Oscillatory Behavior of Respiratory Gas Exchange in Resting Man

This study deals with the dynamics of respiratory gas carbon dioxide concentration are three, ten, twenty, and thirty to forty-five minutes and two hours; in oxygen concentration, three, ten, twenty, and thirty minutes and one and four hours; and in respiratory quotient, one, five, ten, and fifteen minutes and two to four hours. exchange in resting man. Spectral analyses are performed on time series representing four-hour continuous records of ventilation, carbon dioxide release, oxygen takeup, end tidal carbon dioxide concentration, end tidal oxygen concentration, and respiratory quotient. Results imply that the temporal behavior of each of these six variables can be characterized by a superposition of a finite set of self-sustained almost periodic oscillations with periods in the range from one minute to four hours and time dependent stochastic variation. In ventilation, carbon dioxide release, and oxygen takeup, individual components have amplitudes of between five and ten percent of mean values and nominal periods of one, four, ten, and twenty minutes and one and two to four hours. Components in oxygen concentration, carbon dioxide concentration, and respiratory quotient have amplitudes of between two and four percent of mean values.     

An Optimally Controlled Respirator

An optimally controlled respirator was developed. It has three main features: 1) ventilation is controlled by the patient's metabolic rate from continuously measured C02 output, 2) physiologic dead space approximated as a linear function of tidal volume is used to estimate alveolar ventilation, and 3) respiratory rate is computed to minimize ventilatory work.     

On-Line Acquisition of Pulmonary Gas Exchange Data

This paper describes an automatic system for the minute-to-minute collection of pulmonary gas exchange data which may be used to compute the total minute ventilation, oxygen consumption, carbon dioxide production, and respiratory quotient. The data are available in both analogue and digital format, the latter being suited for immediate digital computer processing.     

Noninvasive Transcutaneous Monitoring of Arterial Blood Gases

Valuable clinical and physiological data concerning the function of the cardiopulmonary system can be obtained from continuous monitoring of hemoglobin oxygen saturation (SaO2), oxygen tension (PO2), and carbon dioxide tension (PCO2) in blood. While periodic blood sampling is still used clinically to determine arterial blood gases, it is becoming apparent that the recent introduction of continuous noninvasive monitoring of blood gases can offer many advantages. This paper discusses the historical development and significant accomplishments of various techniques available for transcutaneous blood gas monitoring. Four major areas are reviewed: electrochemistry, spectrophotometry, mass spectrometry, and gas chromatography. For each of these techniques, the theoretical basis, instrumentation, and clinical applications are discussed.     

Interaction Model Between the Circulatory and Respiratory Systems

The present study was prepared in order to illustrate the gas exchange (O2 and CO2) between pulmonary blood and alveolar air. In the model, circulatory and respiratory systems have been separately simulated in order to obtain the driving functions of the interaction model. This last takes into account oxygen and carbon dioxide exchanges between alveolar air and pulmonary blood.     

固定边框的多电压布图规划算法

多电压设计是应对SoC功耗挑战的一种有效方法,但会带来线长、面积等的开销。为减少线长、芯片的空白面积及提高速度,提出了一种改进的固定边框多电压布图方法.对基于NPE（Normalized Polish Expression）表示的布图解,采用形状曲线相加算法来计算其最优的布图实现,并通过增量计算方法来减少计算NPE及多电压分配的时间.为使所得布图解满足给定的边框约束,提出了一个考虑固定边框约束的目标函数,并采用删除后插入（Insertion after Delete,IAD）算子对SA求得布图解进行后优化.实验结果表明,和已有方法相比,所提出方法在线长和空白面积率方面有较明显优势,且所有电路在不同高宽比、不同电压岛数下均实现了极低的空白面积率（< <1%）.     

Closed-Loop Control of an Anesthesia Delivery System: Development and Animal Testing

An anesthesia system which integrates closed-loop control of ventilation, oxygen, nitrous oxide, and anesthetic agent delivery into a closed breathing circuit is described. Breathing circuit volume is regulated by controlling the sum of oxygen and nitrous oxide flow, and oxygen concentration in the breathing circuit is regulated by controlling the ratio of oxygen flow to the sum of oxygen and nitrous oxide flow. End-tidal anesthetic agent concentration is regulated by controlling the agent delivery, and end-tidal carbon dioxide concentration is regulated by controlling the ventilation. After tuning the ventilation and anesthetic delivery controllers in preliminary trials in ten dogs, the system was tested and evaluated in five dogs. All control loops were stable and exhibited time responses to step changes in setpoint or external disturbances which were clinically acceptable. The system makes available the advantages of closed-system anesthesia without encumbering the anesthesiologist with the control tasks associated with the technique.     

