Print exposure as a predictor of word reading and reading comprehension in disabled and nondisabled readers.

The relation of print exposure, measured by a revised version of A. E. Cunningham and K. E. Stanovich's (1990) Title Recognition Test (TRT), to word reading and reading comprehension was examined in disabled and nondisabled readers, Grades 5–9. In disabled readers, the TRT was a significant predictor of word reading when phonological skill was accounted for but not when orthographic ability was added to the regression equation, suggesting that the TRT overlaps considerably with orthographic skill. The TRT significantly predicted nondisabled readers' word reading after both phonological and orthographic skills were accounted for. The TRT contributed significantly to reading comprehension once variance was partialed from higher order reading processes for disabled readers only. The TRT's power to predict comprehension may be ascribed to the effects of print exposure on automaticity of word recognition, knowledge, or familiarization with text structure. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of synthetic speech output and orthographic feedback on spelling in a student with autism: a preliminary study

The number of telephone surveys conducted has increased in Japan, with the telephone directory often used for sampling respondents in telephone surveys. As some subscribers request that their numbers not be listed, they are excluded. The Random Digit Dialing (RDD) survey method, however, not only makes possible smooth data collection, but also random sampling of all subscribers in telephone surveys. The authors conducted a telephone survey in Tokyo using the RDD method to investigate any differences in behavior and demographic or social attributes between listed and unlisted subscribers. These attributes included gender, age, family size, job, and residential area. The findings were as follows: 1) The listing rate in telephone directories was 65.8% among respondents. 2) Old age, large family size and certain residential areas correlated with higher listing rates. 3) Nevertheless, the relationship between listing in the telephone directory and residential area remains somewhat unclear due to the confounding attributes of age and family size. 4) Using Hayashi's second method of quantification, age, family size and occupation correlated with listing frequency. 5) There were also significant differences between listed and unlisted subscribers on questions of health maintenance and lifestyle.     

Treatment research in speech, language and swallowing: lessons from child language disorders

Three major types of treatment research methodologies are described. Studies on child language intervention are reviewed as examples of trends and methodological issues characterizing treatment research in speech, language, and swallowing within the last 2-3 decades. Principles are drawn from that literature and suggestions for future directions are discussed with particular attention to recent efforts to support clinical trials and treatment outcomes research.     

Teaching reading to poor readers in the intermediate grades: A comparison of text difficulty.

The authors compared the influence of text difficulty--reading-level matched or grade-level matched--on the growth of poor readers' reading ability over 18 weeks of 1-to-1 tutoring. Forty-six 3rd-5th graders, including 25 with disabilities, were assigned randomly to 1 of 2 tutoring approaches or a control condition. Significant differences favored tutored children. Between approaches, the only significant difference was oral reading fluency, which favored students who read material at their reading level. Students who began with lower fluency made stronger gains in text matched to reading level; students with higher fluency profited from both treatments. When the 3 groups were combined, fluency was the strongest contributor to reading comprehension outcomes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Predictors of reading comprehension for struggling readers: The case of Spanish-speaking language minority learners.

This longitudinal study examined the process of English reading comprehension at age 11 years for 173 low-achieving Spanish-speaking children. The influence of growth rates, from early childhood (age 4.5 years) to pre-adolescence (age 11 years), in vocabulary and word reading skills on this complex process were evaluated with structural equation modeling. Standardized measures of word reading accuracy and productive vocabulary were administered annually, in English and Spanish, and English reading comprehension measures were administered at age 11 years. Latent growth curve analyses revealed that English skills accounted for all unique variance in English reading comprehension outcomes. Further, expected developmental shifts in the influence of word reading and vocabulary skills over time were not shown, likely on account of students' below-grade-level reading comprehension achievement. This work underscores the need for theoretical models of comprehension to account for students' skill profiles and abilities. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Higher touch and kinesthetic functions in children with former speech/language development disorders: a neuropsychological study

