Differential effects of methamphetamine and haloperidol on the control of an internal clock.

Humans and animals process temporal information as if they were using an internal stopwatch that can be stopped and reset, and whose speed is adjustable. Previous data suggest that dopaminergic drugs affect the speed of this internal stopwatch. Using a paradigm in which rats have to filter out the gaps that (sometimes) interrupted timing, the authors found that methamphetamine and haloperidol also affect the stop and reset mechanism of the internal clock, possibly by modulating attentional components that are dependent on the content and salience of the timed events. This is the fist report of both clock and attentional effects of dopaminergic drugs on interval timing in the same experimental setting. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Contextual modulation of stimulus generalization in rats.

One connectionist analysis of the acquired equivalence/distinctiveness of cues assumes that when similar compounds (e.g., AX and BX) are paired with the same outcome (e.g., food, +; or no food, ?), their components come to activate the same configural unit (ABX). When these compounds are paired with different outcomes, their components will come to address different units. Here, rats received appetitive training with eight compounds (e.g., AX+, BX+, CX?, DX?, AY+, BY?, CY?, DY+) that should generate the following configural units: ABX, CDX, ADY, and BCY. In Experiment 1, rats then received aversive conditioning to A, which should activate and revalue representations ABX and ADY. Subsequently, compounds that provided dual activation (i.e., BX and DY) of one of the revalued configural units (ABX and ADY) were shown to elicit greater fear than those compounds that provided a single source of activation to each unit (i.e., DX and BY). Experiment 2 confirmed and extended these findings. These results provide support for the connectionist analysis outlined above and are consistent with the application of this approach to the acquired equivalence/distinctiveness of cues. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Stimulus generalization as a function of clinical anxiety and direction of generalization.

"This experiment studied stimulus generalization in psychiatric patients as a function of direction of generalization and clinical anxiety. It was found that direction of generalization along the height continuum did not significantly affect the gradient of stimulus generalization. Level of clinical anxiety, as measured by the Taylor Manifest Anxiety Scale, also did not significantly affect the gradient of stimulus generalization. The validity of the Taylor scale with psychiatric patients was discussed briefly." (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of D-cycloserine on extinction of conditioned freezing.

The present study tested the prediction that D-cycloserine (DCS), a partial N-methyl-D-aspartate agonist, would facilitate extinction of conditioned freezing in male Sprague-Dawley rats. Rats received 5 light-shock pairings (conditioning). The following day, rats received 6 light-alone presentations (extinction training). Twenty-four hours later, rats received 1 light-alone presentation (test). Subcutaneous DCS injection before or after extinction training significantly enhanced extinction, and the dose-response curve for this effect was linear. Increasing the delay of DCS administration after extinction training led to a linear decrease in the facilitatory effect. The effect of systemic administration was replicated by intra-basolateral amygdala infusion. These results suggest that DCS facilitates extinction of conditioned freezing by acting on consolidation processes partly mediated by the basolateral amygdala. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Modulation of the Effective Salience of a Stimulus by Direct and Associative Activation of Its Representation.

In 2 experiments, rats received exposure to presentations of a footshock preceded by a given cue. In the PRf (partial reinforcement) condition, this cue also occurred in the absence of the shock; in the CRf (continuous reinforcement) condition, it did not. Subsequent testing in which a new stimulus was used to signal the shock (Experiment 1) showed that the shock was more effective as a reinforcer for the PRf than for the CRf group. In Experiment 2, the shock was used as a conditioned stimulus signaling food delivery, and it was found that conditioning occurred more readily in the PRf than in the CRf group. These results accord with the hypothesis that preexposure to the shock results in a decline in its effective salience but that experience of a cue that signals shock in the absence of the shock itself attenuates this effect and helps maintain stimulus salience. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Differential effects of list strength on recollection and familiarity.

Numerous studies have found a null list strength effect (LSE) for recognition sensitivity: Strengthening memory traces associated with some studied items does not impair recognition of nonstrengthened studied items. In Experiment 1, the author found a LSE using receiver operating characteristic-based measures of recognition sensitivity. To account for the discrepancy between this and prior research, the author (a) argues that a LSE occurs for recollection but not for discrimination based on familiarity, and (b) presents self-report data consistent with this hypothesis. Experiment 2 tested the dual-process hypothesis more directly, using switched-plurality (SP) lures to isolate the contribution of recollection. There was a significant LSE for comparisons involving SP lures; the LSE for discrimination of studied items and nominally unrelated lures (which can be supported by familiarity) was not significant. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Practice effects on two memory retrievals from a single cue.

The effects of practice on 2 retrievals from a single cue were investigated. In Experiment 1, participants were given extended single-task practice and were then tested on a dual memory retrieval task. Performance was consistent with a sequential retrieval model proposed by T. C. Rickard and H. Pashler (2003). In Experiment 2, participants practiced both single- and dual-retrieval tasks extensively. Initially, data from all participants indicated sequential retrieval. However, participants who grouped the 2 response outputs were eventually able to perform the dual task with a latency that approached the prediction of a parallel race model. Models that assume a transition from sequential to parallel retrieval with practice, along with other models that assume an immutable retrieval bottleneck at all practice levels, are considered. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The effects of social and nonsocial censure on stimulus generalization in neurotics and schizophrenics.

