Production of associative sequences in process-reactive schizophrenic and nonschizophrenic groups.

A previous study (Judson & Katahn, 1960) disclosed significant differences between process-reactive schizophrenics in the recall of friends' names over a 10-minute interval. The differences were greater than would have been expected from their recall of animal names and IQ scores. This was interpreted as reflecting a special restriction in interpersonal relationships in a generally impoverished relationship with the environment. The present study sought to extend the findings and employed both schizophrenic and nonschizophrenic patients. Both the process-reactive dimension and diagnostic category made significant independent and interacting contributions to the recall of friends' names, that is, the material with social connotations, but not to the recall of animal names. By subgroups, the rank order of recall from least to greatest, was process schizophrenics, process nonschizophrenics, reactive schizophrenics, reactive nonschizophrenics. The process-reactive distinction thus proved meaningful for nonschizophrenic as well as schizophrenic patients on this material. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Time estimation in process-reactive schizophrenia.

Process and reactive schizophrenics, and reactive schizophrenics and normals were compared as to their responses on a perceptual time-estimation task. Null hypotheses being tested were that groups would not differ in variability or accuracy of response. Schizophrenic (45) and normal (15) subjects were selected from the male patient population and hospital employees, respectively, of a Veteran's Administration hospital. Schizophrenics selected for the study were classified by means of the Abbreviated Becker Elgin Scale. Subjects were individually administered a time-estimation task consisting of seven stimulus cards which were tachistoscopically presented, with exposure speeds at 10, 20, and 30 seconds for each card. Judgments of exposure times were converted into scores based upon ratios of estimated time to actual time. Scores (three) for each card were totaled. Groups were then compared on each of the stimulus cards by means of two-tailed t tests. In accuracy of estimation, process schizophrenics demonstrated significantly less accuracy than did reactives on four of the seven cards; no differences were shown between reactives and normals in accuracy of estimation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Production of associative sequences in schizophrenia and chronic brain syndrome.

"… timing differences in the associative process of schizophrenics and epileptics" was studied. Recall and a "condition of restricted association were employed… . controls were found to differ from the patient groups with respect to gross output of words… . As increased restrictions were imposed on the associative process, disturbances in the thinking of the pathological groups became more apparent… . results suggest that inappropriate responses (intrusions), which appear in the productions of psychotic individuals, are but symptomatic of a more basic disturbance in thought processes… . [Results] discussed within the framework of Hebbian theory and in relation to other theoretical formulations." (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Process-reactive schizophrenia and genetic levels of perception.

"An attempt was made to evaluate the degree of perceptual regression, as defined by Rorschach responses, in reactive and process schizophrenics. The hypothesis that process schizophrenics show a preponderance of gentically lower responses than reactive schizophrenics was confirmed. The data indicate grosser perceptual immaturity within the process schizophrenic group and more adequate and integrated perceptual functioning within the reactive group. Several possible interpretations of these findings are presented." (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Delusional thinking and cognitive organization in schizophrenia.

A delusion can be conceptualized as a form of cognitive reorganization; according to this interpretation a delusion serves to integrate into a meaningful and acceptable whole data which otherwise would be anxiety provoking. On the assumption that the utilization of delusions is representative of a generalized cognitive technique for dealing with ambiguous inputs it was hypothesized that delusional schizophrenics should manifest a stronger tendency to integrate ambiguous stimuli in a laboratory situation than nondelusional schizophrenics. To test the hypothesis 24 delusional and 25 nondelusional schizophrenics were compared on the McGill Closure Test. The results supported the hypothesis. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The process-reactive classification of schizophrenia.

Research on the process-reactive classification of schizophrenia indicates there are 2 groups of schizophrenic patients differing in prognostic and life-history variables. It is also possible to demonstrate differences between the 2 groups in physiological measures and psychological dimensions. The evidence does not support a process-organic vs. a reactive-psychogenic formulation of schizophrenic etiology. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Concept of process-reactive schizophrenia: A critique.

A review of current issues, including (1) the dichotomy vs. continuum view of the process-reactive concept, (2) the question of organic involvement in process schizophrenia, (3) the relationship of severity of illness to the concept, (4) the problem of duration of hospitalization, (5) comparability of criteria, (6) adequacy of control groups, (7) sociocultural diversity, and (8) uniformity of process-reactive differences. (2 p. ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Visual event-related potentials in schizotypal personality disorder and schizophrenia.

Schizophrenia (SZ) occurs among a spectrum of disorders with similar characteristics, including schizotypal personality disorder (SPD). Visual processing disturbances have been reported in both disorders, but it is not yet clear which processes are disturbed in both SZ and SPD, suggestive of a common endophenotype, and which appear only in SZ. In order to address this question, the authors evaluated visual event-related potentials (ERPs) elicited during a line-orientation discrimination task in control, SPD, and SZ participants. Visual ERPs allow specification of both the time course and physiological correlates of visual perception and cognition. SZ patients had smaller P100 and P300a amplitudes and prolonged P300b latency compared to the control group. SZ patients also had smaller N160, N200, P300a, and P300b amplitudes compared to the SPD group. SPD participants did not differ from control participants on any ERP measure. These data documented pervasive abnormalities in visual perception and attention in SZ but not in SPD, suggesting that these visual ERP disturbances may not represent a common endophenotype. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Exploration of cerebellar-dependent associative learning in schizophrenia: Effects of varying and shifting interstimulus interval on eyeblink conditioning.

