Psychotherapy with the mentally retarded: A review of the literature and the implications.

The authors examine psychotherapy as an effective means of providing treatment to the mentally retarded from several theoretical standpoints. The literature on this topic dates back at least 30 years, and in some cases arguably 60 years, and consequently it is not a new area of inquiry. Although, historically, research has been lacking in this area, recent contributions have been promising, and this newer work is explored amid appraising the implications of this modality for today's practitioner who works with the mentally retarded. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Depressive disorders in mentally retarded children. A review of selected literature. Part II

1. The metabolism of 1-(2-methoxyphenyl)-2-methyl-2-(3-pyridyl)-1-propanone (2-MPMP) was studied in the male Sprague-Dawley rat after 50 mg/kg, i.v. dose. 2. Organic solvent extracts of urine samples were directly analysed by reversed-phase gradient hplc. The identified metabolites were also isolated by preparative tlc, and analyzed by direct probe mass spectrometry. In the case of conjugated metabolites, the urine samples were deconjugated by enzyme hydrolysis prior to extraction. The structures of metabolites were confirmed by comparison of their chromatographic behaviours, UV spectra, and mass spectra with those of authentic standards. 3. The metabolites identified in the 0-24-h urine samples were 2-hydroxyphenyl-metyrapone (2-OHPMP) and 2-hydroyphenylmetyrapone N-oxide (2-OHPMP-NO), which were present predominantly as their glucuronide and/or sulphate conjugates. 4. 2-MPMP and four of its metabolites present in the 0-24-h urine samples were quantified by a reversed-phase hplc method. The mean total urinary excretion was 75.4% of the administered dose. The major metabolites present in the urine were conjugates of 2-OHPMP-NO (54.4%) and of 2-OHPMP (18.6%). The excretion of the unchanged drug, unconjugated 2-OHPMP and 2-OHPMP-NO accounted for 1.1, 1.1 and 0.2% of the dose respectively.     

Cognitive and language skills in autistic, mentally retarded, and normal children.

Compared the sensorimotor skills and play behaviors of 16 normal 16–25 mo old children, 16 mentally retarded children (CA 32–80 mo, MA 17–38 mo), and 16 autistic children (CA 39–74 mo, MA 18–38 mo) to identify deficits in object knowledge specific to autism. There were no differences in sensorimotor skills between the 3 groups except that the autistic Ss were deficient in the capacity to imitate gestures and vocalizations. Autistic Ss showed less diverse functional play, particularly directed toward dolls, and less symbolic play both spontaneously and after cuing. Although functional and symbolic play and the ability to imitate were correlated with receptive language for all 3 groups, sensorimotor skills were associated with receptive language only for the normal and the mentally retarded groups. The observation that autism involves deficits in certain cognitive concepts and not others suggests that representational thought may be manifested in 2 systems, only one of which is impaired in the autistic child. Another hypothesis is that the cognitive deficits manifested by autistic children may be related to their impaired social development, because all the areas of cognitive deficit involve significant social components. (23 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The utility of self-management procedures in modifying the classroom behaviors of mentally retarded adolescents

Self-management procedures including the self-recording of points, the self-graphing of progress, and the self-selecting of free time activities were applied to the classroom behaviors of 12-year-old educable mentally retarded subjects. Students were first awarded points for specified appropriate behaviors. Then during the last two treatment phases, they graphed their points earnings and used these points to earn free time activities. A multiple baseline design was used in appraising the comparative effects of these three treatment conditions during spelling and reading periods. All three treatment conditions produced higher rates of appropriate behavior than did baseline conditions; however, the highest levels of appropriate behavior were achieved during the self-selected free time phases.     

Evaluation of a group counseling program designed to enhance social adjustment of mentally retarded adults.

A group of moderately retarded (mean IQ 47, Peabody Picture Vocabulary Test [PPVT]), institutionalized residents (20 males, 24 females) received 10 wks of structured group counseling. The group counseling program, in which the counselor played a dual role as teacher-model and group leader, focused on 5 areas of social and personal adjustment. The residents' improvement was assessed by the PPUT, the Adaptive Behavior Scale, and nomination by peers and ward staff. The experimental and control groups were compared using the pretest scores as the covariate. Results show that in each of the above variables, the experimental group showed a greater mean score than that of the control group. This is interpreted as supporting the contention that group counseling of a primarily verbal nature can be effective in enhancing social adjustment skills of residents with moderate intellectual deficiency. (19 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

English as the second language of deaf children.