36 schizophrenic and 36 neurotic depressive Ss were given a visual-spatial generalization task under either social or nonsocial (impersonal) censure conditions. The following hypotheses derived from previous investigations were tested: (1) schizophrenics would show higher gradients of generalization than neurotic depressives, and (2) generalization gradients would be higher under conditions of social as opposed to nonsocial censure, especially in schizophrenics. The data supported Hypothesis 1 but not Hypothesis 2. There was no evidence for differential responding between these 2 groups with respect to either stimulus generalization or response to censure. It was suggested that hypotheses concerning the schizophrenic's performance in these 2 situations have been biased and oversimplified by use of normal, rather than patient, control groups in previous investigations. (22 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Differential effects of training intertrial interval on acquisition of trace and long-delay fear conditioning in rats.

Many factors govern conditioning effectiveness, including the intertrial interval (ITI) used during training. The present study systematically varied the training ITI during both trace and long-delay fear conditioning. Rats were trained using one of six different ITIs and subsequently tested for conditioning to the white noise conditioned stimulus (CS) and the training context. After trace conditioning, percent freezing to the CS was positively correlated with training ITI, whereas percent freezing to the context was negatively correlated with training ITI. In contrast, when rats were trained using a long-delay paradigm, freezing during the CS test session did not vary as a function of training ITI; rats exhibited robust freezing at all ITIs. The long-delay conditioned rats exhibited relatively low levels of freezing during the context test. Thus, trace is more sensitive than long-delay fear conditioning to variations in the training ITI. These data suggest that training ITI is an important variable to consider when evaluating age or treatment effects, where the optimal ITI may vary with advancing age or pharmacological treatment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Hippocampal formation supports conditioning to memory of a context.

It has been proposed that contextual fear conditioning depends on 2 processes: (a) construction of a conjunctive representation of the features that make up the context and (b) association of the representation with shock. Support for this view comes from studies indicating that prior exposure to the conditioning context facilitates contextual fear conditioning supported by immediate shock. Thus, conditioning produced by immediate shock is to the memory representation of the preexposed context, which is activated by retrieval cues associated with this context. The authors' experiments support this interpretation and indicate that this process depends on an intact hippocampal formation. These results support the hypothesis that the hippocampal formation supports contextual fear conditioning by storing a conjunctive representation of context. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Familiarity-based stimulus generalization of conditioned suppression in rats is dependent on the perirhinal cortex.

We report that bilateral, excitoxic lesions of the perirhinal cortex attenuate rats' familiarity-based stimulus generalization. After surgery, rats were preexposed either to 2 auditory stimuli (A and B) or to only 1 auditory stimulus (B). Following preexposure, all rats received pairings of A and a footshock before assessment of generalized responding (conditioned suppression) to B. Sham rats' generalization was greater when preexposure was to both A and B than when preexposure was to B only. That pattern was abolished in lesioned rats, though no general deficiency was found in other measures of auditory processing. Our findings suggest that the perirhinal cortex is required for rats to encode familiarity as part of stimulus representations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The conditioning and generalization of changes in social perceptual dispositions.

This study examines hypotheses regarding the extent to which social perception may be effected by differential reinforcement and trait generalization. Ss are asked to judge photographs of faces as reflecting either one or the other of the following dimensions: safe-dangerous, good-bad, reliable-unreliable, and relaxed-tense. Selective response by E (saying "right" after the judgment "safe" was made," "wrong" after "dangerous") produced conditioning of the desired response and generalization to the other dimensions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Role of the medial prefrontal cortex in acquired distinctiveness and equivalence of cues.

In the present study, the authors examined the role of the medial prefrontal cortex in acquired equivalence and distinctiveness of cues. Rats were placed in 4 experimental contexts (A, B, C, and D) where they received presentations of 2 auditory stimuli (X and Y). In Contexts A and B, X was paired with food and Y was not, whereas in Contexts C and D, Y was paired with food and X was not. Rats that received sham lesions and those with lesions of the medial prefrontal cortex acquired this configural discrimination equally readily. Rats then received many pellets in A but not in C. After this training, sham-lesion rats exhibited more magazine activity in B than in D (an acquired distinctiveness/acquired equivalence effect), whereas those with medial prefrontal cortex lesions did not. These results indicate that the medial prefrontal cortex is involved in the process by which experience with stimuli influences the degree of generalization between them. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Reinstatement of extinguished fear by β-adrenergic arousal elicited by a conditioned context.

