The prolongation of survival in mice by dietary antioxidants depends on their age by the start of feeding this diet

The effect of daily dietary supplements of an antioxidant mixture (AM) consisting of beta carotene, alpha tocopherol, ascorbic acid, rutin, selenium, and zinc on the survival of male C57BL/6 mice starting at 2, 9, 16, and 23 months of age was investigated. The survival of mice given AM starting at 2 and 9 months of age was found to increase significantly (from 86 to 108 days) compared to the control. The times, of 50, 90, and 100% mortality in mice given AM starting at 2 and 9 months of age increased by 16-9.5% compared to the control, whereas in mice given AM, starting at 16 and 23 months of age, no effect was observed.     

Determination of total dietary fiber in foods and food products by using a single-enzyme, enzymatic-gravimetric method: interlaboratory study

A simplified enzymatic-gravimetric method for total dietary fiber (TDF) determination has been published and used in the Food Composition Laboratory of the U.S. Department of Agriculture since 1988. THis method gives comparable results to AOAC Official Methods 985.29 and 991.43 but the AOAC methods use 100 degrees C (water bath) to gelatinize the sample and a combination of alpha-amylase and an amyloglucosidase to hydrolyze starches, whereas the simplified method incorporates an autoclaving step (121 degrees C) for gelatinization followed by incubation with only amyloglucosidase. The simplified method omits protease hydrolysis and does not require any pH adjustment. Overall, the simplified method cuts cost and is less labor intensive. An interlaboratory study was conducted to validate this method. Blind duplicates of six sample (baked beans, corn bran, roasted peanuts, cooked potatoes, white bread with reduced calories, and cooked white rice) were sent to 11 laboratories. The reproducibility relative standard deviations of the TDF values (without outliers) ranged from 3.46 to 27.6%. The repeatability standard deviations ranged from 0.91 to 14.6%.     

Changes in prevalence, aetiology, age at detection, and associated disabilities in preschool children with hearing impairment born in G?teborg

The prevalence of hearing impairment (HI) in preschool children born in G?teborg in 1980 to 1984 was 2.0 per 1000. This was significantly lower than the 3.8 per 1000 found in a previous study for 1970 to 1974. The decrease took place in the moderate to severe range of HI, while deafness and mild HI remained unchanged during the period. The cause was considered to be prenatal in 58% with heredity in 33% as the main causative factor. Following the introduction of the MPR (Morbilli-Parotitis-Rubella) vaccination programme in Sweden, no cases of rubella- or mumps-induced HI could be found. The number of HI of perinatal origin decreased by half, in spite of the fact that the figures for preterm baby survival almost doubled during the period. Associated disabilities were diagnosed in 62% of the children with HI; speech retardation in 33%, visual abnormalities in 30%, mental retardation in 12% and neuropsychiatric disorders in 9% of the cases. The importance of collaborative efforts between the otolaryngologist and the neurologically and neuropsychiatrically interested paediatrician in the complete evaluation of additional difficulties in the HI child is emphasized.     

Effect of dietary fat, fiber, and monensin on cecal activity in turkeys

Two experiments were conducted to determine the physical, chemical, and microbial properties of turkey cecal droppings and relate them to intake of common dietary components, namely fat, fiber, and the anticoccidial, monensin. Experiment 1 involved collection and analysis of physical and chemical properties of cecal and regular droppings from commercial turkey flocks. Experiment 2 tested the effect of dietary fat, fiber, and monensin on growth performance and cecal activity in male turkeys. Compared to regular excreta, cecal droppings analyzed in Experiment 1 were higher in viscosity and fat content, and lower in dry matter, nitrogen, and fiber content (P < 0.05). High dietary fiber and fat significantly (P < 0.05) improved growth performance in Experiment 2. Prolonged feeding of monensin significantly (P < 0.05) reduced cecal evacuation. Results of chemical composition showed that higher dietary fat and fiber significantly (P < 0.01) reduced the fat percentage of cecal contents, whereas prolonged feeding of monensin increased the fat in both cecal contents and droppings. There was no significant effect of any of the treatments on pH, viscosity, and microbial counts of cecal contents. There is the need to identify and characterize the compound responsible for the high viscosity of cecal droppings.     

