Detection of brain tumour from MRI image using modified region growing and neural network

Abstract

Region growing is an important application of image segmentation in medical research for detection of tumour. In this paper, we propose an effective modified region growing technique for detection of brain tumour. It consists of four steps which includes: (i) pre-processing; (2) modified region growing by the inclusion of an additional orientation constraint in addition to the normal intensity constrain; (3) feature extraction of the region; and (4) final classification using the neural network. The performance of the proposed technique is systematically evaluated using the magnetic resonance imaging (MRI) brain images received from the public sources. For validating the effectiveness of the modified region growing, we have considered the quantity rate parameter. For the evaluation of the proposed technique of tumour detection, we make use of sensitivity, specificity and accuracy values which we compute from finding out false positive, false negative, true positive and true negative. Comparative analyses were made of the normal and the modified region growing using both the Feed Forward Neural Network (FFNN) and Radial Basis Function (RBF) neural network. From the results obtained, we could see that the proposed technique achieved the accuracy of 80% for the testing dataset, which clearly demonstrated the effectiveness of the modified region growing when compared to the normal technique.     

MRI brain image enhancement using brightness preserving adaptive fuzzy histogram equalization

In this article, fuzzy logic based adaptive histogram equalization (AHE) is proposed to enhance the contrast of MRI brain image. Medical image plays an important role in monitoring patient's health condition and giving an effective diagnostic. Mostly, medical images suffer from different problems such as poor contrast and noise. So it is necessary to enhance the contrast and to remove the noise in order to improve the quality of a various medical images such as CT, X‐ray, MRI, and MAMOGRAM images. Fuzzy logic is a useful tool for handling the ambiguity or uncertainty. Brightness Preserving Adaptive Fuzzy Histogram Equalization technique is proposed to improve the contrast of MRI brain images by preserving brightness. Proposed method comprises of two stages. First, fuzzy logic is applied to an input image and then it's output is given to AHE technique. This process not only preserves the mean brightness and but also improves the contrast of an image. A huge number of highly MRI brain images are taken in the proposed method. Performance of the proposed method is compared with existing methods using the parameters namely entropy, feature similarity index, and contrast improvement index and the experimental results show that the proposed method overwhelms the previous existing methods.     

Performance analysis of neural networks for classification of medical images with wavelets as a feature extractor

In this article, we analyze the performance of artificial neural network, in classification of medical images using wavelets as feature extractor. This work classifies the mammographic image, MRI images, CT images, and ultrasound images as either normal or abnormal. We have tested the proposed approach using 50 mammogram images (13 normal and 37 abnormal), 24 MRI brain images (9 normal and 15 abnormal), 33 CT images (11 normal and 22 abnormal), and 20 ultrasound images (6 normal and 14 abnormal). Four kind of neural network models such as BPN (Back Propagation Network), Hopfield, RBF (Radial Basis Function), and PNN (Probabilistic neural network) were chosen for study. To improve diagnostic accuracy, the feature extracted using wavelets such as Harr, Daubechies (db2, db4, and db8), Biorthogonal and Coiflet wavelets are given as input to the neural network models. Good classification percentage of 96% was achieved using the RBF when Daubechies (db4) wavelet based feature extraction was used. We observed that the classification rate is almost high under the RBF neural network for all the dataset considered. © 2015 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 25, 33–40, 2015     

Pixel’s Quantum Image Enhancement Using Quantum Calculus

The current study provides a quantum calculus-based medical image enhancement technique that dynamically chooses the spatial distribution of image pixel intensity values. The technique focuses on boosting the edges and texture of an image while leaving the smooth areas alone. The brain Magnetic Resonance Imaging (MRI) scans are used to visualize the tumors that have spread throughout the brain in order to gain a better understanding of the stage of brain cancer. Accurately detecting brain cancer is a complex challenge that the medical system faces when diagnosing the disease. To solve this issue, this research offers a quantum calculus-based MRI image enhancement as a pre-processing step for brain cancer diagnosis. The proposed image enhancement approach improves images with low gray level changes by estimating the pixel’s quantum probability. The suggested image enhancement technique is demonstrated to be robust and resistant to major quality changes on a variety of MRI scan datasets of variable quality. For MRI scans, the BRISQUE “blind/referenceless image spatial quality evaluator” and the NIQE “natural image quality evaluator” measures were 39.38 and 3.58, respectively. The proposed image enhancement model, according to the data, produces the best image quality ratings, and it may be able to aid medical experts in the diagnosis process. The experimental results were achieved using a publicly available collection of MRI scans.     

