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习近平总书记在全国宣传思想工作会上关于增强脚力、眼力、脑力、笔力的“四力”讲话,为全体新闻工作者指明了方向。新闻工作者要想做到不辱使命和担当就应该不断提升政治理论水平、个人素质和业务水平,增强“四力”的基本功。就新闻工作者如何切实增强“四力”展开分析。 相似文献
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Ye Xu Xiangyi Wu Xiaoxuan Zhang Yan Zu Qian Tan Yuanjin Zhao 《Advanced functional materials》2023,33(1):2209986
Stem cells have demonstrated values in diabetic ulcer (DU) treatments. Challenges in this area are focused on enhancing the localized curative effects of stem cells and improving diabetic wound healing efficiently. Herein, a novel living microneedle (MN) patch is presented as a localized delivery system of bioactive platelet derived growth factor D (PDGF-D) and human adipose-derived stem cells (ADSCs) for DU wound treatment. Compared with traditional complicated stem cell carriers, the MN patch can keep stem cell viability for ADSCs encapsulation and delivery, and possesses good mechanical strengths to penetrate the local skin wounds noninvasively. It is demonstrated that the delivery ADSCs are with the abilities of angiogenesis promotion during the DU wound healing; while the additive PDGF-D can contribute significantly to the proliferation of ADSCs, strengthening the cell function of ADSCs and further facilitating the healing processes. Thus, living MN patches accelerate vascularization, tissue regeneration, and collagen deposition in a wounded diabetic mouse model, suggesting their potential application to DU wound healing and other therapeutic applications. 相似文献
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Haohao Yin Bangguo Zhou Chongke Zhao Liping Sun Wenwen Yue Xiaolong Li Hongyan Li Shaoyue Li Huixiong Xu Yu Chen 《Advanced functional materials》2021,31(24):2102043
Silicene nanosheets, the emerging 2D nanomaterial, as the third topology of silicon-composed materials with distinct physicochemical properties, is a desirable candidate for photothermal-conversion nanoagent (PTA) and drug-delivery nanosystems. Inspired by the individual physiochemical properties and structure features of mesoporous silica and 2D silicene, a distinctive 2D core/shell-structured multifunctional silicon-composed theranostic nanoplatform (Silicene@Silica) is constructed by coating a mesoporous silica layer onto the surface of 2D silicene nanosheets. The well-defined mesopores originating from mesoporous silica shell provide the reservoirs for guest drug molecules and the core of silicene produces heat shock upon NIR-II laser irradiation, aiming to induce the synergistic cancer-therapeutic modality. Importantly, when AQ4N, hypoxia-activated prodrug, is introduced into this system, this nanoplatform (Silicene@Silica–AQ4N) exhibits tumor microenvironment (TME)-responsive and synergistic hyperthermia-augmented therapeutic bioactivity. Such a nanoplatform can amplify the hypoxia of TME by destroying the tumor microcirculation and then further efficiently activate AQ4N, a DNA affinity agent and topoisomerase II inhibitor. The results reveal that this multifunctional theranostic nanoplatform can efficiently eliminate tumors without recurrence. 相似文献
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Siming Yu Guowei Li Penghe Zhao Qikun Cheng Qianjun He Dong Ma Wei Xue 《Advanced functional materials》2019,29(50)
For decades, hydrogen (H2) gas has been recognized as an excellent antioxidant molecule that holds promise in treating many diseases like Alzheimer's, stroke, cancer, and so on. For the first time, active hydrogen is demonstrated to be highly efficient in antibacterial, antibiofilm, and wound‐healing applications, in particular when used in combination with the photothermal effect. As a proof of concept, a biocompatible hydrogen‐releasing PdH nanohydride, displaying on‐demand controlled active hydrogen release property under near‐infrared laser irradiation, is fabricated by incorporating H2 into Pd nanocubes. The obtained PdH nanohydride combines both merits of bioactive hydrogen and photothermal effect of Pd, exhibiting excellent in vitro and in vivo antibacterial activities due to its synergistic hydrogen‐photothermal therapeutic effect. Interestingly, combinational hydrogen‐photothermal treatment is also proved to be an excellent therapeutic methodology in healing rats' wound with serious bacterial infection. Moreover, an in‐depth antibacterial mechanism study reveals that two potential pathways are involved in the synergistic hydrogen‐photothermal antibacterial effect. One is to upregulate bacterial metabolism relevant genes like dmpI, narJ, and nark, which subsequently encode more expression of oxidative metabolic enzymes to generate substantial reactive oxygen species to induce DNA damage and another is to cause severe bacterial membrane damage to release intracellular compounds like DNA. 相似文献