1. The affinities of 10 selective muscarinic receptor antagonists against [3H]-quinuclidinyl benzilate (QNB) binding were determined to characterize the muscarinic receptors present in guinea-pig gallbladder smooth muscle. The highest correlation was obtained for the comparison between the pKi values for the gallbladder smooth muscle and M2 sites. Pirenzepine revealed two binding sites with affinities indicating the presence of muscarinic M2 receptors in abundance and a minor population of an additional site(s). 2. Carbachol produced gallbladder contractions, stimulated phosphoinositide (PI) hydrolysis and inhibited cAMP formation concentration-dependently with pD2 values of 6.12 +/- 0.11, 5.18 +/- 0.33 and 7.19 +/- 0.15, respectively. 3. Pirenzepine, 4-DAMP, HHSiD, pF-HHSiD, AF-DX 116, methoctramine, AQ-RA 741, guanylpirenzepine and AF-DX 384 showed competitive antagonism against carbachol-induced gallbladder contractions. There was no correlation between the pA2 values for the gallbladder and pKi values for the M2 sites, whereas significant correlations were found for the M1, M3 and M4 sites, the best correlation being between the pA2 values for the gallbladder and M4 subtypes. 4. Finally, the presence of both m2 and m4 receptor proteins were demonstrated by Western blot analysis. It is concluded that guinea-pig gallbladder smooth muscle has both muscarinic M2 and M4 receptors, which are coupled to adenylate cyclase inhibition and PI hydrolysis. 5. Although it seems likely that M2 receptors do not play a primary role in carbachol-induced guinea-pig gallbladder contraction, the characterization of the muscarinic subtypes which mediate these contractile responses needs further evidence.     

Personality disorders in patients with eating disorders: a controlled study

A group of 24 eating-disordered female subjects (10 anorexia nervosa--AN--and 14 bulimia nervosa--BN--patients) were interviewed, using a semistructured interview for DSM-III-R Axis-II Personality Disorders (SCID-II). A group of 54 subjects without eating disorder acted as a control group. A high rate of personality disorder (PD) diagnoses occurred in eating disordered subjects (AN and BN patients), with a high prevalence of borderline, dependent, and self-defeating PD. Avoidant and obsessive-compulsive PD were more common in AN patients, whereas BN was associated with histrionic PD. Findings have implications for the assessment and diagnosis of eating-disordered patients and for treatment planning.     

Influence of speech variety on teachers' evaluation of reading comprehension.

Investigated how 2 speech varieties, standard English and Black English, used during an oral reading and recall task influenced 64 White and 8 Black teachers' (mean age 36 yrs) evaluations of reading comprehension and how teachers' attitudes toward Black English related to those evaluations. Measures included the Oral Reading and Recall Evaluation, the Reading Miscue Inventory, and the Language Attitude Scale. Although the proportion of variance accounted for by the overall model was not great (11%), significant contrasts between the evaluations of 2 readers, one a Black English speaker and one a standard English speaker, were found with teachers who held negative attitudes toward Black English. No significant contrasts were found with teachers who held positive attitudes toward Black English. Results indicate that Black English readers were rated lower in reading comprehension than equivalent standard English readers when teachers held a negative attitude toward their language. (16 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The nonword-reading deficit of disabled readers: A developmental interpretation.

This article presents empirical evidence challenging the received wisdom that a nonword-reading deficit is a characteristic trait of disabled readers. On the basis of 2 large-scale empirical studies using the reading-level match design, we argue that a nonword-reading deficit is the consequence of normal developmental differences in word-specific knowledge between disabled readers and younger normal readers (both groups being matched on real-word reading). The first study shows that the nonword-reading deficit varies as a function of age and reading level and that this deficit is not typical for disabled readers. The second study demonstrates that a nonword-reading deficit crucially depends on the sensitivity of the matching word reading task to detect age-related differences in word-specific knowledge between disabled and normal readers. We clarify how these findings can be interpreted within the current framework of the phonological deficit hypothesis and discuss implications for theories of reading development. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Hearing, speech, language, and vestibular disorders in the fetal alcohol syndrome: a literature review

