Impaired priming of new associations in amnesia.

We assessed priming of new associations in amnesic patients and healthy control subjects in a paradigm developed by P. Graf and D. L. Schacter (see record 1986-12203-001). Subjects were presented unrelated word pairs embedded in sentences (e.g., A BELL was hanging over the baby's CRADLE) and were asked to rate how well the sentences related the two words. Subjects were then given a word completion test. They were shown three-letter word stems and were asked to complete the stem with the first word that came to mind. In the same context condition, each word stem was presented together with the word that had appeared in the same sentence during study (e.g., BELL-CRA ). In the different context condition, each stem was presented together with a new word that had never been presented (e.g., APPLE-CRA ). Control subjects completed more words in the same context condition than in the different context condition. In contrast, amnesic patients did not complete any more words in the same context condition than in the different context condition. Indeed, across two experiments none of the amnesic patients exhibited consistent priming of new associations. Thus, although amnesic patients do exhibit entirely normal priming of preexisting memory representations, they do not appear to exhibit priming of new associations in this paradigm. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Benefits of immediate repetition versus long study presentation on memory in amnesia.

Objective: This study aimed to resolve discrepant findings in the literature regarding the effects of massed repetition and a single long study presentation on memory in amnesia. Method: Experiment 1 assessed recognition memory in 9 amnesic patients and 18 controls following presentation of a study list that contained items shown for a single short study presentation, a single long study presentation, and three massed repetitions. In Experiment 2, the same encoding conditions were presented in a blocked rather than intermixed format to all participants from Experiment 1. Results: In Experiment 1, control participants showed benefits associated with both types of extended exposure, and massed repetition was more beneficial than long study presentation, F(2, 34) = 14.03, p F F(2, 50) = 4.80, p = .012, partial η2 = .16. Amnesic patients showed significant and equivalent benefit associated with both types of extended exposure, F(2, 16) = 5.58, p = .015, partial η2 = .41, but control participants again benefited more from massed repetition than from long study presentation, F(2, 34) = 23.74, p     

The realism in older people's confidence judgments of answers to general knowledge questions.

The study investigated 2 aspects of the accuracy (i.e., realism) of confidence judgments of persons age 60–93 years (N = 1,384) regarding their answers to general knowledge questions. These aspects are the level of confidence (calibration) in relation to the proportion of correct answers and the ability to discriminate between correct and incorrect answers by means of confidence judgments. No age differences were found for either of the 2 aspects. Gender differences were found for proportion of correct answers and confidence but not for the realism in the confidence judgments. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Impaired Implicit Memory for Gist Information in Amnesia.

In 2 experiments using a converging associates paradigm, the authors evaluated implicit memory for gist information in amnesic patients. In Experiment 1, participants saw multiple sets of associates, each converging on a nonpresented theme word, and were then tested using an implicit word stem completion test and an explicit cued recall test. Amnesic patients showed intact implicit and impaired explicit memory for studied words, but memory for nonpresented lures was impaired, regardless of retrieval instructions. To evaluate whether impaired implicit memory for lures was due to accelerated forgetting of gist information, short study lists were used in Experiment 2, each consisting of a single set of associates. Amnesics' implicit memory for lures was again impaired. These results point to an inability to encode robust gist representations as the cause of impaired gist memory in amnesia. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Bidirectional priming processes in the Simon task.

The Simon effect is mostly explained in terms of dual-route models, which imply unidirectional activation processes from stimulus features to response features. However, there is also evidence that these preactivated response features themselves prime corresponding stimulus features. From this perspective, the Simon effect should only occur whenever the response is unequivocally mapped to just 1 stimulus feature (one-to-one mapping). If, however, more than 1 stimulus feature is mapped to each spatial response (many-to-one mapping), priming activation should spread and thus reduce or eliminate the Simon effect. In a series of 4 Simon task experiments, the authors compared many-to-one with one-to-one mapping, holding stimulus set size constant. As was expected, the Simon effect was only present with one-to-one mapping but was eliminated with many-to-one mapping. The authors therefore suggest that the Simon effect also depends on priming from response features to stimulus features. Theoretical implications of these findings are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Stimulus-based priming of task choice during voluntary task switching.

