Handedness in first-episode psychotic patients and their first-degree biological relatives.

We evaluated the handedness of 58 schizophrenia patients and 54 of their relatives, 23 patients with major depression with psychosis and 24 of their relatives, 36 patients with bipolar psychosis and 33 of their relatives, and 119 nonpsychiatric Ss and 42 of their relatives. Computerized tomography measures were also available for a subset of the psychotic patients. The schizophrenia patients were significantly more left-handed than any of the other groups, and increased sinistrality was also associated with larger lateral ventricle to brain area ratios. The relatives of the schizophrenia patients did not significantly differ on handedness from either the relatives of the affective psychosis patients or the nonpsychiatric Ss. Findings do not support the notion that left-handedness in schizophrenia is genetically influenced. More research with larger family member data sets is warranted to further explore this possibility. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Anhedonia and perceptual aberration in first-episode psychotic patients and their relatives.

One hundred eighteen psychiatric patients, each experiencing his or her first lifetime episode of psychosis, 125 of their first-degree relatives, and 155 normal subjects were assessed using the physical anhedonia, social anhedonia, and perceptual aberration scales of L. J. Chapman et al (1976; see also PA, Vol 62:3733). We hypothesized that psychotic subjects would obtain higher scores on these scales than their relatives and the controls, and we expected the group of relatives to score more deviantly than the normal controls. The physical anhedonia and social anhedonia scales successfully differentiated the psychiatric patients from the relatives and the latter from the normal subjects. These findings testify to the construct validity of the scales and suggest that they tap a predisposition to psychosis. Unexpectedly, the relatives scored lower on the perceptual aberration scale than did the normal controls, perhaps because the relatives adopted a defensive response set. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Smooth-pursuit eye movement dysfunction and liability for schizophrenia: Implications for genetic modeling.

41 nonpsychiatric Ss, 38 probands with schizophrenia, and 99 of their relatives were studied. Oculomotor functioning was bimodally distributed for probands and relatives. Oculomotor dysfunction was not present in all families with a schizophrenic proband. In those families in which it was present, there were significant phenotypic correlations between oculomotor functioning and schizophrenia-related characteristics. The patterns of familial resemblance in the families in whom oculomotor dysfunction was present were consistent with nonadditive genetic variance contributing both to oculomotor dysfunction and to the relationship between oculomotor dysfunction and clinical symptoms. These results suggest that schizophrenia may be etiologically heterogeneous and that oculomotor dysfunction may help to identify nonadditive genetic variance for this disorder. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Affective reactivity of speech in schizophrenia patients and their nonschizophrenic relatives.

This study compared levels of referential communication disturbance in speech samples from 41 stable schizophrenia outpatients, 46 parents of patients, and 23 nonpsychiatric control participants in affectively positive versus affectively negative conditions. The speech of the patients and parents showed elevated frequencies of reference failures in the affectively positive condition compared with control participants; the speech of the patients became more disordered in the affectively negative condition, whereas the speech of the parents did not. These results support the idea that referential communication disturbances reflect vulnerability, as well as overt illness, but that affective reactivity of these disturbances is associated mainly with the manifest illness. These findings are consistent with biological, cognitive, and psychological theories about the processes underlying stress responsiveness of schizophrenic symptoms more generally. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Smooth-pursuit eye movements: A comparison of two measurement techniques for studying schizophrenia.

Conducted simultaneous recording of smooth-pursuit eye movements by EOG and infrared reflection techniques with 5 psychiatric patients (1 with psychotic depression, 1 with organic brain syndrome, and 3 with schizophrenia) and 5 normal controls. Results show good correspondence between the 2 methods. The parameter of pursuit arrests, previously used to quantify smooth-pursuit performance, was not well correlated in the 2 methods. The natural logarithm of the signal/noise ratio obtained from harmonic regression of digitized and standardized eye movement data provides a valid quantitative assessment of smooth pursuit and suggests that such scoring of EOG records is effective and generally free of artifacts. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Pituitary autoantibodies in patients with hypopituitarism and their relatives

In order to investigate the physiological role of calcitonin gene-related peptide (CGRP) in mollusc, both circulating CGRP-related molecules and gill or mantle carbonic anhydrase activity were analysed during the annual growth of Pecten maximus. CGRP like molecules measured by radioreceptor assay increased significantly during the annual cycle. Similarly, gill carbonic anhydrase activity increased and showed a maximum activity when growth is stimulated to the greatest extent. Correlation studies showed a significant relationship between the tissue weight and either the gill carbonic anhydrase activity or the CGRP-related molecules determined by radioreceptorassay. This observation suggests a possible interaction between carbonic anhydrase activity and CGRP. Accordingly, we searched for a direct effect of CGRP on the gill carbonic anhydrase activity. In gill membranes, CGRP stimulated the carbonic anhydrase activity. The maximum effect was obtained at a CGRP concentration of 50 nM.     