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Haotian Li Jianhua Zhang Lei Yang Huan Cao Zhen Yang Peng Yang Wei Zhang Yiwen Li Xianchun Chen Zhipeng Gu 《Advanced functional materials》2023,33(21):2212193
Bacterial infections represent one of the serious human healthcare threats, and ≈80% of bacterial infections are related to biofilm. So far, there are extensive investigations on the development of robust biomaterials toward the elimination of biofilms and synergistic antibacterial applications. Despite the progress made, concerns have always been raised regarding the sophisticated synthesis and pre-modification of hybrid materials, complicated purification and high-cost work. In this study, a series of robust and integrative nanoparticles (NPs) assembled from two types of natural building blocks (natural polyphenols and tobramycin antibiotics) is successfully fabricated via a one-pot integration approach, which can efficiently destruct the biofilm structure and kill bacteria via enhanced antibiotic infiltration. Notably, natural polyphenols and tobramycin can release from the formed NPs in an on-demand manner in the bacterial-induced environment. The former ones can inhibit quorum sensing within bacteria through competitive combination with autoinducer-2 (AI-2) to remove the existing biofilm, and the latter antibiotics exert high antibacterial activity both in vitro and in vivo. This study provides new inspirations toward robust and synergistic antimicrobial and antibiofilm nanomaterials via the facile integration of naturally occurring molecules. 相似文献
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Xiang Sun Mengshi Wei Xin Pang Lin Lin Qiang Gao Lichao Su Ting Liu Youliang Yao Jibin Song Wei Wang Xiaohui Yan 《Advanced functional materials》2023,33(30):2214619
Sonodynamic bacterial inactivation, a reactive oxygen species (ROS)-empowered approach featuring high penetration depth and low health risk, is explored for antibiotic-free antibacterial treatment. However, the low yield and insufficient diffusion of ROS negatively affect the antibacterial efficacy of sonodynamic treatment, thus hindering its further development. Here an actuator-integrated mechanism is proposed for enhancing the sonodynamic efficacy of loaded sonosensitizers through motion-induced hydrodynamic effects, demonstrated by a porphyrin-decorated gold nanomotor, which can produce ROS for bacterial inactivation while performing multimodal motion via actuation using low-frequency ultrasound. Corroborated by numerical simulation, the experimental results show that the motor's stirring motion significantly increases the yield and diffusion of ROS through fluid flow and frequent interactions between the motor and bacterial targets, resulting in doubled antibacterial efficiency in comparison to a stationary motor. Furthermore, the flow-induced shear forces combined with the frequent interactions constitute a source of mechanical damage and can form a synergy with the antibacterial properties of ROS, enabling an efficient biofilm eradication that is inaccessible by freely suspended porphyrin. In conclusion, this study reports a motion-based strategy to enhance sonodynamic efficacy and provides proof of concept using a sonodynamic gold nanomotor powered by ultrasound. 相似文献
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Xin Fan Yang Gao Fan Yang Jian Liang Low Lei Wang Beate Paulus Yi Wang Andrej Trampuz Chong Cheng Rainer Haag 《Advanced functional materials》2023,33(33):2301986