Fetal alcohol syndrome (FAS) is characterized in part by mental impairment, as well as craniofacial and ocular anomalies. These conditions are traditionally associated with childhood hearing disorders, because they all have a common embryonic origin in malformations of the first and second branchial arches, and have similar critical periods of vulnerability to toxic insult. A review of human and animal research indicates that there are four types of hearing disorders associated with FAS. These are: (1) a developmental delay in auditory maturation, (2) sensorineural hearing loss, (3) intermittent conductive hearing loss due to recurrent serous otitis media, and (4) central hearing loss. The auditory and vestibular systems share the same peripheral apparatuses (the inner ear and eighth cranial nerve) and are embryologically and structurally similar. Consequently, vestibular disorders in FAS children might be expected. The evidence for vestibular dysfunction in FAS is ambiguous, however. Like other syndromes associated with craniofacial anomalies, hearing disorders, and mental impairment, FAS is also characterized by a high prevalence of speech and language pathology. Hearing disorders are a form of sensory deprivation. If present during early childhood, they can result in permanent hearing, language, and mental impairment. Early identification and intervention to treat hearing, language, and speech disorders could therefore result in improved outcome for the FAS child. Specific recommendations are made for intervention and future research.     

Oral language and reading: Reply to Bracken (2005).

Early language competence in preschool relates both directly and indirectly to elementary school reading in both 1st and 3rd grades. Further, comprehensive language skills are more strongly related to early reading than are vocabulary scores alone. In response to a challenge by S. A. Bracken (2005), the current article reaffirms the National Institute of Child Health and Human Development Early Child Care Research Network's (see record 2005-02477-013) findings. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Oral language and code-related precursors to reading: Evidence from a longitudinal structural model.

This study examined code-related and oral language precursors to reading in a longitudinal study of 626 children from preschool through 4th grade. Code-related precursors, including print concepts and phonological awareness, and oral language were assessed in preschool and kindergarten. Reading accuracy and reading comprehension skills were examined in 1st through 4th grades. Results demonstrated that (a) the relationship between code-related precursors and oral language is strong during preschool; (b) there is a high degree of continuity over time of both code-related and oral language abilities; (c) during early elementary school, reading ability is predominantly determined by the level of print knowledge and phonological awareness a child brings from kindergarten; and (d) in later elementary school, reading accuracy and reading comprehension appear to be 2 separate abilities that are influenced by different sets of skills. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Training and transfer-of-learning effects in disabled and normal readers: evidence of specific deficits

Two experiments were conducted to assess the specificity of training and transfer deficits in disabled readers, aged 7 to 9 years. Forty-eight children (reading disabled, age-matched normal controls, and reading-level-matched normal controls) participated in both a reading and a nonreading (music) acquisition paradigm. Children received instruction in grapheme-phoneme and symbol-note correspondence patterns, respectively. Posttraining tests (one day and one week) following rule training compared performance on trained exemplar items with performance on untrained transfer items. Results revealed that normal readers were able to transfer their rule knowledge in both the reading and nonreading (music) acquisition paradigms, while disabled readers were proficient only in the music task, and thus demonstrated transfer deficits specific to learning printed language. Transfer was optimally facilitated for all readers when training procedures included not only presentation of exemplars, but also cues for rule derivation and explicit statement of pattern invariances.     

Accelerating language development through picture book reading: Replication and extension to a videotape training format.

G. J. Whitehurst et al (see record 1989-02401-001) taught mothers specific interactive techniques to use when reading picture books with their preschool-age children. This intervention program, called dialogic reading, produced substantial effects on preschool children's language development. However, the costs of one-on-one training limit the widespread use of dialogic reading techniques. In this study the authors aimed to replicate and extend the results of the original study of dialogic reading by developing and evaluating an inexpensive videotape training package for teaching dialogic reading techniques. Mothers were randomly assigned to receive no training, traditional direct training, or videotape training. Results supported the conclusions of Whitehurst et al: Dialogic reading had powerful effects on children's language skills and indicated that videotape training provided a cost-effective, standardized means of implementing the program. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Maternal speech to infants in a tonal language: Support for universal prosodic features in motherese.