Saccadic system functioning among schizophrenia patients and their first-degree biological relatives.

In Study 1, 30 schizophrenia Ss and 27 nonpsychiatric comparison Ss were presented with a fixation task, a visually guided reflexive saccade (prosaccade) task, a predictive tracking task (0.4-Hz square wave), and an antisaccade task. The 2 groups did not differ on either the fixation or prosaccade tasks. Schizophrenia Ss had an increased number of errors on the antisaccade task and had decreased rightward visually guided saccade amplitudes during the predictive tracking task. In Study 2, 13 psychiatric comparison Ss and 32 1st-degree biological relatives of the schizophrenia Ss were compared with the schizophrenia Ss and a larger and older sample of nonpsychiatric Ss (n?=?33) on the predictive tracking and antisaccade tasks. The groups did not differ on predictive saccadic tracking. The schizophrenia Ss and their 1st-degree biological relatives made more errors on the antisaccade task than both the nonpsychiatric and psychiatric comparison groups (who did not significantly differ). Results are consistent with the notion that dysfunction of dorsolateral prefrontal cortex, caudate nucleus, or both is related to liability for schizophrenia. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

How are psychotic symptoms perceived? A comparison between patients, relatives and the general public

OBJECTIVE: The aim of this study is to compare patients with schizophrenia with their relatives and the general public in their attitudes towards schizophrenic psychotic symptoms. METHOD: We used a case vignette depicting a person with typical schizophrenic psychotic symptoms and compared the attitudes of 44 inpatients and 47 outpatients with schizophrenia, 48 of their relatives and 43 members of the general public. We also compared the attitudes of patients with schizophrenia to their own symptoms and the symptoms described in the vignette. RESULTS: Subjects from the general public tended not to recognise psychotic symptoms as features of mental illness and tended not to consider drug treatment and hospitalisation as required. Sex, education level as well as previous contact with the mentally ill were found to be significant determinants of attitude. The levels of symptom awareness in patients with schizophrenia and their relatives are higher but still relatively low. In addition, we found that patients with schizophrenia who correctly appraised psychotic symptoms in another person were also aware of their own mental symptoms and need of treatment. CONCLUSIONS: The level of recognition of psychotic symptoms and awareness of a need for treatment are low in the general public, as well as in patients with schizophrenia and their relatives. These findings are discussed in relation to the assessment of insight in patients and a need for psychoeducational programs for each group.     

Interplay of four idiotypes and interaction with autoantibodies in lupus patients, their relatives and their spouses

Our aim was to investigate links between systemic lupus erythematosus (SLE)-associated autoantibodies, idiotypes (Id) and genetic predisposition to their development. We studied four public Ids (16/6, WRI 176 beta, RT72 and RT84), identified the Km and Gm phenotypes and sought six selected autoantibodies in 32 SLE patients, 174 of their relatives and 15 spouses. Though anti-double-stranded DNA antibody was uncommon in the relatives (9%), the range of antinuclear reactivities was as broad in the relatives as in the probands. Antibodies to the synthetic peptide U1-RNP-A 35-38 were found in 56% of the patients, 28% of their relatives and 20% of the spouses, whereas antibodies to the Golgi apparatus was present in 7% of the patients, 26% of their relatives and 33% of the spouses. However, most of these family members were unaffected. RT84 Id was positively associated with antibodies to Sm-D peptide 1-20 and to Ro/SSA 60 kD peptide 304-324, but negatively associated with anti-dsDNA activity. The median of age was significantly lower in the RT84 Id-positive than in the RT84 Id-negative individuals. These data suggest that genetic as well as environmental factors are involved in the aetiology of SLE. In addition, RT84-carrying immunoglobulins (Ab2) might be directed to one of many cross-reactive Ids of dsDNA-binding antibodies (Ab1), perhaps down-regulating their production.     

Expressed emotion and familial interaction: A study with agoraphobic and obsessive-compulsive patients and their relatives.

