Neuroleptics block high- but not low-dose heroin place preferences: Further evidence for a two-system model of motivation.

The researchers studied whether 2 separate motivational systems in the brain underlie the rewarding effects of morphine. The brain stem tegmental pedunculopontine nucleus (TPP) is involved in mediating the motivational effects of opiates in nondeprived (drug-naive) rats, whereas dopamine transmission is necessary in mediating the motivational effects of opiates in deprived rats (opiate withdrawal). The results show that heroin's motivational properties obey the same boundary between a nondeprived and a deprived motivational state. Bilateral ibotenic acid lesions of the TPP blocked the acquisition of a place preference for an environment paired with 0.05 mg/kg heroin (a dose that induces no withdrawal aversion) but had no effect on place preference for an environment paired with 0.5 mg/kg heroin (a dose that does induce withdrawal aversion). Dopamine antagonist pretreatment produced the opposite pattern of results. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Everyday life experiences at home: An interaction diary approach to assess marital relationships.

Data were obtained from a convenience nonprobability sample of 6 married couples and 15 couples living together. The age of the husbands ranged from 20–35 yrs and that of their wives from 20–30 yrs. Ss filled out a couple interaction diary, a personality structure test by K. A. Schneewind et al (1983), and D. H. Olson and J. Porter's (1983) questionnaire, FACES II. Happy couples spent more time together at home and during recreation periods than moderately unhappy couples. Presence of the partner was especially rewarding to husbands; wives felt about equally well in situations with the husband present or absent. Happy spouses more often experienced balance of power rather than imbalance and were better able to perceive accurately the other's motivational state than moderately unhappy spouses. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Learning about sex: Conditioning of partner preference: Theoretical comment on Coria-Avila et al. (2005).

Sexual partner preference in female rats has been difficult to establish experimentally because the vaginocervical stimulation the female receives during the preference test can be rewarding or aversive depending on the context. G. A. Coria-Avila, A. J. Ouimet, P. Pacheco, J. Manzo, and J. G. Pfaus (2005) (see record 2005-06959-008) reported that female rats can be conditioned to show partner preference for a male that is scented with a sexually neutral odor if they are mated repeatedly with that male in a paced mating test. These results suggest that establishment of a partner preference depends on rewarding characteristics of the vaginocervical stimulation the female receives during an initial mating and that selection of a sexual partner can be determined by olfactory stimuli associated with that stimulation. These results are discussed within the context of the appetitive-consummatory construct of sexual behavior and the evolutionary significance of conditioned partner preference. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Neurobiology of motivation: Double dissociation of two motivational mechanisms mediating opiate reward in drug-naive versus drug-dependent animals.

Separate brain manipulations double dissociate 2 motivational mechanisms underlying the rewarding effects of opiates. Lesions of the brain-stem tegmental pedunculopontine nucleus block the rewarding properties of morphine in drug-naive, but not in drug-dependent, rats. Neuroleptics (which block the action of the neurotransmitter dopamine) abolished opiate motivational effects in drug-dependent, but not in drug-naive, rats in place conditioning paradigms. This 2nd dopaminergic opiate reward mechanism mediates morphine's alleviation of the withdrawal distress associated with abstinence in opiate-dependent animals. Furthermore, neuroleptic-induced blockade of food-related motivational effects in food-deprived, but not in food-sated (non-food-deprived), animals suggests that the neural substrates of motivational events do not dissociate along the line between different rewarding stimuli but along the line between deprivation and nondeprivation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Testosterone has rewarding affective properties in male rats: Implications for the biological basis of sexual motivation.

