纳米羟基磷灰石的常压合成与表征

以乙二醇为氢氧化钙的溶剂在常压下合成了一种纳米羟基磷灰石晶体。分析结果表明，以乙二醇为氢氧化钙(Ca(OH)2)的溶剂反应合成的羟基磷灰石为细针状的纳米晶体，具有弱结晶结构，为非化学计量，其钙磷摩尔比约为1．66。这种纳米磷灰石晶体和自然骨中的磷灰石晶体在很多方面有相似之处。     

超声条件下羟基磷灰石纳米针状晶体的制备

采用超声波处理技术,在常压下用湿化学沉淀法制备羟基磷灰石纳米针状晶体.通过控制超声处理过程中的超声时间和超声时分散剂的含量,研究了制备过程中超声处理务件对纳米针状经基磷灰石形态和结晶度的影响,得知采用超声处理有助于对人体骨纳米针状晶羟基磷灰石的模拟制备.     

纳米类骨磷灰石晶体合成

采用硝酸钙和磷酸钠水溶液以不同滴定顺序,于70℃下合成了纳米羟基磷灰石(n-HA)沉积物.结果表明,不同的滴定顺序得到的产物都是n-HA晶体,合成的n-HA具有与骨磷灰石晶体十分类似的组成成分、尺寸、结晶度和形貌,因此,合成的n-HA可称为类骨磷灰石晶体.考察了不同滴定顺序对n-HA形貌、结晶度和尺寸的影响;发现相同温度下,磷酸钠滴定硝酸钙得到的磷灰石呈现相对规整的针状晶体,结晶度高,杂质离子少.     

羟基磷灰石纳米针晶与聚酰胺仿生复合生物材料研究

通过溶液共混法制备了羟基磷灰石纳米针晶与聚已二酰已二胺生物医用复合材料,用透射电镜、红外光谱仪和转靶X-射线衍射仪对复合材料的形态、组成和结构进行了分析,证明纳米复合材料中羟基磷灰石针晶与高分子基底之间产生了键合,具有稳定的界面,各种分析表明,这是一种类骨的高强柔韧复合材料,充分发挥了羟基磷灰石优良的生物相容性,在骨修复和组织工程方面具有广阔的应用前景。     

纳米级类骨磷灰石晶体的研制

用一种新的方法制备了纳米级磷灰石晶体。用等离子发射光谱(ICP)检测此磷灰石晶体中钠离子(Na^ )的含量,用红外(IR)、X射线衍射(XRD)、透射电镜(TEM)分析和表征了纳米磷灰石晶体的组成、结构、结晶度和形貌。结果表明此纳米磷灰石晶体有与自然骨磷灰石晶体十分类似的组成、结构、结晶度和形貌,同样含有碳酸根、磷酸氢根和钠离子。     

生物羟基磷灰石的合成

综述了生物羟基磷灰石合成研究的最新进展，重点介绍和评述了羟基磷灰石的合成与制备方法，讨论了各种方法的特点和应用前景。最新的研究动态表明，羟基磷灰石研究从基本的化学反应合成向生物矿化与新生骨引导机理及硬组织再造技术方向发展。同时，羟基磷灰石在金属、陶瓷等植入体表面的涂层、以及天然材料制备羟基磷灰石依然是其合成研究的主要方向。     

羟基磷灰石纳米晶化学合成及生物学评价

综述了羟基磷灰石纳米晶化学制备方法的主要影响因素及优缺点,并讨论了其医学应用中的安全性及生物学评价问题.     

羟基磷灰石（HA）生物复合材料的研究进展

综述了强韧化羟基磷灰石生物复合材料的类型,烧结制备和力学性能等方面的研究进展,并简单介绍了功能性活性ＨＡ生物复合材料。     

水热法制备针状羟基磷灰石

采用水热均相沉淀法制备了针状纳米羟基磷灰石（ＨＡｐ）。考察反应的ｐＨ值,水热温度,水热时间,分散剂对生成羟基磷灰石颗粒大小的影响。结果表明：控制反应物溶液的ｐＨ为１１．０,水热温度１５０℃陈化２０ｈ可以获得结晶良好的羟基磷灰石;随着陈化时间的延长,晶体长度增加;加入分散剂可以降低羟基磷灰石的尺寸,并改善粒径分布。     

纳米羟基磷灰石球状晶体的合成及其吸附特性的研究

以硝酸钙和磷酸氢二铵为先驱体，通过简易的湿法合成制备了纳米级的羟基磷灰石球状晶体(简称HAP)。在适当的条件下，得到了粒径为20nm左右的球状HAP超细粉体。运用XRD和TEM对HAP结晶的形貌及结构进行分析，同时还运用Zeta电位仪研究了纳米羟基磷灰石表面电位随溶液PO4^3-浓度、Ca^2 浓度、离子强度和pH值的变化规律，并且简要地分析了纳米HAP晶体的形貌和尺寸大小与表面静电位的关系。     

