Route instructions in map-based human–human and human–computer dialogue: A comparative analysis

When conveying information about spatial situations and goals, speakers adapt flexibly to their addressee in order to reach the communicative goal efficiently and effortlessly. Our aim is to equip a dialogue system with the abilities required for such a natural, adaptive dialogue. In this paper we investigate the strategies people use to convey route information in relation to a map by presenting two parallel studies involving human–human and human–computer interaction. We compare the instructions given to a human interaction partner with those given to a dialogue system which reacts by basic verbal responses and dynamic visualization of the route in the map. The language produced by human route givers is analyzed with respect to a range of communicative as well as cognitively crucial features, particularly perspective choice and references to locations across levels of granularity. Results reveal that speakers produce systematically different instructions with respect to these features, depending on the nature of the interaction partner, human or dialogue system. Our further analysis of clarification and reference resolution strategies produced by human route followers provides insights into dialogue strategies that future systems should be equipped with.     

Hazard analysis in chemical complexes in Japan—especially those caused by human errors

Accidents al Japanese chemical industrial complexes are examined from the past to the present at the Chiba, Mizushima, Sakai-Senpoku, Yokkaichi, Kashima and Tokushima-Ohtake areas. Comparisons with the number of accidents caused by hard errors and soft errors were made; where the hard errors are defined as the faults of the machines and facilities and the soft errors as the human errors and the faults of the systems. The results may be summarized as follows: the ratio of the number of accidents caused by the hard errors to the soft errors was approximately 2:3 at all areas. Using the data obtained through a questionnaire on the potential accidents from about 200 workers engaged in the chemical industry, comparisons with the causes of the potential accidents and the actual accidents caused by human error were made and the results agreed approximately with the causes of the actual accidents.     

In silico analysis of the binding of agonists and blockers to the β2-adrenergic receptor

Activation of G protein-coupled receptors (GPCRs) is a complex phenomenon. Here, we applied Induced Fit Docking (IFD) in tandem with linear discriminant analysis (LDA) to generate hypotheses on the conformational changes induced to the β(2)-adrenergic receptor by agonist binding, preliminary to the sequence of events that characterize activation of the receptor. This analysis, corroborated by a follow-up molecular dynamics study, suggested that agonists induce subtle movements to the fifth transmembrane domain (TM5) of the receptor. Furthermore, molecular dynamics also highlighted a correlation between movements of TM5 and the second extracellular loop (EL2), suggesting that freedom of motion of EL2 is required for the agonist-induced TM5 displacement. Importantly, we also showed that the IFD/LDA procedure can be used as a computational means to distinguish agonists from blockers on the basis of the differential conformational changes induced to the receptor. In particular, the two most predictive models obtained are based on the RMSD induced to Ser207 and on the counterclockwise rotation induced to TM5.     

Towards the identification of the binding site of benzimidazoles to β-tubulin of Trichinella spiralis: Insights from computational and experimental data

Benzimidazole-2-carbamate derivatives (BzC) are among the most important broad-spectrum anthelmintic drugs for the treatment of nematode infections. BzC selectively bind to the β-tubulin monomer and inhibit microtubule polymerization. However, the crystallographic structure of the nematode tubulin and the mechanism of action are still unknown. Moreover, the relation between the mechanism of action and the binding site of BzC has not yet been explained accurately. By using the amino acid sequence of Trichinella spiralis β-tubulin as a basis and by applying homology modeling techniques, we were able to build a 3D structure of this protein. In order to identify a binding site for BzC, molecular docking and molecular dynamics calculations were carried out with this model. The results were in good agreement with the most common amino acid mutations associated with drug resistance (F167Y, E198A and F200Y) and with the experimental results of competitive inhibition of colchicine binding to tubulin. Besides, Glu198, Thr165, Cys239 and Gln134 were identified as important amino acids in the binding process since they directly interact with BzC in the formation of hydrogen bonds. The results presented in this paper are a step further towards the understanding, at the molecular level, of the mode of action of anthelmintic drugs. These results constitute valuable information for the design or improvement of more potent and selective molecules.     