Evidence from mammalian species, including humans, suggests that testosterone (TST) enhances motivational aspects of sexual behavior, although the mechanism by which TST exerts this effect is unknown. The hypothesis that increases in plasma TST have rewarding affective properties was examined. Acute elevations of plasma TST were induced in intact male rats by systemic administration of a recently developed testosterone-hydroxypropyl-β-cyclodextrin inclusion complex that mimics pulsatile release of the hormone. In a conditioned-place-preference paradigm, rats displayed a preference for an environment previously paired with TST administration (800 μg/kg and 1,200 μg/kg) as opposed to an environment paired with saline administration, indicating that TST has rewarding affective properties. The findings suggest that TST may enhance motivational aspects of mammalian sexual behavior by facilitating acquisition or expression of learned associations between environmental stimuli and sexual activity. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Paper or plastic revisited: Let's keep them both--Reply to Broderick and Stone (2006); Tennen, Affleck, Coyne, Larsen, and DeLongis (2006); and Takarangi, Garry, and Loftus (2006).

The authors review commentaries by J. E. Broderick and A. A. Stone (2006)(see record 2006-03820-007); H. Tennen, G. Affleck, J. C. Coyne, R. J. Larsen, and A. DeLongis (2006)(see record 2006-03820-008); and M. K. T. Takarangi, M. Garry, and E. F. Loftus (2006)(see record 2006-03820-009) on their original article (A. S. Green, E. Rafaeli, N. Bolger, P. Shrout, & H. T. Reis, 2006)(see record 2006-03820-006). The authors were pleased to find more agreement than disagreement regarding the choice of methods for conducting diary studies. It is clear that continued critical evaluation of all diary methods, both paper and plastic, is warranted. However, on the basis of their initial findings, the authors conclude that paper diaries are still likely to have a valuable place in researchers' toolboxes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Special issue on leadership falls behind.

A special issue of the American Psychologist (January 2007) was devoted to leadership. The six articles, by W. Bennis (see record 2006-23492-002); S. J. Zaccaro (see record 2006-23492-003); V. H. Vroom and A. G. Yago (see record 2006-23492-004); B. J. Avolio (see record 2006-23492-005); R. J. Sternberg (see record 2006-23492-006); and R. J. Hackman and R. Wageman (see record 2006-23492-007), were written from an "industrial" perspective that places primary emphasis on positional leaders and their actions. Some readers of this series might conclude that the industrial model best explains leadership. It does not. The ecological perspective offers an alternative that deserves consideration. It is time to end the dominance of the industrial perspective. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

How will we know a lapse when we see one?: Comment on Leri and Stewart (2002).

The article by F. Leri and J. Stewart (see record 2002-06535-001) addresses the validity of animal models of relapse in a more sophisticated manner than does much prior research. These researchers have shown that drug self-administration can be influenced by the presence of drug contingent cues as well as by active self-administration versus passive infusion of "lapse" doses. This research also leads to additional questions about the external validity of animal relapse models. Current relapse models may lack validity because of the parameters of drug exposure, because abstinence is imposed on the organism, and because there is no motivational influence that counters resumption of drug self-administration. F. Leri and J. Stewart's (2002) article encourages a more thorough assessment of the motivational context of relapse models. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Leadership and attachment theory.

Comments on the six articles contained in the special issue of the American Psychologist (January 2007) devoted to leadership, written by W. Bennis (see record 2006-23492-002); S. J. Zaccaro (see record 2006-23492-003); V. H. Vroom and A. G. Yago (see record 2006-23492-004); B. J. Avolio (see record 2006-23492-005); R. J. Sternberg (see record 2006-23492-006); and R. J. Hackman and R. Wageman (see record 2006-23492-007). The current authors opine that the inclusion of attachment theory in the study of leadership could strengthen leadership theories as a whole. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The state of the reward comparison hypothesis: Theoretical comment on Huang and Hsiao (2008).