模拟体液法快速合成羟基磷灰石纳米针

采用模拟体液法快速制备羟基磷灰石（HA）纳米针,并研究了HA生长机制。分析结果表明,仅反应lmin就可以获得宽约5nm,长50-80nm且分散良好的HA纳米针,形貌和尺寸与人体骨中的HA极为相似。反应时间影响合成产物的形貌及物相,短时间内延长反应时间有利于HA纳米针的生长,但反应时间超过48h会导致HA与过量的HPO4,2-反应生成Ca3（PO4）2。     

Preparation of hydroxyapatite-carbon nanotube composite nanopowders

Here we report a simple preparation of composite nanopowders made of hydroxyapatite (HA) and carbon nanotube (CNT). In particular, CNTs were ionically modified to dissolve homogeneously in a series of organic solvents, including tetrahydrofuran and ethanol. The addition of HA nanopowders within the CNTs solution resulted in rapid precipitation of the composite HA-CNTs nanopowders. High resolution electron image revealed individual CNTs were evenly distributed within the cluster of HA nanoparticulates. A maximal concentration of CNTs to be organized within the HA nanopowder was highly dependent on the physicochemical characteristics of HA powders. A pilot biological assessment of the composite powders demonstrated favorable adhesion and growth of tissue cells. The developed HA-CNTs composite nanopowders may be potentially useful as an initial powder source for HA-CNT nanocomposites or coatings in biomedical applications.     

模拟体液法快速合成羟基磷灰石纳米针及其吸附性能研究

采用模拟体液法快速制备羟基磷灰石(HA)纳米针,并研究了HA对牛血清蛋白质(BSA)的吸附性能。采用XRD、TEM、SEAD和FT-IR等分析方法表征样品。结果表明:1min即可快速制备宽约5nm,长为50～80nm且分散良好的HA纳米针,形貌和尺寸与人体中的HA极为相似;反应时间影响合成产物的形貌及物相,短时间内延长反应时间有利于HA纳米针的生长,但反应时间过长会导致HA再次反应生成Ca3(PO4)2;同时,快速制备的HA纳米针具有很强的吸附性能。     

Sol-gel Preparation and Preliminary in vitro Evaluation of Fluorapatite／Hydroxyapatite Solid Solution Films

Fluorapatite/hydroxyapatite solid solution has better biological properties than other apatites, especially used as films or coatings. In this work, sol-gel preparation and in vitro behavior of fluorapatite/hydroxyapatite solid solution films on titanium alloy were investigated. Ca(NO3)2-4H20 and PO(OH)x(OEt)3-x were selected as precursors, and hexafluorophosphoric acid (HPFo) was used as a fluorine containing reagent. The Ca and P precursors were mixed with HPFo to keep the Ca/P molar ratio 1.67. The mixtures refluxed for 12 h were used as dipping sols for the preparation of the films. The phase of the films obtained at 600℃ was apatite. The F contents in the films increased with the concentrations of HPF6 in the dipping sols. The solid solution films were shown to have better stability than hydroxyapatite films, and a reasonably good bioactivity in the in vitro evaluation.     

Snail Shell Derived Natural Hydroxyapatite: Effects on NIH-3T3 Cells for Orthopedic Applications

Hydroxyapatite [HAP] and tricalcium phosphate [ß-TCP] are a class of calcium phosphate related ceramic materials that are widely used in tissue regeneration and biomedical applications owing to their excellent bioactivity and biocompatibility. In this investigation, nanocrystalline pure HAP was prepared via sol–gel method by incorporating snail shell as calcium precursor with different phosphorus sources such as triethyl phosphate/phosphite (without using any additives like pH maintaining solutions or gelling agents). Nanocrystalline HAP and biphasic calcium phosphate (HAP + ß TCP) were prepared from triethyl phosphate and triethyl phosphite precursors, respectively. The prepared material was further characterized by powder XRD, IR, Raman spectroscopy, and thermo-gravimetrical analysis to confirm the phase purity, functional groups, and thermal stability. SEM coupled with EDAX was also used to examine the size, shape of particles, and elemental composition of Ca to P ratio in the material. Different phosphorus based HAP has shown rod and spherical shaped surface morphology which was further confirmed by TEM analysis. MTT assay was performed using NIH-3T3 fibroblast cell lines which indicated that the viability was not affected in various concentrations of pure nanocrystalline HAP (12.5–100 µg/ml). This study confirms the improved biocompatibility of biowaste converted HAP which would have implications in biomedical applications.