁹ cfu cm^?3 resulted in acidification of milk to pH 5.5 within 2.8 h, similar to that achieved in free cell fermentations.     

复凝聚法制备明胶/阿拉伯胶含油微胶囊工艺过程的研究

研究了复凝聚法制备含油微胶囊的工艺过程。以大豆油为囊芯材料,阿拉伯胶与明胶为璧材,研究了溶液pH值,反应温度,反应时间,壁材浓度,搅拌条件等对微胶囊产品质量的影响。发现搅拌速度对微胶囊的粒径大小和分布影响很大。最佳工艺条件为:明胶与阿拉伯胶质量比为1,浓度都为2%,pH值为4.0~4.5,搅拌速度为1500 r/min,反应温度为55℃,凝聚时间为15~20min,固化温度为10℃,固化时间60 min。