Phytic acid, in vitro protein digestibility, dietary fiber, and minerals of pulses as influenced by processing methods

In this study we have shown that an antibody to CD18 identified a population of cells in the rabbit retina that resembled the perivascular macrophage found in other regions of the central nervous system. In the normal retina these cells possessed a ramified morphology and presented in an ordered array on the vitreal surface in association with the epiretinal vessels. Approximately 50% of the perivascular macrophages constitutively expressed MHC class II. In response to interleukin-1 beta (IL-1 beta)-induced inflammation, these cells became activated, as evidenced by a change from a ramified to an ameboid morphology and increased expression of MHC class II, and migrated away from the vessels. These changes were first detected around 3 h post-intraocular challenge coincident with the onset of inflammation. At the peak of the inflammatory response (approximately 24 h post-challenge), many activated perivascular macrophages were no longer associated with the vessels and formed long "cord" of MHC class II+ cells associated with underlying deposits of fibrin. In eyes challenged with heat-inactivated IL-1, no change in the morphology or distribution of the perivascular macrophage was noted. At 3 weeks post-challenge with IL-1, the number and distribution of the perivascular macrophages were restored to baseline values, although with a reduced cell size. Since these changes closely resemble those that occur in non-lymphoid dendritic cells in the skin, heart, and/or kidney following activation with cytokines or bacterial products, the results suggest that the perivascular macrophage represents the dendritic cell of the retina and may thus play an important role in immune surveillance in the eye and maintenance of the blood-retina barrier.     

The prevalence, stability and significance of developmental language delay in preschool children

A sample of 937 children in Dunedin, New Zealand, was assessed at ages three and five years in order to estimate the nature, prevalence, stability and significance of developmental language delays in three-year-olds. Assessments included language development, intelligence, and fine and gross motor-co-ordination. Detailed results are given which described three types of language delay at age three: delayed verbal comprehension only, delayed verbal expression only, and delayed development in both aspects of language. Follow-up testing at age five indicated that the specific language delays were not highly stable, whereas delays in both aspects were highly stable. A large proportion of the latter children gained very low scores on the measures at age five, and they accounted for 84 per cent of all children with very low intelligence. The implications of the results for a screening programme to identify three-year-old children at high risk of later developmental delays are considered.     

Perceptual sensitivity, integral perception, and the similarity classifications of preschool children and adults.

Assessed the developmental role of the salience characteristics of dimensions. In Exp I, 40 children (mean age 4 yrs 5 mo, from upper-middle SES backgrounds were asked to classify compound stimuli according to their similarity. Perceptual sensitivity to the component dimensions of the compounds was varied by means of predisposed and distinctiveness-based salience to determine its effects on the accuracy of similarity classifications. In Exp II, 20 undergraduates completed the same task. Classifications of both the children and adults were more accurate when the salience of the solution-relevant dimension was high than when it was low. Furthermore, sensitization training on a classification-relevant dimension that was initially low in predisposed salience resulted in increasing the subsequent classification accuracy of 4-yr-olds. It was concluded that the similarity classifications of both young children and adults are affected by the salience characteristics of the dimensions of compound stimuli. (7 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Time-to-contact judgment in the locomotion of adults and preschool children.

The hypothesis of D. N. Lee (1976), that approach and deceleration toward a surface can be controlled through the rate of change of the optic variable τ, was examined for natural human locomotion. In Exp 1, 12 adults were asked to perform locomotor tasks that required running at speed and then decelerating so that either the hand or head made a controlled contact with a door. In Exp 2, 12 preschool children performed a relay-running task that required similar control. In Exp 3, 12 children and 12 adults ran with a stick as an extension to their arm length and performed the same task. The results supported Lee's hypothesis for the initial phase of approach, but Ss switched to a separate adjustment phase 2–3 arm lengths from the target. Children did not adopt an appropriate τ strategy for collision avoidance and appeared unable to modify their approach strategy to allow for a hand-held stick. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Epidemiological study of wheeze, doctor diagnosed asthma, and cough in preschool children in Leicestershire

OBJECTIVE: To determine the cumulative prevalences of wheeze and doctor diagnosed asthma and the point prevalences of recurrent cough and wheeze in children aged 5 years and under. DESIGN: Questionnaire survey of population based random sample of children registered on regional authority's child health index for immunisation; questionnaire completed by parents. SETTING: Leicestershire. SUBJECTS: 1650 white children born in 1985-9 who were surveyed in 1990. MAIN OUTCOME MEASURES: Cumulative prevalences of wheeze and doctor diagnosed asthma and point prevalences of recurrent cough and wheeze by age and sex. RESULTS: There were 1422 replies (86.2%; 726 for boys, 696 for girls). Overall, 11.0% (95% confidence interval 9.4% to 12.6%) of children had formally been diagnosed as having asthma, the cumulative prevalence in boys (12.7%) being somewhat higher than in girls (9.2%) (age adjusted odds ratio 1.47, p = 0.03). As expected, the cumulative prevalence of asthma increased significantly with age (7.5% (13/173) in children under 1 year, 15.9% (61/383) in children of 4 years and over; p < 0.001). The cumulative prevalence of wheeze overall was 15.6% (13.7% to 17.5%), being higher in boys (17.6%) than in girls (13.5%) (odds ratio 1.38, p = 0.03). The overall prevalence of recurrent cough without colds was 21.8% (19.6% to 23.9%), with a non-significant excess in boys (23.1% v 20.4%). The overall prevalence of wheezing attacks during the previous 12 months was 13.0% (11.3% to 14.8%) with a non-significant excess in boys (14.5% v 11.5%). CONCLUSIONS: These findings are baseline results and emphasise the importance of studying the age group of interest rather than relying on the recall of parents of school age children.     

