Childhood depression and conduct disorder: II. An analysis of family interaction patterns in the home.

Directly sampled the interaction patterns of families with depressed (DEP), conduct-disordered (CD), mixed DEP-CD, and comparison children (aged 7–14 yrs) in the homes during the evening meal. Observational measures were taken of positive and aversive behaviors and affect expression for both parents, the referred children, and their siblings. Results replicated previous research showing that CD children express high levels of aversive behavior and anger and are part of a family system marked by conflict and aggression. The DEP children were exposed to maternal aversiveness but did not show any evidence of elevated levels of anger or aversiveness. Surprisingly, this was also true for the mixed-disorder children. High levels of depression in both groups of DEP children were associated with low levels of conflict and anger in family members. Overall, siblings showed very similar patterns of behavior and were exposed to similar patterns of parental behavior as the referred children. Results are discussed in terms of family models that emphasize the function of aggression and depression in the maintenance of child psychopathology. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Primary affective disorder: Thought disorder in depression.

To investigate the occurrence of 1 type of thought disorder in depression, here defined as impairment in abstractive performance, 65 hospitalized depressed patients and 49 normal controls were compared on the Category Test (CT). 36 patients had been diagnosed as bipolar and 29 as unipolar. Analysis of covariance indicated that the depressed groups had significantly more errors than the control group on the CT, suggesting that severely depressed patients show the type of thought disorder defined in this study. No significant differences were found, however, between the CT scores of the unipolar and bipolar groups. The possibility that some features of the depressed state can be described as cerebral dysfunction is discussed. (22 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Childhood social interactions and young adult bad conduct.

Case history data of former patients at 2 child guidance clinics that had been subsequently discharged from service because of bad conduct were examined. A major and significant trend was found reflecting an inverse relationship between peer group adjustment and evidence of bad conduct. The adult "bad conduct" group seemed to be characterized as children who had antagonized their peers to an unusual degree. The results demonstrated the predictive value of adjustment in childhood and behavior in adulthood. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Construct accessibility and depression: An examination of cognitive and affective factors.

Two experiments with undergraduates examined the parameters of construct accessibility in depression. In Exp I, 30 depressed and nondepressed (the Beck Depression Inventory) Ss were required to name the colors of tachistiscopically presented depressed-content, neutral-content, and manic-content words. Because of the predicted accessibility and interference effects of the depressed-content words, depressed Ss were predicted to demonstrate longer response latencies to these words than to the non-depressed-content words. Results support the prediction: Nondepressed Ss did not demonstrate differential response latencies. In Exp II (30 Ss), a mood-induction paradigm was used to investigate whether the interference effects obtained in Exp I were due to temporary mood differences between depressed and nondepressed Ss or were a function of more stable depression-associated patterns of information processing. Although predicted group differences were obtained on a mood adjective checklist, no effects were found for task performance. Findings suggest that transient mood is not a sufficient explanation for the results obtained in Exp I. Implications for the understanding of both construct accessibility and depression are discussed. (68 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Social-cognitive interactions, motivation, and cognitive growth in Logo programming and CAI problem-solving environments.

Extending earlier work by D. H. Clements and B. K. Nastasi (1985, 1988), this study investigated whether children working in two educational computing environments—Logo and computer-assisted instruction (CAI) problem-solving—exhibited differing amounts of behaviors indicative of cooperative interaction, conflict and resolution, effectance motivation, and self-evaluation. Ss were 12 fourth and 28 sixth graders randomly assigned to Logo or CAI. Toward the end of 42 treatment sessions, Ss working in pairs were videotaped. Children in Logo evinced more cognitively oriented conflict, attempts at and successful resolution of conflicts, rule making, and pleasure at discovery. Resolution of cognitive conflict more than the occurrence of conflict predicted problem-solving performance and accounted for treatment effects on problem solving. Findings suggest that Logo may foster cognitive growth through opportunities for resolving cognitive conflict and may enhance effectance motivation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Social status and the comorbidity of child depression and conduct disorder.

This study examined the overlap between child depression (DEP) and conduct disorder (CD) as a function of peer social status (i.e., popular, rejected, neglected, controversial, average) in a sample of 1,464 nonreferred 4th graders. Both DEP and CD were measured by self-report, peer nomination, and teacher ratings. Social status was assessed by peer nomination. A strong correlation (.73) was found between DEP and CD, even after accounting for shared method variance by confirmatory factor analysis. Furthermore, the number of Ss who scored high on both DEP and CD was greater than would be expected by chance alone. Multivariate tests revealed that rejected Ss scored higher than average Ss on measures of DEP and CD. Controversial boys also scored higher on measures of CD. However, analyses also revealed that the association between depression and rejected social status might be due to a subgroup of depressed children who also manifested symptoms of CD. Implications for assessment and treatment of child disorders are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self-appraised problem-solving ability, affective states, and psychological distress.

