Microscopic observations of adiabatic shear bands in three different steels

Microscopic observations are made of the shear band material in three different steels: (1) an AISI 1018 cold-rolled steel (CRS), (2) a structural steel (HY-100), and (3) an AISI 4340 vacuum arc remelted (VAR) steel tempered to either of two hardnesses, RHC 44 or 55. To produce the shear bands, specimens were subjected to large shear strains at relatively high strain rates, ≈10³/s, resulting in essentially adiabatic deformation conditions. It was found that whenever the shear band led to fracture of the specimen, the fracture occurred by a process of void nucleation and coalescence; no cleavage was observed on any fracture surface, including the most brittle of the steels tested (RHC = 55). This is presumably due to the softening of the shear band material that results from the local temperature rise occurring during dynamic deformation. Differences in shear band behavior between the various microstructures are also described. Formerly Research Assistant, Brown University     

Microscopic observations of adiabatic shear bands in three different steels

Microscopic observations are made of the shear band material in three different steels: (1) an AISI 1018 cold-rolled steel (CRS), (2) a structural steel (HY-100), and (3) an AISI 4340 vacuum arc remelted (VAR) steel tempered to either of two hardnesses, RHC 44 or 55. To produce the shear bands, specimens were subjected to large shear strains at relatively high strain rates, ≈10³/s, resulting in essentially adiabatic deformation conditions. It was found that whenever the shear band led to fracture of the specimen, the fracture occurred by a process of void nucleation and coalescence; no cleavage was observed on any fracture surface, including the most brittle of the steels tested (RHC = 55). This is presumably due to the softening of the shear band material that results from the local temperature rise occurring during dynamic deformation. Differences in shear band behavior between the various microstructures are also described. Formerly Research Assistant, Brown University     

Differential effectiveness of three clinical interventions for different socioeconomic groupings.

Randomly assigned 91 children referred for emotional and behavioral problems from elementary schools representing a wide socioeconomic range to 1 of 3 forms of psychological intervention (child therapy, parent counseling, and an experimental method called "information feedback"). Outcomes were measured in terms of changes in school grades and Os' ratings of school behavior. All interventions resulted in slightly improved peer relations (as measured by Os). On school grades, there was an Intervention Method * Socioeconomic Level interaction: Information feedback resulted in improved grades for children in upper socioeconomic levels, parent counseling led to improved grades for lower levels, and child therapy (the only intervention in which clinical contacts centered on the child) resulted in lower grades for all levels. (39 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Rate of decline of cortisol concentrations in ovarian follicles following ACTH treatment in the sow

Three milliliters of blood from the present commercially produced heartwater infective blood vaccine (Ball3 stock) was experimentally tested in sheep and cattle for infectivity and efficacy. Results obtained for this vaccine dose were statistically not different from results for the prescribed 5 ml vaccine dose.     

Comparison of three different methods for measurement of plaque-pH in humans after consumption of soft bread and potato chips

Three different techniques for measurement of plaque-pH--the sampling, the microtouch, and the telemetric methods--were compared after subjects had consumed different starch products. Ten volunteers, equipped with partial lower prostheses, incorporating a miniature glass pH electrode, refrained from toothbrushing for 3 days. Four products were tested: (1) soft bread, (2) potato chips, (3) 5% starch, and (4) 5% sucrose. The pH of plaque was measured for 45 min by means of all three of the methods. The results showed that the mean pH at 10 min was 1.5 units lower with the telemetric than with the sampling method and 1.0 unit lower with the telemetric than with the microtouch method. Relatively small differences were found among the effects of the four test products for all three methods, with the clearest distinctions among the pH curves being with the microtouch and telemetric methods. The main conclusions from the present investigation are: (1) that there were large differences in pH levels measured with the sampling, the microtouch, and the telemetric methods, even though they ranked the test products in about the same order, and (2) that the two starchy foods, bread and potato chips, were both easily fermented by dental plaque.     