Patients with panic disorder with agoraphobia (n = 40) or obsessive- compulsive disorder (n = 61) participated in a 10-min problem-solving interaction with their primary relative. Relatives were categorized as hostile or nonhostile toward the patient on the basis of a measure of expressed emotion (EE). Observed interactions between patients and their hostile relatives, relative to those of dyads with a nonhostile relative, were marked by higher rates of relatives' criticism and of patients' negativity but not by higher rates of negative reciprocity. Analyses of sequences indicated that the dyads with a hostile relative had a higher rate of sequences in which the relative was first critical and the patient then negative than was the case for dyads with nonhostile relatives. Moreover, hostile relatives were more frequently critical than nonhostile relatives whether patients' preceding behavior was positive, negative, or neutral. The findings are consistent with the stress-vulnerability model of the effect of EE on mental health, in that patients living with a high EE relative appear to be exposed to higher levels of interpersonal stress. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

How do psychiatric patients experience interactions with their relatives?

Numerous studies have established the prognostic validity of family attitudes and interactional behaviors in psychiatric disorders. However, most have relied on observer-rated rather than patient-rated measures of the family context. Bipolar patients (N?=?31) rated their relatives' verbal behaviors in problem-solving discussions using the Patient's Experiences of a Relative's Affective Style (PERAS) scale. The PERAS had acceptable reliability and internal consistency. Patients' PERAS judgments of the frequencies of harsh and benign criticisms in relatives correlated positively with an observer's affective style (AS) ratings of these same behaviors in relatives. However, patients' ratings of intrusiveness and support in relatives were unrelated to the observer's AS ratings. The PERAS is a promising measure of how patients experience their family interactions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Poor P50 suppression among schizophrenia patients and their first-degree biological relatives

A Western blotting method for the detection of whey milk proteins in commercial soymilks was applied to assess the food safety. Soy proteins and milk proteins were separated by SDS-PAGE in PhastSystem equipment. After the electrophoretic separation, immunodetection with anti-bovine alpha-lactalbumin and anti-bovine beta-lactoglobulin antisera was performed. Adulteration with bovine protein in percentages of 0.1% in soy protein can be detected. Western blotting of bovine alpha-lactalbumin and bovine beta-lactoglobulin was applied to detect adulteration by bovine milk proteins in different soymilks: powdered soymilk and soy infant formulas.     

Motor proficiency and attentional-task performance by psychotic patients.

Investigated the relation between motor proficiency and performance on the Continuous Performance Test (CPT) among 24 schizophrenic inpatients (mean age 34 yrs) and 24 inpatients with affective disorders (mean age 33.8 yrs). Ss completed the Bruininks-Oseretsky Test of Motor Proficiency. A correlational analysis revealed that motor subtest scores were significantly related to CPT performance indexes for all Ss; decreased motor proficiency was related to more CPT errors and longer RTs. Results suggest that CPT performance is related to motoric factors and that deficits on this task may be partially attributable to poor motor abilities. (30 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Smooth pursuit eye movements to extraretinal motion signals: deficits in relatives of patients with schizophrenia

BACKGROUND: Although mounting evidence supports the idea that smooth pursuit abnormality marks the genetic liability to schizophrenia, the precise ocular motor mechanism underlying the abnormality remains unknown. Based on recent findings in schizophrenia, we hypothesize that subtle deficits in the ability to hold online and/or use extraretinal motion information underlie the pursuit abnormality in vulnerable individuals. METHODS: The hypothesis was tested in 69 first-degree, biological relatives of probands with schizophrenia; 26 relatives had schizophrenia spectrum personalities (SSP). Subjects recruited from the community (n=71; 29 with SSP), without a known family history of psychosis, constituted the comparison groups. The traditional smooth pursuit gain measure, which is a ratio of smooth pursuit eye velocity in response to both retinal and extraretinal motion signals and the target velocity, was obtained. In addition, newly developed measures of predictive smooth pursuit (ie, in the presence of only extraretinal motion signals) were obtained. The latter measures were evaluated after the current retinal motion signals were made unavailable by briefly making the target invisible. RESULTS: Relatives, particularly those with SSP, showed significantly poorer predictive pursuit response to extraretinal motion signals (F(2,136)=6.51, P<.005), compared with the community subjects. However, the traditional smooth pursuit gain in response to both retinal and extraretinal motion signals was not different between groups. CONCLUSIONS: These results suggest that relatives of patients with schizophrenia, particularly those with SSP, have specific deficits in predictive pursuit based on only extraretinal motion signals. Normal smooth pursuit gain in response to both retinal and extraretinal motion signals is likely due to compensation based on retinal motion information. The latter suggests normal retinal motion processing and smooth pursuit motor output.     

Rate of binocular rivalry alternation in psychotic and nonpsychotic patients.