Can dissonance engineering improve risk analysis of human–machine systems?

Cognition, Technology & Work - The paper discusses dissonance engineering and its application to risk analysis of human–machine systems. Dissonance engineering relates to sciences and...     

Impact of two types of partner,perceived or actual,in human–human and human–agent interaction

Participants engaged in the Prisoner’s dilemma game with a partner through a computer terminal. We define two types of partner: a perceived partner and an actual partner, and manipulated the two factors independently. A perceived partner means a partner with whom participants imagined themselves to be interacting; instruction given by an experimenter controls the image of the perceived partner. An actual partner can change its behavior. In one scenario participants actually interacted with a human partner, in another scenario their partner was either a mostly cooperating computer agent or a mostly defecting computer agent. Three experiments were performed. The result suggested that the participants’ selection behavior was largely influenced by the instruction given about the partner by the experimenter and not influenced by the partner’s actual behavior. The analysis of the participants’ impressions of the partner showed that the effect of instruction about the partner disappeared. Individual likeability for a partner was very influenced by the partner’s behavior; as the participants incurred more defect actions from the partner, individual likeability for the partner decreased. On the other hand, social likeability for a partner was not so influenced by the partner’s behavior, but rather related to the participants’ own behavior. The participants who made more defect actions rated their partner’s social likeability lower.     

Tests of resonances in the Painlevé analysis

Title of program: TPR Catalogue number: AATA Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland (see application form in this issue) Computer: SIEMENS 7536 Operating system: BS 2000 Programming language used: REDUCE 2 High speed storage required: depends on the problem, minimally 100 Kwords No. of bits in a word: 32 Number of lines in combined program and test deck: 131     

Comparison of numerical methods in stability analysis†

The results of a numerical investigation of a number of techniques for stability analysis of non-linear systems are presented. The methods compared are the Ingwerson and Zubov procedures for construction of Liapounov functions, a number of methods for obtaining optimum Liapounov functions, tracking functions, the alternating extreme radius path, and the method of Luus and Lapidus.     

Automatic binding time analysis for a typed λ-calculus

A binding time analysis imposes a distinction between the computations to be performed early (e.g. at compile-time) and those to be performed late (e.g. at run-time). For the λ-calculus this distinction is formalized by a two-level λ-calculus. We present an algorithm for static analysis of the binding times of a typed λ-calculus with products, sums, lists and general recursive types. Given partial information about the binding times of some of the subexpressions it will complete that information such that (i) early bindings may be turned into late bindings but not vice versa, (ii) the resulting two-level λ-expression reflects our intuition about binding times, e.g. that early bindings are performed before late bindings, and (iii) as few changes as possible have been made compared with the initial binding information. The results can be applied in the implementation of functional languages and in semantics directed compiling.     

Social networking site or social surveillance site? Understanding the use of interpersonal electronic surveillance in romantic relationships

Social network sites (SNSs) are commonly used to maintain existing relationships and form connections with new contacts. Recently, concerns of have been expressed over the way these Web-based technologies are used. Estimates suggest that people are increasingly using SNSs for engaging in the surveillance of others. Given the relatively high rates of prevalence, it can be argued that SNSs have been reinvented into a tool for interpersonal surveillance along with their social networking capabilities. This article expands on the concept of interpersonal electronic surveillance and applies it in the specific context of romantic partners’ use of SNSs. The relationships between surveillance over SNSs and demographic, relational, and Internet use and efficacy variables are studied. The findings reveal that interpersonal surveillance over SNSs is influenced by age, the time individuals spend on their partners’ profiles, the integration of SNSs into daily routines, and Internet self-efficacy.     

