Influence of CYP3A5 polymorphism on tacrolimus blood concentrations in renal transplant patients

Objective Tacrolimus is an immunosuppressive drug with narrow therapeutic range and wide interindividual variation in its pharmacokinetics. Tacrolimus is a substrate of cytochrome P450(CYP)3A5. The aim of this study was to evaluate whether the A6986G polymorphism is associated with tacrolimus concentration /dose ratio. Methods Fifty-two Chinese renal transplant patients were enrolled in this study. Their body weight, dosage and concentration of tacrolimus were observed. CYP3A5 genotype was determined by polymerase chain reaction followed by restriction fragment length polymorphism analysis. Results A significant association was found between tacrolimus levels per dose/kg/d and CYP3A5 gene A6986G polymorphism (P<0.001). The CYP3A5 * 3 * 3 patients have a significantly higher tacrolimus level/dose than CYP3A5 * 1 * 1 and CYP3A5 * 1 * 3. Conclusions CYP3A5 gene A6986G polymorphism is associated with tacrolimus pharmacokinetics and dose requirements. Pharmacogenetic methods could be employed prospectively to help the dose selection and to individualize immunosuppressive therapy according to the result. Foundation item: Project (03GZ3072) supported by the Science and Technology Department of Hunan Province; project (2004035206) supported by the China Postdoctoral Foundation and project (30300383) supported by the National Natural Sciences Foundation of China     

C3A对水泥净浆结粒的影响

对水泥净浆结粒研究发现，熟料中C3A含量的波动，带来结粒量较大的变化，配制5种不同C3A含量的水泥，进行结粒研究。结果表明：C3A是影响水泥净浆结粒的主要因素，水泥结粒量随着水泥矿物成分中C3A的含量的增加而增大；随着净浆结粒程度的加大，体系更倾向于形成颗粒体积较大的结粒；C3A对水泥净浆结粒的作用要远大于水化温度对结粒的影响。     

改性5A分子筛吸附净化PH3的实验研究

为综合利用泥磷制取次磷酸钠反应尾气中的PH3气体,研究了改性5A分子筛吸附净化PH3的相关内容.研究结果表明吸附剂制备过程中较适宜的条件为:改性剂NaCl溶液,改性剂浓度0.3 mol/L,干燥温度110℃,焙烧温度300℃;吸附实验过程中较适宜的气体流速为20 mL/min.     

3-羟基-5-苯基异噁唑的合成研究

使用苯甲酰氯与乙酰乙酸乙酯反应，制得苯甲酰乙酸乙酯。然后经羰基保护，羟胺缩合等反应制得3-羟基-5-苯基异唑，产率≥60％。同时还分离出异构体3-苯基-2-异唑琳酮-5。产品结构经IR、元素分析等确证。     

Influence of nucleating agent on the formation of C4A3S

The reference test methods are carried out parallelly, by means of chemical analysis, X-ray diffraction, differential scanning calorimetry-thermogravimetry, scanning electron microscopy and polarized optical microscope to study the formation of C4A3S in the presence and absence of nucleating agent. The results show that nucleating agent with high calcium and low heat consumption as tricalcium silicate (C3S) promotes the formation of C4A3S and increases desulfurization degree obviously. During calcining raw meals doped with C3S, the grain sizes of C4A3S are larger compared with that without C3S. And at the same calcining level, the mass loss and the heat consumption belonged to CaCO3 decomposition is reduced.     

