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Maud Sabine Cansell Aurélie Battin Pascal Degrace Joseph Gresti Pierre Clouet Nicole Combe 《Lipids》2009,44(3):237-247
The study was undertaken to determine whether eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3),
esterified in phospholipids (PL) as liposomes or in triglycerides (TG) as oil, exhibited comparable fates in liver lipids
and whether these fates were associated with gene expressions related to fatty acid (FA) metabolism. PL and TG mixtures with
close contents in EPA and DHA were administered to rats over 2 weeks. Most relevant events occurred after 3 days for both
treatments. At that time, liposomes, compared with oil, increased the liver content in PL with a FA composition enriched in
n-6 FA, comparable in DHA and much lower in EPA. Moreover, liposomes increased the activity and mRNA levels of carnitine palmitoyltransferase
(CPT) I. In contrast, fish oil exerted opposite effects on CPT I and increased the genic expression of lipogenic enzymes.
Liposomes, unlike fish oil, apparently increased the mRNA levels of acyl-CoA oxidase and the activity of the peroxisomal FA-oxidising
system. Concomitantly, mRNA levels of hepatic lipoprotein receptors were increased with both diets, but intracellular proteins
involved in free FA uptake and lipid synthesis were up-regulated only with liposome-treated rats. The quasi absence of EPA
in hepatic PL of liposome-treated rats on the short term could result from increased β-oxidation activities through metabolic
regulations induced by more available free EPA and other PUFA. 相似文献