Working and long-term memory deficits in schizophrenia: Is there a common prefrontal mechanism?

This study tested the hypothesis that dorsolateral prefrontal cortex deficits contribute to both working memory and long-term memory disturbances in schizophrenia. It also examined whether such deficits were more severe for verbal than nonverbal stimuli. Functional magnetic resonance imaging was used to assess cortical activation during performance of verbal and nonverbal versions of a working memory task and both encoding and recognition tasks in 38 individuals with schizophrenia and 48 healthy controls. Performance of both working memory and long-term memory tasks revealed disturbed dorolateral prefrontal cortex activation in schizophrenia, although medial temporal deficits were also present. Some evidence was found for more severe cognitive and functional deficits with verbal than nonverbal stimuli, although these results were mixed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Functional organization of the right nondominant cortex: Evidence from electrical stimulation.

Studied discrete functional localization for visuo-perceptual, spatial, and nonverbal memory tasks in conjunction with focal electrical stimulation of the exposed right-dominant cortex during awake craniotomies in 22 patients. Results provide evidence for discrete functional localization in the right, nondominant hemisphere. Performance on each task was significantly impaired in association with stimulation of some, but not all, sites in comparison with performance on nonstimulation control trials. There was, generally, a strong dissociation of sites involved in separate functions across individual Ss. Contrary to the notion of diffuse functional organization in the nondominant hemisphere, visuospatial functions in the right hemisphere appear to be as discretely localized as verbal functions in the left hemisphere. Language and language-related functions of naming, reading, short-term verbal memory, nonverbal oral-facial movement, and phonemic identification were assessed in a subgroup of 10 Ss in conjunction with right nondominant cortical stimulation. In right-handed Ss, no disruptions of these tasks were seen with stimulation of sites outside the right face motor cortex itself. In 2 case studies, there was evidence for right cortical involvement in the mediation of 2 nonphonetic symbol-based language systems: Japanese Kanji and Fortran. (French abstract) (72 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Nonverbal indicants of comprehension and noncomprehension in children.

Examined nonverbal indicants of comprehension and noncomprehension in young listeners in the context of referential communication. Relationships between Ss' verbal and nonverbal behavior were also examined. 90 Ss at 4, 6, 8, and 10 yrs of age served as listeners. An adult speaker produced messages of varying informational adequacy. Analyses of videotape records revealed that Ss at each of the 4 ages exhibited markedly different nonverbal behavior in response to informative as compared to uninformative messages. In the absence of verbal responding, Ss at all ages showed more hand movement and longer reaction times when messages were uninformative. Preschoolers made more eye contact with the speaker when the message was uninformative, but their amount of body movement was unaffected; the reverse was true for kindergartners and 2nd graders. The data also reveal that when verbal responding was initiated, it was simply added onto the already established patterns of nonverbal behavior; no evidence was found for the hypothesis that verbal responding replaces or substitutes for nonverbal responses. (18 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Individual differences in cognitive processes.

Studied the effects of verbal ability and sex on performance in a simultaneous matching task. The 537 undergraduates who participated were administered the verbal battery of the Lorge-Thorndike Intelligence Test. Ss with high-verbal ability (high verbals) were much faster than Ss with low-verbal ability (low verbals) in making taxonomic category identity matches and homophone identity matches. Results suggest that verbal ability is related to the speed of retrieval from long-term memory. In addition, high verbals were faster in making physical identity word matches, suggesting that either lexicographically coded information stored in long-term memory is used in such a task or that verbal ability is also related to the speed of retrieval from short-term memory. As expected, males did not differ from females in the time they required to perform any of the matching tasks, although males made slightly more errors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Verbal and visuospatial recall by younger and older subjects: Use of matched tasks.

In this study, 18 older (over age 65, M?=?75.61 years) and 18 younger (below age 40 and over age 17, M?=?26.44 years) healthy volunteers were tested on verbal and visuospatial recall. Tasks were matched on discriminating power. Older Ss performed worse than younger Ss on both tasks. The older Ss also showed a larger deficit in visuospatial than in verbal recall, relative to the younger Ss. These results are consistent with the theory of aging according to which verbal tasks are more resistant to deterioration than are nonverbal tasks. A psychological explanation based on lifetime experience with verbal material is preferred over the physiological explanation advocating faster aging of the right hemisphere. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Inverted-U Function Between Salivary Cortisol and Retrieval of Verbal Memory After Hydrocortisone Treatment.

The present study investigated the effect of a single oral dose of hydrocortisone (cortisol) on retrieval of verbal and nonverbal declarative memory. Fifty-nine healthy participants were randomly assigned to either receive 25 mg cortisol or a placebo 45 min before retrieval in a standardized memory test procedure. There was no global effect of cortisol on either verbal or nonverbal memory. However, a specific negative effect on free recall of associative verbal material appeared. In addition, high responders (salivary cortisol concentration > 68.25 nmol/L) exhibited impaired verbal memory compared with low responders (     

Verbal and nonverbal short-term memory impairment in untreated Parkinson's disease.