Play, aggression, the preschool child, and the family: A review of literature to guide empirically informed play therapy with aggressive preschool children.

Preschool-aged children displaying high levels of aggression repeatedly have been shown to be at significant risk for continued behavior problems and other social and emotional challenges throughout their lifetimes. The present literature review seeks to summarize and integrate findings across the fields of developmental psychology, family studies, child development, and play therapy to inform play therapists' practices with this population. Specifically, findings from research in these fields hold substantial implications for empirically informed ways in which play therapists can include parents within play therapy processes. Affective quality of parent- child interactions emerges as the common theme across all existing literature and is emphasized as a critical focus for play-based therapeutic intervention. Topics for future research by play therapists focusing on this population are suggested. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Nutritional status of Danish rheumatoid arthritis patients and effects of a diet adjusted in energy intake, fish-meal, and antioxidants

This study deals with the nutritional status of Danish RA patients and address the question of whether or not RA can be directly influenced by dietary manipulation. In a prospective, single-blinded study of 6 months duration, 109 patients with active RA were randomly assigned to either treatment with or without a specialized diet. The energy consumption was adjusted to normal standards of body weights and the intake of fish meals and antioxidants were increased. A daily food diary was completed by the patients, and the total intake of 47 different food-elements was calculated. Nutritional status together with disease activity parameters were recorded. At baseline, the Danish RA-patients had neglected food habits with a significant reduction in intake of total energy, of D-vitamin and of E-vitamin. A very low intake of n-3 fatty acids was also found. During the study, 28 of the 109 patients dropped out, introducing a confounding effect on the overall result. In the remaining 81, those following the diet demonstrated a significant improvement in the duration of morning stiffness, number of swollen joints, pain status, and reduced cost of medicine, while doctors global assessment, laboratory data, X-ray, and daily activities were unaltered. In conclusion, dietary analysis and appropriate, corrective advice should be offered to Danish RA patients.     

Multimodal assessment of impulsiveness in abusing, neglecting, and nonmaltreating mothers and their preschool children.

Three groups of 12 mothers who had a history of child abuse (mean age 26.67 yrs), child neglect (mean age 25.75 yrs), or no known history of child maltreatment (mean age 29.08 yrs) and their 48–70 mo old children were compared on the nature and extent of their impulsiveness in a multimodal assessment procedure. Children were also rated by their mothers on the Revised Conners Parent Rating Scale and by their teachers on the Conners Teacher Rating Scale. Results indicate that comparison mothers performed better than did abusing mothers on 2 measures of motor inhibition, a modified Matching Familiar Figures Test and the Stroop Color and Word Test. Neglectful mothers rated their children as having more conduct problems than did comparison mothers. No significant differences were found on the other child measures of impulsiveness. Implications for assessing and treating child maltreatment are discussed. (48 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of switching off the globus pallidus on alimentary and electrophysiologic responses induced by stimulation of the hypothalamus]

In chronic experiments on eight cats a direct electrical stimulation of the lateral hypothalamus evoked: 1) food eating in a state of satiation and 2) a reproduction of a conditioned food-procuring reflex, preliminarily elaborated to an acoustic signal. Bilateral electrolytic ablation of the globus pallidum abolished both reactions, but for different time periods. The first one was restored spontaneously on the 20th to the 46th day; the second disappeared for 2.5 to 8.5 months without spontaneous restoration. Stimulation of the lateral hypothalamus alimentary zones brought about a statistically significant rise of the thresholds of desynchronization reactions in the ipsi- and contralateral sensorimotor cortex. The activating role of the globus pallidum in the organization of a motivational alimentary excitation is discussed.     