Two voluntary task-switching experiments probed the influence of previous exposures to stimuli and categorizations of these stimuli on task choice during subsequent exposures to the same stimuli. Subjects performed origin and size judgments under standard voluntary task-switching instructions to perform the tasks equally often in a random order. Both when subjects voluntarily selected the task on the first exposure (Experiment 1) and when the experimenter manipulated the task on the first exposure (Experiment 2), subjects chose to perform the same task on subsequent exposures significantly more often than would be expected on the basis of the instructions to perform tasks in a random order. Presentation of a previously encountered stimulus may result in the retrieval of a stimulus–task binding or event file that biases task selection as well as task readiness. The pattern of data across the 2 experiments suggests that stimulus-based priming influences task choice through both retrieval of episodes within the context of the experiment and semantic memory mechanisms. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Neuropsychological dissociations between priming and recognition: A single-system connectionist account.

A key claim of current theoretical analyses of the memory impairments associated with amnesia is that certain distinct forms of learning and memory are spared. A compelling example is that amnesic patients and controls are indistinguishable in repetition priming but amnesic patients are impaired at recognizing the study items. The authors show that this pattern of results is predicted by a single-system connectionist model of learning in which amnesia is simulated by a reduced learning rate. They also demonstrate that the model can reproduce the converse pattern in which priming but not recognition is impaired if the input is assumed to be additionally degraded in a priming test. The authors conclude that dissociations between priming and recognition do not require functionally or neurally distinct memory systems. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Defining the boundary: Age-related changes in childhood amnesia.

Childhood amnesia refers to the inability of adults to recall events that occurred during their infancy and early childhood. Although it is generally assumed that children and adolescents also experience childhood amnesia, with limited exceptions, most empirical research on the phenomenon has focused exclusively on adults. Here, we developed a new Timeline procedure to directly compare the early memories reported by children, adolescents, and adults. Overall, the proportion of memories reported before the age of 3 years was greater for the children and adolescents relative to the adults. In addition, the single earliest memory reported by children and adolescents was at a younger age than that reported by adults. In fact, the earliest memories reported by the children and adolescents, but not the adults, were significantly younger than the traditional 3 ?-year-old boundary of childhood amnesia. Regardless of the age of the rememberer, participants' early memories had the same episodic characteristics. We conclude that the boundary and the density of childhood amnesia may increase over the course of human development and that age-related changes in basic memory mechanisms make an important contribution to our understanding of the source of childhood amnesia. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Adult aging effects on semantic and episodic priming in word recognition.

Two experiments compared automatic semantic and episodic priming effects in adult aging. In the 1st experiment, target words were semantically primed; in the 2nd experiment, targets were primed by repetition of semantically unrelated words. Both experiments involved a pronunciation task with response signals at fixed times following target onset. Consequently, priming was measured as improvement in the percentage of correct responses. Priming was also calculated with speed–accuracy measures of intercept and slope. Both types of priming effect were significant in the percentage correct and slope measures, but no age group differences were found. Furthermore, the magnitudes of the priming effects were equivalent. The age-resistant nature of semantic and episodic priming, as well as evidence for a common theoretical mechanism, is discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Benjamin Franklin and shock-induced amnesia.

Shock-induced amnesia received considerable attention after Cerletti popularized electroconvulsive shock therapy in the late 1930s. Yet, often overlooked is the fact that Benjamin Franklin recognized that passing electricity through the head could affect memory for the traumatic event. Franklin described his findings on himself and others in several letters from the mid-1700s, 2 of which were published in his lifetime. What he observed was confirmed in 1783 by physician Jan Ingenhousz, who was one of his correspondents. Although Ingenhousz had lost his memory for his electrical accident and was confused immediately afterward, he felt strangely elated and unusually sharp the next morning. Hence, he called for clinical trials with patients with melancholia who were not responding to more conventional therapies. After Franklin received Ingenhousz's letter, he also called for clinical trials. Neither man, however, tied the possible new cure for melancholia to the memory loss--nor did the operators that began to treat some patients with melancholia successfully with cranial shocks. Only much later would the amnesia be thought to be associated with the cure. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Long-term semantic priming of word meaning.

