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食用含黄酮类物质食物将导致它们在血浆和组织中出现,摄入量和心血管的疾病成反比关系可能是与黄酮类减少了低密度脂蛋白氧化作用。黄酮类对动脉低密度脂蛋白细胞间接氧化作用可通过对他们在脂蛋白动脉的细胞累积来测定,如巨噬细胞。黄酮类可清除反应的氧、氮种类,螯合金属离子和节制低密度脂蛋白联合抗氧化作用,减少低密度脂蛋白氧化作用。通过抑制细胞氧合酶(如烟酰胺、腺嘌呤、二核甙酸、磷酸盐,减少氧化酶的形成)或通过启动细胞抗氧化剂(如谷胱甘肽系统)也能减少巨噬细胞氧化压力。因此,黄酮类植物是有效的天然的抗氧化剂,既能保护反抗动脉细胞和脂蛋白类脂过氧化作用,又能有效的减少动脉粥样硬化的形成。 相似文献
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黄酮类化合物在不同氧化体系中的抗氧化作用研究 总被引:83,自引:3,他引:83
本文采用化学发光体系、TBA法、Rancimat法研究了黄酮类化合物在不同体系中对过氧化作用的抑制,研究发现,黄酮类化合物抑制脂质过氧化同其结构密切相关,可能是黄酮类化合物在抑制脂质过氧化的过程中机理不同所致,并进行了讨论,提出了黄酮类化合物清除活性氧的有效酚羟基的概念。 相似文献
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黄酮类化合物抗氧化作用机制研究进展 总被引:9,自引:0,他引:9
自由基对机体造成的损伤是体内氧化作用的结果。从抑制自由基产生、清除自由基及激活机体抗氧化体系等途径,并从细胞水平及分子水平两个研究层面,对黄酮类化合物的抗氧化作用机制的研究进展进行了综述。 相似文献
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Mulberry Anthocyanin Extracts Inhibit LDL Oxidation and Macrophage-Derived Foam Cell Formation Induced by Oxidative LDL 总被引:2,自引:0,他引:2
ABSTRACT: Low-density lipoprotein (LDL) oxidation plays a role in atherosclerosis; therefore the lower the formation of oxidative LDL (oxLDL), the lower the occurrence of coronary heart diseases (CHD). Mulberry, the fruit of Morus alba L., is used effectively in Chinese medicines for prevention of CHD. However, the mechanism of this action is unclear. Two extracts, MWEs (mulberry water extracts) and MACs (mulberry anthocyanin-rich extracts), which exhibit antioxidative and anti-atherosclerogensis abilities in vitro . Data showed that MWEs and MACs were able to inhibit ( P < 0.05) the relative electrophoretic mobility (REM), ApoB fragmentation, and thiobarbituric acid reaction substances (TBARS) formation in Cu2+ -mediated oxidation LDL. MWEs and MACs also had the ability of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging for reducing the formation of free radicals mediated by copper ions. Furthermore, we observed that MWEs and MACs could decrease ( P < 0.05) macrophage death induced by oxLDL. In addition, the MWEs and MACs also could inhibit ( P < 0.05) the formation of foam cells. Both MWEs and MACs showed a great ability of scavenging radicals, inhibition of LDL oxidation, and decrease in atherogenic stimuli in macrophages, while the efficacy of MACs is 10-fold greater than that of MWEs. It also demonstrated that anthocyanin components in mulberry extracts were regarded as the prevention of atherosclerosis. 相似文献
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Pierre L Teissedre Edwin N Frankel Andrew L Waterhouse Hanna Peleg J Bruce German 《Journal of the science of food and agriculture》1996,70(1):55-61
Current research suggests that wine contains substances that may reduce the mortality rate from coronary diseases. The oxidation of low-density lipoprotein (LDL) is thought to be a key step in the development of atherosclerosis. Phenolic fractions of a Petite Syrah wine were evaluated for their antioxidant activity in inhibiting LDL oxidation in vitro . The more active fractions contained components of the catechin family. The catechin oligomers and the procyanidin dimers (B2, B3, B4, B6, B8) and trimers (C1, C2) were extracted, isolated and purified from grapes seeds. These compounds were