基于SPM5的视觉刺激3T功能磁共振成像数据处理研究

脑功能磁共振成像可以无创伤地观察人脑内部各个脑区的变化。3T高场磁共振成像设备信噪比更佳,提供的信息更详尽以及空间分辨率更高,目前正逐渐在国内外推广使用。SPM5是现今最流行的功能磁共振成像（functional Magnetic Resonance Imaging,fMRI）数据处理软件。文章基于SPM5数据处理软件对3T高场功能磁共振成像设备所获取的视觉刺激实验数据进行分析处理,实验结果更清晰、更直观、更精确地反映了相应脑区的变化。     

中间相C3A对硅酸盐水泥水化的影响

在现有理论基础上,探讨了中间相Ｃ３Ａ对硅酸盐水泥水化反应历程的影响,认为Ｃ３Ａ矿物与硅酸盐矿物水化产物ＣＨ反应仅是中间过程,其反应前后未改革浆体中的ＣＨ浓度,提出了Ｃ３Ａ吸收高浓度处的ＣＨ,经反应将其输到ＣＨ浓度较低的Ｃ３Ａ水化产物周界中,通过在原质下的吸收放出的“囊泵”作用促进硅酸盐水泥水化,该作用是非显著的物理作用,而非化学作用。     

基于HTML5+CSS3实现天气预报网站主题页面

在传统的web设计中,当网页中需要显示动画或特效时,需要使用Java Script脚本或Flash来实现。介绍利用CSS3实现天气预报网站主题页面实现旋转、缩放、移动和过渡等效果。     

滤波连接器用CaTiSiO5-CaTiO3-TiO2系陶瓷接触体的烧成工艺研究

滤波连接器是非常具有开发潜力的电子设备,因此研制性能优良、体积小的陶瓷接触体在市场竞争中极具优势。以CaTiSiO5-CaTiO3-TiO2系介质瓷为研究对象,分析了预烧温度、烧成温度、保温时间等工艺参数对试样密度及介电性能的影响,得到了一组优化的烧成工艺制度。     

Effect of GTA on Gas Transporting SHS of Ti_5Si_3

By doping gas transport agents (GTA), the combustion process and structural formation of SHS can be significantly varied. In this paper, Ti5Sis was synthesized by SHS method using AICI3·6H2O as GTA. The effect of GTA was studied by measuring combustion process parameters. XRD and SEM were used to determine the phases and microstructures of products. The structural formation of 7V6Si3 with different GTA contents was studied by CFQ method. Three mechanisms were deduced.     

赤霉素粉剂中赤霉素的测定

Fe3 + 作氧化剂 ,在沸水浴加热条件下被赤霉素还原产生 Fe2 + ,剩余 Fe3 + 用 F-掩蔽 ,p H=2～8范围内 Fe2 + 与邻菲口罗啉显色形成桔红色络合物 ,其最大吸收波长为 5 1 0 nm,建立了分光光度法测定赤霉素的新方法 ,赤霉素质量浓度在 0～ 1 6 mg/L内服从比耳定律 ,其回归方程为 A=0 .0 6 3 6 6ρ- 0 .0 0 9,相关系数 γ为 0 .9989,测定的表观摩尔吸光系数为 ε510 =1 .1× 1 0 4 L·mol-1·cm-1。此方法用于赤霉素粉剂中赤霉素的测定 ,结果与液相色谱法结果一致     

1-甲基-3-乙基-5-吡唑酸乙酯的合成研究

1-甲基-3-乙基-5-吡唑酸乙酯是杀螨剂吡螨胺的重要中间体.探讨了Knorr环合法制备1-甲基-3-乙基-5吡唑酸乙酯的工艺;合成丙酰丙酮酸乙酯中,对反应温度和反应溶剂进行了优化试验,发现用乙醚作溶剂在5℃以下时,反应收率和中间体含量分别达到90%和95%以上.制备1-甲基-3-乙基-5吡唑酸乙酯中,对反应温度和甲基肼与丙酰丙酮酸乙酯的摩尔比进行了优化试验,发现在0℃以下,摩尔比在1:1.2以上时,目标产物的含量和收率达到95%和85%以上.产品结构经MS,1HNMR,IR表征.     