Administered the Test of English as a Foreign Language (TOEFL) to 13 deaf adolescents with deaf parents and to 13 deaf adolescents with hearing parents. Scores achieved by all Ss on the Paragraph Meaning and Language subtests of the Stanford Achievement Test were also available. Ss with deaf parents scored significantly higher than Ss with hearing parents on all but 1 measure. Performance by hearing, foreign students on the TOEFL was more highly correlated with the performance by Ss with deaf parents than with the performance by Ss with hearing parents. Results indicate that English may be a 2nd language for deaf children and that early experience with sign language may facilitate later learning of English. (27 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Factor analysis of the WISC-R for a group of mentally retarded children and adolescents.

Administered the Wechsler Intelligence Scale for Children--Revised (WISC--R) to 80 retarded youngsters ranging in CA from 6 to 16 yrs. Scaled scores on the 12 tests were correlated, and the matrix was subjected to several factor-analytic techniques. The 3 factors identified for normal children in a previous study of the WISC--R (Verbal Comprehension, Perceptual Organization, and Freedom from Distractibility) also emerged for the retardates, although some differences were observed in the distractibility factor. The WISC--R factor structure for retardates was also similar to the structure of the 1949 WISC that was identified for several groups of institutionalized and noninstitutionalized retardates. Results of the studies involving the 1949 WISC are reviewed critically to help understand the implications of the present findings. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Convulsions in relation to polycythemia: literature review and case description

We investigated the ability of polyethylene glycol 4000 to accelerate thrombin generation in a mixture of prothrombin and factor X at concentrations of 1-30%. In the presence of 5 mM of CaCl2, polyethylene glycol 4000 promoted prothrombin activation at concentrations above 1%. The peak of activation was seen at levels of 14 and 20% of polyethylene glycol 4000. The effect of the polyethylene glycol was remarkably dependent on its molecular weight; molecular weights greater than 2000 were required for accelerating thrombin generation. Under optimal conditions, polyethylene glycol 4000, in the presence of CaCl2, promoted conversion of all of the prothrombin into thrombin and its derivatives. We conclude that polyethylene glycol 4000, at concentrations ranging from 14 to 20%, effectively accelerates thrombin generation in the presence of 5 mM of CaCl2. This new method for preparing thrombin is based on the use of polyethylene glycol 4000 and CaCl2 and is applicable to the manufacture of thrombin.     

Dimensions of adaptive behavior in institutionalized mentally retarded children and adults: developmental perspective

Factor analyses were performed utilizing the subscale scores of the AAMD Adaptive Behavior Scale, Part One, for 3,354 institutionalized mentally retarded children and adults. Eight different age groups were studied to determine (a) the underlying dimensions of adaptive behavior measured by the scale, (b) similarity of factor structure across ages, (c) whether there were developmental changes revealed by factor scores, and (d) the extent to which the above findings would be related to level of retardation. Three salient factorial dimensions--Personal Self-Sufficiency, Community Self-Sufficiency, and Personal-Social Responsibility--appeared across a wide span of age ranges from childhood through senility. The implication of these factors was discussed in terms of the critical period of development, rate of growth, and maximum level of growth of subjects grouped by level of retardation.     

Systematic screening for fragile X syndrome in a cohort of 574 mentally retarded children

The Sense of Coherence Scale is used frequently world-wide and is thought to be appropriate to any population. The purpose of this study was to highlight some of the potential limitations of the scale. Fifteen members of the Pentecostal Movement described several difficulties in completing the scale, especially items measuring manageability and comprehensibility. The following three statements indicate the nature of their interpretation of the items and the ambiguity of their answers as they argued that: (1) the concept of 'I' was interpreted as 'I and God', (2) it is not necessary to understand everything in life, because it is enough that God understands, and (3) life is meaningful in itself because of the salvation. According to this interpretation of the items, every proposed answer could be suitable and consequently, the scores can readily be misconstrued. Many of the respondents proposed additions or changes in the wording to make the scale more suitable. The strong ego-centred items seem to be inappropriate for the participants in this study and other populations might also be confronted with similar difficulties.     

Primary endobronchial non-hodgkins lymphoma: description of a case and review of the literature]

Photosensitive epilepsy is relatively rare. However, a large proportion of individuals with epilepsy perceive that they are at an increased risk of a seizure whilst exposed to specific photic material. The difference between perceived and real risk may be due to inadequate education and misinformation. One half of the participants in the present survey could not recall being informed of the result of the 'gold standard' test for photosensitivity--intermittent photic stimulation during an electroencephalogram. Furthermore, approximately one-third of our sample were apparently given inaccurate and overcautious advice about their everyday exposure to photic material. Better information and advice is crucial to improve this situation in the future. The majority of people with epilepsy (>95%) who are not photosensitive can pursue activities that involve flickering or patterned light, encompassing educational, employment and leisure opportunities, without undue concern.     

