共查询到18条相似文献,搜索用时 62 毫秒
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《广东化工》2021,48(5)
研究介孔硅作为难溶性药物依非韦伦的载体材料在提高其溶解性方面的应用。称取依非韦伦400 mg,溶解于1 mL甲醇,向溶液中加入400 mg介孔硅,采用溶液吸附法制备依非韦伦介孔硅载药物。对比依非韦伦原料药,依非韦伦/介孔硅物理混合物及依非韦伦介孔硅载药物在2%十二烷基硫酸钠水溶液中60min内的溶出曲线;采用扫描电镜表征依非韦伦介孔硅载药物的表面形貌;利用N2吸附对比介孔硅材料载药前后的比表面积和孔容积;通过X-射线衍射、差示扫描量热表征载药物的性质。溶液吸附法制备的依非韦伦介孔硅载药物中依非韦伦含量为29.6%,药物全部以无定型态装载于介孔硅孔道中。与原料药和物理混合物比较,依非韦伦介孔硅载药物的溶出速度明显提高,溶出度与原料药和依非韦伦/介孔硅物理混合物相比提高2.5倍。介孔硅作为载体材料能显著提高依非韦伦的溶解度,为增加难溶性药物溶解度提供新思路。 相似文献
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硅是化妆品生产不可缺少的原料之一。介绍了硅粉、硅悬浮液用于化妆品生产的最新技术, 特别是毛发调理产品中的应用。硅粉作为固体原料有望成为化妆品中新产品的生产原料。 相似文献
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硅是化妆品生产不可缺少的原料之一。介绍了硅粉、硅悬浮液用于化妆品生产的最新技术,特别是毛发调理产品中的应用。硅粉作为固体原料有望成为化妆品扣新产品的生产原料。 相似文献
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Volatility Diagrams for Silica, Silicon Nitride, and Silicon Carbide and Their Application to High-Temperature Decomposition and Oxidation 总被引:1,自引:0,他引:1
Volatility diagrams—isothermal plots showing the partial pressures of two gaseous species in equilibrium with the several condensed phases possible in a system—are discussed for the Si-O and Si-N systems, and extended to the Si-N-O and Si-C-O systems, in which the important ceramic constituents SiO2 , Si3 N4 , Si2 N2 O, and SiC appear as stable phases. Their use in understanding the passiveactive oxidation transitions for Si, Si3 N4 , and SiC are demonstrated. 相似文献
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Krishan L. Luthra 《Journal of the American Ceramic Society》1991,74(5):1095-1103
This study provides new perspectives on why the oxidation rates of silicon carbide and silicon nitride are lower than those of silicon and on the conditions under which gas bubbles can form on them. The effects on oxidation of various rate-limiting steps are evaluated by considering the partial pressure gradients of various species, such as O2 , CO, and N2 . Also calculated are the parabolic rate constants for the situations when the rates are controlled by oxygen and/or carbon monoxide (or nitrogen) diffusion. These considerations indicate that the oxidation of silicon carbide and silicon nitride should be mixed controlled, influenced both by an interface reaction and diffusion. 相似文献
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Takayuki Narushima Michihisa Kato Shin Murase Chiaki Ouchi Yasutaka Iguchi 《Journal of the American Ceramic Society》2002,85(8):2049-2055
The oxidation behavior of a silicon wafer, chemically vapor-deposited SiC, and single-crystal SiC was investigated in an oxygen—2%–7% ozone gas mixture at 973 K. The thickness of the oxide film that formed during oxidation was measured by ellipsometry. The oxidation rates in the ozone-containing atmosphere were much higher than those in a pure oxygen atmosphere. The parabolic oxidation kinetics were observed for both silicon and SiC. The parabolic rate constants varied linearly with the ozone-gas partial pressure. Inward diffusion of atomic oxygen formed by the dissociation of ozone gas through the SiO2 film apparently was the rate-controlling process. 相似文献
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R. Plugaru G. Craciun N. Nastase B. Méndez A. Cremades J. Piqueras E. Nogales 《Journal of Porous Materials》2000,7(1-3):291-294
Luminescence emission of LPCVD polycrystalline silicon films has been studied by cathodoluminescence (CL) in the scanning electron microscope. As-deposited films show visible luminescence with dominant blue band. The relative intensity of blue emission is enhanced by implantation and by slight anodization treatments. Our investigations are consistent with previous PL results and indicate that the origin of blue emission is related to quantum confinement effects. On the other hand, the effect of annealing in these samples is a reduction of the CL signal that could be related to the increase of the nanocrystals size. 相似文献
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Nitridation behavior of silicon powder compacts of various thicknesses with Y2O3 and MgO as sintering additives 下载免费PDF全文
Chika Matsunaga You Zhou Dai Kusano Hideki Hyuga Kiyoshi Hirao 《International Journal of Applied Ceramic Technology》2017,14(6):1157-1163
The effects of the nitriding temperature (1300 and 1350°C), holding time (0‐4 hours), and thickness of Si powder compacts on the nitridation behavior of silicon were investigated by examining the nitridation rates, analyzing phase compositions, and observing the microstructures of nitrided compacts. Si powder compacts doped with Y2O3 and MgO as sintering additives were prepared with thicknesses of 3, 6, and 9 mm. The phases of nitrided compacts were transformed from Si to α‐Si3N4 and β‐Si3N4 with an increase in the nitriding temperature and holding time. The degree of nitridation increased with the nitriding temperature and holding time. The β/(α+β) ratio increased with the nitriding temperature and holding time, and with a decrease in the thickness of the Si powder compacts. However, all compacts exhibited the same tendency for a higher β/(α+β) ratio at the compact surface than in the bulk of the compact. The variation in the β/(α+β) ratio for each compact decreased with an increase in the nitriding temperature and holding time. 相似文献
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T. V. Barinova I. P. Borovinskaya 《International Journal of Self-Propagating High-Temperature Synthesis》2009,18(1):30-33
Combustion of silicon powders containing organic dopants in nitrogen gas under pressure was found to yield a mixture of α-Si3N4, β-Si3N4, SiC, and Si2N2O. Relative amount of these compounds in combustion product was found to depend on the pressure of nitrogen gas, type and
concentration of dopants, combustion geometry, and cooling rate. The formation of α-Si3N4 was found to occur in the presence of oxygen-containing dopants. The type of dopant was also found to affect the morphology
of product particles.
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