Rate of decline of percentage CD4+ cells is faster in HIV-1 than in HIV-2 infection

Increasing evidence suggests that the pathogenesis of HIV-1 is different from that of HIV-2. Thus, we have measured, longitudinally at various times over a median follow-up of 2.1 years, the percentage CD4+ cells of 94 patients infected with HIV-1 and 164 patients infected with HIV-2. The pattern of decline of CD4% over time was linear for patients with either infection. Multilevel statistical modeling techniques showed that after stratifying for HIV status, the rate of decline of CD4% was faster among patients who died than among those who survived (difference in rate of decline = 2.34% CD4+ cells/year; p = 0.0002). After stratifying for survival status, the rate of decline was faster and less variable among patients infected with HIV-1 than among patients infected with HIV-2 (difference in rate of decline = 1.12% CD4+ cells/year; p = 0.05). The proportion of patients who showed no fall in CD4+ cells was higher in HIV-2 than in HIV-1 infection (p = 0.026). These data suggest fundamental differences between the two infections, with HIV-1 being more pathogenic resulting in a faster and more homogeneous rate of decline than HIV-2. In HIV-2 infection, disease in many patients progresses slowly, but in some the advance is just as fast as that in HIV-1 infection. The reasons for this marked heterogeneity need elucidation to understand the disease and to target therapeutic interventions against HIV-2 in those most at risk.     

"On the myth of intellectual decline in adulthood": Erratum.

Reports an error in the original article by J. L. Horn and G. Donaldson (American Psychologist, 1976, Vol 31[10], 701–719; see record 1977-07954-001). On page 717 the sentence that begins with the last line of the left-hand measure should read "The effect is shown by comparing (e.g., over 5 years) the first-test and retest average scores for those who do and those who do not survive for a while longer (another 5 years).' (The following abstract of this article originally appeared in PA, Vol 57:7954). Considers that careful review of the logical and empirical bases for the myth argument indicates that there is little to justify it. There is evidence that some of the abilities of intelligence improve throughout substantial parts of adulthood, or at least do not decline as much or as early as other abilities. Perhaps some individuals manage to avoid decrements which affect others. Positive sampling bias and wishful thinking in the conduct and interpretation of research tend to work against finding support for any decrement hypothesis that may be true. Yet the evidence suggests that if one lives long enough, decrement in at least some of the important abilities of intelligence is likely to occur. However, the reasonable interpretations that are possible for existing results are too complex… (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Intraobserver variability of pulsatility index measurements in three fetal vessels in the first trimester

PURPOSE: The intraobserver repeatability of pulsatility index measurements in 3 fetal vessels in the early weeks of gestation was evaluated. METHODS: The pulsatility index was calculated from the flow velocity waveforms from 3 fetal vessels in a series of 58 uneventful, low-risk, singleton first-trimester pregnancies using transvaginal color Doppler sonography. The intraobserver repeatability was expressed as the intraclass correlation coefficient. Mean menstrual age at the time of the examination was 10.3 weeks (range, 7.6-13). RESULTS: Flow velocity waveforms from the umbilical artery, abdominal aorta, and middle cerebral artery were obtained in 100% (58/58), 98.3% (57/58), and 100% (34/34) of cases, respectively. The intraclass correlation coefficients for these vessels were 0.89, 0.79, and 0.93, respectively. CONCLUSIONS: The intraobserver repeatability was acceptable for all the vessels studied.     

Prospective evaluation of three smoking interventions in 205 recovering alcoholics: One-year results of Project SCRAP-Tobacco.

205 (113 male, 92 female) nonhospitalized recovering alcoholics with >3 mo of continuous abstinence from alcohol and drugs and relatively heavy tobacco dependence (Fagerstrom Tolerance Questionnaire score?=? 7.7; mean number of cigarettes per day, 26.8; mean number of years smoked, 24.4) were randomized to standard treatment (ST) American Lung Association quit program plus nicotine anonymous meetings (n?=?70), behavioral counseling plus physical exercise (BEX; n?=?72), or behavioral counseling plus nicotine gum (BNIC; n?=?63). A 3?×?4 repeated measures design was used to evaluate the effectiveness of the interventions on smoking outcome at baseline, posttreatment, and 6- and 12-mo follow-ups. Self-reported smoking status was verified with biochemical and informant report. Verified self-report indicated that significantly more smokers in BEX quit by posttreatment (60%) than in either BNIC (52%) or ST (31%), χ–2(2, N?=?205)?=?17.85, p?     