An efficient automated methodology for detecting and segmenting the ischemic stroke in brain MRI images

Brain tumor and brain stroke are two important causes of death in and around the world. The abnormalities in brain cell leads to brain stroke and obstruction in blood flow to brain cells leads to brain stroke. In this article, a computer aided automatic methodology is proposed to detect and segment ischemic stroke in brain MRI images using Adaptive Neuro Fuzzy Inference (ANFIS) classifier. The proposed method consists of preprocessing, feature extraction and classification. The brain image is enhanced using Heuristic histogram equalization technique. Then, texture and morphological features are extracted from the preprocessed image. These features are optimized using Genetic Algorithm and trained and classified using ANFIS classifier. The performance of the proposed ischemic stroke detection system is analyzed in terms of sensitivity, specificity, accuracy, positive predictive value, negative predictive value, and Mathew's correlation coefficient.     

Comparative analysis of Alzheimer's disease classification by CDR level using CNN,feature selection,and machine-learning techniques

Magnetic resonance imaging (MRI) of brain needs an impeccable analysis to investigate all its structure and pattern. This analysis may be a sharp visual analysis by an experienced medical professional or by a computer aided diagnosis system that can help to predict, what may be the recent condition. Similarly, on the basis of various information and technique, a system can be designed to detect whether a patient is prone to Alzheimer's disease or not. And this task of detection of abnormalities at an initial stage from brain MRI is a major challenge in the field of neurosciences. The main idea behind our research is to utilize the deep layers feature extraction benefited from deep neural network architecture, without extensive hardware resource training, and classifying the image on a basis of simple machine-learning algorithm with selected best features in order to reduce work load, classification error and hardware utilization time. We have utilized convolution neural network (CNN) layer using similar architecture like that of Alexnet with some parametric change, for the automatic extraction of features of images obtained from slice extraction of whole brain MRI whereas 13 manual features based on gray level co-occurrence matrix were also extracted to test the impact of this features on ranking. If we had only classified using CNN network, the misclassification rate was much higher. So, feature selection is achieved with feature ranking algorithms like Mutinffs, ReliefF, Laplacian and UDFS and so on and also tested with different machine-learning techniques like Support Vector Machine, K-Nearest Neighbor and Subspace Ensemble under different testing condition. The performance of the result is satisfactory with classification accuracy around 98% to 99% with 7:3 ratio of random holdout partition of training to testing image sets and also with fivefolds of cross-validation on the same set using a standardized template.     

A Learning Based Brain Tumor Detection System

Brain tumor is one of the most dangerous disease that causes due to uncontrollable and abnormal cell partition. In this paper, we have used MRI brain scan in comparison with CT brain scan as it is less harmful to detect brain tumor. We considered watershed segmentation technique for brain tumor detection. The proposed methodology is divided as follows: pre-processing, computing foreground applying watershed, extract and supply features to machine learning algorithms. Consequently, this study is tested on big data set of images and we achieved acceptable accuracy from K-NN classification algorithm in detection of brain tumor.     

Brain tumor severity analysis using modified multi‐texton histogram and hybrid kernel SVM

Magnetic resonance image (MRI) segmentation refers to a process of assigning labels to set of pixels or multiple regions. It plays a major role in the field of biomedical applications as it is widely used by the radiologists to segment the medical images input into meaningful regions. In recent years, various brain tumor detection techniques are presented in the literature. In this article, we have developed an approach to brain tumor detection and severity analysis is done using the various measures. The proposed approach comprises of preprocessing, segmentation, feature extraction, and classification. In preprocessing steps, we need to perform skull stripping and then, anisotropic filtering is applied to make image suitable for extracting features. In feature extraction, we have modified the multi‐texton histogram (MTH) technique to improve the feature extraction. In the classification stage, the hybrid kernel is designed and applied to training of support vector machine to perform automatic detection of tumor region in MRI images. For comparison analysis, our proposed approach is compared with the existing works using K‐cross fold validation method. From the results, we can conclude that the modified multi‐texton histogram with non‐linear kernels has shown the accuracy of 86% but the MTH with non‐linear kernels shows the accuracy of 83.8%.     