Rats avoid intake of a gustatory cue following pairings with a drug of abuse, such as morphine or cocaine. Despite the well-established rewarding properties of these drugs, the reduction in intake of the taste cue has been interpreted as a conditioned taste aversion for decades. In 1997, I proposed the reward comparison hypothesis suggesting that rats avoided intake of the drug-associated taste cue because the value of the taste cue pales in comparison to the highly rewarding drug of abuse expected in the near future. In this issue of Behavioral Neuroscience, A. C. W. Huang and S. Hsiao (see record 2008-17011-002) challenge the reward comparison hypothesis by showing parallels between amphetamine and LiCl-induced suppression of CS intake. This commentary addresses the current state of the reward comparison hypothesis in the context of the experiments completed by Huang and Hsiao and their new task-dependent drug effects hypothesis. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Diversity and leadership.

Comments on the six articles contained in the special issue of the American Psychologist (January 2007) devoted to leadership, written by W. Bennis (see record 2006-23492-002); S. J. Zaccaro (see record 2006-23492-003); V. H. Vroom and A. G. Yago (see record 2006-23492-004); B. J. Avolio (see record 2006-23492-005); R. J. Sternberg (see record 2006-23492-006); and R. J. Hackman and R. Wageman (see record 2006-23492-007). The current authors express concern that the special issue failed to include attention to issues of diversity and intersecting identities as they pertain to leadership. A Special Issue Part II on Diversity and Leadership is being proposed to (a) advance new models of leadership, (b) expand on existing leadership theories, and (c) incorporate diversity and multiple identities in the formulation of more inclusive leadership research and theory. The goal of this special issue will be to revise our theories of leadership and our understanding of effective leadership to include gender, racial/ethnic minority status, sexual orientation, and disability status. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Alerting and orienting in Alzheimer's disease: Are they interdependent? Reply to Festa et al. (2006).

The area of contention between E. Festa-Martino, B. R. Ott, and W. C. Heindel (2004; see record 2004-12990-007) and A. Tales and colleagues (A. Tales, J. L. Muir, A. Bayer, R. Jones, & R. J. Snowden, 2002; A. Tales, J. L. Muir, A. Bayer, & R. J. Snowden, 2002; see record 2002-06031-015) is whether the Alzheimer's disease (AD)-related increased spatial orienting effect is attributable directly to the decreased phasic alerting effect or whether they are two separate effects. In a subsequent study, A. Tales, R. J. Snowden, M. Brown, and G. Wilcock (2006; see record 2006-20657-014) have provided evidence to suggest that the increased spatial orienting effect in AD is not necessarily the result of a decreased phasic alerting effect, as an AD-related increase in spatial orienting effect occurred under conditions in which the phasic alerting effect was the same for both groups. In a commentary to this article, E. K. Festa, B. R. Ott, and W. C. Heindel (2006; see record 2006-20657-015) discuss what they suggest may be potential confounding factors within the authors' study. In this reply, further data in support of the authors' interpretation are provided, and the authors address the points highlighted by Festa et al. (2006). In addition, the authors request that if Festa et al. (2006) are to account for the changes in spatial orienting effects in AD in terms of the shifts in the phasic alerting effects, then how do they postulate how so small a change in one can produce so large a change in the other? (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Tegmental pedunculopontine glutamate and GABA-B synapses mediate morphine reward.

The tegmental pedunculopontine nucleus (TPP) of the midbrain is critical in mediating the acute rewarding effects of opiates. However, the circuitry and neurochemistry underlying this effect has not been determined. Here we identify TPP receptors and cell types involved in systemic morphine reward and suggest an anatomical and neurochemical model for reward in the TPP. Simple hypothetical anatomical models for serial cell arrangements and receptors in the TPP were proposed and predictions of behavioral outcome (reward or no reward) then were made, based on the administration of agonists and antagonists directly into the TPP of rats. We report that TPP-administered NMDA produced rewarding effects, although GABA agonists and antagonists had no motivational effects on their own. However, the NMDA receptor antagonist AP-7 and the GABA-B receptor antagonist saclofen, while having no motivational effects on their own, blocked systemic morphine reward as measured by conditioned place preference. These results provide positive evidence for GABA-B and glutamate synapses in the TPP, which mediates systemic morphine reward and suggest that a serial pathway for morphine reward in the TPP is unlikely. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Clonidine antagonizes the aversive effects of opiate withdrawal and the rewarding effects of morphine only in opiate withdrawn rats.