Preliminary observations on the behavior of immunoglobulins in diabetics treated by different methods

IgG, IgM and IgA values were determined in 45 diabetic patients of various ages and both sexes (30 treated with oral hypoglycaemising drugs and 15 with insulin). A marked departure from normal serum IgA values in subjects receiving oral hypoglycaemising preparations for at least 4 yr was the only alteration worthy of note.     

The practice of geriatric psychiatry in three countries: observations of an American in the British Isles

The author compares the practice of geriatric psychiatry among three countries: Ireland, the United Kingdom and the United States. The two main areas reviewed are how the practice of geriatric psychiatry is done, and the mental health services available in each country, including organizational characteristics. The US is the most entrepreneurial of the three, Britain's greatest strength is the uniformity and comprehensiveness of its services, and Ireland provides an excellent model for nations of comparable size. Considerable change is occurring in all three countries.     

Changes in bacterial populations in the colon of pigs fed different sources of dietary fibre, and the development of swine dysentery after experimental infection

Swine dysentery (SD) is a disease which can be controlled by feeding a diet low in dietary fibre. The influence of source and inclusion level of dietary fibre both on bacterial populations in the colon, and on subsequent development of SD in pigs experimentally infected with Serpulina hyodysenteriae was evaluated. In Experiment 1, pigs were fed a low-fibre diet based on cooked rice and a animal protein supplement, or the same diet containing added insoluble (iNSP, fed as oaten chaff) or soluble (sNSP, fed as guar gum) non-starch polysaccharides, resistant starch (RS), or a combination of the last two (sNSP/RS). In Experiment 2, different levels of RS were added to the diet. With the base rice diet and with the addition of iNSP, the total number of colonic bacteria was low, the Gram-positive population predominated, S. hyodysenteriae did not colonize and SD did not develop. Synergistic bacteria (Fusobacterium necrophorum and Fus. nucleatum), which have been reported to facilitate colonization by S. hyodysenteriae, were found only among isolates from pigs fed the sNSP/RS diet, and these animals developed SD. Addition of RS to the diet increased total bacterial counts and stimulated growth of Gram-negative bacteria in the colon. In Experiment 1, this permitted colonization by S. hyodysenteriae, but not expression of SD. In contrast, in Experiment 2, this level of inclusion and two others allowed both colonization and development of SD. In conclusion, the addition of sNSP and/or RS to an otherwise protective rice-based diet generated changes in the large intestine microbiota which might have some influence on proliferation of S. hyodysenteriae and the development of SD.     

Reproducibility of three different methods of measuring baroreflex sensitivity in normal subjects

1. Baroreflex sensitivity is a useful tool for investigating cardiovascular reflexes in a number of clinical settings. Several different methods of measuring baroreflex sensitivity are available. In order to determine a clinically useful non-invasive method of measuring baroreflex sensitivity we compared two methods (spectral analysis and the Valsalva manoeuvre) with regard to reproducibility, agreement with a standard invasive method (phenylephrine infusion) and failure rate.2.Twenty-six healthy subjects aged 22 to 63 years attended on three separate occasions for measurement of baroreflex sensitivity using the different methods. The effect of a recent head-up tilt on baroreflex sensitivity was measured.3. Reproducibility was best for the low-frequency component of the spectral method [coefficient of variation 25.0% (range 3.5-42.4%)] and worst for the Valsalva method [coefficient of variation 29.3% (range 13.8-93.1%)]. Both non-invasive methods overestimated values compared with the phenylephrine method [bias of low-frequency component of the spectral method, 1.17 (0.38-3.6); bias of the Valsalva method, 1.13 (0.19-6.7)]. The high-frequency component of the spectral method did not agree with the phenylephrine method.4. The spectral analysis method had the fewest failures (seven subjects with a failure on at least one occasion), and the phenylephrine method the most (16 subjects with a failure on at least one occasion). A short head-up tilt did not affect the subsequent non-invasive measurement of baroreflex sensitivity.5. It was concluded that the low-frequency component of the spectral method was the most clinically useful non-invasive measurement of baroreflex sensitivity.     