According to the social problem-solving model, a positive problem orientation wards off negative affect and promotes positive affect to enhance problem solving. It was hypothesized that the Problem-Solving Confidence and Personal Control factors on the Problem-Solving Inventory (P. P. Heppner, 1988) constitute facets of the problem orientation component; therefore, these variables should be significantly associated with negative affect, positive affect, and psychological distress over time. In a series of studies, a positive problem orientation was prospectively associated with greater positive and lower negative affect under a variety of conditions. However, the relation of the problem orientation variables to distress appeared to be mediated by trait affectivity. Results are interpreted in light of the social problem-solving model, and implications for counseling are discussed. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Childhood family antecedents of dependency and self-criticism: Implications for depression.

Presents an etiologic model of how relationships with parents in childhood influence differential vulnerability to distinctive depressive experiences associated with issues of dependency or self-criticism. 86 female undergraduates were administered a battery of measures, including the Depressive Experiences Questionnaire, to measure Ss' current experiences of dependency and self-criticism. These were correlated with their retrospective reports of parental behavior in childhood. It was predicted that Ss high on dependency would report the mother as being the more dominant parent and as emphasizing strict control, expressing inconsistent affection, and expecting conformity to authority rather than achievement. Individuals high on self-criticism, in contrast, would report the father as more dominant and both parents as emphasizing strict control, expressing inconsistent affection, and expecting achievement and success rather than passive conformity. Results generally support these predictions and complement the findings of other recent studies of depressed individuals' memories of their parents' childrearing practices. (20 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Enhancement of social learning family interventions for childhood conduct disorder.

Identifies approaches for maximizing treatment gains for the conduct-disordered child. Relevant studies were organized into 3 approaches: enhancements and expansions (a) within a dyadic (parent–child) interaction model, (b) within a broad-based model that acknowledges a wider range of family influences, and (c) through a multisystems model. Social learning family intervention (SLFI) enhancements within the dyadic model have centered on either the strengthening of parental skills already included in the SLFI regimen or the adding of new interactional strategies. Some gains, but only partial success, have been achieved with the dyadic model supplements. SLFI expansions from a broad-based model have focused on parental adjustment, parental expectations during treatment, and social-environmental stressors. The multisystems adjuncts to SLFI include cognitive-behavioral interventions to affect peer relations and ecological approaches to sweep across domains. The broad-based and multisystems expansions have produced promising but undertested treatment regimens. Related areas of investigation included therapy process research, medication combined with SLFI, and the involvement of fathers in treatment. Recommendations are offered for improvement of SLFI research. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Shifts in affective balance during cognitive therapy of major depression.

32 outpatient depressives were treated by experienced therapists during a 16- to 20-wk, 20- to 24-session cognitive-behavioral therapy (CBT) protocol. Patients were classified as CBT responders (n?=?22) or nonresponders (n?=?10) on the basis of independent clinical ratings of Hamilton Rating Scale for Depression severity. Point and confidence interval estimation procedures yielded results consistent with hypotheses derived from the states-of-mind (SOM; R. M. Schwartz and G. L. Garamoni, 1986) model. At posttreatment, CBT responders shifted the balance of positivity and negativity to the optimal range, whereas nonresponders remained in a predominantly negative SOM. Response status was related more strongly to change in positivity than in negativity. Findings support the view that clinical response to CBT depends on reducing negativity and increasing positivity until an optimal balance is achieved. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Adult physical health outcomes of adolescent girls with conduct disorder, depression, and anxiety

We have previously shown that feather formation in chick embryonic skin depends on accumulation of sulphated glycosaminoglycans in the underlying mesenchyme, and that addition of spermidine to chick embryo fibroblasts increases the extracellular sulphated glycosaminoglycans. In the present work, using histological, histochemical and biochemical procedures, we have investigated the effects on glycosaminoglycan accumulation and on epithelial differentiation of adding spermidine and bis-cyclohexylammonium sulphate, a spermidine inhibitor, to embryonic chick skin cultures. Our results demonstrate that spermidine induces an accumulation of sulphated glycosaminoglycan and an increase in feather formation, suggesting that the morphogenetic effect of spermidine may be dependent on specific glycosaminoglycan accumulation.     