tested for their inhibition of LDL oxidation, along with other monomeric wine phenolics. The procyanidin dimers B2 and B8, and trimer C1, and the monomers catechin, epicatechin and myricetin had the highest antioxidant activity. The procyanidin dimers B3, B4 and C2 and the monomers gallic acid, quercetin, caffeic acid, and rutin, and a group of compounds that included the dimer B6, ellagic acid, sinapic acid, cyanidin had lower antioxidant activity and α-tocopherol had the least activity. Thus, the numerous phenolic compounds found in wine are potent antioxidants in inhibiting LDL oxidation in vitro . 相似文献
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从枇杷叶中提取分离制备科罗索酸,采用体外Cu~(2+)诱导低密度脂蛋白(low density lipoprotein,LDL)氧化损伤的体外化学反应模型及2,2’-偶氮二(2-甲基丙基咪)二盐酸盐(2,2’-azobis-2-methyl-propanimidamide dihydrochloride,AAPH)诱导人主动脉内皮细胞(human aortic endothelial cells,HAECs)氧化损伤的细胞模型,考察枇杷叶科罗索酸对LDL氧化过程的抑制作用及对动脉血管内皮细胞氧化损伤的保护作用。体外实验结果表明,枇杷叶科罗索酸在体外10~100μmol/L剂量范围内能有效延长LDL氧化过程中的迟滞期,降低反应动力学曲线的曲线下面积以及降低脂质过氧化物的生成,表明科罗索酸在体外能有效抑制Cu~(2+)诱导的LDL氧化。细胞实验结果表明,在2~10μmol/L剂量范围内能有效降低AAPH所致HAECs的乳酸盐脱氢酶漏出量,维护细胞结构的完整性;提高受损细胞的超氧化物歧化酶、谷胱甘肽过氧化物酶活性,从而提升内皮细胞抵抗氧化应激的能力;降低细胞处于sub-G1/G0状态的比例,减少AAPH所致细胞的坏死或凋亡。表明枇杷叶科罗索酸能在细胞水平有效保护HAECs免受AAPH氧化应激损伤。 相似文献
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麦胚黄酮抗动脉粥样硬化体内机制的研究 总被引:3,自引:0,他引:3
研究不同剂量的麦胚黄酮(Flavonoids of Wheat Germ)对高脂血症大鼠血清和肝脏中胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、肝体比值以及血清中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH—Px)和脂质过氧化物(LPO)的影响。结果表明,麦胚黄酮可明显地降低大鼠血清和肝脏中TC、TG的含量(P〈0.01,P〈0.05),提高HDL—C的含量(P〈0.01),另外,麦胚黄酮对高脂血症大鼠具有较强的抗氧化作用,能显著降低血清和组织中LPO含量(P〈0.01),提高SOD和GSH—Px的活性(P〈0.05)。提示,麦胚黄酮具有治疗和预防动脉粥样硬化的作用。 相似文献
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V. Sorrenti C. Di Giacomo A. Russo R. Acquaviva M.L. Barcellona A. Vanella 《Journal of food science》2004,69(6):C480-C484
ABSTRACT: Oxidative modification of low-density lipoprotein (LDL) appears to play a pivotal role in atherosclerosis. In the present study the effect of several concentrations of rutin, its aglycon quercetin, cyanidin 3- O -β-d-glucoside, its aglycon cyanidin, hydroxycinnamic acids, and a standardized red orange ( Citrus sinensis varieties) extract (ROE) on LDL oxidation was tested. Lipid peroxidation was monitored by conjugated diene formation and by different electrophoretic mobility of native LDL and oxidized LDL. Results obtained in the present study suggest specific effects of flavonoids tested and, in particular, of ROE on the prevention of LDL oxidation involved in the development of cardiovascular diseases. 相似文献
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以DPPH自由基、超氧阴离子自由基、羟自由基和总还原力为指标,测定体外抗氧化能力;以小鼠血清中SOD、CAT、GSH-Px活性和MDA含量为测定指标,测定体内抗氧化能力。结果显示:壶瓶碎米荠含硒粗黄酮对自由基具有一定的清除作用,在实验考察的自由基中,除超氧阴离子外其余均显示出良好的抗氧化效果且随着剂量的增加呈现出良好的线性;动物实验中壶瓶碎米荠两种粗黄酮均能提高小鼠SOD、CAT、GSH-Px活性,降低MDA含量并呈现出良好的线性效果,含硒粗黄酮抗氧化效果显著高于普通粗黄酮,与阳性对照VC效果相似。当壶瓶碎米荠含硒粗黄酮剂量达到100 mg/kg时,芦丁实验组、粗黄酮实验组小鼠体重降低,出现轻微毒害作用,而含硒粗黄酮处理组体重差异不显著,从侧面说明硒具有一定增强免疫力的效果。 相似文献
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乌桕叶主要黄酮类物质的定性定量 总被引:4,自引:0,他引:4
通过硅胶和Sephadex LH-20凝胶柱色谱分离乌桕叶黄酮类物质,HPLC鉴别其纯度和定量,UV、IR、NMR、LC-MS定性,结果显示乌桕叶所含主要黄酮类物质为槲皮素、山柰酚及其组成的甙,其中槲皮素、山柰酚和槲皮素甙百分含量分别为0.0965、0.1232、0.6975。 相似文献