Differential involvement of cortical receptor mechanisms in working, short-term and long-term memory

Rats received, through bilaterally implanted indwelling cannulae, 0.5 microliter infusions of 6-cyano-7-nitroquinoxaline2,3-dione (CNQX) (0.5 microgram), D-2-amino-5-phophono pentanoic acid (AP5) (5.0 micrograms), muscimol (0.5 microgram), scopolamine (2.0 micrograms), SCH23390 (2.5 micrograms), saline or a vehicle into the CA1 region of the hippocampus, or into the antero-lateral prefrontal (PRE), posterior parietal (PP) and entorhinal cortex (EC). The infusions were given 6 min prior to one-trial step-down inhibitory avoidance training in order to measure their effect on working memory (WM), or immediately post-training in order to measure their effect on short-term (STM) and long-term memory (LTM), 1.5 and 24 h later, respectively. WM was inhibited by CNQX or muscimol given into any of the cortical areas, by SCH23390 given into CA1, PRE or PP, and by scopolamine given into PRE or EC. STM was unaffected by any of the treatments given into PRE, and was inhibited by CNQX or muscimol given into CA1, PP and EC and by scopolamine given into PP, and enhanced by SCH given into CA1. LTM was inhibited by CNQX, muscimol, scopolamine or SCH23390 given into PRE, by scopolamine given into PP, by SCH23390 given into the entorhinal cortex, and by AP5, CNQX, muscimol or scopolamine given into CA1. The results indicate a differential involvement of the various neurotransmitter systems in the three types of memory in the various brain areas, and a separation of the mechanisms and of the regions involved in each. In addition, some of the findings suggested links between WM and LTM processing in PRE, between WM and STM processing in EC and PP, and between all three types of memory in CA1.     

The effects of word co-occurance on short-term memory: Associative links in long-term memory affect short-term memory performance.

In immediate serial recall tasks, high-frequency words are recalled better than low-frequency words. This has been attributed to high-frequency words' being better represented and providing more effective support to a redintegration process at retrieval (C. Hulme et al., 1997). In studies of free recall, there is evidence that frequency of word co-occurrence, rather than word frequency per se, may explain the recall advantage enjoyed by high-frequency words (J. Deese, 1960). The authors present evidence that preexposing pairs of low-frequency words, so as to create associative links between them, has substantial beneficial effects on immediate serial recall performance. These benefits, which are not attributable to simple familiarization with the words per se, do not occur for high-frequency words. These findings indicate that associative links between items in long-term memory have important effects on short-term memory performance and suggest that the effects of word frequency in short-term memory tasks are related to differences in interitern associations in long-term memory. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Phonotactic influences on short-term memory

The impact of phonotactic probabilities on serial recall was investigated in a series of experiments. In Experiments 1A and 1B, 7 and 8 year olds were tested on their serial recall of monosyllabic words and of nonwords varying in phonotactic frequencies. A recall advantage to words over nonwords remained when stimuli were balanced for phonotactic probability, but nonword recall showed superior accuracy for high over low probability nonwords, as in Experiment 2. The nonword frequency effect appears to reflect the frequency of constituent syllables rather than biphones. Both lexicality and high phonotactic frequency led to increased proportions of full over partial recall of the memory stimuli. These findings indicate that decayed memory traces in phonological short-term memory can be reconstructed using either lexical or phonotactic knowledge.     

Organization of visual short-term memory.