Extended previous research (J. A. Cooper et al, 1991) and examined whether the impairment in verbal and nonverbal short-term memory (STM) documented in chronically treated patients with Parkinson's disease (PD) is attributable to the pathology of the disease or to antiparkinsonian drug therapy. Verbal recall by a group of 58 never-treated PD patients was virtually perfect when the retention intervals were distractor free but was impaired, as compared with a matched group of 34 healthy control Ss, following distractor-filled intervals. Nonverbal recall by the PD group showed significant forgetting after distractor-free but not distractor-filled intervals. Recall was not related to depressive symptoms, motor disability, or distractor task performance. Thus, STM impairment in PD occurs for both verbal and nonverbal material and arises directly from the disease pathology rather than from antiparkinsonian medication. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Race differences on nonverbal analogy test performance as a function of verbal strategy training.

Hypothesized that the relatively poor performance of Black students on nominally nonverbal reasoning tests (A. R. Jensen's Level II) (see record 1974-24027-001) may be due to their failure to use verbal problem-solving strategies efficiently and spontaneously. 200 4th and 5th graders, both Black and White, showed no race differences on Level I ability (digit-span memory). Half of the Ss of each race were then trained to use a verbal strategy on nonverbal analogies. For Ss who received no special training there were significant race differences on the analogies test (p     

Verbal and nonverbal memory processing in patients with obsessive-compulsive disorder: Its relationship to clinical variables.

Memory deficits have been reported in several neuropsychological studies of obsessive-compulsive disorder (OCD). Dysfunction in nonverbal memory has been consistently reported, whereas findings on verbal memory are more heterogeneous. The authors studied 50 patients with OCD who were matched for sex, age, educational level, and hand dominance with 50 healthy controls (HC). Cognitive performance in both groups was assessed on verbal and nonverbal memory tasks, and several clinical variables were also assessed in the patient group. Patients with OCD showed a pattern of cognitive dysfunction with alterations in areas of nonverbal memory (recall and recognition), and verbal memory (learning and recall). Older age at onset of OCD was associated with poorer performance on verbal memory tasks. Low scores on some verbal memory tasks were associated with severity of OCD, and nonverbal memory was influenced by depressive symptoms. The study suggests the existence of dysfunction in the execution of verbal and nonverbal memory tasks in OCD; the influence of clinical variables depends on the specific neuropsychological function. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Negativism in verbal and nonverbal responses of autistic children.

Studied negativism in 9 autistic, 9 behavior-disturbed, and 9 normal 5-12 yr olds in 3 different stimulus conditions (verbal requests for verbal responses, verbal requests for nonverbal responses, and nonverbal requests for nonverbal responses). Each condition included 2 tasks, which were requested 15 consecutive times. Ss demonstrated that they could perform the tasks before testing, and their responses were scored according to the similarity between the response and the request. Results demonstrate that the autistic and behavior-disturbed Ss responded similarly, except when requests required verbal responses, in which case the autistic Ss were much more negative. Results suggest applications to diagnostic and therapeutic interventions. (17 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Mother–child interactional style in abuse, neglect, and control groups: Naturalistic observations in the home.

Examined mother–child interactional patterns in an urban environment. Three groups of mothers (n?=?12/group) were included in the study: (a) Ss with a known history of child abuse, (b) Ss with a known history of child neglect, and (c) Ss with no known history of child maltreatment. Ss and their children were observed in their homes on 3 consecutive days for 90 min each day. Interactions were described via a coding system of 11 major interactional patterns; dependent variables included verbal and nonverbal behaviors as well as measures of total interaction. Results indicate that the groups differed on several variables. Dysfunctional Ss showed significantly fewer positive behaviors than did the controls on verbal and nonverbal measures. Also, the abusive Ss showed significantly higher rates of verbal and physical aggression; the neglectful mothers had the lowest overall rates of interaction. The maltreated children also exhibited fewer positive behaviors and more aggressive behaviors. Results are discussed in terms of current theories of child maltreatment and of the treatment of dysfunctional families. (24 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Development of conversational responsiveness: Preschoolers' use of responsive listener cues and relevant comments.

Examined how the use of responsive listener cues (e.g., head nods, uh-hums, yesses, gazes, smiles) and relevant comments changes over the preschool years by videorecording 33 children (aged 29–67 mo) as they listened to an adult speaker talk about his experiences. Older Ss used more head nods and spent more time talking, smiling, and gazing than did younger Ss. In addition, age was significantly correlated with use of relevant comments but not the use of irrelevant comments. Furthermore, the Ss who used more responsive nonverbal cues tended to also engage in more responsive verbal behaviors. The relationship between the development of nonverbal and verbal behaviors is discussed. (40 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Age-related changes in verbal and nonverbal memory during early childhood.