The researchers asked whether clonidine, an α?-noradrenergic agonist, would block selectively the motivational effects of opiate withdrawal and whether clonidine's effects would respect the boundary between nondeprived and deprived motivational states. In a place conditioning paradigm, clonidine (0.05 mg/kg ip) blocked the rewarding effects of morphine in opiate-withdrawn rats (as well as the aversive properties of withdrawal itself), but did not affect morphine place preferences (2 and 20 mg/kg) in drug-naive rats. Furthermore, clonidine blocked the acquisition of morphine (15 mg/kg), but not LiCI (15 mg/kg), conditioned taste aversions in water-deprived rats. The results suggest that the motivational system activated in deprived animals includes dopaminergic and noradrenergic components that are in series with each other. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Axial coordination and reduction potentials of the sixteen hemes in high-molecular-mass cytochrome c from Desulfovibrio vulgaris (Hildenborough)

A spectroelectrochemical study is described of the sixteen hemes in the high-molecular-mass, monomeric cytochrome c (Hmc) from the periplasmic space of Desulfovibrio vulgaris, strain Hildenborough. One of the hemes has special properties. In the oxidized state at pH 7 it is predominantly high-spin, S = 5/2, with a g perpendicular value of less than 6 indicative of quantum-mechanical mixing with a low-lying (800 cm-1) S = 3/2 state; the balance is probably a low-spin derivative. The high-spin heme has an Em.7.5 value of +61 mV. The fifteen other hemes are low-spin bis-histidine coordinated with Em.7.5 values of approximately -0.20 V. Two of these hemes exhibit very anisotropic EPR spectra with a g1 value of 3.65 characteristic for strained bis-histidine coordination. A previous proposal, namely that methionine is coordinated to one of the hemes [Pollock, W.B.R., Loufti, M. Bruschi, M. Rapp-Giles, B.J., Wall, J. & Voordouw, G. (1991) J. Bacteriol. 173, 220] is disproved using spectroscopic evidence. Contrasting electrochemical data sets from two previous studies [Tan, J. & Cowan, J.A. (1990) Biochemistry 29, 4886; Bruschi, M., Bertrand, P., More, C., Leroy, G., Bonicel, J., Haladjian, J., Chottard, G., Pollock, W.B.R. & Voordouw, G. (1992) Biochemistry 31, 3281] are not consistent with our EPR titration results and are not reproducible. Hmc can be reduced by D. vulgaris Fe-hydrogenase in the presence of molecular hydrogen.     

Roles of Social Pain and Defense Mechanisms in Response to Social Exclusion: Reply to Panksepp (2005) and Corr (2005).

In comments on G. MacDonald and M. R. Leary (2005), J. Panksepp (2005) (see record 2005-01973-005) argued for more emphasis on social pain mechanisms, whereas P. J. Corr (2005) (see record 2005-01973-006) argued for more emphasis on physical defense mechanisms. In response to the former, the authors clarify their positions on the topics of anger, the usefulness of rat models, the role of analgesic mechanisms, and basic motivational processes. In response to the latter, the authors clarify their positions on the topics of the relation of social exclusion to fear, the value of the pain affect construct, and the nature of the social pain experience. The authors conclude that consideration of the roles of both social pain and defense mechanisms is essential to best understand human response to social exclusion. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

"Integrating neural networks into decision-making and motivational theory: Rethinking VIE theory": Erratum.