The authors examined the organization of visual short-term memory (VSTM). Using a change-detection task, they reported that VSTM stores relational information between individual items. This relational processing is mediated by the organization of items into spatial configurations. The spatial configuration of visual objects is important for VSTM of spatial locations, colors, and shapes. When color VSTM is compared with location VSTM, spatial configuration plays an integral role because configuration is important for color VSTM, whereas color is not important for location VSTM. The authors also examined the role of attention and found that the formation of configuration is modulated by both top-down and bottom-up attentional factors. In summary, the authors proposed that VSTM stores the relational information of individual visual items on the basis of global spatial configuration. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Two circuits to convert short-term memory into long-term memory

In this prospective study we tested the hypothesis that atropine administration, which is known to increase heart rate and cardiac output in infants, will result in a faster onset of neuromuscular block with atracurium. Thirty infants scheduled for elective surgery had anaesthesia induced with nitrous oxide and halothane. Fifteen patients were given atropine and 15 patients acted as controls. All the infants were given atracurium 0.5 mg.kg-1, and neuromuscular block was recorded with the Datex 221 neuromuscular transmission monitor. Although atropine caused an increase in heart rate compared to the control group (median 164 [range 151-182] vs 120 [98-160]min-1 P < 0.0001), there was not a statistically significant difference in the onset of neuromuscular block between the two groups. We conclude that onset of neuromuscular block after atracurium is determined mainly by noncirculatory factors and less by the circulation time to the muscle. The effect of atropine on the time course of neuromuscular block might be different with faster acting neuromuscular blockers.     

Binomial variability in short-term memory.

Experiments in short-term memory usually collect binary data, e.g., an item is either correctly recalled or not. If the probability of recall is constant for Ss and/or items under a given condition, the proportion based on n observations can be transformed to angles by the arcsin transformation and will have variance 1/n. Violations of the assumptions are discussed and different strategies for pooling are assessed by conventional analysis of variance. Illustrative experiments with distractor and probe techniques, paired-associates and serial presentation, and single-trial free recall are briefly presented. The correspondence between observed and expected results seems good; apparently considerable latitude is possible in pooling Ss or items in data analyses of experiments in short-term memory. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Slope analysis in short-term memory.

Presents procedures for transforming dichotomously scored data from short-term memory experiments into slope measures for evaluation by analysis of variance techniques. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Binding in short-term visual memory.

The integration of complex information in working memory, and its effect on capacity, shape the limits of conscious cognition. The literature conflicts on whether short-term visual memory represents information as integrated objects. A change-detection paradigm using objects defined by color with location or shape was used to investigate binding in short-term visual memory. Results showed that features from the same dimension compete for capacity, whereas features from different dimensions can be stored in parallel. Binding between these features can occur, but focused attention is required to create and maintain the binding over time, and this integrated format is vulnerable to interference. In the proposed model, working memory capacity is limited both by the independent capacity of simple feature stores and by demands on attention networks that integrate this distributed information into complex but unified thought objects. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Exploring developmental differences in visual short-term memory and working memory.

Although visuospatial short-term memory tasks have been found to engage more executive resources than do their phonological counterparts, it remains unclear whether this is due to intrinsic differences between the tasks or differences in participants’ experience with them. The authors found 11-year-olds’ performances on both visual short-term and working memory tasks to be more greatly impaired by an executive suppression task (random number generation) than were those of 8-year-olds. Similar findings with adults (e.g., Kane & Engle, 2000) suggest that the imposition of a suppression task may have overloaded the older children’s executive resources, which would otherwise be used for deploying strategies for performing the primary tasks. Conversely, the younger children, who probably never had the capacity or know-how to engage these facilitative strategies in the first place, performed more poorly in the single task condition but were less affected in the dual task condition. These findings suggest that differences in the children’s ability to deploy task-relevant strategy are likely to account for at least part of the executive resource requirements of visual memory tasks. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Emerging attributes in monkey short-term memory.

Conducted 2 experiments to examine the role of recency information and stimulus novelty and familiarity in delayed-matching-to-sample (DMTS) performance. Five female 5–8 yr old macaques (one of which was not included in Exp II) were tested on DMTS problems in which the correct and incorrect choice stimuli were both familiar, both relatively novel, or different in familiarity. Initially, novelty and familiarity exerted their influence as preferences (familiar stimuli were preferred). As more training was given, however, novelty and familiarity began to act as discriminative attributes. For example, Ss came to use the fact that the to-be-remembered stimulus was relatively novel to reject alternative choice stimuli that were more familiar. Theories of animal memory based on a single memory attribute cannot address these results. (12 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Trial-to-trial carryover in auditory short-term memory.