Diabetic ulcers induced by multidrug-resistant (MDR) bacteria have severely endangered diabetic populations. These ulcers are very challenging to treat because the local high glucose concentration can both promote bacterial growth and limit the immune system's bactericidal action. Herein, a glucose oxidase-peroxidase (GOx-POD) dual-enzyme mimetic (DEM) bionanocatalyst, Au@CuBCats is synthesized to simultaneously control glucose concentration and bacteria in diabetic ulcers. Specifically, the AuNPs can serve as GOx mimics and catalyze the oxidation of glucose for the formation of H2O2; the H2O2 can then be further catalytically converted into OH via the POD-mimetic copper single atoms. Notably, the unique copper single atoms coordinated by one oxygen and two nitrogen atoms (CuN2O1) exhibit better POD catalytic performance than natural peroxidase. Further DFT calculations are conducted to study the catalytic mechanism and reveal the advantage of this CuN2O1 structure as compared to other copper single-atom sites. Both in vitro and in vivo experiments confirm the outstanding antibacterial therapeutic efficacy of the DEM bionanocatalyst. This new bionanocatalyst will provide essential insights for the next generation of antibiotic-free strategies for combating MDR bacterial diabetic ulcers, and also offer inspiration for designing bionanocatalytic cascading medicines. 相似文献
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Zhiyong Song Yang Wu Qi Cao Huajuan Wang Xiangru Wang Heyou Han 《Advanced functional materials》2018,28(23)
To satisfy the ever‐growing demand in bacterial infection therapy and other fields of science, great effort is being devoted to the development of methods to precisely control drug release and achieve targeted use of an active substance at the right time and place. Here, a new strategy for bacterial infection combination therapy based on the light‐responsive zeolitic imidazolate framework (ZIF) is reported. A pH‐jump reagent is modified into the porous structure of ZIF nanoparticles as a gatekeeper, allowing the UV‐light (365 nm) responsive in situ production of acid, which subsequently induces pH‐dependent degradation of ZIF and promotes the release of the antibiotic loaded in the mesopores. The combination of the UV‐light, the pH‐triggered precise antibiotic release, and the zinc ions enables the light‐activated nanocomposite to significantly inhibit bacteria‐induced wound infection and accelerate wound healing, indicating a switchable and synergistic antibacterial effect. The light irradiated accumulation of acid ensures the controlled release of antibiotic and controlled degradation of ZIF, suggesting the therapeutic potential of the metal–organic frameworks‐based smart platform for controlling bacterial infection. 相似文献
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Tianhe Huang Guan Wang Mohammad-Ali Shahbazi Yuancheng Bai Jingrui Zhang Guobing Feng Elham Asadian Fatemeh Ghorbani-Bidkorpeh Zhiyuang Yang Yuanai Li Qingqing Huo Yingxin Liu Dongfei Liu 《Advanced functional materials》2023,33(2):2210627
A versatile surface decoration strategy to efficiently encapsulate water-soluble peptides is developed. By assembling peptide molecules into nanoparticles, diverse physiochemical properties of these compacted molecules are equalized to the surface properties of nanoparticles. Primarily driven by the generic electrostatic attractions, the surface of as-prepared peptide nanoparticles is decorated with charged amino acids-grafted poly(lactic-co-glycolic acid). This adsorbed polymer layer versatilely blocks the phase transfer of peptide nanoparticles by increasing their affinity to the dispersed phase solvent molecules. Attributed to the ultrahigh encapsulation efficiencies (> 96%), the peptide mass fraction inside the obtained microcomposites is higher than 48%. The plasma calcium level has been efficiently reduced for ≈3 weeks with only one single injection of salmon calcitonin-encapsulated microcomposite in osteoporotic rats. Similarly, one single injection of exenatide-encapsulated microcomposites efficiently controls the glycemic level in type 2 diabetic rats for up to 3 weeks. Overall, the developed versatile surface decoration strategy efficiently encapsulates peptides and improves their pharmacokinetic features, regardless of the molecular structure of peptide cargos. 相似文献
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Yuan Xiong Qian Feng Li Lu Kangkang Zha Tao Yu Ze Lin Yiqiang Hu Adriana C. Panayi Vahideh Nosrati-Ziahmagi Xiangyu Chu Lang Chen Mohammad-Ali Shahbazi Bobin Mi Guohui Liu 《Advanced functional materials》2023,33(10):2213066