The influence of empathy in human–robot relations

The idea of robotic companions capable of establishing meaningful relationships with humans remains far from being accomplished. To achieve this, robots must interact with people in natural ways, employing social mechanisms that people use while interacting with each other. One such mechanism is empathy, often seen as the basis of social cooperation and prosocial behaviour. We argue that artificial companions capable of behaving in an empathic manner, which involves the capacity to recognise another's affect and respond appropriately, are more successful at establishing and maintaining a positive relationship with users. This paper presents a study where an autonomous robot with empathic capabilities acts as a social companion to two players in a chess game. The robot reacts to the moves played on the chessboard by displaying several facial expressions and verbal utterances, showing empathic behaviours towards one player and behaving neutrally towards the other. Quantitative and qualitative results of 31 participants indicate that users towards whom the robot behaved empathically perceived the robot as friendlier, which supports our hypothesis that empathy plays a key role in human–robot interaction.     

Culture of sedimentation in the human–technology interaction

New technologies inspire new interface paradigms. Promising utility of new interfaces continues attracting their modification. It is argued that in order for human users to share phenomenological experiences through multimodal systems, they need to deal with embedded computers. This paper discusses the embodied nature of communication and a need for the development of a postphenomenology of technology, which plays a vital role in the material culture.     

The experience of enchantment in human–computer interaction

Improving user experience is becoming something of a rallying call in human–computer interaction but experience is not a unitary thing. There are varieties of experiences, good and bad, and we need to characterise these varieties if we are to improve user experience. In this paper we argue that enchantment is a useful concept to facilitate closer relationships between people and technology. But enchantment is a complex concept in need of some clarification. So we explore how enchantment has been used in the discussions of technology and examine experiences of film and cell phones to see how enchantment with technology is possible. Based on these cases, we identify the sensibilities that help designers design for enchantment, including the specific sensuousness of a thing, senses of play, paradox and openness, and the potential for transformation. We use these to analyse digital jewellery in order to suggest how it can be made more enchanting. We conclude by relating enchantment to varieties of experience.An earlier version of this paper was presented at Chi’2004 Fringe.     

Molecular basis for benzimidazole resistance from a novel β-tubulin binding site model

Benzimidazole-2-carbamate derivatives (BzCs) are the most commonly used antiparasitic drugs for the treatment of protozoan and helminthic infections. BzCs inhibit the microtubule polymerization mechanism through binding selectively to the β-tubulin subunit in which mutations have been identified that lead to drug resistance. Currently, the lack of crystallographic structures of β-tubulin in parasites has limited the study of the binding site and the analysis of the resistance to BzCs. Recently, our research group has proposed a model to explain the interaction between the BzCs and a binding site in the β-tubulin. Herein, we report the homology models of two susceptible (Haemonchus contortus and Giardia intestinalis) parasites and one unsusceptible (Entamoeba histolytica) generated using the structure of the mammal Ovis aries, considered as a low susceptible organism, as a template. Additionally, the mechanism by which the principal single point mutations Phe167Tyr, Glu198Ala and Phe200Tyr could lead to resistance to BzCs is analyzed. Molecular docking and molecular dynamics studies were carried out in order to evaluate the models and the ligand–protein complexes’ behaviors. This study represents a first attempt towards understanding, at the molecular level, the structural composition of β-tubulin in all organisms, also suggesting possible resistance mechanisms. Furthermore, these results support the importance of benzimidazole derivative optimization in order to design more potent and selective (less toxic) molecules for the treatment of parasitic diseases.     

Fourier analysis of diamond discretization¶in particle transport

This paper analyzes, theoretically and numerically, the diamond discretization (DD) of free particle transport equations. DD is one of the most commonly used discretizations used in particle transport theory, with applications ranging from the propagation of neutrons in nuclear physics to that of near-infra-red photons in medical imaging. Based on the theory of scalar hyperbolic equations in the Fourier domain, we show that DD performs very well when the boundary data are smooth and the absorption coefficient small. However, because high frequency modes are not damped at all by DD even in the dissipative case, several unphysical modes appear when the boundary conditions are not so smooth. These spurious oscillations are analyzed carefully and displayed numerically. Received: July 2000 / Accepted: January 2001