气相传输SHS合成Ti_5Si_3的结构形成过程

测定了Ti5Si3系统气相传输SHS合成的过程参数,采用燃烧波峰淬熄法研究了气相传输助剂对燃烧产物结构形成过程的影响。发现掺加一定量的气相传输助剂可使化学反应速度提高,对应于不同气相传输助剂含量的体系存在三种不同的产物结构形成过程。     

基于S3C2440A的低功耗网络故障诊断设备的硬件设计

在野外环境中,通过网络故障诊断设备对丧失网络功能的设备进行故障检测,但由于野外客观条件的限制,网络故障诊断设备采用电池供电方式,因此在设计中需要延长电池使用时间保障设备正常运行．针对采用S3C2440A处理器的网络故障诊断设备,在设计中融入低功耗的思想,在不影响其正常工作的前提下,采用了分模块供电、动态切换CPU工作模式等措施来降低设备的功耗,使设备的总体功耗大大降低,延长了网络故障诊断设备工作时间．     

A5/1算法可抵抗相关攻击的改进方法

在介绍A5/1算法的线性初始化弱点基础上,通过分析基于择多逻辑的互钟控机制的非平衡输出特点,详细论述了由此带来的相关攻击漏洞,指出了A5/1算法丢弃起始100比特远不能保证算法安全性。针对该漏洞,将互钟控移位延伸到了A5/1算法初始化过程中,从而有效堵塞了该漏洞,增强了A5/1算法的安全性。     

Upeonversion Luminescence of Er3＋, Tin3＋ and Yb3＋ Co-doped Gd3Ga5O12 Nanocrystals

A series of Er3+,Tm3+ and Yb3+ doped Gd3Ga5O12 nanocrystals were prepared by a combustion method.The X-ray diffraction(XRD),field emission scanning electron microscope(FESEM)and upconversion(UC)emission spectra were used to characterize the samples.The results of XRD indicate that Gd3Ga5O12:Er3+,Tm3+,Yb3+ nanocrystals with cubic phase can be obtained.Under the excitation of a 980 nm laser,the different rare earth ions doped Gd3Ga5O12 nanocrystals show upconversion luminescence involving the green emission attributed to the 2H11/2→4I15/2,4S3/2→4I15/2 transitions of Er3+ ions,respectively,the red emissions assigned to the 4F9/2→4I15/2 transitions of Er3+ ions and the 1G4→3F4 as well as 3F2,3→3H6 transitions of Tm3+ ions,respectively,the blue emission attributed to 1G4→3H6 transitions of Tm3+ions,and the near-infrared assigned to the 3H4→3H6 transitions of Tm3+ ions.The CIE coordinates for the samples are calculated.The dependence of their upconversion luminescence properties on Yb3+ ion concentration is investigated.     

N－3，5－二氯苯基丁二酰亚胺的合成研究

研究了Ｎ－３，５－二氯苯基丁二酰亚胺合成工艺。详细讨论了影响产物收率的主要因素。首次提出了先经回流再脱水的新工艺，合成收率达９０％以上。     

Formation mechanism of Ti5Si3 powder by mechanical alloying

The formation mechanism of stoichiometry Ti5Si3 by mechanical alloying (MA) from elemental powders has been investigated. The results of XRD and SEM analyses of the powder show that Ti5Si3 can be synthesized by MA in a planetary mill with two different formation mechanisms. Ti5Si3 was formed gradually with the mechanical collusion reaction (MCR) mechanism under a lower impact energy, and the Ti5Si3 was formed abruptly with the self-propagating high-temperature synthesis (SHS) formation mecha-nism under a higher impact energy.     

以NTO为主体的钝感炸药的性能及应用

为了探索新的钝感药剂,对以3-硝基-1,2,4三唑-5-酮(NTO)为主体的药剂发展进行了综述.研究表明:NTO是一种能量高、安全性好、成本低并与常用材料相容的钝感炸药,以其为主体的配方在能量方面可超过B炸药,并且能够通过钝感弹药试验,因而有利于提高弹药的本质安全和威力.选择可与之发生较强酸碱作用的粘结剂和适当的工艺可以克服其酸性高和溶于水的缺陷.