The prosodic features of maternal speech addressed to 2-month-old infants were measured quantitatively in a tonal language, Mandarin Chinese, to determine whether the features are similar to those observed in nontonal languages such as English and German. Speech samples were recorded when 8 Mandarin-speaking mothers addressed an adult and their own infants. Eight prosodic features were measured by computer: fundamental frequency (pitch), frequency range per sample, frequency range per phrase, phrase duration, pause duration, number of phrases per sample, number of syllables per phrase, and the proportion of phrase time as opposed to pause time per sample. Results showed that fundamental frequency was significantly higher and exhibited a larger range over the entire sample as well as a larger range per phrase in infant-directed as opposed to adult-directed speech. Durational analyses indicated significantly shorter utterances and longer pauses in infant-directed speech. Significantly fewer phrases per sample, fewer syllables per phrase, and less phrase-time per sample occurred in infant-directed speech. This pattern of results for Mandarin motherese is similar to that reported in other languages and suggests that motherese may exhibit universal prosodic features. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Analysis of speech disorders in acute pseudobulbar palsy: a longitudinal study of a patient with lingual paralysis

Adoptive transfer of host defense cells may be able to correct an otherwise defective generation of competent immune cells in patients with cancer. Ex vivo-grown cytotoxic macrophages (MAC) able to recognize and destroy tumor cells but not normal cells are effective in murine models of metastasizing tumors. After the development of large-scale technology to generate MAC in vitro from blood monocytes (MO), clinical trials in cancer patients have proven the feasibility and safety of infusing >3 x 10(9) autologous MO-derived MAC activated by interferon-gamma or lipopolysaccharide. Various modalities of adoptive immunotherapy with human MAC have been realized: routes of application used were intravenous, intraperitoneal, intrapleural, and through selective hepatic artery perfusion. In addition, MAC have been generated from MO collected after granulyte-macrophage colony-stimulating factor treatment in vivo. Biodistribution studies using 111indium-labeled cells have revealed localization of MAC to sites of bulk tumor growth on regional infusion as well as to liver metastases on systemic application. Malignant ascites disappeared in about 50% of patients after intraperitoneal treatment, yet no other evidence of therapeutic efficacy of MAC could be demonstrated. Further advances of adoptive transfer of MO-derived cells are developed with emphasis on the generation of antigen-presenting cells primed in vitro with tumor cells or specific peptides.     

A clinical experience with a hierarchically controlled myoelectric hand prosthesis with vibro-tactile feedback

The decline of plasma fibronectin after surgery, trauma, and burn, as well as during severe sepsis after injury, appears to limit hepatic Kupffer cell phagocytic activity. Intravenous infusion of gelatin-coated particles to simulate blood-borne particulate collagenous tissue debris in the circulation after injury also depletes plasma fibronectin. We used soluble gelatin conjugated with 125I-labeled dilactitol tyramine (DLT-gelatin) as a model of soluble collagenous tissue debris. We studied its blood clearance as well as organ localization in normal and postburn rats. Fibronectin-deficient plasma harvested early after burn exhibited limited ability to support in vitro phagocytic uptake of the gelatinized microparticles by Kupffer cells in liver tissue from normal rats. However, Kupffer cells in liver tissue from normal and postburn rats phagocytized the test particles at a normal rate when incubated in normal plasma. The DLT-gelatin ligand bound to fibronectin in a dose-dependent manner as verified by its capture with anti-fibronectin coated plastic wells when coincubated with purified fibronectin. By gel filtration chromatography, the binding of fibronectin with the DLT-gelatin ligand was readily detected, resulting in the formation of a high-molecular-weight complex. In normal animals the plasma clearance and liver localization of 125I-DLT-gelatin was competitively inhibited by infusion of excess nonradioactive gelatin. The blood clearance and liver localization of the soluble gelatin ligand were also impaired after burn injury during periods of fibronectin deficiency similarly to the pattern observed with gelatin-coated microparticles. By autoradiography, the cellular site for the uptake of the 125I-DLT-gelatin was primarily but not exclusively hepatic Kupffer cells; 125I-DLT-asialofetuin and 125I-DLT-ovalbumin were removed by hepatocytes and sinusoidal endothelial cells, respectively. Thus, gelatin conjugated with 125I-DLT can be used to simulate blood-borne soluble collagenous tissue debris after burn. It rapidly binds to plasma fibronectin before its hepatic Kupffer cell removal, and its blood clearance is markedly delayed after burn injury during periods of plasma fibronectin deficiency.