Using a short-term recognition memory task, the authors evaluated the carryover across trials of 2 types of auditory information: the characteristics of individual study sounds (item information) and the relationships between the study sounds (study set homogeneity). On each trial, subjects heard 2 successive broadband study sounds and then decided whether a subsequently presented probe sound had been in the study set. On some trials, the similarity of the probe item to stimuli presented on the preceding trial was manipulated. This item information interfered with recognition, and false alarms increased from 0.4% to 4.4%. Moreover, the interference was tuned so that only stimuli that were very similar to each other interfered. On other trials, the relationship among stimuli was manipulated to alter the criterion subjects used in making recognition judgments. The effect of this manipulation was confined to the trial on which the criterion change was generated and did not affect the subsequent trial. These results demonstrate the existence of a sharply tuned carryover of auditory item information but no carryover of the effects of study set homogeneity. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Parrel processing in visual short-term memory.

Visual short-term memory for the contrast and spatial frequency of sinusoidal gratings was measured in a delayed discrimination task in which the 2 stimuli to be compared were separated in time by 1-10 s interstimulus intervals (ISIs). Delayed discrimination thresholds for spatial frequency and contrast were compared, both when the 2 types of thresholds were measured in separate blocks of trials and when the 2 types of measures were randomly intermixed in an uncertainty paradigm, which required participants to process information about both dimensions on each trial. In both cases, accuracy of memory for spatial frequency was independent of ISI, but memory for contrast decreased as ISI increased. Performance was lower in the uncertainty case, but only by an amount predicted by statistical decision theory for independent sources. The results are consistent with a model assuming a set of parallel special-purpose visual discrimination and short-term memory mechanisms. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Attention gating in short-term visual memory.

Investigated attention shift to a stream of numerals, in rapid serial visual presentation, using 3 graduate students with normal or corrected-to-normal vision. Ss detected a target embedded in a stream of letters presented at the left of fixation and, as quickly as possible, shifted their attention to a stream of numerals at the right of fixation. They attempted to report, in order, the 4 earliest occurring numerals after the target. Numerals appeared at rates of 4.6, 6.9, 9.2, and 13.4 sec. Analyses demonstrated that, for all Ss, targets, and numeral rates, the relative position of numerals in the response sequence showed clustering, disorder, and folding. Reported numerals tended to cluster around a stimulus position 400 msec after the target. Numerals were reported in an apparently haphazard order. The actual order of report resulted from a mixture of correctly ordered numerals with numerals ordered in the direction opposite to their order of presentation. Results are quantitatively described by a strength theory of order and are efficiently predicted by a computational attention gating model (AGM). The AGM may be derived from a more general attention model that assumes that (a) after detection of the target, an attention gate opens briefly to allow numerals to enter a visual short-term memory and (b) subsequent order of report depends on both item strength (how wide the gate was open during the numeral's entry) and on order information (item strength times cumulative strength of prior numerals). (78 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Modality effects in short-term verbal memory.

Argues that for short-term memory, auditory presentation is consistently superior to visual presentation, with the difference restricted to recently presented items. A review of the literature indicates that recall increases with fast presentation rates when auditory presentation is used in a serial recall task; otherwise, recall decreases as presentation rate increases. Some puzzling findings on dichotic and bisensory split-span memory are shown to be related to aspects of the modality difference, notably the strong sequential associations in auditory memory. (116 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Interference effects in schizophrenic short-term memory.