In vitro and in vivo studies on the role of dimethylsulfoxide (DMSO) in resensibilization of bacterial strains resistant to antibiotics and chemotherapeutic agents

Resensibilization in vitro to seven antibiotics under the influence of DMSO was studied in 624 resistant strains of five species of bacteria (E. coli, S. typhi, S. pyogenes, S. viridans, S. aureus), 61 strains of tubercle bacilli resistant to isonicotinic acid hydrazide (INH) and 19 strains of tubercle bacilli resistant to rifampicin (RMP). DMSO in concentrations of 0.1-10.0% caused reversion of sensitivity in strains of E. coli, S. pyogenes and S. viridans. Reversion in vivo of sensitivity to INH of tubercle bacilli was studied in experimental tuberculosis of guinea pigs. Tubercle bacilli previously resistant to INH recovered complete sensitivity to the drug, enabling animals infected with the INH-resistant strain of bacilli to be treated with INH.     

Variable expression of Mn SOD in three different human melanoma cell lines

The mechanism of age-related cortical bone loss was investigated in 229 Japanese women, 41-94 years of age, by metacarpal bone mass measurement. While no significant correlation was found between bone width and age, a significant increase in bone marrow width, and significant decreases in cortical bone density and total bone mass were observed in association with aging (P < 0.0001). There was a significant negative correlation between total bone mass and bone marrow width (r = -0.239; P < 0.0005), and significant positive correlations between both total bone mass and cortical bone density (r = 0.539; P < 0.0001) and cortical bone width (r = 0.839; P < 0.0001). The findings suggested that age-related cortical bone loss in middle-aged and elderly women resulted from two different factors; a decrease in cortical bone density caused by progression of intracortical porosity, and a decrease in cortical bone width as a result of bone loss on the endosteal surface. The latter had a greater influence on an age-related cortical bone loss than the former.     

Antiatherogenic effects of the antioxidant BO-653 in three different animal models

Antioxidants have been proposed to have antiatherogenic potential by their inhibition of low density lipoprotein (LDL) oxidation. Here, we report an antioxidant, BO-653 (2,3-dihydro-5-hydroxy-2, 2-dipentyl-4,6-di-tert-butylbenzofuran), designed to exhibit antioxidative potency comparable to that of alpha-tocopherol, but yet possess a high degree of lipophilicity comparable to that of probucol. BO-653 exhibits a high affinity for LDL and is well distributed in aortic vessels in vivo. In atherosclerosis models of rabbits and mice, BO-653 has been shown to be able to suppress the formation of atherosclerotic lesions without untoward side effects. Specifically, there was no reduction of high density lipoprotein levels. This antioxidant provides additional evidence in support of the oxidized-LDL hypothesis, and itself is a promising candidate antioxidant for clinical use.     

Inactivation of single cardiac Na+ channels in three different gating modes

In small cell-attached patches containing one and only one Na+ channel, inactivation was studied in three different gating modes, namely, the fast-inactivating F mode and the more slowly inactivating S mode and P mode with similar inactivation kinetics. In each of these modes, ensemble-averaged currents could be fitted with a Hodgkin-Huxley-type model with a single exponential for inactivation (tauh). tauh declined from 1.0 ms at -60 mV to 0.1 ms at 0 mV in the F mode, from 4.6 ms at -40 mV to 1.1 ms at 0 mV in the S mode, and from 4.5 ms at -40 mV to 0.8 ms at +20 mV in the P mode, respectively. The probability of non-empty traces (net), the mean number of openings per non-empty trace (op/tr), and the mean open probability per trace (popen) were evaluated at 4-ms test pulses. net inclined from 30% at -60 mV to 63% at 0 mV in the F mode, from 4% at -90 mV to 90% at 0 mV in the S mode, and from 2% at -60 mV to 79% at +20 mV in the P mode. op/tr declined from 1.4 at -60 mV to 1.1 at 0 mV in the F mode, from 4.0 at -60 mV to 1.2 at 0 mV in the S mode, and from 2.9 at -40 mV to 1.6 at +20 mV in the P mode. popen was bell-shaped with a maximum of 5% at -30 mV in the F mode, 48% at -50 mV in the S mode, and 16% at 0 mV in the P mode. It is concluded that 1) a switch between F and S modes may reflect a functional change of inactivation, 2) a switch between S and P modes may reflect a functional change of activation, 3) tauh is mainly determined by the latency until the first channel opening in the F mode and by the number of reopenings in the S and P modes, 4) at least in the S and P modes, inactivation is independent of pore opening, and 5) in the S mode, mainly open channels inactivate, and in the P mode, mainly closed channels inactivate.