Distinct mechanisms of plasma LDL lowering by dietary fiber in the guinea pig: specific effects of pectin, guar gum, and psyllium

Pectin (PE), guar gum (GG), and psyllium (PSY) lower plasma low density lipoprotein (LDL) cholesterol concentrations in guinea pigs with different orders of magnitude by inducing defined alterations in hepatic cholesterol homeostasis (Fernandez et al. 1994. Am. J. Clin. Nutr. 59: 869-879; 61: 127-134 and 1995. J. Lipid Res. 36: 1128-1138). To further explore specific mechanisms responsible for the differences in plasma and hepatic cholesterol lowering, the effects of these fibers were evaluated on cholesterol absorption, hepatic cholesterol 7 alpha-hydroxylase activity, the rate-limiting enzyme of bile acid synthesis, and in vivo LDL transport to target specific primary and secondary mechanisms accounting for the observed responses. Fibers were fed with physiological (0.04%), low cholesterol (LC), or pharmacological high cholesterol (HC) (0.25%) levels to assess whether cholesterol intake influences plasma LDL lowering mechanisms. Intake of PE, GG, or PSY with LC or HC diets lowered plasma and hepatic cholesterol concentrations (P < 0.001). PE and PSY up-regulated 7 alpha-hydroxylase activity 3-fold with LC and PE by 5-fold with HC diets. In contrast, GG intake had no effect on 7 alpha-hydroxylase activity. Cholesterol absorption was reduced 30% by PE intake while no differences were found between control and PSY groups. GG reduced cholesterol absorption only with HC diets. Intake of PE, GG, or PSY with HC diets resulted in faster plasma LDL fractional catabolic rates (FCR) (P < 0.01) with no effect on LDL apoB flux rates (FR) or pool size, suggesting that fiber reduced LDL cholesterol concentration without decreasing the number of LDL particles. In addition to reducing LDL apoB FR, PE and PSY increased LDL FCR with HC diets while GG effects were limited to lowering LDL apoB FR. These results indicate that the distinctive reductions in hepatic cholesterol induced by PE, GG, and PSY associated with plasma cholesterol lowering result from different mechanisms specific to each fiber and that the levels of dietary cholesterol contribute to the different metabolic responses.     

Nature-nurture in the classroom: entrance age, school readiness, and learning in children

The impact of entrance age on reading and mathematics achievement in 1st grade was examined. Methodological problems with past research were identified, including small size of achievement differences, failure to take background variables into account, and confusion of achievement levels with degree of learning. Using a pre-post design, growth of reading and mathematics was examined in younger 1st graders, older 1st graders, and older kindergarteners. Comparisons of background information on these groups with children who were either held out prior to or retained an extra year in kindergarten, produced minimal background differences. Results revealed that younger 1st graders made as much progress over the school year as did older 1st graders and made far more progress than older kindergarteners. Overall, findings demonstrated that, in itself, entrance age was not a good predictor of learning or academic risk.     

Development of motion-defined figure-ground segregation in preschool and older children, using a letter-identification task

BACKGROUND: Three-month-old infants can discriminate motion-defined (MD) form, but we do not know the age at which this ability reaches adult levels. Previous psychophysical evidence suggests that different neural mechanisms are involved in the processing of luminance-defined (LD) and MD spatial form in adults. This difference may be reflected in the development of LD versus MD form identification in children. METHODS: We measured speed threshold for identifying MD letters, letter-chart (i.e, Snellen) acuity for high-contrast LD letters and single-letter acuity for high- and low-contrast LD letters. Forty-seven children between 3 and 12 years of age and 20 adult subjects were tested. RESULTS: Development to the adult level was observed as follows: low-contrast single-letter acuity before 3 years; high-contrast single-letter acuity by 5 to 6 years; the ability to identify MD letters by 7 to 8 years; letter-chart acuity by 9 to 10 years. CONCLUSIONS: MD form identification continues to mature in preschool children. LD form identification also matures in this age group but with a different time course. MD letters are not equivalent to low-contrast letters developmentally. Our findings provide further support for the hypothesis that the spatial aspects of MD and LD form are processed separately to some extent.     

Intolerance of ambiguity in preschool children: Psychometric considerations, behavioral manifestations, and parental correlates.

Conducted 3 experiments in a longitudinal study of ego development in which multiple measures were administered at 3, 4, 5, 6, or 7 yrs of age and in which information about the parents and parent–child interactions was also obtained. 57 female and 63 male preschoolers were reliably evaluated with respect to intolerance of ambiguity at 3? and 4? yrs of age by independent sets of nursery school teachers. Ss relatively intolerant of ambiguity were comparatively hesitant to enter, narrow in deploying attention within, and premature in imposing structure upon 3 ambiguous experimental situations. Early intolerance of ambiguity in boys was significantly related to later intolerance of ambiguity, general anxiety, structure-seeking behaviors, and less effective cognitive functioning when the boys were age 7. Early intolerance of ambiguity in girls was related, when the girls were age 7, to a pattern of highly stable peer relationships in which the girls played nonassertive roles. Fathers of boys intolerant of ambiguity described themselves as relatively distant and authoritarian, and in a standardized teaching situation were impatient, critical, and less resourceful while interacting with their sons. Mothers of girls intolerant of ambiguity described themselves as nurturant, and in the teaching situation were emotionally supportive and task structuring with their daughters. (28 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)