Presented 35 lists of 7 digits to 24 16-41 yr old schizophrenic patients and 24 16-39 yr old matched normal controls. Items in the different serial positions were probed randomly in a series of 7 recall trials for each list. Input interference resulting from interpolation of items between presentation and recall of the probed item was the same for both groups. Output interference resulting from interpolation of responses between presentation and recall was greater for schizophrenics than for normals. Significant differences in error patterns were also found. It is concluded that output interference is a major causative factor in the schizophrenic recall deficit. (34 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Elective memory deficiencies and restricted cortical lesions

60 subjects with restricted cortical lesions, 7 with diffuse cortical disease, 7 with bilateral lesions of the hippocampo-mamillo-thalamic circuit and 36 normal subjects underwent immediate reproduction tests and training tests in the following three categories: audio-verbal, visuo-spatial, gestural. Subjects with lesions of the H.M.T. circuit had normal results in the three immediate reproduction tests and failed in the three training tests. Subjects with diffuse cortical lesions showed pathological results in all the tests. Subjects with restricted cortical lesions showed selective deficiencies in certain tests; there was no systematic connection between failure in the immediate reproduction test and failure in the corresponding training test. The results were analysed having regard to the location of the lesion but also to the symptoms.     

Item repetition in short-term memory: Ranschburg repeated

In serial recall from short-term memory, repeated items are recalled well when close together (repetition facilitation), but not when far apart (repetition inhibition; the Ranschburg effect). These effects were re-examined with a new scoring scheme that addresses the possibility that repetitions are distinct tokens in memory. Repetition facilitation and repetition inhibition proved robust, and were shown to interact with the temporal grouping of items (Experiment 1), which affected the probability of detecting repetition (Experiments 2A and 2B). It is argued that detection of a repetition is necessary for repetition facilitation, attributable to the tagging of immediate repetition, whereas the failure to detect or remember a repetition results in repetition inhibition, attributable to an automatic suppression of previous responses and a bias against guessing repeated items (Experiment 3). The findings are discussed in relation to models of short-term memory and the phenomenon of repetition blindness.     

Imagery and interference in sequential short-term memory.

Conducted an experiment with 132 college students to compare the disruptive effects of irrelevant information (names of colors) superimposed on relevant information (bands of colors) with the effects of irrelevant information occupying the interval between stimuli. Irrelevant information disrupted performance only when it occupied the interval between stimuli, suggesting that interference was primarily with the rehearsal process and not with the perceptual process. It made no difference whether the names of colors were the same as or different from the bands of colors. Analysis of control conditions suggests that Ss can better "keep track" of colors than color names. Results are discussed in terms of visual imagery and the spatial window model of "keeping-track" performance. (French summary) (16 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Enhanced visual short-term memory for angry faces.

Although some views of face perception posit independent processing of face identity and expression, recent studies suggest interactive processing of these 2 domains. The authors examined expression–identity interactions in visual short-term memory (VSTM) by assessing recognition performance in a VSTM task in which face identity was relevant and expression was irrelevant. Using study arrays of between 1 and 4 faces and a 1,000-ms retention interval, the authors measured recognition accuracy for just-seen faces. Results indicated that significantly more angry face identities can be stored in VSTM than happy or neutral face identities. Furthermore, the study provides evidence to exclude accounts for this angry face benefit based on physiological arousal, opportunity to encode, face discriminability, low-level feature recognition, expression intensity, or specific face sets. Perhaps processes activated by the presence of specifically angry expressions enhance VSTM because memory for the identities of angry people has particular behavioral relevance. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The production effect in memory: Evidence that distinctiveness underlies the benefit.

The production effect is the substantial benefit to memory of having studied information aloud as opposed to silently. MacLeod, Gopie, Hourihan, Neary, and Ozubko (2010) have explained this enhancement by suggesting that a word studied aloud acquires a distinctive encoding record and that recollecting this record supports identifying a word studied aloud as “old.” This account was tested using a list discrimination paradigm, where the task is to identify in which of 2 studied lists a target word was presented. The critical list was a mixed list containing words studied aloud and words studied silently. Under the distinctiveness explanation, studying an additional list all aloud should disrupt the production effect in the critical list because remembering having said a word aloud in the critical list will no longer be diagnostic of list status. In contrast, studying an additional list all silently should leave the production effect in the critical list intact. These predictions were confirmed in 2 experiments. (PsycINFO Database Record (c) 2010 APA, all rights reserved)