Automated detection of glioblastoma tumor in brain magnetic imaging using ANFIS classifier

This article proposes a novel and efficient methodology for the detection of Glioblastoma tumor in brain MRI images. The proposed method consists of the following stages as preprocessing, Non‐subsampled Contourlet transform (NSCT), feature extraction and Adaptive neuro fuzzy inference system classification. Euclidean direction algorithm is used to remove the impulse noise from the brain image during image acquisition process. NSCT decomposes the denoised brain image into approximation bands and high frequency bands. The features mean, standard deviation and energy are computed for the extracted coefficients and given to the input of the classifier. The classifier classifies the brain MRI image into normal or Glioblastoma tumor image based on the feature set. The proposed system achieves 99.8% sensitivity, 99.7% specificity, and 99.8% accuracy with respect to the ground truth images available in the dataset.     

CANFIS based glioma brain tumor classification and retrieval system for tumor diagnosis

Brain tumor classification and retrieval system plays an important role in medical field. In this paper, an efficient Glioma Brain Tumor detection and its retrieval system is proposed. The proposed methodology consists of two modules as classification and retrieval. The classification modules are designed using preprocessing, feature extraction and tumor detection techniques using Co‐Active Adaptive Neuro Fuzzy Inference System (CANFIS) classifier. The image enhancement can be achieved using Heuristic histogram equalization technique as preprocessing and further texture features as Local Ternary Pattern (LTP) features and Grey Level Co‐occurrence Matrix (GLCM) features are extracted from the enhanced image. These features are used to classify the brain image into normal and abnormal using CANFIS classifier. The tumor region in abnormal brain image is segmented using normalized graph cut segmentation algorithm. The retrieval module is used to retrieve the similar segmented tumor regions from the dataset for diagnosing the tumor region using Euclidean algorithm. The proposed Glioma Brain tumor classification methodology achieves 97.28% sensitivity, 98.16% specificity and 99.14% accuracy. The proposed retrieval system achieves 97.29% precision and 98.16% recall rate with respect to ground truth images.     

The spatial statistics of structural magnetic resonance images: application to post-acquisition quality assessment of brain MRI images

This report describes a new quality evaluation method for structural magnetic resonance images (MRI) of the brain. Pixels in MRI images are regarded as regionalized random variables that exhibit distinct and organized geographic patterns. We extract geo-spatial local entropy features and build three separate Gaussian distributed quality models upon them using 250 brain MRI images of different subjects. The MRI images were provided by Alzheimer's disease neuroimaging initiative (ADNI). Image quality of a test image is predicted in a three-step process. In the first step, three separate geo-spatial feature vectors are extracted. The second step standardizes each quality model using corresponding geo-spatial feature vector extracted from the test image. The third step computes image quality by transforming the standardized score to probability. The proposed method was evaluated on images without perceived distortion and images degraded by different levels of motion blur and Rician noise as well as images with different configurations of bias fields. Based on the performance evaluation, our proposed method will be suitable for use in the field of clinical research where quality evaluation is required for the brain MRI images acquired from different MRI scanners and different clinical trial sites before they are fed into automated image processing and image analysis systems.     