Three experiments investigated facilitation in synonym decisions as a function of prior synonym decision trials that were either identical or semantically related. Experiment 1 demonstrated that semantically related prime trials produced less facilitation than identical prime trials, but facilitation from both persisted over 14 intervening trials. Experiments 2 and 3 demonstrated that word meaning retrieval without meaning comparison in prime trials was sufficient for persistent facilitation in semantically related targets, and meaning comparison was necessary for repetition priming to show greater facilitation than semantic priming. Results suggest that semantic priming in this task may solely reflect strength changes in abstract semantic representations, whereas repetition priming may reflect additional nondeclarative memory for operations performed in prime events. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Nicotine effects on general semantic priming in Parkinson's disease.

In young healthy nonsmokers, effects of nicotine on semantic processing have been observed under strategy-based priming procedures but not under more general priming procedures (Holmes, Chenery, & Copland, 2008; Holmes, Chenery, & Copland, 2010). Effects of nicotine under general priming procedures, however, may be mediated by baseline priming levels that are below optimum such as when compromised by disease. Nicotinic mechanisms may be involved in the cognitive sequalae of Parkinson's disease (PD). Evidence suggests that semantic processing may be compromised in PD but the potential benefit of nicotinic stimulation is unknown. This study investigated the effects of nicotine on semantic processing in nonsmokers with PD (n = 12) and nonsmoking matched controls (n = 17) using general priming procedures. Specifically, an automatic priming task (0.15 relatedness proportion, RP, and 200 ms stimulus onset asynchrony, SOA) and a controlled priming task (0.8 RP and 1000 ms SOA) were used. Prime-target category relation (category related, noncategory related) was also manipulated. Transdermal nicotine patches (7 mg/24 h) were administered in a double-blind, placebo-controlled, crossover design. For the automatic task, nicotine did not influence priming effects for PD. Unexpectedly, compromised automatic priming for controls was ameliorated. For the controlled task, nicotine influenced priming effects for PD but not controls. The patterns of priming and nicotine effects across the tasks suggest an age-related slowing of the rate of semantic activation for controls, which may be exacerbated in PD. Overall, the findings indicate that nicotine can improve compromised semantic processing in PD, and also influence semantic processing in healthy older individuals. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Long-term priming of neighbours biases the word recognition process: Evidence from a lexical decision task.

The role of orthographically similar words (i.e., neighbours) in the word recognition process has been studied extensively using short-term priming paradigms (e.g., Colombo, 1986). Here we demonstrate that long-term effects of neighbour priming can also be obtained. Experiment 1 showed that prior study of a neighbour (e.g., TANGO) increased later lexical decision performance for similar words (e.g., MANGO), but decreased performance for similar pseudowords (e.g., LANGO). Experiment 2 replicated this bias effect and showed that the increase in lexical decision performance due to neighbour priming is selectively due to words from a relatively sparse neighbourhood. Explanations of the bias effect in terms of lexical activation and episodic memory retrieval are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Test sequence priming in recognition memory.

The authors examined priming within the test sequence in 3 recognition memory experiments. A probe primed its successor whenever both probes shared a feature with the same studied item (interjacent priming), indicating that the study item like the probe is central to the decision. Interjacent priming occurred even when the 2 probes did not themselves share any features: A lure that shared a single feature with a study item primed a lure that shared a different feature with the same study item. The experiments distinguished interjacent priming from other types of facilitation. Interjacent priming indicates that a study item that is like the probe is more relevant to the decision than other study items, contrary to global memory models. It also shows that negative decisions depend on contradiction, not insufficient familiarity, because lures, as well as targets, benefited. The data are discussed in terms of a recall check within a dual-process theory, but the authors prefer a single-process resonance model with separate decision mechanisms for yes and no responses (D. J. K. Mewhort & E. E. Johns, 2005). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of alcohol priming on social disinhibition.

Recent studies have suggested that exposure to rudimentary alcohol cues activates mental representations of alcohol expectancies in long-term memory, thereby promoting expectancy-consistent behavior changes. However, reliance in these previous studies on self-report measures raises the possibility that prior findings were an artifact of experimental demand. The present study was aimed at ruling out this alternative explanation by reinvestigating the effects of alcohol priming on nonconsumptive behavior using an implicit measure of social disinhibition. In three experiments, participants were exposed to either alcohol or control beverage images, then asked to type as quickly as possible the first word that came to mind in response to a series of provocative (e.g., feces) and neutral (e.g., chair) stimulus words. Participants’ response times were surreptitiously measured. Results revealed that participants exposed to images of alcohol, relative to control beverages, were faster to generate free associations to provocative, but not neutral, words, suggesting enhanced social disinhibition. This effect was limited to conditions of heightened evaluation, ruling out alternative explanations based on knowledge activation or arousal. Participants reported no suspicions regarding the connection between the image viewing and free association tasks nor any awareness that their response times had been collected. Results suggest that the behavioral effects of alcohol priming do not result from demand characteristics and offer the first evidence that exposure to rudimentary alcohol-related stimuli may suffice to influence social disinhibition in a manner akin to that expected to result from actual or placebo alcohol consumption. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Masked priming effects with syllabic neighbors in a lexical decision task.