Interaction among retarded children as a function of their relative language skills.

It has long been recognized that the quality of interpersonal relations affects the behavior of individuals with mental retardation. The question to be assessed here was the effect of the skill of individual reacting with the mental retardate upon the behavior of the retardate. This study is a modified replication of an earlier one (Rosenberg, 1959). Ss of an institution for mental retardates were categorized re: verbal facility. Group of Ss was then formed containing pairs of Highs and Lows on this test, and interpersonal behavior was assessed in a play room situation. The results indicate that Lows and Highs interact with each other effectively, whereas heterogeneity of grouping inhibits social interaction. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Research-based language intervention strategies adapted for deaf and hard of hearing children

Strategies found to facilitate the language development of young, hearing children are reviewed in this paper, and adaptations and examples for use with deaf and hard-of-hearing children are provided as alternatives to simply advising professionals and parents to increase the quantity of conversation with these children. It is suggested that adults accelerate the language acquisition of deaf and hard-of-hearing students by capitalizing on the linguistic opportunities provided in particular environments, rearranging environments, being responsive to indications that children have comprehended messages and are open to risk communication, and specifically by intervening on form, content, and use skills. The author challenges professionals to document empirically the usefulness of each language intervention technique presented here.     

Communication between deaf children and their hearing mothers: the role of language, gesture, and vocalizations

In the present longitudinal study, 20 deaf and 20 hearing children were observed during free play with their hearing mothers when the children were 22 months and 3 years of age. Compared to hearing children, deaf children were severely language delayed, with deaf 3-year-olds using less language (speech or sign) than hearing 22-month-olds. Deaf children communicated primarily through nonlinguistic vocalizations, with increasing use of gesture from 22 months to 3 years of age. Although mothers of deaf children used more visual communication than mothers of hearing children, they still primarily communicated through speech. In addition, deaf children did not visually attend to much of their mothers' communication. Therefore, deaf children received much less communication than hearing children. These results suggest that intervention efforts should be focused on increasing the quantity of perceived linguistic input by the child.     

Von-Voss-Cherstvoy syndrome (DK-Focomelia): description of the first case in Spain and a literature review

Because hypercellularity is an important feature in acute serum sickness (AcSS), we quantified glomerular proliferation with immunoperoxidase staining using anti-proliferating cell nuclear antigen (PCNA Mab) and studied its relationship with lymphocyte infiltration (M108 Mab). AcSS was induced in 31 New Zealand White rabbits; group A (n = 14), with proteinuria, sacrificed 6-8 days after immunization; group B (n = 10), without proteinuria, sacrificed 6-7 days after immunization; group C (n = 7), sacrificed prior to development of AcSS. Four normal rabbits were included as controls. Intraglomerular proliferation (PCNA-positive cells/glomerular cross section) was increased in group A (12.2 +/- SEM, 1.84) but not in groups B (0.93 +/- 0.17) and C (0.37 +/- 0.05), which were similar to controls (0.66 +/- 0.06). Lymphocyte infiltration (lymphs/glomerular cross section) increased with time and was more prominent in rabbits with proteinuria (1.9 +/- 0.21, P < 0.001 vs controls). Lymphocyte infiltration was correlated with proliferative activity (Spearman correlation, r = 0.67, P < 0.0001). There was correlation between the severity of glomerular deposition of IgG and C3 and glomerular proliferation and proteinuria. These studies demonstrate a chronological association between lymphocyte infiltration and proliferative activity in AcSS.     

Relative effectiveness of behavioral and reflective group counseling with parents of mentally retarded children.

Evaluated the relative effectiveness of behavioral and reflective group parent counseling. Ss were 51 mothers of mentally retarded children who were assigned to behavioral, reflective, or waiting-list control groups. 6 success criteria, including direct observations, attitudinal scales, maternal reports, and frequency counts, were used to measure outcome (e.g., Hereford Parent Attitude Survey and the Missouri Behavior Problem Checklist). Both types of counseling had a beneficial effect relative to the untreated controls, but the behavioral method resulted in a significantly greater magnitude of improvement. The consistency of these results across measures strongly suggests that the behavioral technique was the treatment of choice for counseling parents of the retarded. (29 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)