Diabetic foot ulcer (DFU) is one of the most common complications of diabetes, bringing physical and mental challenges for patients due to the lack of efficient curative therapy. Despite considerable advances in pharmacological and surgical approaches, clinical trials for DFU patients remain disappointing due to the local overactive and excessive inflammation. Immunomodulatory hydrogels has significant advantages to overcome the clinical challenge of DFUs therapy. Here, recent fabrication and regenerative advances in the utilization of functional hydrogels for altering the immune microenvironment of DFUs are comprehensively reviewed. The pathological features and the healing processes of DFUs, followed by summarizing the physicochemical properties essential for the design of regenerative hydrogels for immunomodulation in DFUs, are briefly introduced. Then, the potential immuno-therapeutic modalities of hydrogels and emerging trends used to treat DFUs via multitherapeutic approaches and enhanced efficacy and safety are discussed. Taken together, by linking the structural properties of hydrogels to their functions in DFU therapy with a particular focus on immunomodulatory stimuli, this review can promote further advances in designing advanced hydrogels for DFUs, resulting in improved diabetic wound repair through translation into clinical setting in the near future. 相似文献
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Weilin Meng Ze Lin Xuan Cheng Shuangqian Gou Rong Wang Pengzhen Bu Yan Li Bobin Mi Yongsheng Yu Qian Feng Kaiyong Cai 《Advanced functional materials》2024,34(22):2314202
For various chronic wounds, bacterial infection is one of the important reasons that hinder their healing. Ion-crosslinked antibacterial hydrogel dressings based on Ag+, Cu2+ and Zn2+, have made progress in clinical application. However, the toxicity of released metal ions cannot be ignored. Therefore, how to ensure the antibacterial performance of hydrogel dressing while reducing the amount of metal ions is a major challenge for the fabrication of metal ion based antibacterial hydrogel. In this study, a general method is proposed to design cationic ion-crosslinked hydrogel based on thiourea groups. Taking the hydrogel formed by mixing thiourea modified hyaluronic acid (H-ANCSN) with Ag+ (HA-NCSN/Ag+ hydrogel) as an example, the characteristics and application potential of this kind of hydrogel are thoroughly explored. Due to the strong cationic chelation characteristics of thiourea groups, HA-NCSN/Ag+ hydrogel can gel at low Ag+ concentration and achieve long-term slow release of Ag+ at stable concentration to balance the antibacterial and biocompatible properties. Moreover, this dynamic thiourea-Ag+ crosslinking also endowed the hydrogel with the property of “gelation and encapsulation first, injection to cover wound when necessary”. Then, the mangiferin self-assembled nanoparticles are loaded into HA-NCSN/Ag+ hydrogel as the radical oxygen species scavenger. 相似文献
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目的：观察微波治疗机（HYJ-Ⅲ）治疗对非坏疽性糖尿病足其疗效及安全性。方法：选择非坏疽性糖尿病足患者90例,按住院号末位单双号分组的原则分为试验组（45例）和对照组（45例）,对照组采用常规治疗,试验组采用常规治疗加微波治疗机（HYJ-Ⅲ）治疗,动态观察及比较糖尿病足的愈合效果。结果：两组比较,试验组显著优于对照组（P〈0．05）,两组均未发现明显不良反应。结论：微波治疗机（HYJ-Ⅲ）能促进糖尿病足患者创面的愈合,缩短住院时间,方便、舒适,无不良反应。 相似文献
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Zenan Zeng Yachao Li Kefurong Deng Dongzhe Zou Liguo Liu Beiling Guo Yiming Liu Cheng Shen Xiaoyu Liang Xianghui Xu 《Advanced functional materials》2024,34(18):2311315
Antimicrobial therapy remains one of the major global challenges, particularly in the absence of effective treatment strategies for drug-resistant bacteria. In this study, a comprehensive treatment approach is proposed for drug-resistant bacterial wound infections based on the development of thermal-cascade multifunctional therapeutic systems (MTSs), spanning from the design of functional nanoscale materials to macroscopic smart hydrogel. Within the MTSs, functional antibiotic-loaded hybrid nanoclusters enable targeted therapeutic delivery and synergistic mild hyperthermia-antibiotic treatment, strongly suppressing drug-resistant bacteria while demonstrating excellent biocompatibility with normal cells and tissues. Furthermore, near-infrared irradiation can trigger the photothermal effects of hybrid nanoclusters to induce gelation of thermal-sensitive hydrogel, forming MTSs to serve as highly adaptable, drug-enriched protective dressings for infected wounds. Both in vitro and in vivo results substantiate that MTSs enhance the bioavailability of therapeutic agents (including bacterial internalization and tissue penetration), exert synergistic effects to completely eradicate drug-resistant bacteria, promoted wound healing and revascularization, and demonstrate excellent biocompatibility. This work offers an innovative demonstration to address drug-resistant bacterial infections through the advancement of sophisticated material systems. 相似文献