Homeless youth in London: I. Childhood antecedents and psychiatric disorder

Previous studies have shown that triggering multiple myeloma (MM) cells via CD40 induces IL-6-mediated autocrine growth as well as increased expression of cell surface adhesion molecules including CD11a, CD11b, CD11c, and CD18. In this study, we generated the 5E2 mAb which targets an antigen that is induced upon CD40 ligand (CD40L) activation of MM cells. Immunofluorescence, immunoprecipitation, and protein sequencing studies identified the target antigen of 5E2 mAb as the 86-kD subunit of the Ku autoantigen. We demonstrate that increased cell surface expression of Ku on CD40L-treated cells is due to migration of Ku from the cytoplasm to the cell surface membrane. Moreover, cell surface Ku on CD40L-treated MM cells mediates homotypic adhesion of tumor cells, as well as heterotypic adhesion of tumor cells to bone marrow stromal cells and to human fibronectin; and 5E2 mAb abrogates IL-6 secretion triggered by tumor cell adherence to bone marrow stromal cells. These data suggest that CD40L treatment induces a shift of Ku from the cytoplasm to the cell surface, and are the first to show that Ku functions as an adhesion molecule. They further suggest that cell surface Ku may play a role in both autocrine and paracrine IL-6-mediated MM cell growth and survival.     

Antisocial personality disorder, conduct disorder, and substance abuse in schizophrenia.

The validity of subtypes based on antisocial personality disorder (APD) or childhood conduct disorder without adult APD (CD only) in patients with schizophrenia (or schizoaffective disorder) and a substance use disorder (abuse or dependence) was examined. APD patients scored lower on personality measures related to socialization and higher on antisocial bebavior, psychopathy, and aggression. APD patients also reported higher rates of aggression and legal problems. APD, and to a lesser extent CD only, was associated with more severe psychiatric symptoms, an earlier age of onset of substance abuse, more severe symptoms of substance abuse, and a stronger family history of substance abuse and psychiatric hospitalization. The findings suggest that schizophrenia patients with APD represent a high-risk subgroup vulnerable to more severe substance abuse, psychiatric impairment, aggression, and legal problems. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Family process and adaptation to children with mental retardation: Disruption and resilience in family problem-solving interactions.

Family problem-solving interactions were examined in families (N?=?165) of school-aged children with mild or moderate mental retardation (MR) and a comparison sample (N?=?52). The results demonstrated a disruptive impact of children with MR in the form of more directiveness by mothers and fathers, less supportive problem solving by single mothers, and less active problem solving by the target children in the MR group. Nevertheless, the absence of high rates of aversive behaviors in the MR group and the similarities in siblings' behaviors across the groups suggested that the MR families were also resilient in the face of special demands. Role differences among mothers, fathers, and siblings also were highly consistent in the two groups. Evidence of difficulties for single mothers and problem behaviors by other children in the family suggested that mental retardation is one of many challenges that families learn to cope with successfully. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self-knowledge and social inference: I. The impact of cognitive/affective and behavioral data.

Two studies investigated the sources of information that people would perceive as diagnostic of self. In Study 1, 40 undergraduates completed a questionnaire in which they rated private thoughts and feelings, other peoples' as well as their own, as far more informative and prototypic of self than overt actions. In Study 2, 48 undergraduate speakers participated in a structured interview during which they revealed either a sample of their past thoughts and feelings, a sample of their past behavior, or a mixture of these 2 types of information to 71 undergraduate observers who watched and listened from behind a 1-way mirror. The interviews offering cognitive/affective revelations were perceived, both by the speakers themselves and by observers, to be more informative than interviews offering behavioral revelations. Analyses from both studies, however, suggest that the tendency to weight cognitive/affective information more heavily than behavioral information may be stronger and more consistent for self-perception than social perception. Study 2, in particular, indicates that speakers made more extreme dispositional inferences based on cognitive/affective interviews, whereas observers did not. Ratings of interpersonal liking closely paralleled ratings of perceived informativeness for the questionnaire responses in Study 1 but not for the responses to explicit revelations of thoughts and feeling vs behavior in Study 2. Sex differences were also observed on several measures. (38 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Diagnostic conundrum of oppositional defiant disorder and conduct disorder.

Evidence for a diagnostic distinction of oppositional defiant disorder (ODD) and conduct disorder (CD) is reviewed, and alternative conceptualizations and definitions for the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) are considered. Studies suggest that CD and ODD are strongly and developmentally related but clearly different. Factor analyses indicate that distinct covarying groups of ODD and CD symptoms can be identified, but certain symptoms relate to both (particularly mild aggression and lying). Age of onset for ODD is earlier than for most CD symptoms. Nearly all youths with CD have a history of ODD, but not all ODD cases progress to CD. The disorders demonstrate the same forms of parental psychopathology and family adversity but to a greater degree for CD than for ODD. Alternative conceptualizations for the disorders are presented for further study before the introduction of the DSM-IV. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Comorbid panic disorder and major depression: Implications for cognitive–behavioral therapy.