Five experiments examined the reinstatement of fear (freezing) produced by recent reexposure to a dangerous context. Rats were trained to fear a conditioned stimulus (CS) and a distinctive context with shock. The CS was then extinguished. A 2-min interval between reexposure to the dangerous context and presentation of the extinguished CS in a different context reinstated freezing when the CS was tested the next day. Propranolol (a β-adrenergic antagonist) blocked reinstatement of extinguished fear without decreasing freezing to a nonextinguished CS. Administration of epinephrine (an adrenergic agonist) reinstated extinguished fear without reexposure to the dangerous context. The results suggest a role for β-adrenergic activity elicited by exposure to a conditioned context in the reinstatement of extinguished fear. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Two roles of the context in Pavlovian fear conditioning.

At both empirical and theoretical levels, multiple functional roles of contextual information upon memory performance have been proposed without a clear dissociation of these roles. Some theories have assumed that contexts are functionally similar to cues, whereas other views emphasize the retrieval facilitating properties of contextual information. In Experiment 1, we observed that one critical parameter, the spacing of trials, could determine whether the context would function as a conditioned stimulus or as a retrieval cue for memories trained in different phases. Experiments 2 and 3 doubly dissociated these functions by selectively disrupting one role but not the other, and vice versa. Overall, these observations identify one determinant of different functions of contextual information and pose a major challenge to theories of learning that assume exclusively one or the other function of the context. Moreover, these data emphasize the importance of parametric variations on behavioral control, which has critical implications for studies designed to understand the role of the hippocampus in processing of contextual attributes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Differential effects of cue changes and task changes on task-set selection costs.

A task-switching paradigm with a 2:1 mapping between cues and tasks was used to separate cue-switching processes (indexed through pure cue-switch costs) from actual task-switching processes (indexed through additional costs in case of cue and task changes). A large portion of total switch costs was due to cue changes (Experiments 1 and 2), and cue-switch costs but not task-switch costs were sensitive to effects of practice (Experiment 1) and preparation (Experiment 2). In contrast, task-switch costs were particularly sensitive to response-priming effects (Experiments 1 and 2) and task-set inhibition (Experiment 3). Results suggest two processing stages relevant during task-set selection: cue-driven retrieval of task rules from long-term memory and the automatic application of rules to a particular stimulus situation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The retention and generalization of operant conditioning effects in an interview situation.

In a study of the conditioning of complex verbal habits, each of 30 female Ss had her established verbal habits assessed in 2 sessions by being asked to talk about herself. In subsequent sessions, the Ss in the experimental groups were positively reinforced (by a head nod and an "mm-hm") for either independence or affection statements, whereas control groups Ss were reinforced every 30 sec. regardless of the content of their speech. The results showed that: conditioning occurred, i.e., the experimental Ss increased in their use of the reinforced category; retention also occurred, i.e., the conditioning effects were stable over a 24-hr. period; and generalization did not occur. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Transfer of the effects of verbal conditioning.

Experimental Ss were verbally conditioned to use more future tense responses in making up sentences. Transfer effects were assessed using a 2nd sentence completion task containing certain stimulus cues present on the original task. Transfer of learning was demonstrated on the basis of a grossly defined, 2-step gradient of similarity of stimulus cues contained on the learning and transfer tasks. The variables of S's awareness and S's sex did not lead to statistically significant between-group differences. The response form (written vs. oral) also failed to demonstrate a significant effect. (15 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Differential outcome effects in Pavlovian biconditional and ambiguous occasion setting tasks.

Three experiments with rats explored the differential outcome effect (DOE) using a Pavloian magazine approach conditioning preparation. Experiment 1 compared groups trained on a biconditional discrimination (AX+, AY?, BX?, BY+) with differential or nondifferential outcomes, and Experiment 2 examined this using an ambiguous occasion setting task (e.g., AX+, X?, Y+, AY?). In both experiments, subjects trained with differential outcomes learned the tasks better than subjects trained with nondifferential outcomes. Furthermore, subjects given differential outcome training learned the positive occasion setting component of the ambiguous task more efficiently than the negative occasion setting component, although both were enhanced by differential outcome training. Experiment 3 demonstrated that the ambiguous occasion setting task was reversed more readily when the target–outcome relations (as opposed to the modulator–outcome relations) were maintained during the reversal phase. These data suggest that an acquired distinctiveness effect may be responsible for the DOE in Pavlovian learning. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Mediated generalization and the incubation effect as a function of manifest anxiety.

"Two groups of 45 Ss each were chosen on the basis of extreme scores on the MAS [Taylor Manifest Anxiety Scale]. A conditioned PGR was first established by repeated pairings of a critical word (CS) with a raucous buzzer. Tests of mediated generalization were made following training, using as generalization stimuli, words to which the CS was associated as determined by free associations of a standardization group. In order to investigate the incubation effect the Ss were divided following training into three subgroups differing in the length of the rest interval between conclusion of training and the institution of extinction trials (immediate extinction, 10-min. interval, and 24-hr. interval). The results indicated heightened responsivity towards words associated with the CS, thus indicating that mediated generalization had taken place. It was also found that extreme MAS scores were directly related to the magnitude of mediated generalization responsivity." Level of manifest anxiety was found to be directly related to conditioning responsivity as well as to resistance to extinction. 20 references. (PsycINFO Database Record (c) 2010 APA, all rights reserved)