In the present experiment, age-related changes in verbal and nonverbal memory performance by 2- to 4-year-old children were assessed. All children participated in the same unique event, and their memory of that event was assessed after a 24-hr delay. Overall, children's performance on each memory measure increased as a function of age. Furthermore, children's performance on both the verbal and nonverbal memory tests was related to their language ability; children with more advanced language skills reported more during the verbal interview and exhibited superior nonverbal memory relative to children with less advanced language skills. Finally, children's verbal recall of the event lagged behind both their nonverbal recall and their general verbal skill. It is hypothesized that despite large strides in language acquisition, preschool-age children continue to rely primarily on nonverbal representations of past events. The findings have important implications for the phenomenon of childhood amnesia. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Referential communication and reading performance in learning disabled children over a 3-year period.

Examined the ability of 30 learning disabled (LD) and 30 non-LD (NLD) 6- and 7-yr-olds to understand a sequence of instructions, communicate the steps in a sequence to others, and rephrase their verbal messages across a 3-yr period using a referential communication task. In order to perform the puzzle-box task correctly, Ss had to execute 6 steps in an invariant sequence. After Ss demonstrated a perfect nonverbal enactment of the sequence, they were asked to communicate all information about how to open the box to a puppet. Upon completion, the puppet feigned poor memory and asked the Ss to explain the step-by-step process again. Subsequently, the puppet requested that Ss rephrase their explanation of each step by either a verbal or nonverbal rephrase request. Results reveal that LD children differed from NLD peers consistently on referential communication over the 3-yr period in terms of listener competence and speaker competence. For LD Ss, the ability to produce competent verbal messages was highly related to reading comprehension both concurrently and 3 yrs later. By the 3rd yr, NLD Ss were better able to rephrase information, indicating a growing awareness of the speaker's responsibility in communication. Findings suggest that the communication measures studied play very different roles for LD and NLD Ss with regard to reading achievement. (27 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Behavioral and cardiovascular responses to interpersonal challenges among male offspring of essential hypertensives.

Behavioral, cardiovascular, and self-report measures of cognitive and affective responses to 2 interpersonal challenges were examined among 20 men with a positive (FH+) and 20 with a negative (FH–) family history of hypertension. Heart rate (HR) and blood pressure (BP) were measured throughout the laboratory session; Ss were requested to self-report positive and negative conditions, state anger, and state anxiety that occurred during interactions with a male and female confederate. Behavioral responses to interpersonal tasks were videotaped, coded, and categorized into 4 major groupings (positive verbal, positive nonverbal, negative verbal, and negative nonverbal). FH+ individuals exhibited significantly higher resting HR and systolic BP reactivity to both interactions than FH– counterparts. Analyses of behavioral responses for both interactions revealed significantly more negative verbal and nonverbal behavior and less positive nonverbal behavior among FH+ as compared with FH– Ss. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Explanations for visual cue primacy in judgments of honesty and deceit.

Examined the validity of the distraction hypothesis (Maier & Thurber, 1968). Ss were undergraduate students who watched a videotaped interview and rated the veracity of an actress who played the role of a college student. Study 1 disconfirmed the distraction hypothesis. Ss relied on nonverbal cues to make judgments of veracity, but the presence of nonverbal cues did not distract Ss from processing verbal content. Study 2 tested an alternate explanation, the situational familiarity hypothesis. Study 2 found that judgments in familiar situations were influenced primarily by verbal content cues, whereas those in unfamiliar situations were influenced by both verbal and nonverbal cues. Findings indicate that situational factors influence information processing and affect the relative importance of verbal and nonverbal cues in judgments of veracity. Generalizability of prior deception research is questioned. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Implicit memory for nonverbal associations

A color-naming priming task was used to examine implicit memory for new nonverbal associations. Implicit memory was observed for associations between words and colors and between abstract shapes and colors. The authors also asked whether nonverbal association priming might occur more readily than verbal association priming. Colored compound nonwords were used as stimuli, and participants were asked to attend either to the 2 syllables of the compound nonword or to the compound nonword and the color in which it was printed. The authors found that the association formed depended on which attributes of the stimuli were attended to and were not more readily formed for nonverbal material. The results demonstrate that tasks that encourage unitization between the elements to be associated facilitate associative priming.     

Brain attack. Acute therapeutic interventions. Free radical scavengers and antioxidants

This study used tests of content memory (item recognition of words and abstract designs), context memory (order recognition of verbal and nonverbal items), and working memory (recognition at a short retention interval) to examine patterns of performance in 27 schizophrenic patients, 52 chronic alcoholic patients, and 66 healthy control participants. When performance was age- and IQ-adjusted the schizophrenia group was significantly impaired in item and order recognition of verbal and nonverbal material; the alcoholic group was impaired only in order recognition for both material types. Item- and order-recognition deficits in the schizophrenia group were greatest at the shortest retention intervals, a pattern previously observed in patients with Parkinson's disease, suggesting a prominence of a working memory deficit in schizophrenia.