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Prospects of plasma medicine: Applications of Tissue Tolerable Plasmas (TTP) Based on the current knowledge on the physical properties and biological effects of tissue tolerable plasma (ttp) potential perspectives of plasma medicine are discussed. Currently, the foundations for the following medical applications of ttp are developed by an interdisciplinary research team: Prevention and/or treatment of diseases such as chronic wounds, skin and mucosal infectious diseases, localized tumors, promotion of angiogenesis, and tissue ablation Inhibition and/or elimination of biofilms by prevention of biofilm development due to surface treatment and/or plasma steered application of antimicrobial active layers with drug delivery function on foreign objects implanted into humans (implantable prosthesis, contact lenses, stents etc.) as well as elimination of biofilms by direct action of ttp on surfaces and tissues (chronic wounds, tooth surface, prosthesis) promotion of the incorporation of implants into viable tissue by changing the surface of materials (hydrophobicity) Promotion of penetration of topically applied drugs with therapeutic results Assessment of veterinary indications Improved cleaning performance in reprocessing of medical devices by surface modification.  相似文献   

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Transferability – a fundamental problem for fatigue life prediction Frequently specimen fatigue data have to be applied for fatigue life assessment of components and structures. It has to be assured that such data are relevant for the component under consideration. Equally it has to be assured that constant amplitude S-N data can be used for fatigue assessment in the case of spectrum loading. It is shown that application of transfer functions which are often of empirical nature requires an understanding of basic principles of material and component behaviour. Life prediction concepts should acknowledge the existence and relative portion of the crack initiation and crack propagation phases which are dominated by different mechanisms.  相似文献   

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Hot work tools are subjected to complex thermal and mechanical loads during hot forming processes. Locally, the stresses can exceed the material's yield strength in highly loaded areas. During mass production, this leads to cyclic plastic deformations and thermomechanical fatigue of the tools, which can be a major lifetime limiting factor. However, established concepts for thermomechanical fatigue life assessment of hot work tools do not exist, since this aspect first reached attention in the last years with the needs for higher resource and energy efficiency as well as optimized manufacturing processes (e. g. in the frame of Industrie 4.0). Hence, in this paper, the contemporary industrially used concepts for dimensioning hot forming tools regarding the tooling fatigue life are presented. Furthermore an overview of existing plasticity and lifetime models is given. The models are divided in phenomenological and mechanism based models. The review shows that further research is essential in this field.  相似文献   

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MOCH-Method – a Contribution to the Determination of Adhesion of Coatings A method is proposed to determine the fracture mechanics characteristics. A ?crack”? is produced in a well defined area by partial contamination. K- and G-factors are calculated by the compliance method. The fracture surfaces are investigated.  相似文献   

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Determination of input data for numerical design of sheet steels – Report on a common research project of the steel and automotive industry Within the scope of a common research project of the steel and automotive industry, 20 sheet steels have been investigated to obtain input data for FE‐analysis. In detail, elastic, plastic and fatique characteristical values were determined by several testing institutes for a period of 3 years. The investigated sheet steels differ with regard to the microstructure and the steel concept. Beside several ferritic steels, multiphase steels like dual phase‐, complex phase‐ and TRIP steels as well as 2 austenitic stainless steels were characterised. The starting materials and selected steels with a defined predeformation and heat treatment were investigated. Within this project, the partners developed a testing and documentation precept in which the ways and means were fixed to reach the defined steel condition and to enable a standardised testing and data output for the material database, realised by the automotive industry. Before the actual elastic, plastic and fatique testing, a reception test for all steels was carried out to characterise the materials with regard to the microstructure, surface condition, chemical composition and mechanical properties, obtained in the quasistatic tensile test. The results of the different testing institutes (elastic, plastic and fatique) will be presented in separate publications in detail. As a result of this project it became obvious that the investigated steels can be divided into steel groups which show a similar strain hardening behaviour. Thus, a prediction of mechanical values and flow curves for cognate steels within one steel group seems to be possible. This subject will be the focus of further investigations within the scope of a new project started on January 1st, 2003.  相似文献   

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