Four lexical decision experiments using a masked priming paradigm were conducted to analyze whether the previous presentation of a syllabic neighbor (a word sharing the same 1st syllable) influences recognition performance. The results showed an inhibitory effect of more frequent syllabic primes and some facilitation of nonword syllabic primes (Experiments 1-3). When monosyllabic pairs were used (Experiment 3), no priming effects of the 2 initial letters were found. Finally, when using only syllables as primes, latencies to words were shorter when preceded by primes that corresponded to the 1st syllable than by primes that contained 1 letter more or less than the lst syllable (Experiment 4). Results are interpreted using activation models that take into account a syllabic level of representation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Long-term repetition priming of briefly identified objects.

The authors provide evidence that long-term memory encoding can occur for briefly viewed objects in a rapid serial visual presentation list, contrary to claims that the brief presentation and quick succession of objects prevent encoding by disrupting a memory consolidation process that requires hundreds of milliseconds of uninterrupted processing. Subjects performed a search task in which each item was presented for only 75 ms. Nontargets from the search task generated priming on 2 subsequent indirect memory tests: a search task and a task requiring identification of visually masked objects. Additional experiments revealed that information encoded into memory for these nontargets included perceptual and conceptual components, and that these results were not due to subjects maintaining items in working memory during list presentation. These results are consistent with recent neurophysiological evidence showing that stimulus processing can occur at later stages in the cognitive system even when a subsequent new stimulus is presented that initiates processing at earlier stages. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Conceptual and perceptual priming and dissociation in chronic posttraumatic stress disorder.

Cognitive models of posttraumatic stress disorder (PTSD) assert that memory processes play a significant role in PTSD (see e.g., Ehlers & Clark, 2000). Intrusive reexperiencing in PTSD has been linked to perceptual processing of trauma-related material with a corresponding hypothesized lack of conceptual processing. In an experimental study that included clinical participants with and without PTSD (N = 50), perceptual priming and conceptual priming for trauma-related, general threat, and neutral words were investigated in a population with chronic trauma-induced complaints as a result of the Troubles in Northern Ireland. The study used a new version of the word-stem completion task (Michael, Ehlers, & Halligan, 2005) and a word-cue association task. It also assessed the role of dissociation in threat processing. Further evidence of enhanced perceptual priming in PTSD for trauma stimuli was found, along with evidence of lack of conceptual priming for such stimuli. Furthermore, this pattern of priming for trauma-related words was associated with PTSD severity, and state dissociation and PTSD group made significant contributions to predicting perceptual priming for trauma words. The findings shed light on the importance of state dissociation in trauma-related information processing and posttraumatic symptoms. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Electrodermal measures in experimental amnesia.

14 Ss equated with respect to hypnotizability were subjected to electrodermal orienting response (OR) adaptation to tone stimulation. ? the Ss were hypnotized, ? were not. Adaptation of the OR was conducted under hypnosis, with suggestion of amnesia both under hypnosis and as a posthypnotic suggestion. The control group yielded progressive adaptation curves, while "amnesia" produced a lifting of the adaptation. (16 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Some characteristics of posthypnotic amnesia.

This experiment investigated (a) the differences in post-hypnotic amnesic characteristics of Ss with high and low hypnotic susceptibility and (b) the extent of the amnesia. The experimental Ss were presented 6 words under hypnosis with instructions for amnesia. The simulation Ss pretended they were hypnotized and received the words with instructions for posthypnotic amnesia. The control Ss were given the words with instructions only to remember them. Recognition, recall, and associative tests, administered immediately after, assessed the amnesia. Posthypnotic amnesia impaired recall and recognition among the experimental Ss, but did not reduce the availability of the words as associative responses. The simulating Ss overplayed their amnesic role and also showed impaired performance on the associative tests. (15 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)