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Nowadays, antibiotic abuse increases the emergence of multidrug‐resistant bacterial strains, which is the major reason for the failure of conventional antibiotic therapies. Therefore, developing novel antibacterial materials or therapies is an urgent demand. In the present study, photothermal and NO‐releasing properties are integrated into a single nanocomposite to realize more efficient bactericidal effects. To this end, polydopamine (PDA) coated iron oxide nanocomposite (Fe3O4@PDA) is used as a photoconversion agent and the core, first three generation dendritic poly(amidoamine) (PAMAM‐G3) is grafted on the surface of Fe3O4@PDA, and subsequently NO is loaded with the formation of NONOate. The resultant Fe3O4@PDA@PAMAM@NONOate displays controllable NO release property under intermittent 808 nm laser irradiation and excellent bacteria‐separation efficiency. Moreover, excellent synergistic photothermal and NO antibacterial effects are observed against both Gram‐negative Escherichia coli and Gram‐positive Staphylococcus aureus, where bacterial viability and biofilm are significantly reduced. An antibacterial mechanism study reveals that the materials first adsorb onto the bacterial membrane, then cause damage to the membrane by the increased local temperature and the released NO under laser irradiation conditions, finally leak the intracellular components like DNA and induce bacteria death. The work provides a novel way for designing of antibacterial materials with higher efficiency. 相似文献
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As a key type of emerging thermoelectric material, tin telluride (SnTe) has received extensive attention because of its low toxicity and eco‐friendly nature. The recent trend shows that band engineering and nanostructuring can enhance thermoelectric performance of SnTe as intermediate temperature (400–800 K) thermoelectrics, which provides an alternative for toxic PbTe with the same operational temperature. This review highlights the key strategies to enhance the thermoelectric performance of SnTe materials through band engineering, carrier concentration optimization, synergistic engineering, and structure design. A fundamental analysis elucidates the underpinnings for the property improvement. This comprehensive review will boost the relevant research with a view to work on further performance enhancement of SnTe materials. 相似文献
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本文结合非电类电工电子实验班学生的特点,对我校非电类电工电子实验教学改革进行了探索:将单一的验证型实验改为分阶段组合式的验证型实验+提高型实验+综合型实验。教学结果表明,分阶段组合式的实验教学模式能够提高学生的实践能力、创新能力和创新意识。 相似文献
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目的:分析激光治疗糖尿病眼底病变过程中的不安全因素.方法:回顾性分析223例散瞳后用法国"光太"眼底激光机行眼底血管病变的治疗过程.对激光机的故障情况、患者的治疗效果、医护人员的防护现状三方面进行调查.结果:运行4年来,眼底激光机发生故障5次:患者治疗有效率84.6%,无严重并发症:在治疗过程中,除主治医生配带防护眼罩外,辅助医护人员不注意对激光的安全防护.结论:在激光治疗糖尿病眼底病变的过程中,机器性能稳定安全,疗效确切,但医护人员的防护意识急需加强. 相似文献
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Excellent fatigue resistance is a prerequisite for flexible energy devices to achieve high and stable performance under repeated deformation state. Inspired by the sophisticated interfacial architecture of nacre, herein a super fatigue‐resistant graphene‐based nanocomposite with integrated high tensile strength and toughness through poly(dopamine)‐nickel ion (Ni2+) chelate architecture that mimics byssal threads is demonstrated. These kind of synergistic interfacial interactions of covalent and ionic bonding effectively suppress the crack propagation in the process of fatigue testing, resulting in superhigh fatigue life of this bioinspired graphene‐based nanocomposite (BGBN). In addition, the electrical conductivity is well kept after fatigue testing. The proposed synergistic interfacial interactions could serve as a guideline for fabricating high‐performance multifunctional BGBNs with promising applications in flexible energy devices, such as flexible electrodes for supercapacitors and lithium batteries, etc. 相似文献