乙醇浓度预测的多元线性回归模型建立及验证

设计了由光源、气室、探测器和控制器等组成的非分散红外吸收系统,往气室内通入不同浓度的多组分气体（含有乙醇、二氧化碳和水蒸气）,采用红外光谱仪进行光谱数据采集,得到多组分气体混合光谱图。根据数据集样本求解回归系数,建立了多元线性回归模型,并进行干扰修正以降低二氧化碳和水蒸气对乙醇浓度预测的影响。对建立的多元线性回归模型进行评价,结果表明:模型真实有效且具有良好的线性回归效果,可以用于预测气体浓度,乙醇、二氧化碳和水蒸气浓度预测误差均在可接受的范围之内,其中乙醇浓度预测误差最小,不超过2.0×10-4。通过干扰修正尽可能排除二氧化碳和水蒸气的干扰,能够较准确地预测乙醇浓度。     

Studies on the temperature distribution of a thick film transcutaneous oxygen sensor and its thermal influences on oxygen measurement

The partial pressures of gases, namely oxygen and carbon dioxide, in the arterial blood are important parameters for doctors to determine the respiratory conditions of patients. Currently in practice, there are a number of ways to measure these parameters, one of which is transcutaneous blood gas monitoring. This technique is a popular noninvasive measurement method for obtaining fast and relatively accurate responses. In this investigation, thick film technology has been employed to develop an amperometric oxygen sensor which consists of a heating module to elevate the temperature at the skin surface to transcutaneous levels. The heating module includes a heating element and its temperature is regulated by a temperature control circuit. Using an infrared camera, the transient and steady-state temperature distributions as well as the stability of the heating element have been analysed. The influence of temperature on the oxygen sensing module is also studied. In addition, a three-dimensional theoretical model is established to evaluate the thermal response of the sensor and subsequently compared with the results from the practical prototype. With this model, the design stages can be simplified and future heating modules for transcutaneous sensors could be generated and improved more easily and effectively.     

Optical Fluorescence and Its Application to an Intravascular Blood Gas Monitoring System

Optical fluorescence has an extensive history of application in the laboratory to the measurement of ionic concentrations and the partial pressures of oxygen and carbon dioxide. The use of optical fluorescence based sensors to fulfill a recognized need for continuous invasive monitoring of arterial blood gases offers a number of inherent advantages. However, the requirements placed upon a blood gas probe and supporting instrumentation appropriate for use in the clinical environment result in significant design challenges in selection of suitable fluorescent dyes, maintenance of mechanical integrity while obtaining required miniaturization of sensors, and in the transmission, acquisition, and processing of low level light signals. An optical fluorescence based intravascular blood gas monitoring system has been developed which is particularly suited for the critical care and surgical settings and which has a sensor probe that can be introduced into the patient via a radial artery catheter. This system has shown an excellent agreement of measured with true values of pH, pCO2, and P02 in both in vitro and animal studies. Linear regression analysis of typical in vitro data, where true levels were established via tonometry and standardization to a high accuracy laboratory pH measuring instrument, shows slope/intercept values very close to 1.0/0.0 and correlation coefficients of greater than 0.99 for all three parameters.     

A Theoretical Analysis of the Continuous Distribution of Specific Tidal Volume Throughout the Lung with Special Reference to Anatomical Dead Space

The author proposes an analysis of the continuous distribution of specific tidal volume throughout the lung which, to some extent, takes into account the dead space constituted by the bronchial tree.     

汽车尾气分析仪设计

随着汽车数量的不断增多,汽车尾气己成为空气污染的重要来源。文中设计了一种汽车尾气分析仪系统,实现了对汽车尾气中CO、HC、CO₂、O₂和NO含量的检测。设计采用部分信号调理电路,并应用Pspice电路仿真软件进行了电路仿真,仿真结果显示了调理电路的放大、滤波效果。能根据国家标准对相关参数进行处理,实现了各项测量数据的显示、判断、存档、查询、统计、标定等功能。     

干冰微粒喷射清洗技术

简要介绍了随着工艺节点的缩小,传统RCA清洗方法在硅片清洗工艺中的局限性和弊端,进而提出了以CO2为介质的新型干冰微粒喷射清洗方法。从CO2的物理特性出发,论述了CO2流经喷枪后形成干冰微粒的机理,并简要分析了干冰微粒喷射技术对颗粒污染物和有机污染物的清洗机理。在此基础上,介绍了自主研发的一台基于干冰微粒喷射技术的半导体清洗设备,对该设备的结构和各部分的作用作了简要介绍,论述了使用该设备对硅片进行清洗的工艺流程。通过对比实验发现,采用压强为8 MPa、纯度为5N的CO2作为气源,喷嘴前压强设置为11 MPa,使用该设备可以达到很好的清洗效果。     

光子晶体光纤CO2气体传感器的研究

为了能高灵敏度地检测CO₂气体的体积分数,基于红外光谱吸收原理,设计了一种以9m长的空芯光子晶体光纤作为传感单元的CO₂气体传感器。利用该传感器测量了不同体积分数的CO₂在同一吸收波长下的吸收光谱图。结果表明,气体的吸收光强和气体的体积分数之间呈线性变化,与比尔-朗伯定律一致;传感器的灵敏度可达4.389×10-5W。可通过加长光子晶体光纤的长度,来增加气体吸收的有效距离,使传感系统获得较高灵敏度。     