To determine the relationship between binocular rivalry rate and the presence of psychopathology, rivalry rate measures for 2 1-min. observation periods were taken from 3 matched groups of organic, schizophrenic, and nonorganic-nonpsychotic patients. The rate of the nonorganic-nonpsychotic group increased significantly over observation periods relative to the other groups, a result consistent with other data which suggests that rate provides some measure of cognitive efficiency. Differences in rate between organic and schizophrenic groups were not found, contrary to previous report. Procedural variables which could account for the discrepancy are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Intestinal permeability in patients with Crohn''s disease and ulcerative colitis and their first degree relatives

A method has been devised for predicting the ability of drugs to cross the blood-brain barrier. The criteria depend on the amphiphilic properties of a drug as reflected in its surface activity. The assessment was made with various drugs that either penetrate or do not penetrate the blood-brain barrier. The surface activity of these drugs was quantified by their Gibbs adsorption isotherms in terms of three parameters: (i) the onset of surface activity, (ii) the critical micelle concentration, and (iii) the surface area requirement of the drug at the air/water interface. A calibration diagram is proposed in which the critical micelle concentration is plotted against the concentration required for the onset of surface activity. Three different regions are easily distinguished in this diagram: a region of very hydrophobic drugs which fail to enter the central nervous system because they remain adsorbed to the membrane, a central area of less hydrophobic drugs which can cross the blood-brain barrier, and a region of relatively hydrophilic drugs which do not cross the blood-brain barrier unless applied at high concentrations. This diagram can be used to predict reliably the central nervous system permeability of an unknown compound from a simple measurement of its Gibbs adsorption isotherm.     

Antisaccades and smooth pursuit eye tracking and schizotypy

Although severe combined immunodeficient (SCID) mice are considered useful as an animal model for human hematopoietic diseases, the complete reconstruction of human hematopoietic cells can not be established even in these mice. This appears to be because human cytokines, adhesion molecules and extracellular matrices which support differentiation and growth of human hematopoietic cells differ from those in animals. To improve this animal model, we attempted to produce transgenic (Tg) mice producing human interleukin 3 (hIL-3) and human granulocyte macrophage colony stimulating factor (hGM-CSF) with the homozygote of the scid gene. We established two Tg mouse lines, one releasing both 0.5-1 ng/ml of hIL-3 and 0.05-0.2 ng/ml of hGM-CSF in their sera and another releasing only high (2-10 ng/ml) levels of hGM-CSF. When human cytokine-dependent myeloid cell line, TF-1, was subcutaneously transplanted into these two Tg-SCID mouse lines, TF-1 could be successfully engrafted and grew in all lines of Tg-SCID mice but not in control mice. We also observed that TF-1 grows in GM-CSF Tg-SCID mice in a dose dependent manner in vivo and IL-3 shows an additive effect on its growth. These results indicated that these Tg-SCID mice were an useful in vivo model for investigating human leukemogenesis, especially the role of IL-3 and GM-CSF in leukemogenesis.     

Somatic therapy as discussed by psychotic patients.

The verbatim, tape-recorded account of an unrehearsed meeting of a group of patients at a neuropsychiatric hospital is presented. The patients were brought together to participate in a panel discussion on mental illness as part of a public information project. Their reactions to somatic treatment methods are included. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Comments on "Smooth-pursuit eye movements: A comparison of two measurement techniques" by Lindsey, Holzman, Haberman, and Yasillo.

D. T. Lindsey et al (1978) reported that the qualitative comparability of smooth-pursuit eye movement recordings derived from EOG and infrared reflection techniques is high. When Ss were examined who displayed what P. S. Holzman et al (1978) have labeled in their schizophrenic patients a "Type II" tracking dysfunction, there was poor correspondence between the 2 methods, indicating that the spikes evident in Type II tracking do not stem from movement of the eyes. (5 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Relationship of gender and marital status with symptomatology in psychotic patients.

Examined the relationship of gender and marital status with ratings of symptoms in 882 psychiatric patients (521 males and 361 females) diagnosed as schizophrenic on the DSM-II. Analysis of total symptom scores revealed an interactive effect of gender and marital status; married women (mean age 37.02 yrs) had the highest total symptom scores, whereas married men (mean age 34.88 yrs) had the lowest. Factor analysis of the symptom ratings yielded 9 symptom factors: Ideational Symptoms, Anhedonia, Cognitive Disorientation, Suicidal Tendencies, Vegetative Symptoms, Hostility, Anxiety, Narcotic Abuse, and Alcohol Abuse. Factor scores were then computed to investigate possible gender and marital status differences in symptom pattern. Different profiles of symptoms as a function of gender were found. Females scored higher on the factors defined by affective symptoms, namely, Anhedonia, Suicidal Tendencies, and Vegetative Symptoms. They also scored higher on Cognitive Disorientation. The only factor on which males scored higher than females was Alcohol Abuse. Results are discussed in light of selection and protection theories of the relationship between marital status and mental health. (30 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)