Eyeblink conditioning abnormalities have been reported in schizophrenia, but the extent to which these anomalies are evident across a range of delay intervals (i.e., interstimulus intervals; ISIs) is unknown. In addition, the effects of ISI shifts on learning are unknown, though such manipulations can be informative about the plasticity of cerebellar timing functions. Therefore, the primary purpose of the present study was to investigate the interactions between ISI manipulations and learning in schizophrenia. A standard delay eyeblink conditioning procedure with four different interstimulus intervals (ISIs; 250, 350, 550, 850 ms) was employed. Each eyeblink conditioning experiment was immediately followed by another with a different ISI, thus permitting the characterization of conditioned response (CR) learning at one ISI and the extent to which CRs could be generated at a different latency following an ISI shift. Collapsing across all conditions, the schizophrenia group (n = 55) had significantly fewer conditioned responses and longer onset latencies than age-matched controls (n = 55). Surprisingly, shifting to a new ISI had negligible effects on conditioned response rates in both groups. These findings contribute to evidence of robust eyeblink conditioning abnormalities in schizophrenia and suggest impaired cerebellar function, but underscore the need for more research to clarify the source of these abnormalities and their relationship to clinical manifestations of schizophrenia. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Schizotaxia, schizotypy, schizophrenia.

"I hypothesize that the statistical relation between schizotaxia, schizotypy, and schizophrenia is class inclusion: All schizotaxics become on all actually existing social learning regimes, schizotypic in personality organization; but most of these remain compensated. A minority, disadvantaged by other… constitutional weaknesses, and put on a bad regime by schizophrenogenic mothers… are thereby potentiated into clinical schizophrenia. What makes schizotaxia etiologically specific is its role as a necessary condition… . It is my strong personal conviction that… schizophrenia, while its content is learned, is fundamentally a neurological disease of genetic origin." (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Differential autonomic responsiveness in the process-reactive classification of schizophrenia.

"This investigation consisted of two studies which were concerned with the relationship between the process-reactive classification of schizophrenia and autonomic nervous system activity… . [Both]… studies revealed that the patients classified as 'reactive' exhibited a significantly greater fall in blood pressure after the administration of mecholyl than the process patients… . It was concluded that the process-reactive classification seems to provide a fruitful frame of reference for research in schizophrenia." (31 ref.) From Psyc Abstracts 36:01:1JS60K. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Context processing in schizotypal personality disorder: Evidence of specificity of impairment to the schizophrenia spectrum.

Working memory abnormalities, which are particularly pronounced on context processing tasks, appear relatively specific to schizophrenia spectrum illnesses compared with other psychotic disorders. However, the specificity of context processing deficits to schizotypal personality disorder (SPD), a prototype of schizophrenia, has not been studied. The authors administered 3 versions of the modified AX Continuous Performance Test and an N-back working memory test to 63 individuals with SPD and 25 with other personality disorders, as well as 42 healthy controls. For the AX Continuous Performance Test standard and degraded versions, there was a significant Trial Type × Delay × Group interaction, as SPDs made significantly more errors reflecting poor maintenance of context and fewer errors reflecting good maintenance of context. SPDs also demonstrated poor performance on the N-back, especially at the 2-back condition. Context processing errors and N-back accuracy scores were related to disorganization symptoms. These findings, which are quite similar to those previously reported in patients with schizophrenia, suggest that context processing deficits are specific to the schizophrenia spectrum and are not a reflection of overall psychopathology. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Associative disturbance as a function of chronicity in schizophrenia.

47 male schizophrenics hospitalized from 8 days to 21 yr. 5 mo. were tested for signs of associative disturbance by means of a word association task. 3 measures of associative behavior were employed: "over-all" associative behavior, "most common" associative behavior, and "least common" associative behavior. The extent of discrepancy between the performance of the experimental group and that of a norm sample suggested that associative disturbance is more prevalent in the chronic stages of schizophrenia than in the acute stages. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Perceptual closure in schizophrenia.

The concept of closure has been more frequently investigated using normal Ss than psychotic patients. The present study utilizes schizophrenics and compares their performance with a comparable group of hospitalized nonpsychotic Ss. Taylor's (1960) test of closure was used. Tendency to closure tended to be lower for the schizophrenics than for the nonschizophrenics, with schizophrenics on drugs (and, hence, manifesting a greater degree of personality disorganization than the other schizophrenic Ss) showing no tendency towards closure. The results are related to 2 theories of schizophrenia, one which involves a deficit in the energizing or arousal systems in the brain, and the other, an inability to maintain a set in the way normal Ss do. From Psyc Abstracts 36:04:4JQ31S. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Differences in developmental experience, defensiveness, and personality organization between two classes of problem drinkers.

Family background, personality data, and defensive behavior were studied to test the Knight distinction between 2 kinds of alcoholics: essential and reactive. Data analysis supported the predictions. The findings has implications for research which attempts to study the problem of alcoholism but without making a necessary distinction regarding their Ss. From Psyc Abstracts 36:04:4JK59R. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Lateralized perceptual organization deficits on the global-local task in schizotypal personality disorder.

Right and left hemisphere contributions to perceptual organization functions were examined using a divided-attention version of the global-local task in a sample of 21 unmedicated participants diagnosed with schizotypal personality disorder (SPD) and 20 controls. The SPD participants showed an abnormal global processing advantage. When the visual angle of the hierarchical stimuli was increased from 3° to 9°, the controls showed an increasing local processing advantage, but the SPD participants continued to show an abnormal global processing advantage. These findings suggest a local processing deficit on divided-attention versions of the global-local task in schizophrenia spectrum disorders. Female SPD participants, who had less severe interpersonal deficit symptoms, showed a more abnormal global processing advantage. Hemispheric and processing resource mechanisms that might explain these findings are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)