Computer aided brain tumor detection system using watershed segmentation techniques

Magnetic Resonance Imaging (MRI) is an advanced medical imaging technique that has proven to be an effective tool in the study of the human brain. In this article, the brain tumor is detected using the following stages: enhancement stage, anisotropic filtering, feature extraction, and classification. Histogram equalization is used in enhancement stage, gray level co‐occurrence matrix and wavelets are used as features and these extracted features are trained and classified using Support Vector Machine (SVM) classifier. The tumor region is detected using morphological operations. The performance of the proposed algorithm is analyzed in terms of sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV). The proposed system achieved 0.95% of sensitivity rate, 0.96% of specificity rate, 0.94% of accuracy rate, 0.78% of PPV, and 0.87% of NPV, respectively. © 2015 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 25, 297–301, 2015     

Computational intelligence techniques for human brain MRI classification

This study proposes an image classification methodology that automatically classifies human brain magnetic resonance (MR) images. The proposed methods contain four main stages: Data acquisition, preprocessing, feature extraction, feature reduction and classification, followed by evaluation. First stage starts by collecting MRI images from Harvard and our constructed Egyptian database. Second stage starts with noise reduction in MR images. Third stage obtains the features related to MRI images, using stationary wavelet transformation. In the fourth stage, the features of MR images have been reduced using principles of component analysis and kernel linear discriminator analysis (KLDA) to the more essential features. In last stage, the classification stage, two classifiers have been developed to classify subjects as normal or abnormal MRI human images. The first classifier is based on K‐Nearest Neighbor (KNN) on Euclidean distance. The second classifier is based on Levenberg‐Marquardt (LM‐ANN). Classification accuracy of 100% for KNN and LM‐ANN classifiers has been obtained. The result shows that the proposed methodologies are robust and effective compared with other recent works.     

Classification of brain hemorrhage computed tomography images using OzNet hybrid algorithm

Classification of brain hemorrhage computed tomography (CT) images provides a better diagnostic implementation for emergency patients. Attentively, each brain CT image must be examined by doctors. This situation is time-consuming, exhausting, and sometimes leads to making errors. Hence, we aim to find the best algorithm owing to a requirement for automatic classification of CT images to detect brain hemorrhage. In this study, we developed OzNet hybrid algorithm, which is a novel convolution neural networks (CNN) algorithm. Although OzNet achieves high classification performance, we combine it with Neighborhood Component Analysis (NCA) and many classifiers: Artificial neural networks (ANN), Adaboost, Bagging, Decision Tree, K-Nearest Neighbor (K-NN), Linear Discriminant Analysis (LDA), Naïve Bayes and Support Vector Machines (SVM). In addition, Oznet is utilized for feature extraction, where 4096 features are extracted from the fully connected layer. These features are reduced to have significant and informative features with minimum loss by NCA. Eventually, we use these classifiers to classify these significant features. Finally, experimental results display that OzNet-NCA-ANN excellent classifier model and achieves 100% accuracy with created Dataset 2 from Brain Hemorrhage CT images.     

基于OCT成像的淡水无核珍珠内部缺陷自动检测方法

光学相干层析技术(OCT)作为一种高分辨率的无损光学检测手段,已被用于珍珠的内部质量检测。针对淡水无核珍珠质层内部缺陷检测的需求,提出一种通过光学相干层析图像实现淡水无核珍珠内部缺陷自动检测的方法。根据珠层灰度变化的特点,识别图像中缺陷区域的梯度特征和缺陷位置变化特征,并利用缺陷特征建立反向传播神经网络模型。实验中采集了内部无缺陷和内部有多种类型缺陷淡水无核珍珠的光学相干层析图像各20幅,对图像进行预处理并提取特征,利用K-means算法检测样本类型与所提取特征的匹配度,用特征与类型相匹配的样本特征训练反向传播神经网络模型,使用反向传播网络模型对淡水无核珍珠内部缺陷层进行分类识别。实验结果表明该方法提取特征的匹配度为92.5%,分类准确率达到100%,验证了该方法的可行性和有效性,提出的方法能够作为淡水无核珍珠内部缺陷识别和自动分类的有效手段。     

Multiclass Stomach Diseases Classification Using Deep Learning Features Optimization