Panic disorder and major depression frequently coexist, yet the implications of comorbidity for psychological treatments have rarely been studied. The objective of this study was to evaluate whether pretreatment comorbidity of major depression affects the outcome of cognitive–behavioral treatment (CBT) of panic disorder. Thirty-seven clients who met diagnostic criteria for both panic and major depression participated in 10 sessions of individual CBT for panic. Treatment outcome was contrasted with the outcome of 53 clients having only panic disorder who received the same treatment. The cooccurrence of depression did not adversely affect CBT for panic. These results have implications for clinical practice and theoretical implications for the nature of the relationship between panic and depression. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Childhood and adolescent depression: a review of the past 10 years. Part I

OBJECTIVE: To qualitatively review the literature of the past decade covering the epidemiology, clinical characteristics, natural course, biology, and other correlates of early-onset major depressive disorder (MDD) and dysthymic disorder (DD). METHOD: A computerized search for articles published during the past 10 years was made and selected studies are presented. RESULTS: Early-onset MDD and DD are frequent, recurrent, and familial disorders that tend to continue into adulthood, and they are frequently accompanied by other psychiatric disorders. These disorders are usually associated with poor psychosocial and academic outcome and increased risk for substance abuse, bipolar disorder, and suicide. In addition, DD increases the risk for MDD. There is a secular increase in the prevalence of MDD, and it appears that MDD is occurring at an earlier age in successive cohorts. Several genetic, familial, demographic, psychosocial, cognitive, and biological correlates of onset and course of early-onset depression have been identified. Few studies, however, have examined the combined effects of these correlates. CONCLUSIONS: Considerable advances have been made in our knowledge of early-onset depression. Nevertheless, further research is needed in understanding the pathogenesis of childhood mood disorders. Toward this end, studies aimed at elucidating mechanisms and interrelationships among the different domains of risk factors are needed.     

Sources of covariation among attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder: The importance of shared environment.

Research has documented high levels of covariation among childhood externalizing disorders, but the etiology of this covariation is unclear. To unravel the sources of covariation among attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and conduct disorder (CD), the authors studied 11-year-old twins (N/&=/&1,506) from the Minnesota Twin Family Study. Symptom counts for each of these disorders were obtained from interviews administered to the twins and their mothers. A model was fit that allowed the parsing of genetic, shared environmental (factors that make family members similar to each other), and nonshared environmental (factors that make family members different from each other) contributions to covariation. The results revealed that although each disorder was influenced by genetic and environmental factors, a single shared environmental factor made the largest contribution to the covariation among ADHD, ODD, and CD. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Demographics, family history, premorbid functioning, developmental characteristics, and course of patients with deteriorated affective disorder

OBJECTIVE: This exploratory study examined the characteristics of a group of unusual and previously undescribed patients with major affective disorder who not only had been continuously symptomatic for prolonged periods of time but were also so functionally impaired that they required years of continuous care in psychiatric facilities or by family members. METHOD: Twenty-seven inpatients with major mood disorders and 29 inpatients with schizophrenia were recruited from a large state hospital; 27 outpatients with major mood disorders were recruited from an affiliated outpatient facility. The research battery included the Structured Clinical Interview for DSM-III-R--Patient Version, the Premorbid Adjustment Scale, and a semistructured interview designed to assess demographic, family history, developmental, and course information. RESULTS: Inpatients with deteriorated affective disorder differed from outpatients with nondeteriorated affective disorder along several important dimensions, including family history of mental illness, birth-related problems, physical disorders in infancy, premorbid functioning, presence of mixed episodes and rapid cycling, and medication non-compliance between hospitalizations. Inpatients with deteriorated affective disorder differed from inpatients with schizophrenia on the Premorbid Adjustment Scale. Patients with bipolar affective disorder differed from those with unipolar disorder on many of the variables associated with deterioration of functioning. CONCLUSIONS: Birth-related problems, physical disorders in infancy, and poor premorbid adjustment in childhood and adolescence appear to play an important role in deterioration of functioning among patients with unipolar depression. Disruption in treatment because of medication noncompliance and the appearance of mixed episodes and rapid cycling are associated with functional decline in bipolar affective disorder. Several characteristics previously considered specific to deterioration of functioning in schizophrenia, such as a high rate of birth complications and poor premorbid adjustment, appear to be associated with functional deterioration among patients with major depression as well.