Reports an error in "Integrating neural networks into decision-making and motivational theory: Rethinking VIE theory" by Robert G. Lord, Paul J. Hanges and Ellen G. Godfrey (Canadian Psychology/Psychologie Canadienne, 2003[Feb], Vol 44[1], 21-38). The paper by Lord, Henges and Godfrey, referred to in some of the commentaries (this issue), was accepted as part of the Special Section on psychology without boundaries. However, it was inadvertently published in a previous issue. The full reference is: Lord, R. G., Hanges, P. J., & Godfrey, E. G. (2003). Integrating neural networks into decision-making and motivational theory: Rethinking VIE theory. Canadian Psychology, 44 (1), 21-38. (The following abstract of the original article appeared in record 2003-01537-005.) Uses a reformulation of V. H. Vroom's (1964) VIE (Valence-Instrumentality-Expectancy) theory to illustrate the potential value of neuropsychologically based models of cognitive processes. Vroom's theory posits that people's decisions are determined by their affective reactions to certain outcomes (valences), beliefs about the relationship between actions and outcomes (expectancies), and perceptions of the association between primary and secondary outcomes (instrumentalities). One of the major criticisms of this type of theory is that the computations it requires are unrealistically time-consuming and often exceed working memory capacity. In this paper, the authors maintain that if an individual has extensive experience with a problem situation, he or she can process decisions about that situation using neural networks that operate implicitly so that cognitive resources are not exhausted by simple computations; instead, the computations are performed implicitly by neural networks. By thinking about VIE from a neural network standpoint, at least one of its problems is eliminated, and several new insights into decision-making are provided. The authors use simulation methodology to show that such a model is both viable and can reflect the effects of current goals on choice processes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Reward and Aversive Stimuli Produce Similar Nonphotic Phase Shifts.

Circadian rhythms in rodents respond to arousing, nonphotic stimuli that contribute to daily patterns of entrainment. To examine whether the motivational significance of a stimulus is important for eliciting nonphotic circadian phase shirts in Syrian hamsters (Mesocricetus auratus), the authors compared responses to a highly rewarding stimulus (lateral hypothalamic brain stimulation reward [BSR]) and a highly aversive stimulus (footshock). Animals were housed on a 14:10-hr light-dark cycle until test day, when they were given a 1-hr BSR session (trained animals) or a 1-mA electric footshock at 1 of 8 circadian times, and were maintained in constant dark thereafter. Both BSR pulses and footshock produced nonphotic phase response curves. These results support the hypothesis that arousal resulting from the motivational significance of a stimulus is a major factor in nonphotic phase shifts. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sensitization to morphine induced by viral-mediated gene transfer

Repeated administration of morphine sensitizes animals to the stimulant and rewarding properties of the drug. It also selectively increases expression of GluR1 (an AMPA glutamate receptor subunit) in the ventral tegmental area, a midbrain region implicated in morphine action. By viral-mediated gene transfer, a causal relation is shown between these behavioral and biochemical adaptations: Morphine's stimulant and rewarding properties are intensified after microinjections of a viral vector expressing GluR1 into the ventral tegmental area. These results confirm the importance of AMPA receptors in morphine action and demonstrate specific locomotor and motivational adaptations resulting from altered expression of a single localized gene product.     

Which heavy drinking college students benefit from a brief motivational intervention?

Heavy drinking among college students is common and is often harmful. A previously reported randomized trial revealed that a brief motivational intervention (BMI) reduced the alcohol consumption of heavy drinking college students (K. B. Carey, M. P. Carey, S. A. Maisto, & J. M. Henson, 2006). For this study, the researchers conducted supplemental analyses of hypothesized predictors of change using the same sample (N = 495). Greater readiness to change, higher levels of self-regulation, and less engagement in social comparison all independently predicted reductions in drinking outcomes. Furthermore, self-regulation, social comparison, and future time perspective interacted with BMI and predicted drinks per week. As expected, greater self-regulation skills enhanced response to the BMI; the remaining interaction effects were unexpected. Overall, these findings suggest that BMIs produce relatively robust effects. (PsycINFO Database Record (c) 2010 APA, all rights reserved)