In the area of medical image processing, stomach cancer is one of the most important cancers which need to be diagnose at the early stage. In this paper, an optimized deep learning method is presented for multiple stomach disease classification. The proposed method work in few important steps—preprocessing using the fusion of filtering images along with Ant Colony Optimization (ACO), deep transfer learning-based features extraction, optimization of deep extracted features using nature-inspired algorithms, and finally fusion of optimal vectors and classification using Multi-Layered Perceptron Neural Network (MLNN). In the feature extraction step, pre-trained Inception V3 is utilized and retrained on selected stomach infection classes using the deep transfer learning step. Later on, the activation function is applied to Global Average Pool (GAP) for feature extraction. However, the extracted features are optimized through two different nature-inspired algorithms—Particle Swarm Optimization (PSO) with dynamic fitness function and Crow Search Algorithm (CSA). Hence, both methods’ output is fused by a maximal value approach and classified the fused feature vector by MLNN. Two datasets are used to evaluate the proposed method—CUI WahStomach Diseases and Combined dataset and achieved an average accuracy of 99.5%. The comparison with existing techniques, it is shown that the proposed method shows significant performance.     

Morphological feature extraction and KNG-CNN classification of CT images for early lung cancer detection

Lung cancer is a dangerous disease causing death to individuals. Currently precise classification and differential diagnosis of lung cancer is essential with the stability and accuracy of cancer identification is challenging. Classification scheme was developed for lung cancer in CT images by Kernel based Non-Gaussian Convolutional Neural Network (KNG-CNN). KNG-CNN comprises of three convolutional, two fully connected and three pooling layers. Kernel based Non-Gaussian computation is used for the diagnosis of false positive or error encountered in the work. Initially Lung Image Database Consortium image collection (LIDC-IDRI) dataset is used for input images and a ROI based segmentation using efficient CLAHE technique is carried as preprocessing steps, enhancing images for better feature extraction. Morphological features are extracted after the segmentation process. Finally, KNG-CNN method is used for effectual classification of tumour > 30mm. An accuracy of 87.3% was obtained using this technique. This method is effectual for classifying the lung cancer from the CT scanned image.     

Multimodal brain tumor detection and classification using deep saliency map and improved dragonfly optimization algorithm

In the last decade, there has been a significant increase in medical cases involving brain tumors. Brain tumor is the tenth most common type of tumor, affecting millions of people. However, if it is detected early, the cure rate can increase. Computer vision researchers are working to develop sophisticated techniques for detecting and classifying brain tumors. MRI scans are primarily used for tumor analysis. We proposed an automated system for brain tumor detection and classification using a saliency map and deep learning feature optimization in this paper. The proposed framework was implemented in stages. In the initial phase of the proposed framework, a fusion-based contrast enhancement technique is proposed. In the following phase, a tumor segmentation technique based on saliency maps is proposed, which is then mapped on original images based on active contour. Following that, a pre-trained CNN model named EfficientNetB0 is fine-tuned and trained in two ways: on enhanced images and on tumor localization images. Deep transfer learning is used to train both models, and features are extracted from the average pooling layer. The deep learning features are then fused using an improved fusion approach known as Entropy Serial Fusion. The best features are chosen in the final step using an improved dragonfly optimization algorithm. Finally, the best features are classified using an extreme learning machine (ELM). The experimental process is conducted on three publically available datasets and achieved an improved accuracy of 95.14, 94.89, and 95.94%, respectively. The comparison with several neural nets shows the improvement of proposed framework.     

Improved chicken swarm optimization to classify dementia MRI images using a novel controlled randomness optimization algorithm

The objective of this research paper is to categorize the magnetic resonance imaging (MRI) images as demented (DEM) or nondemented (ND) using improved chicken swarm optimization technique (ICSO). In literature, CSO technique is widely used to solve numerical optimization and feature selection problem. Using this optimization technique for medical image classification problem will be a pioneering idea. If this technique is directly used to classify the medical images, it provides poor results. Hence, appropriate enhancements are made on the original algorithm using a novel controlled randomness optimization algorithm and control parameter tuning. Cross-over and Rooster selection methods are also implemented in cascaded manner for further performance improvization. All the experiments are made for two cases: with and without statistical features. The brain MRI images of 65 ND and 52 DEM subjects obtained from the Open Access Series of Imaging Studies website are used in this analysis. The ICSO without statistical features provides the highest accuracy of 86.32%, whereas the original chicken swarm optimization technique provides the accuracy of 52.13% and 52.99% with and without statistical features, respectively.