柔性有机发光器件封装材料气体渗透率的质谱法测量

柔性有机电致发光器件(FOLED)封装材料的研究已成为目前国内外FOLED研究的热点。如何测量水蒸汽、氧气和其他活性气体对FOLED封装材料的渗透率, 是FOLED封装材料研究的一个重要课题。提出用质谱分析技术解决柔性有机电致发光器件封装材料气体渗透率的测量问题, 建立了一个封装材料渗透率的质谱法测量系统。介绍了该系统的原理, 利用该系统测量了水蒸汽、氧气和二氧化碳等气体对PET塑料, 以及水蒸汽对ITO薄膜、银薄膜等材料的渗透率。所获得的实验结果与其他文献报道的数据进行了比较, 证明质谱法测量的结果是可信的。     

Intrusion detection in RFID system using computational intelligence approach for underground mines

The radio frequency identification technology (RFID) is commonly used for object tracking and monitoring. In this paper, we discuss a model for intrusion detection system based on RFID to identify the abnormal behavior of underground mines' toxic gases. This model consists of various types of sensor nodes that are integrated with RFID tag, which are deployed in the underground mines by using Zigbee protocol. It consists of coordinators, routers, and sensor nodes, according to different capabilities and the probabilities of intrusive activities that occur in underground mines. It can detect the real‐time abnormal behavior of the toxic gases viz. methane, carbon monoxide, carbon dioxide, hydrogen sulfide, and nitrogen dioxide gases, using artificial neural network middleware techniques. It increases the detection accuracy and reduces the false alarm rate, using multilayer perceptron, radial basis function network, and probabilistic and general regression neural network (PNN/GRNN) techniques. The simulations are performed on the toxic gas dataset, which has been generated in a real‐time scenario by using different gas sensors. The real‐time dataset contains intrusive and nonintrusive values of methane, carbon monoxide, carbon dioxide, hydrogen sulfide, and nitrogen dioxide gases. Experimentally, the PNN/GRNN provides higher detection accuracy as 90.153% for carbon monoxide, 86.713% for carbon dioxide, 93.752% for hydrogen sulfide, and 75.472% for nitrogen dioxide. The PNN/GRNN also provides low false alarm rate as 9.85% for carbon monoxide, 13.29% for carbon dioxide, 6.24% for hydrogen sulfide, and 24.53% for nitrogen dioxide compared with the multilayer perceptron and radial basis function networks.     

Development of a time-cycled volume-controlled pressure-limited respirator and lung mechanics system for total liquid ventilation

Total liquid ventilation can support gas exchange in animal models of lung injury. Clinical application awaits further technical improvements and performance verification. Our aim was to develop a liquid ventilator, able to deliver accurate tidal volumes, and a computerized system for measuring lung mechanics. The computer-assisted, piston-driven respirator controlled ventilatory parameters that were displayed and modified on a real-time basis. Pressure and temperature transducers along with a lineal displacement controller provided the necessary signals to calculate lung mechanics. Ten newborn lambs (<6 days old) with respiratory failure induced by lung lavage, were monitored using the system. Electromechanical, hydraulic, and data acquisition/analysis components of the ventilator were developed and tested in animals with respiratory failure. All pulmonary signals were collected synchronized in time, displayed in real-time, and archived on digital media. The total mean error (due to transducers, analog-to-digital conversion, amplifiers, etc.) was less than 5% compared with calibrated signals. Components (tubing, pistons, etc.) in contact with exchange fluids were developed so that they could be readily switched, a feature that will be important in clinical settings. Improvements in gas exchange and lung mechanics were observed during liquid ventilation, without impairment of cardiovascular profiles. The total liquid ventilator maintained accurate control of tidal volumes and the sequencing of inspiration/expiration. The computerized system demonstrated its ability to monitor in vivo lung mechanics, providing valuable data for early decision making.     

基于STC89C52维生环境报警器的设计

本文采用低功耗器件并采用合适的硬件方案设计了一种高铁维生坏境报警器,通过电池供应电能能够方便安装和携带,同时有着较低的功耗.高铁车厢室是乘客休息和工作出行提供休息的一个场所.相对来说,其环境较为封闭,车厢中有着比较集中的人员密度,相应的就使得空气中的废气浓度较高,特别是当车厢环境较差,门窗紧闭时,乘客会受到二氧化碳一定...     

A System for Measurement of Oxygen Consumption and Control of Inspired Carbon Dioxide

A system that monitors oxygen consumptions and replaces oxygen as needed to a spirometer under automatic control is presented. The system permits the regulation of the inspired carbon dioxide concentration at a specified level and monitoring of the expired carbon dioxide concentration.